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References from Secreted ISG15 induced by Chlamydia trachomatis infection exerts immunomodulatory effects on IFN-γ defense and inflammation. Local targets link to admitted publications; unresolved targets remain external evidence.
Global estimates of the prevalence and incidence of four curable sexually transmitted infections in 2012 based on systematic review and global reporting
10.1371/journal.pone.0143304 · 2015 · External reference
Chlamydia trachomatis infection in women with secondary infertility
10.1016/j.fertnstert.2007.05.070 · 2009 · External reference
Urogenital Chlamydia trachomatis serovars in men and women with a symptomatic or asymptomatic infection: an association with clinical manifestations?
10.1128/jcm.38.6.2292-2296.2000 · 2000 · External reference
Clinical practice. Genital chlamydial infections
10.1056/nejmcp030542 · 2003 · External reference
Immunity, immunopathology, and human vaccine development against sexually transmitted Chlamydia trachomatis
10.4161/hv.29683 · 2014 · External reference
The chlamydial developmental cycle
10.1016/j.femsre.2005.03.002 · 2005 · External reference
Chlamydia trachomatis responds to heat shock, penicillin induced persistence, and IFN-gamma persistence by altering levels of the extracytoplasmic stress response protease HtrA
10.1186/1471-2180-8-190 · 2008 · External reference
Imbalanced oxidative stress causes chlamydial persistence during non-productive human herpes virus co-infection
10.1371/journal.pone.0047427 · 2012 · External reference
Demonstration of persistent infections and genome stability by whole-genome sequencing of repeat-positive, Same-Serovar Chlamydia trachomatis collected from the female genital tract
10.1093/infdis/jix155 · 2017 · External reference
Chlamydia trachomatis persistence in vitro: an overview
10.1086/652394 · 2010 · External reference
Immune-mediated control of Chlamydia infection
2008 · External reference
Innate and adaptive immunity in female genital tract: cellular responses and interactions
10.1111/j.0105-2896.2005.00287.x · 2005 · External reference
Genital Chlamydia trachomatis: understanding the roles of innate and adaptive immunity in vaccine research
10.1128/cmr.00105-13 · 2014 · External reference
Pathogenesis of genital tract disease due to Chlamydia trachomatis
10.1086/652397 · 2010 · External reference
Cytokine polymorphisms and severity of tubal damage in women with Chlamydia-associated infertility
10.1086/597620 · 2009 · External reference
Chlamydia evasion of neutrophil host defense results in NLRP3 dependent myeloid-mediated sterile inflammation through the purinergic P2X7 receptor
10.1038/s41467-021-25749-3 · 2021 · External reference
Macrophages in tissue repair, regeneration, and fibrosis
10.1016/j.immuni.2016.02.015 · 2016 · External reference
Protective and pathogenic functions of macrophage subsets
10.1038/nri3073 · 2011 · External reference
Macrophage biology in development, homeostasis and disease
10.1038/nature12034 · 2013 · External reference
Genital tract infection with Chlamydia trachomatis fails to induce protective immunity in gamma interferon receptor-deficient mice despite a strong local immunoglobulin A response
10.1128/iai.65.3.1032-1044.1997 · 1997 · External reference
c-Myc plays a key role in IFN-γ-induced persistence of Chlamydia trachomatis
10.7554/elife.76721 · 2022 · External reference
An adaptive Chlamydia trachomatis-specific IFN-γ-Producing CD4+ T cell response is associated with protection against Chlamydia reinfection in women
10.3389/fimmu.2018.01981 · 2018 · External reference
VACCINES. A mucosal vaccine against Chlamydia trachomatis generates two waves of protective memory T cells
10.1126/science.aaa8205 · 2015 · External reference
T cell responses to Chlamydia
10.1093/femspd/ftab014 · 2021 · External reference
Monitoring the T cell response to genital tract infection
10.1073/pnas.0603866103 · 2006 · External reference
Innate IFN-γ is essential for systemic Chlamydia muridarum control in mice, while CD4 T cell-dependent IFN-γ production is highly redundant in the female reproductive tract
2021 · External reference
IFNγ: signalling, epigenetics and roles in immunity, metabolism, disease and cancer immunotherapy
10.1038/s41577-018-0029-z · 2018 · External reference
Role of NK cells in early host response to chlamydial genital infection
10.1128/iai.66.12.5867-5875.1998 · 1998 · External reference
NK cell-mediated processing of Chlamydia psittaci drives potent anti-bacterial Th1 immunity
10.1038/s41598-019-41264-4 · 2019 · External reference
IL-22 initiates an IL-18-dependent epithelial response circuit to enforce intestinal host defence
10.1038/s41467-022-28478-3 · 2022 · External reference
Biological and clinical roles of IL-18 in inflammatory diseases
10.1038/s41584-023-01053-w · 2024 · External reference
The STING pathway in response to chlamydial infection
10.1016/j.micpath.2019.103950 · 2020 · External reference
STING-dependent recognition of cyclic di-AMP mediates type I interferon responses during Chlamydia trachomatis infection
10.1128/mbio.00018-13 · 2013 · External reference
ISG15 in antiviral immunity and beyond
10.1038/s41579-018-0020-5 · 2018 · External reference
The ISG15 conjugation system broadly targets newly synthesized proteins: implications for the antiviral function of ISG15
10.1016/j.molcel.2010.05.002 · 2010 · External reference
ISG15 conjugation system targets the viral NS1 protein in influenza A virus-infected cells
10.1073/pnas.0909144107 · 2010 · External reference
Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation
10.1038/nature13801 · 2015 · External reference
Identification of a ubiquitin family protein as a novel neutrophil chemotactic factor
10.1016/j.bbrc.2003.08.038 · 2003 · External reference
Cysteine-reactive free ISG15 generates IL-1β-producing CD8α+ dendritic cells at the site of infection
10.4049/jimmunol.1701322 · 2018 · External reference
Mycobacterial disease and impaired IFN-γ immunity in humans with inherited ISG15 deficiency
10.1126/science.1224026 · 2012 · External reference
Extracellular ISG15 signals cytokine secretion through the LFA-1 integrin receptor
10.1016/j.molcel.2017.10.003 · 2017 · External reference
Intestinal epithelial cells express immunomodulatory ISG15 during active ulcerative colitis and Crohn’s disease
10.1093/ecco-jcc/jjaa022 · 2020 · External reference
The impact of ISGylation during Mycobacterium tuberculosis infection in mice
10.1016/j.micinf.2016.12.006 · 2017 · External reference
ISG15 counteracts Listeria monocytogenes infection
10.7554/elife.06848 · 2015 · External reference
Chlamydia trachomatis infection alters host cell transcription in diverse cellular pathways
10.1086/367962 · 2003 · External reference
Early transcriptional landscapes of chlamydia trachomatis-infected epithelial cells at single cell resolution
10.3389/fcimb.2019.00392 · 2019 · External reference
Organoids of the female reproductive tract
10.1007/s00109-020-02028-0 · 2021 · External reference
ISG15-Induced IL-10 is a novel anti-inflammatory myeloid axis disrupted during active tuberculosis
10.4049/jimmunol.1701120 · 2018 · External reference
Combined stimulation with interleukin-18 and interleukin-12 potently induces interleukin-8 production by natural killer cells
10.1159/000477172 · 2017 · External reference
Cutting edge: priming of NK cells by IL-18
10.4049/jimmunol.181.3.1627 · 2008 · External reference
Chlamydia trachomatis infection of epithelial cells induces the activation of caspase-1 and release of mature IL-18
10.4049/jimmunol.165.3.1463 · 2000 · External reference
Chlamydia muridarum induction of glandular duct dilation in mice
10.1128/iai.00154-15 · 2015 · External reference
Interferon-stimulated gene 15 in hepatitis B-related liver diseases
10.18632/oncotarget.11955 · 2016 · External reference
ISG15 is critical in the control of Chikungunya virus infection independent of UbE1L mediated conjugation
10.1371/journal.ppat.1002322 · 2011 · External reference
Inflammatory signaling in macrophages: transitions from acute to tolerant and alternative activation states
10.1002/eji.201141783 · 2011 · External reference
A circulating cell population showing both M1 and M2 monocyte/macrophage surface markers characterizes systemic sclerosis patients with lung involvement
10.1186/s12931-018-0891-z · 2018 · External reference
Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation
10.1038/ni.3205 · 2015 · External reference
Interferon gamma induces reversible metabolic reprogramming of M1 macrophages to sustain cell viability and pro-inflammatory activity
10.1016/j.ebiom.2018.02.009 · 2018 · External reference
Brief Report: Interferon-γ-mediated immunopathology potentiated by toll-like receptor 9 activation in a murine model of macrophage activation syndrome
10.1002/art.40683 · 2019 · External reference
Inflammasome-dependent IFN-γ drives pathogenesis in Streptococcus pneumoniae meningitis
10.4049/jimmunol.1201687 · 2012 · External reference
Regulation and functions of the IL-10 family of cytokines in inflammation and disease
10.1146/annurev-immunol-031210-101312 · 2011 · External reference
B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice
10.1073/pnas.1107913108 · 2011 · External reference
Biology and therapeutic potential of interleukin-10
10.1084/jem.20190418 · 2020 · External reference
Macrophage activation and polarization as an adaptive component of innate immunity
10.1016/b978-0-12-417028-5.00006-5 · 2013 · External reference
Chronic Toxoplasma gondii Infection exacerbates secondary polymicrobial sepsis
10.3389/fcimb.2017.00116 · 2017 · External reference
Chlamydia-driven ISG15 expression dampens the immune response of epithelial cells independently of ISGylation
2024 · External reference
Role of human macrophage polarization in inflammation during infectious diseases
10.3390/ijms19061801 · 2018 · External reference
Macrophage activation and polarization: nomenclature and experimental guidelines
10.1016/j.immuni.2014.06.008 · 2014 · External reference
M1 means kill; M2 means heal
10.4049/jimmunol.1701135 · 2017 · External reference
Macrophages and the recovery from acute and chronic inflammation
10.1146/annurev-physiol-022516-034348 · 2017 · External reference
ISG15, an interferon-stimulated ubiquitin-like protein, is not essential for STAT1 signaling and responses against vesicular stomatitis and lymphocytic choriomeningitis virus
10.1128/mcb.25.15.6338-6345.2005 · 2005 · External reference
Fate mapping analysis of lymphoid cells expressing the NKp46 cell surface receptor
10.1073/pnas.1112064108 · 2011 · External reference
the plasmid-encoded pGP3 promotes Chlamydia evasion of acidic barriers in both stomach and vagina
10.1128/iai.00844-18 · 2019 · External reference
