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References from Early-life RSV infection modulates innate immune events, preferentially enhancing allergen-induced type 2 lung inflammation in females. Local targets link to admitted publications; unresolved targets remain external evidence.
Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis
10.1016/s0140-6736(10)60206-1 · 2010 · External reference
Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study
10.1016/s0140-6736(17)30938-8 · 2017 · External reference
Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis
10.1016/s0140-6736(22)00478-0 · 2022 · External reference
Respiratory syncytial virus--a comprehensive review
10.1007/s12016-013-8368-9 · 2013 · External reference
Viral infections and the development of asthma in children
2013 · External reference
The relationship between respiratory syncytial virus infections and the development of wheezing and asthma in children
10.1097/01.all.0000200506.62048.06 · 2006 · External reference
Genes associated with RSV lower respiratory tract infection and asthma: the application of genetic epidemiological methods to understand causality
10.2217/fvl.15.55 · 2015 · External reference
Determinants of asthma after severe respiratory syncytial virus bronchiolitis
10.1016/j.jaci.2012.02.010 · 2012 · External reference
Global burden of asthma among children
10.5588/ijtld.14.0170 · 2014 · External reference
Enhanced allergic responsiveness after early childhood infection with respiratory viruses: Are long-lived alternatively activated macrophages the missing link?
10.1093/femspd/ftw047 · 2016 · External reference
Sex-associated TSLP-induced immune alterations following early-life RSV infection leads to enhanced allergic disease
10.1038/s41385-019-0171-3 · 2019 · External reference
Exposure of neonates to respiratory syncytial virus is critical in determining subsequent airway response in adults
10.1186/1465-9921-7-107 · 2006 · External reference
Age at first viral infection determines the pattern of T cell-mediated disease during reinfection in adulthood
10.1084/jem.20020943 · 2002 · External reference
The enhancement or prevention of airway hyperresponsiveness during reinfection with respiratory syncytial virus is critically dependent on the age at first infection and IL-13 production
10.4049/jimmunol.175.3.1876 · 2005 · External reference
Evidence for a causal relationship between respiratory syncytial virus infection and asthma
10.1586/eri.11.92 · 2011 · External reference
Human infant respiratory syncytial virus (RSV)-specific type 1 and 2 cytokine responses ex vivo during primary RSV infection
10.1086/518249 · 2007 · External reference
Type 1 and type 2 cytokine imbalance in acute respiratory syncytial virus bronchiolitis
10.1164/rccm.200210-1148oc · 2003 · External reference
Respiratory syncytial virus and other respiratory viruses during the first 3 months of life promote a local TH2-like response
10.1016/j.jaci.2005.07.012 · 2005 · External reference
Increased T-helper Cell 2 Response in Infants With Respiratory Syncytial Virus Bronchiolitis Hospitalized Outside Epidemic Peak
10.1097/inf.0000000000002505 · 2020 · External reference
Asthma, the sex difference
10.1097/mcp.0b013e3283410038 · 2011 · External reference
IL-33-experienced group 2 innate lymphoid cells in the lung are poised to enhance type 2 inflammation selectively in adult female mice
10.1186/s12931-024-03043-2 · 2024 · External reference
Sex differences in mouse models of asthma
10.1139/y07-116 · 2007 · External reference
Androgen signaling negatively controls group 2 innate lymphoid cells
10.1084/jem.20161807 · 2017 · External reference
Respiratory Syncytial Virus Disease Is Mediated by Age-Variable IL-33
10.1371/journal.ppat.1005217 · 2015 · External reference
Testosterone Attenuates Group 2 Innate Lymphoid Cell-Mediated Airway Inflammation
10.1016/j.celrep.2017.10.110 · 2017 · External reference
Elevated Levels of Type 2 Respiratory Innate Lymphoid Cells in Human Infants with Severe Respiratory Syncytial Virus Bronchiolitis
10.1164/rccm.201812-2366oc · 2019 · External reference
Defining the contribution of SNPs identified in asthma GWAS to clinical variables in asthmatic children
10.1186/1471-2350-14-100 · 2013 · External reference
Genetics of interleukin 1 receptor-like 1 in immune and inflammatory diseases
10.2174/138920210793360907 · 2010 · External reference
Approaches to the Prevention and Treatment of Respiratory Syncytial Virus Infection in Children: Rationale and Progress to Date
10.1007/s40272-023-00606-6 · 2024 · External reference
Predicted inactivation of viruses of relevance to biodefense by solar radiation
10.1128/jvi.79.22.14244-14252.2005 · 2005 · External reference
Preparation of Respiratory Syncytial Virus with High or Low Content of Defective Viral Particles and Their Purification from Viral Stocks
2016 · External reference
Building a better neonatal mouse model to understand infant respiratory syncytial virus disease
10.1186/s12931-015-0244-0 · 2015 · External reference
Adjuvant-dependent regulation of interleukin-17 expressing γδ T cells and inhibition of Th2 responses in allergic airways disease
10.1186/s12931-014-0090-5 · 2014 · External reference
Female-specific enhancement of eosinophil recruitment and activation in a type 2 innate inflammation model in the lung
10.1093/cei/uxad100 · 2024 · External reference
IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation
10.4049/jimmunol.0901575 · 2009 · External reference
STAT6 inhibitory peptide reduces dendritic cell migration to the lymph nodes to control Th2 adaptive immunity in the mouse lung
10.1002/eji.201847534 · 2019 · External reference
STAT6 inhibitory peptide given during RSV infection of neonatal mice reduces exacerbated airway responses upon adult reinfection
10.1189/jlb.4a0215-062rr · 2017 · External reference
Perinatal Activation of the Interleukin-33 Pathway Promotes Type 2 Immunity in the Developing Lung
10.1016/j.immuni.2016.10.031 · 2016 · External reference
Lung-resident eosinophils represent a distinct regulatory eosinophil subset
10.1172/jci85664 · 2016 · External reference
Phenotypic plasticity and targeting of Siglec-F(high) CD11c(low) eosinophils to the airway in a murine model of asthma
10.1111/all.12776 · 2016 · External reference
Sex Differences in IL-33-Induced STAT6-Dependent Type 2 Airway Inflammation
10.3389/fimmu.2019.00859 · 2019 · External reference
A Major Population of Functional KLRG1- ILC2s in Female Lungs Contributes to a Sex Bias in ILC2 Numbers
10.4049/immunohorizons.1800008 · 2018 · External reference
A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis
10.1084/jem.20130351 · 2013 · External reference
Interleukin-33 (IL-33): A nuclear cytokine from the IL-1 family
10.1111/imr.12619 · 2018 · External reference
The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1
10.1073/pnas.0812690106 · 2009 · External reference
Environmental allergens induce allergic inflammation through proteolytic maturation of IL-33
10.1038/s41590-018-0067-5 · 2018 · External reference
Th2 cytokines and asthma. Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists
10.1186/rr40 · 2001 · External reference
IL-5-induced airway eosinophilia--the key to asthma?
10.1034/j.1600-065x.2001.790118.x · 2001 · External reference
Interleukin-13 in asthma pathogenesis
10.1007/s11882-004-0057-6 · 2004 · External reference
Innate immunological function of TH2 cells in vivo
10.1038/ni.3244 · 2015 · External reference
MHCII-mediated dialog between group 2 innate lymphoid cells and CD4(+) T cells potentiates type 2 immunity and promotes parasitic helminth expulsion
10.1016/j.immuni.2014.06.016 · 2014 · External reference
Combined forced oscillation and forced expiration measurements in mice for the assessment of airway hyperresponsiveness
10.1186/1465-9921-11-82 · 2010 · External reference
The relationship between bronchiolitis and childhood asthma; a follow-up study of 100 cases of bronchiolitis
10.1016/0021-8707(59)90054-1 · 1959 · External reference
Respiratory syncytial virus infection during infancy and asthma during childhood in the USA (INSPIRE): a population-based, prospective birth cohort study
10.1016/s0140-6736(23)00811-5 · 2023 · External reference
Early-life respiratory syncytial virus disease and long-term respiratory health
10.1016/s2213-2600(24)00246-7 · 2024 · External reference
Adults face increased asthma risk after infant RSV bronchiolitis and reduced respiratory health-related quality of life after RSV pneumonia
10.1111/apa.12662 · 2014 · External reference
Asthma and allergy patterns over 18 years after severe RSV bronchiolitis in the first year of life
10.1136/thx.2009.121582 · 2010 · External reference
Poor airway function in early infancy and lung function by age 22 years: a non-selective longitudinal cohort study
10.1016/s0140-6736(07)61379-8 · 2007 · External reference
Comparing Postnatal Development of Gonadal Hormones and Associated Social Behaviors in Rats, Mice, and Humans
10.1210/en.2018-00220 · 2018 · External reference
Chronic IL-33 expression predisposes to virus-induced asthma exacerbations by increasing type 2 inflammation and dampening antiviral immunity
10.1016/j.jaci.2017.07.051 · 2018 · External reference
Respiratory Syncytial Virus Disease Severity Is Associated with Distinct CD8+ T-Cell Profiles
10.1164/rccm.201903-0588oc · 2020 · External reference
Allergens and the airway epithelium response: gateway to allergic sensitization
10.1016/j.jaci.2014.06.036 · 2014 · External reference
The alarmin interleukin-33 drives protective antiviral CD8⁺ T cell responses
10.1126/science.1215418 · 2012 · External reference
The interleukin-33-p38 kinase axis confers memory T helper 2 cell pathogenicity in the airway
10.1016/j.immuni.2015.01.016 · 2015 · External reference
IL-17E (IL-25) and IL-17RB promote respiratory syncytial virus-induced pulmonary disease
10.1189/jlb.0913482 · 2014 · External reference
NK cell deficiency predisposes to viral-induced Th2-type allergic inflammation via epithelial-derived IL-25
10.4049/jimmunol.1001758 · 2010 · External reference
Thymic stromal lymphopoietin is induced by respiratory syncytial virus-infected airway epithelial cells and promotes a type 2 response to infection
2012 · External reference
Critical Role of TSLP Receptor on CD4 T Cells for Exacerbation of Skin Inflammation
10.4049/jimmunol.1900758 · 2020 · External reference
Allergen-Experienced Group 2 Innate Lymphoid Cells Acquire Memory-like Properties and Enhance Allergic Lung Inflammation
10.1016/j.immuni.2016.06.017 · 2016 · External reference
Group 2 innate lymphoid cells are critical for the initiation of adaptive T helper 2 cell-mediated allergic lung inflammation
10.1016/j.immuni.2014.01.011 · 2014 · External reference
A chimeric A2 strain of respiratory syncytial virus (RSV) with the fusion protein of RSV strain line 19 exhibits enhanced viral load, mucus, and airway dysfunction
10.1128/jvi.01853-08 · 2009 · External reference
Innate Type 2 Responses to Respiratory Syncytial Virus Infection
10.3390/v12050521 · 2020 · External reference
