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References from BBK32 attenuates antibody-dependent complement-mediated killing of infectious Borreliella burgdorferi isolates. Local targets link to admitted publications; unresolved targets remain external evidence.
Epidemiology of Lyme disease
10.1016/j.idc.2015.02.010 · 2015 · External reference
Lyme Disease in Humans
2021 · External reference
Estimating the Frequency of Lyme Disease Diagnoses, United States, 2010-2018
10.3201/eid2702.202731 · 2021 · External reference
Lyme disease testing by large commercial laboratories in the United States
10.1093/cid/ciu397 · 2014 · External reference
Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes
10.1038/nrmicro2714 · 2012 · External reference
Lyme Disease Pathogenesis
10.21775/9781913652616.13 · 2021 · External reference
OspC facilitates Borrelia burgdorferi invasion of Ixodes scapularis salivary glands
10.1172/jci200419894 · 2004 · External reference
Essential role for OspA/B in the life cycle of the Lyme disease spirochete
10.1084/jem.20031960 · 2004 · External reference
Essential role of the response regulator Rrp2 in the infectious cycle of Borrelia burgdorferi
10.1128/iai.00467-08 · 2008 · External reference
Live Imaging
2021 · External reference
Borrelia burgdorferi spatiotemporal regulation of transcriptional regulator bosR and decorin binding protein during murine infection
10.1038/s41598-020-69212-7 · 2020 · External reference
The Brilliance of Borrelia: Mechanisms of Host Immune Evasion by Lyme Disease-Causing Spirochetes
10.3390/pathogens10030281 · 2021 · External reference
Immune Response to Borrelia: Lessons from Lyme Disease Spirochetes
10.21775/9781913652616.18 · 2021 · External reference
Changing of the guard: How the Lyme disease spirochete subverts the host immune response
10.1074/jbc.rev119.008583 · 2020 · External reference
Borrelia burgdorferi elicited-IL-10 suppresses the production of inflammatory mediators, phagocytosis, and expression of co-stimulatory receptors by murine macrophages and/or dendritic cells
10.1371/journal.pone.0084980 · 2013 · External reference
Suppression of Long-Lived Humoral Immunity Following Borrelia burgdorferi Infection
10.1371/journal.ppat.1004976 · 2015 · External reference
Complement-mediated serum sensitivity among spirochetes that cause Lyme disease
10.1128/iai.65.4.1228-1236.1997 · 1997 · External reference
Complement Evasion Contributes to Lyme Borreliae-Host Associations
10.1016/j.pt.2020.04.011 · 2020 · External reference
Complement: a key system for immune surveillance and homeostasis
10.1038/ni.1923 · 2010 · External reference
Complement System Part II: Role in Immunity
10.3389/fimmu.2015.00257 · 2015 · External reference
Complement System Part I - Molecular Mechanisms of Activation and Regulation
10.3389/fimmu.2015.00262 · 2015 · External reference
Protection of host cells by complement regulators
10.1111/imr.12475 · 2016 · External reference
Structure and activation of the C1 complex of complement: unraveling the puzzle
10.1016/j.it.2004.04.008 · 2004 · External reference
Natural antibody affects survival of the spirochete Borrelia burgdorferi within feeding ticks
10.1128/iai.69.10.6456-6462.2001 · 2001 · External reference
Passive immunizing activity of sera from mice infected with Borrelia burgdorferi
10.1128/iai.61.11.4696-4702.1993 · 1993 · External reference
Complement Evasion by Lyme Disease Spirochetes
10.1016/j.tim.2020.05.004 · 2020 · External reference
Complement evasion by Borrelia burgdorferi: it takes three to tango
10.1016/j.pt.2012.12.001 · 2013 · External reference
Hide and Seek: How Lyme Disease Spirochetes Overcome Complement Attack
10.3389/fimmu.2016.00385 · 2016 · External reference
Borrelia burgdorferi complement regulator-acquiring surface proteins (BbCRASPs): Expression patterns during the mammal-tick infection cycle
10.1016/j.ijmm.2007.10.002 · 2008 · External reference
Complement regulator-acquiring surface proteins of Borrelia burgdorferi: Structure, function and regulation of gene expression
10.1016/j.ttbdis.2012.10.039 · 2013 · External reference
New Insights Into CRASP-Mediated Complement Evasion in the Lyme Disease Enzootic Cycle
10.3389/fcimb.2020.00001 · 2020 · External reference
CspA-mediated binding of human factor H inhibits complement deposition and confers serum resistance in Borrelia burgdorferi
10.1128/iai.00318-09 · 2009 · External reference
Mutational analyses of the BbCRASP-1 protein of Borrelia burgdorferi identify residues relevant for the architecture and binding of host complement regulators FHL-1 and factor H
10.1016/j.ijmm.2008.09.002 · 2009 · External reference
Functional characterization of BbCRASP-2, a distinct outer membrane protein of Borrelia burgdorferi that binds host complement regulators factor H and FHL-1
10.1111/j.1365-2958.2006.05318.x · 2006 · External reference
Analysis of the OspE determinants involved in binding of factor H and OspE-targeting antibodies elicited during Borrelia burgdorferi infection in mice
10.1128/iai.71.6.3587-3596.2003 · 2003 · External reference
Stage-specific global alterations in the transcriptomes of Lyme disease spirochetes during tick feeding and following mammalian host adaptation
10.1111/mmi.12882 · 2015 · External reference
BosR and PlzA reciprocally regulate RpoS function to sustain Borrelia burgdorferi in ticks and mammals
10.1172/jci166710 · 2023 · External reference
Binding of the complement inhibitor C4b-binding protein to Lyme disease Borreliae
10.1016/j.molimm.2009.11.028 · 2010 · External reference
Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival
10.1111/cmi.12786 · 2017 · External reference
The molecular determinants of classical pathway complement inhibition by OspEF-related proteins of Borrelia burgdorferi
10.1016/j.jbc.2024.107236 · 2024 · External reference
Outer surface lipoproteins from the Lyme disease spirochete exploit the molecular switch mechanism of the complement protease C1s
10.1016/j.jbc.2022.102557 · 2022 · External reference
Lipoproteome screening of the Lyme disease agent identifies inhibitors of antibody-mediated complement killing
10.1073/pnas.2117770119 · 2022 · External reference
Conformational dynamics of complement protease C1r inhibitor proteins from Lyme disease- and relapsing fever-causing spirochetes
10.1016/j.jbc.2023.104972 · 2023 · External reference
A Structural Basis for Inhibition of the Complement Initiator Protease C1r by Lyme Disease Spirochetes
10.4049/jimmunol.2100815 · 2021 · External reference
Structural determination of the complement inhibitory domain of Borrelia burgdorferi BBK32 provides insight into classical pathway complement evasion by Lyme disease spirochetes
2019 · External reference
Borrelia burgdorferi BBK32 Inhibits the Classical Pathway by Blocking Activation of the C1 Complement Complex
10.1371/journal.ppat.1005404 · 2016 · External reference
Inactivation of the fibronectin-binding adhesin gene bbk32 significantly attenuates the infectivity potential of Borrelia burgdorferi
10.1111/j.1365-2958.2005.05042.x · 2006 · External reference
Identification of a 47 kDa fibronectin-binding protein expressed by Borrelia burgdorferi isolate B31
10.1046/j.1365-2958.1998.01127.x · 1998 · External reference
Mapping the ligand-binding region of Borrelia burgdorferi fibronectin-binding protein BBK32
10.1128/iai.69.6.4129-4133.2001 · 2001 · External reference
BBK32, a fibronectin binding MSCRAMM from Borrelia burgdorferi, contains a disordered region that undergoes a conformational change on ligand binding
10.1074/jbc.m401691200 · 2004 · External reference
Glycosaminoglycan binding by Borrelia burgdorferi adhesin BBK32 specifically and uniquely promotes joint colonization
10.1111/cmi.12407 · 2015 · External reference
Bioluminescent imaging of Borrelia burgdorferi in vivo demonstrates that the fibronectin-binding protein BBK32 is required for optimal infectivity
10.1111/j.1365-2958.2011.07801.x · 2011 · External reference
Biomechanics of Borrelia burgdorferi Vascular Interactions
10.1016/j.celrep.2016.08.013 · 2016 · External reference
Vascular binding of a pathogen under shear force through mechanistically distinct sequential interactions with host macromolecules
10.1111/mmi.12045 · 2012 · External reference
Fibronectin binding protein BBK32 of the Lyme disease spirochete promotes bacterial attachment to glycosaminoglycans
10.1128/iai.74.1.435-441.2006 · 2006 · External reference
Accurate structure prediction of biomolecular interactions with AlphaFold 3
10.1038/s41586-024-07487-w · 2024 · External reference
Borrelia burgdorferi protein BBK32 binds to soluble fibronectin via the N-terminal 70-kDa region, causing fibronectin to undergo conformational extension
10.1074/jbc.m114.578419 · 2014 · External reference
Decreased infectivity in Borrelia burgdorferi strain B31 is associated with loss of linear plasmid 25 or 28-1
10.1128/iai.69.1.446-455.2001 · 2001 · External reference
Motor rotation is essential for the formation of the periplasmic flagellar ribbon, cellular morphology, and Borrelia burgdorferi persistence within Ixodes scapularis tick and murine hosts
10.1128/iai.03097-14 · 2015 · External reference
Genetic transformation of Borrelia burgdorferi
2011 · External reference
Isolation and cultivation of Lyme disease spirochetes
1984 · External reference
A plasmid-encoded nicotinamidase (PncA) is essential for infectivity of Borrelia burgdorferi in a mammalian host
10.1046/j.1365-2958.2003.03452.x · 2003 · External reference
Borrelia miyamotoi FbpA and FbpB Are Immunomodulatory Outer Surface Lipoproteins With Distinct Structures and Functions
10.3389/fimmu.2022.886733 · 2022 · External reference
Electrotransformation of the spirochete Borrelia burgdorferi
1995 · External reference
Genetic Transformation and Complementation
10.1007/978-1-4939-7383-5_15 · 2018 · External reference
A guided tour into subcellular colocalization analysis in light microscopy
10.1111/j.1365-2818.2006.01706.x · 2006 · External reference
Borrelia burgdorferi binds fibronectin through a tandem beta-zipper, a common mechanism of fibronectin binding in staphylococci, streptococci, and spirochetes
10.1074/jbc.m501731200 · 2005 · External reference
A novel fibronectin binding motif in MSCRAMMs targets F3 modules
10.1371/journal.pone.0005412 · 2009 · External reference
Allosteric Regulation of Fibronectin/α5β1 Interaction by Fibronectin-Binding MSCRAMMs
10.1371/journal.pone.0159118 · 2016 · External reference
On-Off Kinetics of Engagement of FNI Modules of Soluble Fibronectin by β-Strand Addition
2015 · External reference
The absence of linear plasmid 25 or 28-1 of Borrelia burgdorferi dramatically alters the kinetics of experimental infection via distinct mechanisms
10.1128/iai.71.8.4608-4613.2003 · 2003 · External reference
The Classical Complement Pathway Is Required to Control Borrelia burgdorferi Levels During Experimental Infection
10.3389/fimmu.2018.00959 · 2018 · External reference
Fibronectin-binding protein of Borrelia hermsii expressed in the blood of mice with relapsing fever
10.1128/iai.01582-14 · 2014 · External reference
Serum complement C4b, fibronectin, and prolidase are associated with the pathological changes of pulmonary tuberculosis
10.1186/1471-2334-14-52 · 2014 · External reference
Stuck in the Middle: Fibronectin-Binding Proteins in Gram-Positive Bacteria
10.3389/fmicb.2016.01504 · 2016 · External reference
The remarkably multifunctional fibronectin binding proteins of Staphylococcus aureus
10.1007/s10096-016-2763-0 · 2016 · External reference
Localization of the domains of the Haemophilus ducreyi trimeric autotransporter DsrA involved in serum resistance and binding to the extracellular matrix proteins fibronectin and vitronectin
10.1128/iai.00819-08 · 2009 · External reference
The Staphylococcus aureus polysaccharide capsule and Efb-dependent fibrinogen shield act in concert to protect against phagocytosis
10.1099/mic.0.000293 · 2016 · External reference
Fibronectin binds to the C1q component of complement
10.1073/pnas.79.13.4198 · 1982 · External reference
Characterization of the opsonic and monocyte adherence functions of the specific fibronectin fragment that enhances phagocytosis of particulate activators
10.4049/jimmunol.134.3.1844 · 1985 · External reference
Extracellular signal-regulated kinase 1/2 is required for complement component C1q and fibronectin dependent enhancement of Fcγ- receptor mediated phagocytosis in mouse and human cells
10.1186/s12865-020-00393-6 · 2020 · External reference
Multifunctional and Redundant Roles of Borrelia burgdorferi Outer Surface Proteins in Tissue Adhesion, Colonization, and Complement Evasion
10.3389/fimmu.2016.00442 · 2016 · External reference
Further characterization of complement regulator-acquiring surface proteins of Borrelia burgdorferi
10.1128/iai.69.12.7800-7809.2001 · 2001 · External reference
Complement resistance of Borrelia burgdorferi correlates with the expression of BbCRASP-1, a novel linear plasmid-encoded surface protein that interacts with human factor H and FHL-1 and is unrelated to Erp proteins
10.1074/jbc.m308343200 · 2004 · External reference
Identification and functional characterization of complement regulator-acquiring surface protein 1 of the Lyme disease spirochetes Borrelia afzelii and Borrelia garinii
10.1128/iai.73.4.2351-2359.2005 · 2005 · External reference
Polymorphic factor H-binding activity of CspA protects Lyme borreliae from the host complement in feeding ticks to facilitate tick-to-host transmission
10.1371/journal.ppat.1007106 · 2018 · External reference
Elucidating the Immune Evasion Mechanisms of Borrelia mayonii, the Causative Agent of Lyme Disease
10.3389/fimmu.2019.02722 · 2019 · External reference
Host Immune Evasion by Lyme and Relapsing Fever Borreliae: Findings to Lead Future Studies for Borrelia miyamotoi
10.3389/fimmu.2017.00012 · 2017 · External reference
Immune evasion of Borrelia miyamotoi: CbiA, a novel outer surface protein exhibiting complement binding and inactivating properties
10.1038/s41598-017-00412-4 · 2017 · External reference
Human complement regulators C4b-binding protein and C1 esterase inhibitor interact with a novel outer surface protein of Borrelia recurrentis
10.1371/journal.pntd.0000698 · 2010 · External reference
Molecular characterization of the interaction of Borrelia parkeri and Borrelia turicatae with human complement regulators
10.1128/iai.00089-10 · 2010 · External reference
The Borrelia hermsii factor H binding protein FhbA is not required for infectivity in mice or for resistance to human complement in vitro
10.1128/iai.01892-14 · 2014 · External reference
A CRISPR interference platform for selective downregulation of gene expression in Borrelia burgdorferi
10.1128/aem.02519-20 · 2021 · External reference
Cas9-mediated endogenous plasmid loss in Borrelia burgdorferi
10.1371/journal.pone.0278151 · 2022 · External reference
Inducible CRISPRi-Based Operon Silencing and Selective in Trans Gene Complementation in Borrelia burgdorferi
10.1128/jb.00468-22 · 2023 · External reference
A Borrelia burgdorferi LptD homolog is required for flipping of surface lipoproteins through the spirochetal outer membrane
10.1111/mmi.15072 · 2023 · External reference