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References from Identification of the human cytomegalovirus gHgLgO trimer as the central player in virion infectivity. Local targets link to admitted publications; unresolved targets remain external evidence.
Pathogenesis of human cytomegalovirus in the immunocompromised host
10.1038/s41579-021-00582-z · 2021 · External reference
Cytomegalovirus vaccines under clinical development
10.1016/s2055-6640(20)30872-4 · 2016 · External reference
Vaccination against the human cytomegalovirus
10.1016/j.vaccine.2018.02.089 · 2019 · External reference
Lessons from Acquired Natural Immunity and Clinical Trials to Inform Next-Generation Human Cytomegalovirus Vaccine Development
10.1146/annurev-virology-100220-010653 · 2022 · External reference
Pathogen at the Gates: Human Cytomegalovirus Entry and Cell Tropism
10.3390/v10120704 · 2018 · External reference
The structural basis of herpesvirus entry
10.1038/s41579-020-00448-w · 2021 · External reference
The m74 gene product of murine cytomegalovirus (MCMV) is a functional homolog of human CMV gO and determines the entry pathway of MCMV
10.1128/jvi.02441-09 · 2010 · External reference
HCMV spread and cell tropism are determined by distinct virus populations
10.1371/journal.ppat.1001256 · 2011 · External reference
UL74 of human cytomegalovirus contributes to virus release by promoting secondary envelopment of virions
10.1128/jvi.01550-07 · 2008 · External reference
A human cytomegalovirus gO-null mutant fails to incorporate gH/gL into the virion envelope and is unable to enter fibroblasts and epithelial and endothelial cells
10.1128/jvi.02249-09 · 2010 · External reference
Platelet-derived growth factor-α receptor is the cellular receptor for human cytomegalovirus gHgLgO trimer
10.1038/nmicrobiol.2016.82 · 2016 · External reference
A derivative of platelet-derived growth factor receptor alpha binds to the trimer of human cytomegalovirus and inhibits entry into fibroblasts and endothelial cells
10.1371/journal.ppat.1006273 · 2017 · External reference
Importance of Highly Conserved Peptide Sites of Human Cytomegalovirus gO for Formation of the gH/gL/gO Complex
10.1128/jvi.01339-16 · 2016 · External reference
Human cytomegalovirus glycoprotein complex gH/gL/gO uses PDGFR-α as a key for entry
2017 · External reference
Cryo-Electron Microscopy Structure and Interactions of the Human Cytomegalovirus gHgLgO Trimer with Platelet-Derived Growth Factor Receptor Alpha
2021 · External reference
Structures of HCMV Trimer reveal the basis for receptor recognition and cell entry
10.1016/j.cell.2021.01.036 · 2021 · External reference
The Human Cytomegalovirus Trimer and Pentamer Promote Sequential Steps in Entry into Epithelial and Endothelial Cells at Cell Surfaces and Endosomes
2018 · External reference
Identification of functionally important domains of human cytomegalovirus gO that act after trimer binding to receptors
10.1371/journal.ppat.1010452 · 2022 · External reference
Non-redundant and redundant roles of cytomegalovirus gH/gL complexes in host organ entry and intra-tissue spread
2015 · External reference
The murine cytomegalovirus chemokine homolog, m131/129, is a determinant of viral pathogenicity
10.1128/jvi.73.8.6800-6809.1999 · 1999 · External reference
Virus progeny of murine cytomegalovirus bacterial artificial chromosome pSM3fr show reduced growth in salivary Glands due to a fixed mutation of MCK-2
10.1128/jvi.00545-11 · 2011 · External reference
Murine cytomegalovirus CC chemokine homolog MCK-2 (m131-129) is a determinant of dissemination that increases inflammation at initial sites of infection
10.1128/jvi.75.20.9966-9976.2001 · 2001 · External reference
Receptor-binding properties of a soluble form of human cytomegalovirus glycoprotein B
10.1128/jvi.72.3.1826-1833.1998 · 1998 · External reference
Role of PDGF receptor-α during human cytomegalovirus entry into fibroblasts
2018 · External reference
The N Terminus of Human Cytomegalovirus Glycoprotein O Is Important for Binding to the Cellular Receptor PDGFRα
10.1128/jvi.00138-19 · 2019 · External reference
A peptide inhibitor of cytomegalovirus infection from human hemofiltrate
10.1128/aac.00854-13 · 2013 · External reference
A viral regulator of glycoprotein complexes contributes to human cytomegalovirus cell tropism
10.1073/pnas.1419875112 · 2015 · External reference
Expression Levels of Glycoprotein O (gO) Vary between Strains of Human Cytomegalovirus, Influencing the Assembly of gH/gL Complexes and Virion Infectivity
10.1128/jvi.00606-18 · 2018 · External reference
Polymorphisms in Human Cytomegalovirus Glycoprotein O (gO) Exert Epistatic Influences on Cell-Free and Cell-to-Cell Spread and Antibody Neutralization on gH Epitopes
2020 · External reference
A guide to simple and informative binding assays
10.1091/mbc.e10-08-0683 · 2010 · External reference
The host exosome pathway underpins biogenesis of the human cytomegalovirus virion
10.7554/elife.58288 · 2020 · External reference
Transforming growth factor-beta (TGF-beta) receptor proteoglycan. Cell surface expression and ligand binding in the absence of glycosaminoglycan chains
1989 · External reference
Herpesviruses and heparan sulfate: an intimate relationship in aid of viral entry
10.1172/jci200113799 · 2001 · External reference
Early inhibitors of human cytomegalovirus: state-of-art and therapeutic perspectives
10.1016/j.pharmthera.2011.04.007 · 2011 · External reference
A Systems View of the Heparan Sulfate Interactome
10.1369/0022155420988661 · 2021 · External reference
An unbiased screen for human cytomegalovirus identifies neuropilin-2 as a central viral receptor
2018 · External reference
OR14I1 is a receptor for the human cytomegalovirus pentameric complex and defines viral epithelial cell tropism
10.1073/pnas.1814850116 · 2019 · External reference
Human Cytomegalovirus Cell Tropism and Host Cell Receptors
10.3390/vaccines7030070 · 2019 · External reference
Heparan sulfate proteoglycan binding by herpes simplex virus type 1 glycoproteins B and C, which differ in their contributions to virus attachment, penetration, and cell-to-cell spread
10.1128/jvi.72.7.6119-6130.1998 · 1998 · External reference
A human cytomegalovirus glycoprotein complex designated gC-II is a major heparin-binding component of the envelope
10.1128/jvi.66.3.1761-1764.1992 · 1992 · External reference
Human cytomegalovirus glycoprotein B is required for virus entry and cell-to-cell spread but not for virion attachment, assembly, or egress
10.1128/jvi.01251-08 · 2009 · External reference
Glycoprotein N of human cytomegalovirus protects the virus from neutralizing antibodies
10.1371/journal.ppat.1002999 · 2012 · External reference
A role for 3-O-sulfated heparan sulfate in promoting human cytomegalovirus infection in human iris cells
10.1128/jvi.00109-15 · 2015 · External reference
Single-cell analysis of memory B cells from top neutralizers reveals multiple sites of vulnerability within HCMV trimer and pentamer
10.1016/j.immuni.2023.10.009 · 2023 · External reference
Induction of tubulogenesis in telomerase-immortalized human microvascular endothelial cells by glioblastoma cells
10.1006/excr.2001.5424 · 2002 · External reference
Cloning and sequencing of a highly productive, endotheliotropic virus strain derived from human cytomegalovirus TB40/E
10.1099/vir.0.83286-0 · 2008 · External reference
The contribution of pUL74 to growth of human cytomegalovirus is masked in the presence of RL13 and UL128 expression
10.1099/jgv.0.000475 · 2016 · External reference
The disulfide bonds in glycoprotein E2 of hepatitis C virus reveal the tertiary organization of the molecule
10.1371/journal.ppat.1000762 · 2010 · External reference
Two-step red-mediated recombination for versatile high-efficiency markerless DNA manipulation in Escherichia coli
10.2144/000112096 · 2006 · External reference
DIA-NN: neural networks and interference correction enable deep proteome coverage in high throughput
10.1038/s41592-019-0638-x · 2020 · External reference
The MaxQuant computational platform for mass spectrometry-based shotgun proteomics
10.1038/nprot.2016.136 · 2016 · External reference
The PRIDE database resources in 2022: a hub for mass spectrometry-based proteomics evidences
10.1093/nar/gkab1038 · 2022 · External reference
