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References from Spatio-genetically coordinated TPR domain-containing proteins modulate c-di-GMP signaling in Vibrio vulnificus. Local targets link to admitted publications; unresolved targets remain external evidence.
Vibrio spp.: Life Strategies, Ecology, and Risks in a Changing Environment
10.3390/d14020097 · 2022 · External reference
The Vibrios: Scavengers, Symbionts, and Pathogens from the Sea
10.1007/s00248-020-01524-7 · 2020 · External reference
Vibrio biofilms: so much the same yet so different
10.1016/j.tim.2008.12.004 · 2009 · External reference
Vibrio spp. infections
10.1038/s41572-018-0005-8 · 2018 · External reference
Biodiversity of vibrios
10.1128/mmbr.68.3.403-431.2004 · 2004 · External reference
Ocean warming and spread of pathogenic vibrios in the aquatic environment
10.1007/s00248-012-0163-2 · 2013 · External reference
Vibrio species involved in seafood-borne outbreaks (Vibrio cholerae, V. parahaemolyticus and V. vulnificus): Review of microbiological versus recent molecular detection methods in seafood products
10.1080/10408398.2017.1384715 · 2019 · External reference
Cholera and other types of vibriosis: a story of human pandemics and oysters on the half shell
10.1086/375600 · 2003 · External reference
Vibrio vulnificus Infection
2023 · External reference
Vibrio vulnificus: Review of Mild to Life-threatening Skin Infections
10.12788/cutis.0183 · 2021 · External reference
The Biology of Vibrio vulnificus
10.1128/microbiolspec.ve-0001-2014 · 2015 · External reference
Climate warming and increasing Vibrio vulnificus infections in North America
10.1038/s41598-023-28247-2 · 2023 · External reference
Economic Burden of Major Foodborne Illnesses Acquired in the United States
2015 · External reference
Densities of Vibrio vulnificus in the intestines of fish from the U.S. Gulf Coast
10.1128/aem.60.3.984-988.1994 · 1994 · External reference
The fish pathogen Vibrio vulnificus biotype 2: epidemiology, phylogeny, and virulence factors involved in warm-water vibriosis
10.1128/microbiolspec.ve-0005-2014 · 2015 · External reference
Transmission to eels, portals of entry, and putative reservoirs of Vibrio vulnificus serovar E (biotype 2)
10.1128/aem.67.10.4717-4725.2001 · 2001 · External reference
Phylogeny and life cycle of the zoonotic pathogen Vibrio vulnificus
10.1111/1462-2920.15137 · 2020 · External reference
Vibrios associated with plankton in a coastal zone of the Adriatic Sea (Italy)
10.1111/j.1574-6941.1999.tb00615.x · 1999 · External reference
Prevalence and characterization of Vibrio vulnificus isolated from shrimp products imported into Denmark
10.4315/0362-028x-60.9.1132 · 2016 · External reference
Isolation, identification and phenotypic and molecular characterization of pathogenic Vibrio vulnificus isolated from Litopenaeus vannamei
10.1371/journal.pone.0186135 · 2017 · External reference
Integration of Vibrio vulnificus into marine aggregates and its subsequent uptake by Crassostrea virginica oysters
10.1128/aem.03095-12 · 2013 · External reference
Distribution of Vibrio vulnificus in the Chesapeake Bay
10.1128/aem.62.2.717-724.1996 · 1996 · External reference
Bacterial biofilms: from the natural environment to infectious diseases
10.1038/nrmicro821 · 2004 · External reference
Persistent bacterial infections and persister cells
10.1038/nrmicro.2017.42 · 2017 · External reference
Symbiosis in the microbial world: from ecology to genome evolution
2018 · External reference
The role of biofilms as environmental reservoirs of antibiotic resistance
10.3389/fmicb.2015.01216 · 2015 · External reference
Persister cells, dormancy and infectious disease
10.1038/nrmicro1557 · 2007 · External reference
Biofilms: an emergent form of bacterial life
10.1038/nrmicro.2016.94 · 2016 · External reference
Biofilms and cyclic di-GMP (c-di-GMP) signaling: lessons from Pseudomonas aeruginosa and other bacteria
10.1074/jbc.r115.711507 · 2016 · External reference
Diversity of c-di-GMP-binding proteins and mechanisms
10.1128/jb.00333-15 · 2015 · External reference
Mechanisms of cyclic-di-GMP signaling in bacteria
10.1146/annurev.genet.40.110405.090423 · 2006 · External reference
C-di-GMP: the dawning of a novel bacterial signalling system
10.1111/j.1365-2958.2005.04697.x · 2005 · External reference
Cyclic di-GMP: second messenger extraordinaire
10.1038/nrmicro.2016.190 · 2017 · External reference
Cyclic di-GMP as a second messenger
10.1016/j.mib.2006.02.010 · 2006 · External reference
Cache Domains That are Homologous to, but Different from PAS Domains Comprise the Largest Superfamily of Extracellular Sensors in Prokaryotes
10.1371/journal.pcbi.1004862 · 2016 · External reference
Sensory Perception in Bacterial Cyclic Diguanylate Signal Transduction
10.1128/jb.00433-21 · 2022 · External reference
Spatial organization enhances versatility and specificity in cyclic di-GMP signaling
10.1515/hsz-2020-0202 · 2020 · External reference
Trigger phosphodiesterases as a novel class of c-di-GMP effector proteins
10.1098/rstb.2015.0498 · 2016 · External reference
PilZ domain is part of the bacterial c-di-GMP binding protein
10.1093/bioinformatics/bti739 · 2006 · External reference
GIL, a new c-di-GMP-binding protein domain involved in regulation of cellulose synthesis in enterobacteria
10.1111/mmi.12672 · 2014 · External reference
Cyclic diguanosine monophosphate represses bacterial flagella synthesis by interacting with the Walker A motif of the enhancer-binding protein FleQ
10.1073/pnas.1318972110 · 2013 · External reference
Identification of FleQ from Pseudomonas aeruginosa as a c-di-GMP-responsive transcription factor
10.1111/j.1365-2958.2008.06281.x · 2008 · External reference
Vibrio cholerae VpsT regulates matrix production and motility by directly sensing cyclic di-GMP
10.1126/science.1181185 · 2010 · External reference
Cyclic di-GMP allosterically inhibits the CRP-like protein (Clp) of Xanthomonas axonopodis pv. citri
10.1128/jb.00845-09 · 2009 · External reference
A cyclic-di-GMP receptor required for bacterial exopolysaccharide production
10.1111/j.1365-2958.2007.05879.x · 2007 · External reference
Tetrameric c-di-GMP mediates effective transcription factor dimerization to control Streptomyces development
10.1016/j.cell.2014.07.022 · 2014 · External reference
Cyclic di-GMP Regulates TfoY in Vibrio cholerae To Control Motility by both Transcriptional and Posttranscriptional Mechanisms
10.1128/jb.00578-17 · 2018 · External reference
Recognition of the bacterial second messenger cyclic diguanylate by its cognate riboswitch
10.1038/nsmb.1701 · 2009 · External reference
The Vc2 cyclic di-GMP-dependent riboswitch of Vibrio cholerae regulates expression of an upstream putative small RNA by controlling RNA stability
10.1128/jb.00293-19 · 2019 · External reference
The Stand-Alone PilZ-Domain Protein MotL Specifically Regulates the Activity of the Secondary Lateral Flagellar System in Shewanella putrefaciens
10.3389/fmicb.2021.668892 · 2021 · External reference
Three PilZ domain proteins, PlpA, PixA and PixB, have distinct functions in regulation of motility and development in Myxococcus xanthus
2021 · External reference
The PilZ domain is a receptor for the second messenger c-di-GMP: the PilZ domain protein YcgR controls motility in enterobacteria
10.1074/jbc.c600179200 · 2006 · External reference
PilZ domain protein FlgZ mediates cyclic di-GMP-dependent swarming motility control in Pseudomonas aeruginosa
10.1128/jb.00196-16 · 2016 · External reference
Structure of PP4397 reveals the molecular basis for different c-di-GMP binding modes by Pilz domain proteins
10.1016/j.jmb.2010.03.007 · 2010 · External reference
Structures of the activator of K. pneumonia biofilm formation, MrkH, indicates PilZ domains involved in c-di-GMP and DNA binding
10.1073/pnas.1607503113 · 2016 · External reference
Environmental Calcium Initiates a Feed-Forward Signaling Circuit That Regulates Biofilm Formation and Rugosity in Vibrio vulnificus
10.1128/mbio.01377-18 · 2018 · External reference
Two novel genes identified by large-scale transcriptomic analysis are essential for biofilm and rugose colony development of Vibrio vulnificus
2023 · External reference
Correction: The cabABC Operon Essential for Biofilm and Rugose Colony Development in Vibrio vulnificus
2015 · External reference
Calcium-dependent site-switching regulates expression of the atypical iam pilus locus in Vibrio vulnificus
10.1111/1462-2920.14763 · 2020 · External reference
Calcium promotes exopolysaccharide phase variation and biofilm formation of the resulting phase variants in the human pathogen Vibrio vulnificus
10.1111/j.1462-2920.2010.02369.x · 2011 · External reference
Overlapping and unique contributions of two conserved polysaccharide loci in governing distinct survival phenotypes in Vibrio vulnificus
10.1111/j.1462-2920.2011.02564.x · 2011 · External reference
The proline variant of the W[F/L/M][T/S]R cyclic di-GMP binding motif suppresses dependence on signal association for regulator function
10.1128/jb.00344-17 · 2017 · External reference
Complex Control of a Genomic Island Governing Biofilm and Rugose Colony Development in Vibrio vulnificus
10.1128/jb.00190-18 · 2018 · External reference
A master regulator brpR coordinates the expression of multiple loci for robust biofilm and rugose colony development in Vibrio vulnificus
10.3389/fmicb.2021.679854 · 2021 · External reference
Identification of a c-di-GMP-regulated polysaccharide locus governing stress resistance and biofilm and rugose colony formation in Vibrio vulnificus
10.1128/iai.01188-09 · 2010 · External reference
A Regulatory Network Controls cabABC Expression Leading to Biofilm and Rugose Colony Development in Vibrio vulnificus
10.3389/fmicb.2019.03063 · 2020 · External reference
Flagellar brake protein YcgR interacts with motor proteins MotA and FliG to regulate the flagellar rotation speed and direction
10.3389/fmicb.2023.1159974 · 2023 · External reference
The c-di-GMP binding protein YcgR controls flagellar motor direction and speed to affect chemotaxis by a “backstop brake” mechanism
10.1016/j.molcel.2010.03.001 · 2010 · External reference
PlzD modifies Vibrio vulnificus foraging behavior and virulence in response to elevated c-di-GMP
2023 · External reference
A repeating amino acid motif in CDC23 defines a family of proteins and a new relationship among genes required for mitosis and RNA synthesis
10.1016/0092-8674(90)90745-z · 1990 · External reference
Tandem-repeat protein domains across the tree of life
10.7717/peerj.732 · 2015 · External reference
TPR proteins: the versatile helix
10.1016/j.tibs.2003.10.007 · 2003 · External reference
Tetratricopeptide repeat motifs in the world of bacterial pathogens: role in virulence mechanisms
10.1128/iai.01035-12 · 2013 · External reference
The TPR snap helix: a novel protein repeat motif from mitosis to transcription
10.1016/0968-0004(91)90070-c · 1991 · External reference
Structural and functional discussion of the tetra-trico-peptide repeat, a protein interaction module
10.1016/j.str.2012.01.006 · 2012 · External reference
The tetratricopeptide repeat: a structural motif mediating protein-protein interactions
10.1002/(sici)1521-1878(199911)21:11<932::aid-bies5>3.0.co;2-n · 1999 · External reference
Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes
10.1073/pnas.0231020100 · 2003 · External reference
Structural basis of presequence recognition by the mitochondrial protein import receptor Tom20
10.1016/s0092-8674(00)80691-1 · 2000 · External reference
Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA), a candidate gene for polycystic ovary syndrome
10.1093/humrep/den065 · 2008 · External reference
Mutations in a new photoreceptor-pineal gene on 17p cause Leber congenital amaurosis
10.1038/71732 · 2000 · External reference
Molecular characterization of the mouse mtprd gene, a homologue of human tprd: unique gene expression suggesting its critical role in the pathophysiology of down syndrome
10.1093/oxfordjournals.jbchem.a022043 · 1998 · External reference
Tetratricopeptide repeats are essential for PcrH chaperone function in Pseudomonas aeruginosa type III secretion
10.1111/j.1574-6968.2005.00099.x · 2006 · External reference
Tetratricopeptide repeats in the type III secretion chaperone, LcrH: their role in substrate binding and secretion
10.1111/j.1365-2958.2005.04923.x · 2006 · External reference
Type IV pili in Francisella tularensis: roles of pilF and pilT in fiber assembly, host cell adherence, and virulence
10.1128/iai.01726-07 · 2008 · External reference
Protein kinase and phosphatase signaling in Mycobacterium tuberculosis physiology and pathogenesis
10.1016/j.bbapap.2009.09.008 · 2010 · External reference
Sel1-like repeat proteins in signal transduction
10.1016/j.cellsig.2006.05.034 · 2007 · External reference
High-throughput 3D tracking of bacteria on a standard phase contrast microscope
10.1038/ncomms9776 · 2015 · External reference
Bacteria can exploit a flagellar buckling instability to change direction
10.1038/nphys2676 · 2013 · External reference
A conserved cell-pole determinant organizes proper polar flagellum formation
2024 · External reference
A multidomain hub anchors the chromosome segregation and chemotactic machinery to the bacterial pole
10.1101/gad.199869.112 · 2012 · External reference
Analysis of HubP-dependent cell pole protein targeting in Vibrio cholerae uncovers novel motility regulators
10.1371/journal.pgen.1009991 · 2022 · External reference
HubP, a polar landmark protein, regulates flagellar number by assisting in the proper polar localization of FlhG in Vibrio alginolyticus
10.1128/jb.00462-16 · 2016 · External reference
Function and Structure of FlaK, a Master Regulator of the Polar Flagellar Genes in Marine Vibrio
10.1128/jb.00320-22 · 2022 · External reference
FlrA, a sigma54-dependent transcriptional activator in Vibrio fischeri, is required for motility and symbiotic light-organ colonization
10.1128/jb.185.12.3547-3557.2003 · 2003 · External reference
The novel sigma54- and sigma28-dependent flagellar gene transcription hierarchy of Vibrio cholerae
10.1046/j.1365-2958.2001.02348.x · 2001 · External reference
Biofilm Development
10.1128/microbiolspec.mb-0001-2014 · 2015 · External reference
A Symphony of Cyclases: Specificity in Diguanylate Cyclase Signaling
10.1146/annurev-micro-090816-093325 · 2017 · External reference
Identification of Three New GGDEF and EAL Domain-Containing Proteins Participating in the Scr Surface Colonization Regulatory Network in Vibrio parahaemolyticus
10.1128/jb.00409-20 · 2021 · External reference
Cyclic diguanylate is a ubiquitous signaling molecule in bacteria: insights into biochemistry of the GGDEF protein domain
10.1128/jb.187.5.1792-1798.2005 · 2005 · External reference
Studying GGDEF Domain in the Act: Minimize Conformational Frustration to Prevent Artefacts
2021 · External reference
Activation of the diguanylate cyclase PleD by phosphorylation-mediated dimerization
10.1074/jbc.m704702200 · 2007 · External reference
Integration of cyclic di-GMP and quorum sensing in the control of vpsT and aphA in Vibrio cholerae
10.1128/jb.05167-11 · 2011 · External reference
A diguanylate cyclase acts as a cell division inhibitor in a two-step response to reductive and envelope stresses
2016 · External reference
Cell cycle-dependent dynamic localization of a bacterial response regulator with a novel di-guanylate cyclase output domain
10.1101/gad.289504 · 2004 · External reference
c-di-GMP-related phenotypes are modulated by the interaction between a diguanylate cyclase and a polar hub protein
10.1038/s41598-020-59536-9 · 2020 · External reference
Biochemical analysis of GTPase FlhF which controls the number and position of flagellar formation in marine Vibrio
10.1038/s41598-018-30531-5 · 2018 · External reference
Regulation of the Single Polar Flagellar Biogenesis
10.3390/biom10040533 · 2020 · External reference
Recruitment of the earliest component of the bacterial flagellum to the old cell division pole by a membrane-associated signal recognition particle family GTP-binding protein
10.1016/j.jmb.2009.05.075 · 2009 · External reference
Interdependent Polar Localization of FlhF and FlhG and Their Importance for Flagellum Formation of Vibrio parahaemolyticus
10.3389/fmicb.2021.655239 · 2021 · External reference
Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine
10.1016/s0092-8674(00)80830-2 · 2000 · External reference
Ligand binding by TPR domains
10.1110/ps.062092506 · 2006 · External reference
Structural Basis for Translocation of a Biofilm-supporting Exopolysaccharide across the Bacterial Outer Membrane
10.1074/jbc.m115.711762 · 2016 · External reference
The TPR domain of PgaA is a multifunctional scaffold that binds PNAG and modulates PgaB-dependent polymer processing
10.1371/journal.ppat.1010750 · 2022 · External reference
A lasting symbiosis: how Vibrio fischeri finds a squid partner and persists within its natural host
10.1038/s41579-021-00557-0 · 2021 · External reference
A lasting symbiosis: how the Hawaiian bobtail squid finds and keeps its bioluminescent bacterial partner
10.1038/s41579-021-00567-y · 2021 · External reference
A single regulatory gene is sufficient to alter bacterial host range
10.1038/nature07660 · 2009 · External reference
Vibrio halioticoli sp. nov., a non-motile alginolytic marine bacterium isolated from the gut of the abalone Haliotis discus hannai
10.1099/00207713-48-2-573 · 1998 · External reference
Pathogenic bacterium Vibrio harveyi: an endosymbiont in the marine parasitic ciliate protozoan Cryptocaryon irritans
10.1007/s13131-017-1050-y · 2017 · External reference
GefB, a GGDEF domain-containing protein, affects motility and biofilm formation of Vibrio parahaemolyticus and is regulated by quorum sensing regulators
10.1016/j.gene.2024.148968 · 2025 · External reference
C-di-GMP: the dawning of a novel bacterial signalling system
10.1111/j.1365-2958.2005.04697.x · 2005 · External reference
Complete Genome Sequence of the Pathogenic Vibrio vulnificus Type Strain ATCC 27562
10.1128/genomea.00907-17 · 2017 · External reference
Improved allelic exchange vectors and their use to analyze 987P fimbria gene expression
10.1016/s0378-1119(97)00619-7 · 1998 · External reference
Identification of a Wzy polymerase required for group IV capsular polysaccharide and lipopolysaccharide biosynthesis in Vibrio vulnificus
10.1128/iai.00932-07 · 2007 · External reference
Identification of a membrane-bound transcriptional regulator that links chitin and natural competence in Vibrio cholerae
10.1128/mbio.01028-13 · 2014 · External reference
A Tad pilus promotes the establishment and resistance of Vibrio vulnificus biofilms to mechanical clearance
10.1038/s41522-018-0052-7 · 2018 · External reference
Experimental reproducibility in flow-chamber biofilms
10.1099/00221287-146-10-2409 · 2000 · External reference
Quantification of biofilm structures by the novel computer program COMSTAT
10.1099/00221287-146-10-2395 · 2000 · External reference
Single-step method for β-galactosidase assays in Escherichia coli using a 96-well microplate reader
10.1016/j.ab.2016.03.017 · 2016 · External reference
Accurate structure prediction of biomolecular interactions with AlphaFold 3
10.1038/s41586-024-07487-w · 2024 · External reference
UCSF ChimeraX: Structure visualization for researchers, educators, and developers
10.1002/pro.3943 · 2021 · External reference
BLAST+: architecture and applications
10.1186/1471-2105-10-421 · 2009 · External reference
Muscle5: High-accuracy alignment ensembles enable unbiased assessments of sequence homology and phylogeny
10.1038/s41467-022-34630-w · 2022 · External reference
HMMER web server: 2018 update
10.1093/nar/gky448 · 2018 · External reference
TPRpred: a tool for prediction of TPR-, PPR- and SEL1-like repeats from protein sequences
10.1186/1471-2105-8-2 · 2007 · External reference
BUSCO update: novel and streamlined workflows along with broader and deeper phylogenetic coverage for scoring of eukaryotic, prokaryotic, and viral genomes
10.1093/molbev/msab199 · 2021 · External reference
RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies
10.1093/bioinformatics/btu033 · 2014 · External reference
Interactive Tree of Life (iTOL) v6: recent updates to the phylogenetic tree display and annotation tool
10.1093/nar/gkae268 · 2024 · External reference
