Research graph
References from SARS-CoV-2 encoded ORF3a interacts with YY1 to promote latent HCMV reactivation. Local targets link to admitted publications; unresolved targets remain external evidence.
Pathogenesis of human cytomegalovirus in the immunocompromised host
10.1038/s41579-021-00582-z · 2021 · External reference
The pathogenesis of human cytomegalovirus
10.1002/path.4437 · 2015 · External reference
Overview of Human Cytomegalovirus Pathogenesis
10.1007/978-1-0716-1111-1_1 · 2021 · External reference
Therapeutic vaccines for herpesviruses
10.1172/jci179483 · 2024 · External reference
Epigenetics and Genetics of Viral Latency
10.1016/j.chom.2016.04.008 · 2016 · External reference
Models of HCMV latency and reactivation
10.1016/s0966-842x(03)00149-5 · 2003 · External reference
Rethinking human cytomegalovirus latency reservoir
10.1111/nyas.14994 · 2023 · External reference
Spread of human cytomegalovirus (HCMV) after infection of human hematopoietic progenitor cells: model of HCMV latency
10.1182/blood.v90.6.2482 · 1997 · External reference
Temporal dynamics of HCMV gene expression in lytic and latent infections
10.1016/j.celrep.2022.110653 · 2022 · External reference
FOXO transcription factors activate alternative major immediate early promoters to induce human cytomegalovirus reactivation
10.1073/pnas.2002651117 · 2020 · External reference
The Pentamer glycoprotein complex inhibits viral Immediate Early transcription during Human Cytomegalovirus infections
10.1073/pnas.2408078121 · 2024 · External reference
Chromatin control of human cytomegalovirus infection
2023 · External reference
HCMV latency: what regulates the regulators?
10.1007/s00430-019-00581-1 · 2019 · External reference
Latency and reactivation of human cytomegalovirus
10.1099/vir.0.81891-0 · 2006 · External reference
Promoter-regulatory region of the major immediate early gene of human cytomegalovirus
10.1073/pnas.81.3.659 · 1984 · External reference
Role of the cytomegalovirus major immediate early enhancer in acute infection and reactivation from latency
10.1007/s00430-007-0069-7 · 2008 · External reference
NF-kappa B activation of the cytomegalovirus enhancer is mediated by a viral transactivator and by T cell stimulation
10.1002/j.1460-2075.1989.tb08610.x · 1989 · External reference
The promoter-regulatory region of the major immediate-early gene of human cytomegalovirus responds to T-lymphocyte stimulation and contains functional cyclic AMP-response elements
10.1128/jvi.63.7.3026-3033.1989 · 1989 · External reference
The CREB site in the proximal enhancer is critical for cooperative interaction with the other transcription factor binding sites to enhance transcription of the major intermediate-early genes in human cytomegalovirus-infected cells
10.1128/jvi.02239-08 · 2009 · External reference
The activator protein 1 binding motifs within the human cytomegalovirus major immediate-early enhancer are functionally redundant and act in a cooperative manner with the NF-{kappa}B sites during acute infection
10.1128/jvi.01713-10 · 2011 · External reference
Activator protein-1 transactivation of the major immediate early locus is a determinant of cytomegalovirus reactivation from latency
10.1073/pnas.2009420117 · 2020 · External reference
The transcription factor YY1 binds to negative regulatory elements in the human cytomegalovirus major immediate early enhancer/promoter and mediates repression in non-permissive cells
10.1093/nar/22.13.2453 · 1994 · External reference
Analysis of proteins binding to the proximal promoter region of the human cytomegalovirus IE-1/2 enhancer/promoter reveals both consensus and aberrant recognition sequences for transcription factors Sp1 and CREB
10.1093/nar/20.13.3287 · 1992 · External reference
Two Sp1/Sp3 binding sites in the major immediate-early proximal enhancer of human cytomegalovirus have a significant role in viral replication
10.1128/jvi.79.15.9597-9607.2005 · 2005 · External reference
The Elk-1 and serum response factor binding sites in the major immediate-early promoter of human cytomegalovirus are required for efficient viral replication in quiescent cells and compensate for inactivation of the NF-kappaB sites in proliferating cells
10.1128/jvi.02141-09 · 2010 · External reference
Ets-2 Repressor Factor (ERF) mediates repression of the human cytomegalovirus major immediate-early promoter in undifferentiated non-permissive cells
10.1099/vir.0.18633-0 · 2003 · External reference
Gfi-1 encodes a nuclear zinc finger protein that binds DNA and functions as a transcriptional repressor
10.1128/mcb.16.8.4024 · 1996 · External reference
Inhibition of human cytomegalovirus immediate-early gene expression by cyclin A2-dependent kinase activity
10.1128/jvi.07181-11 · 2012 · External reference
Cyclin-dependent kinase activity controls the onset of the HCMV lytic cycle
10.1371/journal.ppat.1001096 · 2010 · External reference
A BMPR2/YY1 Signaling Axis Is Required for Human Cytomegalovirus Latency in Undifferentiated Myeloid Cells
10.1128/mbio.00227-21 · 2021 · External reference
YY1 Is a Structural Regulator of Enhancer-Promoter Loops
10.1016/j.cell.2017.11.008 · 2017 · External reference
Multiple mechanisms of transcriptional repression by YY1
10.1128/mcb.17.7.3723 · 1997 · External reference
Identification of a negative regulatory domain in the human papillomavirus type 18 promoter: interaction with the transcriptional repressor YY1
10.1002/j.1460-2075.1992.tb05563.x · 1992 · External reference
Human transcription factor YY1 represses human immunodeficiency virus type 1 transcription and virion production
10.1128/jvi.68.2.905-910.1994 · 1994 · External reference
Transcriptional repression by YY1, a human GLI-Krüppel-related protein, and relief of repression by adenovirus E1A protein
10.1016/0092-8674(91)90189-6 · 1991 · External reference
Virological and Immunological Outcomes of Coinfections
10.1128/cmr.00111-17 · 2018 · External reference
Towards Understanding and Identification of Human Viral Co-Infections
10.3390/v16050673 · 2024 · External reference
Virology-The next fifty years
10.1016/j.cell.2024.07.025 · 2024 · External reference
Mechanisms of long COVID and the path toward therapeutics
10.1016/j.cell.2024.07.054 · 2024 · External reference
Coinfection with influenza A virus enhances SARS-CoV-2 infectivity
10.1038/s41422-021-00473-1 · 2021 · External reference
Distinguishing features of long COVID identified through immune profiling
10.1038/s41586-023-06651-y · 2023 · External reference
A Case of Coinfection with SARS-COV-2 and Cytomegalovirus in the Era of COVID-19
2020 · External reference
SARS-CoV-2 Infection and CMV Dissemination in Transplant Recipients as a Treatment for Chagas Cardiomyopathy: A Case Report
10.3390/tropicalmed6010022 · 2021 · External reference
Cytomegalovirus haemorrhagic enterocolitis associated with severe infection with COVID-19
10.1136/bmjgast-2020-000556 · 2021 · External reference
Cytomegalovirus haemorrhagic colitis complicating COVID-19 in an immunocompetent critically ill patient: A case report
10.1002/ccr3.3600 · 2020 · External reference
Herpes simplex virus and cytomegalovirus reactivations among severe COVID-19 patients
10.1186/s13054-020-03252-3 · 2020 · External reference
Convalescent plasma, cytomegalovirus infection, and persistent leukopenia in COVID-19 recovery phase: What is the link?
10.4103/jpgm.jpgm_1168_20 · 2021 · External reference
COVID-19 pneumonia, immunosuppression, and cytomegalovirus activation: A perspective
10.4103/jpgm.jpgm_55_21 · 2021 · External reference
COVID-19 and Cytomegalovirus Co-infection: A Challenging Case of a Critically Ill Patient with Gastrointestinal Symptoms
2020 · External reference
Chronic viral coinfections differentially affect the likelihood of developing long COVID
10.1172/jci163669 · 2023 · External reference
Characterization of a novel coronavirus associated with severe acute respiratory syndrome
10.1126/science.1085952 · 2003 · External reference
SARS-CoV-2 ORF3a Protein as a Therapeutic Target against COVID-19 and Long-Term Post-Infection Effects
10.3390/pathogens13010075 · 2024 · External reference
COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets
10.1038/s41586-021-03570-8 · 2021 · External reference
Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia
10.1038/s41586-020-03148-w · 2021 · External reference
Open reading frame UL26 of human cytomegalovirus encodes a novel tegument protein that contains a strong transcriptional activation domain
10.1128/jvi.76.10.4836-4847.2002 · 2002 · External reference
Biphasic recruitment of transcriptional repressors to the murine cytomegalovirus major immediate-early promoter during the course of infection in vivo
10.1128/jvi.02380-09 · 2010 · External reference
NFκB and Cyclic AMP Response Element Sites Mediate the Valproic Acid and UL138 Responsiveness of the Human Cytomegalovirus Major Immediate Early Enhancer and Promoter
10.1128/jvi.00029-23 · 2023 · External reference
Neutrality of the canonical NF-kappaB-dependent pathway for human and murine cytomegalovirus transcription and replication in vitro
10.1128/jvi.78.2.741-750.2004 · 2004 · External reference
Human cytomegalovirus G protein-coupled receptor US28 promotes latency by attenuating c-fos
10.1073/pnas.1816933116 · 2019 · External reference
A novel diG motif in ORF3a protein of SARS-Cov-2 for intracellular transport
10.3389/fcell.2022.1011221 · 2022 · External reference
The Why of YY1: Mechanisms of Transcriptional Regulation by Yin Yang 1
10.3389/fcell.2020.592164 · 2020 · External reference
SARS-CoV-2 viral protein ORF3A injures renal tubules by interacting with TRIM59 to induce STAT3 activation
10.1016/j.ymthe.2022.12.008 · 2023 · External reference
Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC
10.1096/fj.201802418r · 2019 · External reference
A BMPR2/YY1 Signaling Axis Is Required for Human Cytomegalovirus Latency in Undifferentiated Myeloid Cells
10.1128/mbio.00227-21 · 2021 · External reference
SARS-CoV-2 infection drives an inflammatory response in human adipose tissue through infection of adipocytes and macrophages
2022 · External reference
ACE2-dependent and -independent SARS-CoV-2 entries dictate viral replication and inflammatory response during infection
10.1038/s41556-024-01388-w · 2024 · External reference
SARS-CoV-2 and chronic hepatitis B: Focusing on the possible consequences of co-infection
10.1016/j.jcvp.2023.100167 · 2023 · External reference
Clinical challenge of co-infection of SARS-CoV-2 with influenza during the influenza circulation season: suggestions for prevention
10.18683/germs.2023.1384 · 2023 · External reference
CD169-mediated restrictive SARS-CoV-2 infection of macrophages induces pro-inflammatory responses
10.1371/journal.ppat.1010479 · 2022 · External reference
Impairment of antiviral immune response and disruption of cellular functions by SARS-CoV-2 ORF7a and ORF7b
10.1016/j.isci.2022.105444 · 2022 · External reference
SARS-CoV-2 suppresses IFNβ production mediated by NSP1, 5, 6, 15, ORF6 and ORF7b but does not suppress the effects of added interferon
10.1371/journal.ppat.1009800 · 2021 · External reference
Inhibition of the RLR signaling pathway by SARS-CoV-2 ORF7b is mediated by MAVS and abrogated by ORF7b-homologous interfering peptide
10.1128/jvi.01573-23 · 2024 · External reference
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signaling
10.1038/s41392-020-00438-7 · 2020 · External reference
NLRP12 Senses the SARS-CoV-2 Membrane Protein and Promotes an Inflammatory Response
10.1093/infdis/jiad458 · 2024 · External reference
Multiple mechanisms are implicated in the regulation of NF-kappa B activity during human cytomegalovirus infection
10.1073/pnas.90.3.1107 · 1993 · External reference
Endoplasmic reticulum-associated SARS-CoV-2 ORF3a elicits heightened cytopathic effects despite robust ER-associated degradation
10.1128/mbio.03030-23 · 2024 · External reference
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
10.1038/s41586-020-2286-9 · 2020 · External reference
SARS-COV-2 viroporins activate the NLRP3-inflammasome by the mitochondrial permeability transition pore
10.3389/fimmu.2023.1064293 · 2023 · External reference
Spontaneous NLRP3 inflammasome-driven IL-1-β secretion is induced in severe COVID-19 patients and responds to anakinra treatment
10.1016/j.jaci.2022.05.029 · 2022 · External reference
SARS-CoV-2 ORF3a induces COVID-19-associated kidney injury through HMGB1-mediated cytokine production
10.1128/mbio.02308-24 · 2024 · External reference
Contribution of SARS-CoV-2 Accessory Proteins to Viral Pathogenicity in K18 Human ACE2 Transgenic Mice
10.1128/jvi.00402-21 · 2021 · External reference
YY1 complex in M2 macrophage promotes prostate cancer progression by upregulating IL-6
10.1136/jitc-2022-006020 · 2023 · External reference
The Two Sides of YY1 in Cancer: A Friend and a Foe
10.3389/fonc.2019.01230 · 2019 · External reference
YY1 Is an Inducer of Cancer Metastasis
10.1615/critrevoncog.2017021314 · 2017 · External reference
YY1lo NKT cells are dedicated IL-10 producers
10.1038/s41598-020-60229-6 · 2020 · External reference
YY1 (Yin-Yang 1), a transcription factor regulating systemic inflammation, is involved in cognitive impairment of depression
10.1111/pcn.13510 · 2023 · External reference
Oxymatrine Ameliorates Lupus Nephritis by Targeting the YY1-Mediated IL-6/STAT3 Axis
10.3390/ijms252212260 · 2024 · External reference
Caspase-dependent regulation and subcellular redistribution of the transcriptional modulator YY1 during apoptosis
10.1128/mcb.25.9.3704-3714.2005 · 2005 · External reference
Viral and host network analysis of the human cytomegalovirus transcriptome in latency
10.1073/pnas.2416114122 · 2025 · External reference
Human cytomegalovirus gene expression during infection of primary hematopoietic progenitor cells: a model for latency
10.1073/pnas.252630899 · 2002 · External reference
The murine stromal cell line AFT024 acts specifically on human CD34+CD38- progenitors to maintain primitive function and immunophenotype in vitro
1998 · External reference
Nervous system consequences of COVID-19
10.1126/science.abm2052 · 2022 · External reference
Morphological, cellular, and molecular basis of brain infection in COVID-19 patients
10.1073/pnas.2200960119 · 2022 · External reference
K18- and CAG-hACE2 Transgenic Mouse Models and SARS-CoV-2: Implications for Neurodegeneration Research
10.3390/molecules27134142 · 2022 · External reference
Functional profiling of a human cytomegalovirus genome
10.1073/pnas.2334032100 · 2003 · External reference
A novel cell culture system modeling the SARS-CoV-2 life cycle
2021 · External reference
The R203M and D377Y mutations of the nucleocapsid protein promote SARS-CoV-2 infectivity by impairing RIG-I-mediated antiviral signaling
2025 · External reference
SARS-CoV-2 virulence factor ORF3a blocks lysosome function by modulating TBC1D5-dependent Rab7 GTPase cycle
10.1038/s41467-024-46417-2 · 2024 · External reference
Circular RNA SMARCA5 inhibits cholangiocarcinoma via microRNA-95-3p/tumor necrosis factor receptor associated factor 3 axis
10.1097/cad.0000000000001487 · 2023 · External reference
A prominent and conserved role for YY1 in Xist transcriptional activation
10.1038/ncomms5878 · 2014 · External reference
TRIM59-mediated ferroptosis enhances neuroblastoma development and chemosensitivity through p53 ubiquitination and degradation
2024 · External reference
Site-specific SUMOylation of viral polymerase processivity factor: a way of localizingtoND10 subnuclear domains for restricted and self-controlled reproduction of herpesvirus
10.1080/21505594.2021.2000689 · 2021 · External reference
