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References from The African swine fever virus p22 inhibits the JAK-STAT signaling pathway by promoting the TAX1BP1-mediated degradation of the type I interferon receptor. Local targets link to admitted publications; unresolved targets remain external evidence.
Autophagy in the pathogenesis of disease
10.1016/j.cell.2007.12.018 · 2008 · External reference
Cargo recognition and trafficking in selective autophagy
10.1038/ncb2979 · 2014 · External reference
African Swine Fever Virus Armenia/07 Virulent Strain Controls Interferon Beta Production through the cGAS-STING Pathway
10.1128/jvi.02298-18 · 2019 · External reference
Autophagy during viral infection - a double-edged sword
10.1038/s41579-018-0003-6 · 2018 · External reference
Sorting nexin 5 mediates virus-induced autophagy and immunity
10.1038/s41586-020-03056-z · 2021 · External reference
The ORF7a protein of SARS-CoV-2 initiates autophagy and limits autophagosome-lysosome fusion via degradation of SNAP29 to promote virus replication
10.1080/15548627.2022.2084686 · 2023 · External reference
Picornavirus VP3 protein induces autophagy through the TP53-BAD-BAX axis to promote viral replication
10.1080/15548627.2024.2350270 · 2024 · External reference
The nucleoprotein of influenza A virus inhibits the innate immune response by inducing mitophagy
10.1080/15548627.2022.2162798 · 2023 · External reference
African Swine Fever Virus Protein E199L Promotes Cell Autophagy through the Interaction of PYCR2
10.1007/s12250-021-00375-x · 2021 · External reference
African swine fever virus protein p17 promotes mitophagy by facilitating the interaction of SQSTM1 with TOMM70
10.1080/21505594.2023.2232707 · 2023 · External reference
The MGF300-2R protein of African swine fever virus is associated with viral pathogenicity by promoting the autophagic degradation of IKKα and IKKβ through the recruitment of TOLLIP
10.1371/journal.ppat.1011580 · 2023 · External reference
The African swine fever virus MGF300-4L protein is associated with viral pathogenicity by promoting the autophagic degradation of IKKβ and increasing the stability of IκBα
10.1080/22221751.2024.2333381 · 2024 · External reference
African Swine Fever Virus L83L Negatively Regulates the cGAS-STING-Mediated IFN-I Pathway by Recruiting Tollip To Promote STING Autophagic Degradation
10.1128/jvi.01923-22 · 2023 · External reference
African swine fever virus ubiquitin-conjugating enzyme pI215L inhibits IFN-I signaling pathway through STAT2 degradation
10.3389/fmicb.2022.1081035 · 2022 · External reference
African swine fever virus maintains de novo global cellular protein synthesis and inhibits stress granules formation via dephosphorylating eIF2α
10.1016/j.vetmic.2024.109988 · 2024 · External reference
Cytoplasmic Mechanisms of Recognition and Defense of Microbial Nucleic Acids
10.1146/annurev-cellbio-100617-062903 · 2018 · External reference
Mechanisms of type-I- and type-II-interferon-mediated signalling
10.1038/nri1604 · 2005 · External reference
Type I interferon signaling, regulation and gene stimulation in chronic virus infection
10.1016/j.smim.2019.05.001 · 2019 · External reference
Interferon-stimulated genes: a complex web of host defenses
10.1146/annurev-immunol-032713-120231 · 2014 · External reference
Type I Interferon (IFN)-Regulated Activation of Canonical and Non-Canonical Signaling Pathways
10.3389/fimmu.2020.606456 · 2020 · External reference
The receptor of the type I interferon family
2007 · External reference
Inactivation of Interferon Receptor Promotes the Establishment of Immune Privileged Tumor Microenvironment
10.1016/j.ccell.2017.01.004 · 2017 · External reference
Secreted LRPAP1 binds and triggers IFNAR1 degradation to facilitate virus evasion from cellular innate immunity
10.1038/s41392-023-01630-1 · 2023 · External reference
Respiratory syncytial virus non-structural protein 1 facilitates virus replication through miR-29a-mediated inhibition of interferon-α receptor
10.1016/j.bbrc.2016.08.142 · 2016 · External reference
Feline calicivirus strain 2280 p30 antagonizes type I interferon-mediated antiviral innate immunity through directly degrading IFNAR1 mRNA
10.1371/journal.ppat.1008944 · 2020 · External reference
Matrix Metalloproteinase 9 Facilitates Hepatitis B Virus Replication through Binding with Type I Interferon (IFN) Receptor 1 To Repress IFN/JAK/STAT Signaling
10.1128/jvi.01824-16 · 2017 · External reference
Cryo-EM Structure of the African Swine Fever Virus
2019 · External reference
Architecture of African swine fever virus and implications for viral assembly
10.1126/science.aaz1439 · 2019 · External reference
A Proteomic Atlas of the African Swine Fever Virus Particle
10.1128/jvi.01293-18 · 2018 · External reference
Protein p22 of African swine fever virus: an early structural protein that is incorporated into the membrane of infected cells
10.1016/0042-6822(91)90490-3 · 1991 · External reference
African swine fever virus replication and genomics
10.1016/j.virusres.2012.10.020 · 2013 · External reference
Evaluation of the Function of the ASFV KP177R Gene, Encoding for Structural Protein p22, in the Process of Virus Replication and in Swine Virulence
10.3390/v13060986 · 2021 · External reference
A High-Throughput Method to Analyze the Interaction Proteins With p22 Protein of African Swine Fever Virus In Vitro
10.3389/fvets.2021.719859 · 2021 · External reference
Deletion of the H240R Gene of African Swine Fever Virus Decreases Infectious Progeny Virus Production Due to Aberrant Virion Morphogenesis and Enhances Inflammatory Cytokine Expression in Porcine Macrophages
10.1128/jvi.01667-21 · 2022 · External reference
Inhibition of African Swine Fever Virus Replication by Porcine Type I and Type II Interferons
10.3389/fmicb.2020.01203 · 2020 · External reference
A role for ubiquitin in selective autophagy
10.1016/j.molcel.2009.04.026 · 2009 · External reference
The role of Atg proteins in autophagosome formation
10.1146/annurev-cellbio-092910-154005 · 2011 · External reference
Multifaceted roles of TAX1BP1 in autophagy
10.1080/15548627.2022.2070331 · 2023 · External reference
Expression, purification and crystallization of the SKICH domain of human TAX1BP1
10.1107/s2053230x14006396 · 2014 · External reference
African swine fever control and prevention: an update on vaccine development
10.1080/22221751.2022.2108342 · 2022 · External reference
African swine fever virus isolate, Georgia, 2007
10.3201/eid1412.080591 · 2008 · External reference
African Swine Fever Virus Undergoes Outer Envelope Disruption, Capsid Disassembly and Inner Envelope Fusion before Core Release from Multivesicular Endosomes
10.1371/journal.ppat.1005595 · 2016 · External reference
Treatment with interferon-alpha delays disease in swine infected with a highly virulent CSFV strain
10.1016/j.virol.2015.04.024 · 2015 · External reference
Recombinant beta interferon could clear the low-dose infected porcine reproductive and respiratory syndrome virus (PRRSV) in MARC-145 cells
10.4149/av_2016_03_290 · 2016 · External reference
Porcine alpha interferon inhibit Japanese encephalitis virus replication by different ISGs in vitro
10.1016/j.rvsc.2013.08.008 · 2013 · External reference
SARS-CoV-2 Disrupts Proximal Elements in the JAK-STAT Pathway
2021 · External reference
African Swine Fever Virus Cysteine Protease pS273R Inhibits Type I Interferon Signaling by Mediating STAT2 Degradation
2023 · External reference
Zika virus NS5 protein inhibits type I interferon signaling via CRL3 E3 ubiquitin ligase-mediated degradation of STAT2
2024 · External reference
Duplicated genes within the variable right end of the genome of a pathogenic isolate of African swine fever virus
10.1099/0022-1317-74-10-2125 · 1993 · External reference
The African swine fever virus I10L protein inhibits the NF-κB signaling pathway by targeting IKKβ
10.1128/jvi.00569-23 · 2023 · External reference
MGF360-9L Is a Major Virulence Factor Associated with the African Swine Fever Virus by Antagonizing the JAK/STAT Signaling Pathway
10.1128/mbio.02330-21 · 2022 · External reference
African swine fever virus pH240R enhances viral replication via inhibition of the type I IFN signaling pathway
2024 · External reference
African Swine Fever Virus MGF505-7R Interacts with Interferon Regulatory Factor 9 to Evade the Type I Interferon Signaling Pathway and Promote Viral Replication
10.1128/jvi.01977-22 · 2023 · External reference
Role of p38 protein kinase in the ligand-independent ubiquitination and down-regulation of the IFNAR1 chain of type I interferon receptor
10.1074/jbc.m111.238766 · 2011 · External reference
Mammalian casein kinase 1alpha and its leishmanial ortholog regulate stability of IFNAR1 and type I interferon signaling
10.1128/mcb.00478-09 · 2009 · External reference
ADP-ribosyltransferase PARP11 modulates the interferon antiviral response by mono-ADP-ribosylating the ubiquitin E3 ligase β-TrCP
10.1038/s41564-019-0428-3 · 2019 · External reference
Nix interacts with WIPI2 to induce mitophagy
10.15252/embj.2023113491 · 2023 · External reference
Nix is a selective autophagy receptor for mitochondrial clearance
10.1038/embor.2009.256 · 2010 · External reference
Replication and virulence in pigs of the first African swine fever virus isolated in China
10.1080/22221751.2019.1590128 · 2019 · External reference
Preparation and epitope mapping of monoclonal antibodies against African swine fever virus p22 protein
10.1016/j.ijbiomac.2023.128111 · 2024 · External reference
Hemadsorption and cytopathic effect produced by African Swine Fever virus in swine bone marrow and buffy coat cultures
1960 · External reference