Research graph
References from MAP3K15 facilitates multiple viral genes expression in crustaceans via Dorsal-CC-CL-STAT axis besides the JNK/P38 pathway. Local targets link to admitted publications; unresolved targets remain external evidence.
The mitogen activated protein kinase signal transduction pathway: from the cell surface to the nucleus
10.1016/0898-6568(94)90041-8 · 1994 · External reference
Signaling to NF-kappaB by Toll-like receptors
10.1016/j.molmed.2007.09.002 · 2007 · External reference
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
10.1126/science.8197455 · 1994 · External reference
Berberine as a natural modulator of inflammatory signaling pathways in the immune system: Focus on NF-κB, JAK/STAT, and MAPK signaling pathways
10.1002/ptr.7407 · 2022 · External reference
Epstein-Barr virus induces MCP-1 secretion by human monocytes via TLR2
10.1128/jvi.00403-07 · 2007 · External reference
The JAK-STAT transcriptional regulator, STAT-5, activates the ATM DNA damage pathway to induce HPV 31 genome amplification upon epithelial differentiation
10.1371/journal.ppat.1003295 · 2013 · External reference
Suppression of STAT-1 expression by human papillomaviruses is necessary for differentiation-dependent genome amplification and plasmid maintenance
10.1128/jvi.05007-11 · 2011 · External reference
Multiple NF-κB sites in HIV-1 subtype C long terminal repeat confer superior magnitude of transcription and thereby the enhanced viral predominance
10.1074/jbc.m112.397158 · 2012 · External reference
Binding of c-Rel to STAT5 target sequences in HTLV-I-transformed T cells
10.1038/sj.onc.1202430 · 1999 · External reference
Modulation of NF-κB signalling by microbial pathogens
10.1038/nrmicro2539 · 2011 · External reference
Primate Lentiviruses Modulate NF-κB Activity by Multiple Mechanisms to Fine-Tune Viral and Cellular Gene Expression
10.3389/fmicb.2017.00198 · 2017 · External reference
A review on the morphology, molecular characterization, morphogenesis and pathogenesis of white spot syndrome virus
10.1111/j.1365-2761.2007.00877.x · 2008 · External reference
Complete genome sequence of the shrimp white spot bacilliform virus
10.1128/jvi.75.23.11811-11820.2001 · 2001 · External reference
NF-kappaB- and c-Jun-dependent regulation of human cytomegalovirus immediate-early gene enhancer/promoter in response to lipopolysaccharide and bacterial CpG-oligodeoxynucleotides in macrophage cell line RAW 264.7
10.1111/j.1432-1033.2004.04011.x · 2004 · External reference
Genome-wide expression analysis reveal host genes involved in immediate-early infections of different sheeppox virus strains
10.1016/j.gene.2021.145850 · 2021 · External reference
Interferon Gamma Inhibits Varicella-Zoster Virus Replication in a Cell Line-Dependent Manner
10.1128/jvi.00257-19 · 2019 · External reference
Shrimp STAT was hijacked by white spot syndrome virus immediate-early protein IE1 involved in modulation of viral genes
10.1016/j.fsi.2016.10.051 · 2016 · External reference
White Spot Syndrome Virus Establishes a Novel IE1/JNK/c-Jun Positive Feedback Loop to Drive Replication
10.1016/j.isci.2019.100752 · 2020 · External reference
White spot syndrome virus annexes a shrimp STAT to enhance expression of the immediate-early gene ie1
10.1128/jvi.01880-06 · 2007 · External reference
Comparative Transcriptome Analysis Reveals That WSSV IE1 Protein Plays a Crucial Role in DNA Replication Control
10.3390/ijms23158176 · 2022 · External reference
Characterization of white spot syndrome virus immediate-early gene promoters
10.1099/vir.0.047274-0 · 2013 · External reference
Identification of the immediate-early genes of white spot syndrome virus
10.1016/j.virol.2008.12.007 · 2009 · External reference
Litopenaeus vannamei NF-κB is required for WSSV replication
10.1016/j.dci.2014.02.016 · 2014 · External reference
Shrimp NF-κB binds to the immediate-early gene ie1 promoter of white spot syndrome virus and upregulates its activity
10.1016/j.virol.2010.06.046 · 2010 · External reference
Remodeling of the ribosomal quality control and integrated stress response by viral ubiquitin deconjugases
10.1038/s41467-023-43946-0 · 2023 · External reference
Mitogen-activated protein kinase cascades and regulation of gene expression
10.1016/s0952-7915(96)80131-2 · 1996 · External reference
Single-particle imaging of stress-promoters induction reveals the interplay between MAPK signaling, chromatin and transcription factors
10.1038/s41467-020-16943-w · 2020 · External reference
Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases
10.1128/mmbr.00031-10 · 2011 · External reference
Functions of MAP3Ks in antiviral immunity
10.1007/s12026-023-09401-4 · 2023 · External reference
ASK family and cancer
10.1016/j.jbior.2017.05.003 · 2017 · External reference
Structure-based mechanism of preferential complex formation by apoptosis signal-regulating kinases
10.1126/scisignal.aay6318 · 2020 · External reference
Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1
10.1093/emboj/17.9.2596 · 1998 · External reference
A TrxR inhibiting gold(I) NHC complex induces apoptosis through ASK1-p38-MAPK signaling in pancreatic cancer cells
10.1186/1476-4598-13-221 · 2014 · External reference
The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response
10.1126/scisignal.aab1883 · 2015 · External reference
ASK3 responds to osmotic stress and regulates blood pressure by suppressing WNK1-SPAK/OSR1 signaling in the kidney
10.1038/ncomms2283 · 2012 · External reference
Cells recognize osmotic stress through liquid-liquid phase separation lubricated with poly(ADP-ribose)
10.1038/s41467-021-21614-5 · 2021 · External reference
Phenotypic dimorphism between honeybee queen and worker is regulated by complicated epigenetic modifications
10.1016/j.isci.2023.106308 · 2023 · External reference
Human genetics uncovers MAP3K15 as an obesity-independent therapeutic target for diabetes
2022 · External reference
Genetic analysis of the X chromosome in people with Lewy body dementia nominates new risk loci
10.1038/s41531-024-00649-7 · 2024 · External reference
The shrimp IKK-NF-κB signaling pathway regulates antimicrobial peptide expression and may be subverted by white spot syndrome virus to facilitate viral gene expression
10.1038/cmi.2013.30 · 2013 · External reference
Microarray and RT-PCR screening for white spot syndrome virus immediate-early genes in cycloheximide-treated shrimp
10.1016/j.virol.2005.01.047 · 2005 · External reference
White spot syndrome virus hijacks host PP2A-FOXO axes to promote its propagation
10.1016/j.ijbiomac.2023.128333 · 2024 · External reference
Peroxiredoxin 4 Interacts With Domeless and Participates in Antibacterial Immune Response Through the JAK/STAT Pathway
10.3389/fimmu.2022.907183 · 2022 · External reference
Binding of a C-type lectin’s coiled-coil domain to the Domeless receptor directly activates the JAK/STAT pathway in the shrimp immune response to bacterial infection
2017 · External reference
Identification of a c-Jun homolog from Litopenaeus vannamei as a downstream substrate of JNK in response to WSSV infection
10.1016/j.dci.2014.12.012 · 2015 · External reference
The role of Litopenaeus vannamei p38 in white spot syndrome virus infection
10.1016/j.dci.2013.12.005 · 2014 · External reference
A PP6-ASK3 Module Coordinates the Bidirectional Cell Volume Regulation under Osmotic Stress
10.1016/j.celrep.2018.02.045 · 2018 · External reference
MAPKKK15 gene from shrimp Litopenaeus vannamei is transcribed in larva development stages and contributes to WSSV pathogenesis
10.1016/j.aquaculture.2020.736324 · 2021 · External reference
Human cytomegalovirus early protein pUL21a promotes efficient viral DNA synthesis and the late accumulation of immediate-early transcripts
10.1128/jvi.01599-10 · 2011 · External reference
White spot syndrome virus IE1 protein blocks the integrin-FAK signaling to enhance viral infection in shrimp
10.1016/j.fsi.2024.110073 · 2025 · External reference
Function of shrimp STAT during WSSV infection
10.1016/j.fsi.2014.04.002 · 2014 · External reference
WSSV infection activates STAT in shrimp
10.1016/j.dci.2008.03.003 · 2008 · External reference
Characterization of the promoter of white spot syndrome virus immediate-early gene wsv249
10.1016/j.virusres.2018.05.012 · 2018 · External reference
RING-H2 protein WSSV249 from white spot syndrome virus sequesters a shrimp ubiquitin-conjugating enzyme, PvUbc, for viral pathogenesis
10.1128/jvi.79.14.8764-8772.2005 · 2005 · External reference
The JAK/STAT signaling pathway: from bench to clinic
10.1038/s41392-021-00791-1 · 2021 · External reference
Differential activities of the Drosophila JAK/STAT pathway ligands Upd, Upd2 and Upd3
10.1016/j.cellsig.2011.01.020 · 2011 · External reference
Identification of the first invertebrate interleukin JAK/STAT receptor, the Drosophila gene domeless
10.1016/s0960-9822(01)00524-3 · 2001 · External reference
Eye transformer is a negative regulator of Drosophila JAK/STAT signaling
10.1096/fj.10-162784 · 2010 · External reference
The JAK-STAT pathway in Drosophila
10.1016/s0168-9525(97)01006-8 · 1997 · External reference
Identification of a JAK/STAT pathway receptor domeless from Pacific white shrimp Litopenaeus vannamei
10.1016/j.fsi.2015.01.023 · 2015 · External reference
Interferon functional analog activates antiviral Jak/Stat signaling through integrin in an arthropod
10.1016/j.celrep.2021.109761 · 2021 · External reference
Characterization of a 2-Cys peroxiredoxin IV in Marsupenaeus japonicus (kuruma shrimp) and its role in the anti-viral immunity
10.1016/j.fsi.2013.09.018 · 2013 · External reference
Molecular cloning and characterization of the translationally controlled tumor protein from Fenneropenaeus chinensis
10.1007/s11033-008-9369-2 · 2009 · External reference
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
10.1006/meth.2001.1262 · 2001 · External reference
