Research graph
References from TNF signaling mediates cellular immune function and promotes malaria parasite killing in the mosquito Anopheles gambiae. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
2021 · External reference
Mosquito-Borne Diseases Emergence/Resurgence and How to Effectively Control It Biologically
10.3390/pathogens9040310 · 2020 · External reference
Vector biology meets disease control: using basic research to fight vector-borne diseases
10.1038/s41564-018-0214-7 · 2019 · External reference
Implications of insecticide resistance for malaria vector control with long-lasting insecticidal nets: a WHO-coordinated, prospective, international, observational cohort study
10.1016/s1473-3099(18)30172-5 · 2018 · External reference
Converting endogenous genes of the malaria mosquito into simple non-autonomous gene drives for population replacement
10.7554/elife.58791 · 2021 · External reference
Gene drive mosquitoes can aid malaria elimination by retarding Plasmodium sporogonic development
10.1126/sciadv.abo1733 · 2022 · External reference
Gene-drive suppression of mosquito populations in large cages as a bridge between lab and field
10.1038/s41467-021-24790-6 · 2021 · External reference
Molecular interactions between Anopheles stephensi midgut cells and Plasmodium berghei: the time bomb theory of ookinete invasion of mosquitoes
10.1093/emboj/19.22.6030 · 2000 · External reference
Functional genomic analysis of midgut epithelial responses in Anopheles during Plasmodium invasion
10.1016/j.cub.2005.06.044 · 2005 · External reference
Epithelial nitration by a peroxidase/NOX5 system mediates mosquito antiplasmodial immunity
10.1126/science.1209678 · 2012 · External reference
Regulation of anti-Plasmodium immunity by a LITAF-like transcription factor in the malaria vector Anopheles gambiae
10.1371/journal.ppat.1002965 · 2012 · External reference
Plasmodium falciparum evades mosquito immunity by disrupting JNK-mediated apoptosis of invaded midgut cells
10.1073/pnas.1423586112 · 2015 · External reference
Hemocyte differentiation mediates innate immune memory in Anopheles gambiae mosquitoes
10.1126/science.1190689 · 2010 · External reference
The role of hemocytes in anopheles gambiae antiplasmodial immunity
10.1159/000353765 · 2014 · External reference
Hemocyte differentiation mediates the mosquito late-phase immune response against Plasmodium in Anopheles gambiae
10.1073/pnas.1420078112 · 2015 · External reference
Activation of mosquito complement antiplasmodial response requires cellular immunity
10.1126/sciimmunol.aal1505 · 2017 · External reference
Chemical depletion of phagocytic immune cells in Anopheles gambiae reveals dual roles of mosquito hemocytes in anti-Plasmodium immunity
10.1073/pnas.1900147116 · 2019 · External reference
Mosquito midgut prostaglandin release establishes systemic immune priming
10.1016/j.isci.2019.07.012 · 2019 · External reference
Prostaglandin E2 Signaling Mediates Oenocytoid Immune Cell Function and Lysis, Limiting Bacteria and Plasmodium Oocyst Survival in Anopheles gambiae
10.3389/fimmu.2021.680020 · 2021 · External reference
Mosquito hemocyte-mediated immune responses
10.1016/j.cois.2014.07.002 · 2014 · External reference
Mosquito cellular immunity at single-cell resolution
10.1126/science.abc0322 · 2020 · External reference
Single-cell analysis of mosquito hemocytes identifies signatures of immune cell subtypes and cell differentiation
10.7554/elife.66192 · 2021 · External reference
Spatial and temporal in vivo analysis of circulating and sessile immune cells in mosquitoes: hemocyte mitosis following infection
10.1186/1741-7007-11-55 · 2013 · External reference
Characterization of hemocytes from the mosquitoes Anopheles gambiae and Aedes aegypti
10.1016/j.ibmb.2006.08.010 · 2006 · External reference
Genome-wide transcriptomic profiling of Anopheles gambiae hemocytes reveals pathogen-specific signatures upon bacterial challenge and Plasmodium berghei infection
10.1186/1471-2164-10-257 · 2009 · External reference
Insulin-like peptide 3 stimulates hemocytes to proliferate in anautogenous and facultatively autogenous mosquitoes
10.1242/jeb.243460 · 2022 · External reference
Blood feeding and insulin-like peptide 3 stimulate proliferation of hemocytes in the mosquito Aedes aegypti
10.1371/journal.ppat.1002274 · 2011 · External reference
Anopheles gambiae hemocytes exhibit transient states of activation
10.1016/j.dci.2015.10.020 · 2016 · External reference
Blood feeding induces hemocyte proliferation and activation in the African malaria mosquito, Anopheles gambiae Giles
2014 · External reference
Hemocyte differentiation to the megacyte lineage enhances mosquito immunity against Plasmodium
2022 · External reference
A mosquito lipoxin/lipocalin complex mediates innate immune priming in Anopheles gambiae
10.1038/ncomms8403 · 2015 · External reference
Inhibitors of Eicosanoid Biosynthesis Reveal that Multiple Lipid Signaling Pathways Influence Malaria Parasite Survival in Anopheles gambiae
10.3390/insects10100307 · 2019 · External reference
Death by TNF: a road to inflammation
10.1038/s41577-022-00792-3 · 2023 · External reference
The TNF family of ligands and receptors: Communication modules in the immune system and beyond
10.1152/physrev.00045.2017 · 2019 · External reference
Origin and evolution of TNF and TNF receptor superfamilies
10.1016/j.dci.2011.03.031 · 2011 · External reference
Identification of a TNF-TNFR-like system in malaria vectors (Anopheles stephensi) likely to influence Plasmodium resistance
10.1038/s41598-022-23780-y · 2022 · External reference
Evolution of TNF Signaling Mechanisms
10.1016/s0960-9822(02)00954-5 · 2002 · External reference
The Drosophila TNF ortholog Eiger: Emerging physiological roles and evolution of the TNF system
10.1016/j.smim.2014.05.003 · 2014 · External reference
Transiently “Undead” Enterocytes Mediate Homeostatic Tissue Turnover in the Adult Drosophila Midgut
10.1016/j.celrep.2020.108408 · 2020 · External reference
Extracellular Reactive Oxygen Species Drive Apoptosis-Induced Proliferation via Drosophila Macrophages
10.1016/j.cub.2015.12.064 · 2016 · External reference
A Drosophila model targets Eiger/TNFα to alleviate obesity-related insulin resistance and macrophage infiltration
10.1242/dmm.050388 · 2023 · External reference
Crystal cell rupture after injury in Drosophila requires the JNK pathway, small GTPases and the TNF homolog Eiger
10.1242/jcs.03420 · 2007 · External reference
The Drosophila TNF ortholog eiger is required in the fat body for a robust immune response
10.1159/000315050 · 2010 · External reference
Drosophila eiger mutants are sensitive to extracellular pathogens
10.1371/journal.ppat.0030041 · 2007 · External reference
Phagocytosis Is the Sole Arm of Drosophila melanogaster Known Host Defenses That Provides Some Protection Against Microsporidia Infection
10.3389/fimmu.2022.858360 · 2022 · External reference
Variation of TNF modulates cellular immunity of gregarious and solitary locusts against fungal pathogen Metarhizium anisopliae
10.1073/pnas.2120835119 · 2022 · External reference
A Drosophila Tumor Suppressor Gene Prevents Tonic TNF Signaling through Receptor N-Glycosylation
10.1016/j.devcel.2018.05.012 · 2018 · External reference
The Drosophila tumor necrosis factor receptor, Wengen, couples energy expenditure with gut immunity
10.1126/sciadv.add4977 · 2023 · External reference
Eiger and its receptor, Wengen, comprise a TNF-like system in Drosophila
10.1038/sj.onc.1206715 · 2003 · External reference
Use of clodronate liposomes to deplete phagocytic immune cells in Drosophila melanogaster and Aedes aegypti
10.3389/fcell.2021.627976 · 2021 · External reference
Rickettsia parkeri hijacks tick hemocytes to manipulate cellular and humoral transcriptional responses
10.3389/fimmu.2023.1094326 · 2023 · External reference
A genome-wide CRISPR screen in Anopheles mosquito cells identifies essential genes and required components of clodronate liposome function
2024 · External reference
Molecular Profiling of Phagocytic Immune Cells in Anopheles gambiae Reveals Integral Roles for Hemocytes in Mosquito Innate Immunity
10.1074/mcp.m116.060723 · 2016 · External reference
Plasmodium Oocysts: Overlooked Targets of Mosquito Immunity
10.1016/j.pt.2016.08.012 · 2016 · External reference
The Plasmodium bottleneck: malaria parasite losses in the mosquito vector
10.1590/0074-0276130597 · 2014 · External reference
The Aedes aegypti toll pathway controls dengue virus infection
2008 · External reference
Caspar controls resistance to Plasmodium falciparum in diverse anopheline species
10.1371/journal.ppat.1000335 · 2009 · External reference
An evolutionary conserved function of the JAK-STAT pathway in anti-dengue defense
10.1073/pnas.0905006106 · 2009 · External reference
The Anopheles innate immune system in the defense against malaria infection
10.1159/000353602 · 2014 · External reference
The Drosophila TNF Eiger Is an Adipokine that Acts on Insulin-Producing Cells to Mediate Nutrient Response
10.1016/j.cmet.2016.03.003 · 2016 · External reference
Midgut Epithelial Dynamics Are Central to Mosquitoes’ Physiology and Fitness, and to the Transmission of Vector-Borne Disease
10.3389/fcimb.2021.653156 · 2021 · External reference
Heterogeneity of midgut cells and their differential responses to blood meal ingestion by the mosquito, Aedes aegypti
10.1016/j.ibmb.2020.103496 · 2020 · External reference
Regulation of midgut cell proliferation impacts Aedes aegypti susceptibility to dengue virus
10.1371/journal.pntd.0006498 · 2018 · External reference
Tumor necrosis factor receptors: pleiotropic signaling complexes and their differential effects
10.3389/fimmu.2020.585880 · 2020 · External reference
Drosophila TNFRs Grindelwald and Wengen bind Eiger with different affinities and promote distinct cellular functions
10.1038/s41467-021-22080-9 · 2021 · External reference
Tumor necrosis factor-α signaling in macrophages
10.1615/critreveukargeneexpr.v20.i2.10 · 2010 · External reference
The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics
10.3390/ijms22052719 · 2021 · External reference
The STAT Pathway Mediates Late-Phase Immunity against Plasmodium in the Mosquito Anopheles gambiae
10.1016/j.chom.2009.04.003 · 2009 · External reference
Ingested human insulin inhibits the mosquito NF-κB-dependent immune response to Plasmodium falciparum
10.1128/iai.00024-12 · 2012 · External reference
Human IGF1 extends lifespan and enhances resistance to Plasmodium falciparum infection in the malaria vector Anopheles stephensi
10.1242/jeb.078873 · 2013 · External reference
Human IGF1 regulates midgut oxidative stress and epithelial homeostasis to balance lifespan and Plasmodium falciparum resistance in Anopheles stephensi
10.1371/journal.ppat.1004231 · 2014 · External reference
Mammalian transforming growth factor beta1 activated after ingestion by Anopheles stephensi modulates mosquito immunity
10.1128/iai.71.6.3000-3009.2003 · 2003 · External reference
MAPK ERK signaling regulates the TGF-beta1-dependent mosquito response to Plasmodium falciparum
10.1371/journal.ppat.1000366 · 2009 · External reference
The role of TNF-alpha in chronic inflammatory conditions, intermediary metabolism, and cardiovascular risk
10.1194/jlr.r600021-jlr200 · 2007 · External reference
Some strains of Plasmodium falciparum, a human malaria parasite, evade the complement-like system of Anopheles gambiae mosquitoes
10.1073/pnas.1121183109 · 2012 · External reference
The human malaria parasite Pfs47 gene mediates evasion of the mosquito immune system
10.1126/science.1235264 · 2013 · External reference
Plasmodium falciparum evades immunity of anopheline mosquitoes by interacting with a Pfs47 midgut receptor
10.1073/pnas.1917042117 · 2020 · External reference
OrthoDB v11: annotation of orthologs in the widest sampling of organismal diversity
10.1093/nar/gkac998 · 2023 · External reference
Extracellular vesicles secreted by Brugia malayi microfilariae modulate the melanization pathway in the mosquito host
10.1038/s41598-023-35940-9 · 2023 · External reference
