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References from Lumpy skin disease virus 001/156 protein is a virulence factor that suppresses interferon production through impairing IRF3 dimerization. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
External reference
10.1007/978-3-7643-7557-7
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2008 · External reference
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Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7
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Vaccinia virus proteins A52 and B14 Share a Bcl-2-like fold but have evolved to inhibit NF-kappaB rather than apoptosis
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Vaccinia virus protein K7 is a virulence factor that alters the acute immune response to infection
10.1099/vir.0.052670-0 · 2013 · External reference
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10.1111/j.1865-1682.2011.01242.x · 2012 · External reference
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Genome of lumpy skin disease virus
10.1128/jvi.75.15.7122-7130.2001 · 2001 · External reference
Constitutive proteins of lumpy skin disease virion assessed by next-generation proteomics
10.1128/jvi.00723-23 · 2023 · External reference
The 135 Gene of Goatpox Virus Encodes an Inhibitor of NF-κB and Apoptosis and May Serve as an Improved Insertion Site To Generate Vectored Live Vaccine
10.1128/jvi.00190-18 · 2018 · External reference
RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway
10.1016/j.cell.2009.06.015 · 2009 · External reference
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
10.1126/science.1232458 · 2013 · External reference
Vaccinia Virus Protein C6: A Multifunctional Interferon Antagonist
10.1007/978-981-10-7572-8_1 · 2018 · External reference
Structural insights into interferon regulatory factor activation
10.1016/j.cellsig.2009.12.005 · 2010 · External reference
Triggering the interferon antiviral response through an IKK-related pathway
10.1126/science.1081315 · 2003 · External reference
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway
10.1038/ni921 · 2003 · External reference
The A137R Protein of African Swine Fever Virus Inhibits Type I Interferon Production via the Autophagy-Mediated Lysosomal Degradation of TBK1
2022 · External reference
DDX19 Inhibits Type I Interferon Production by Disrupting TBK1-IKKε-IRF3 Interactions and Promoting TBK1 and IKKε Degradation
10.1016/j.celrep.2019.01.029 · 2019 · External reference
X-ray crystal structure of IRF-3 and its functional implications
10.1038/nsb1001 · 2003 · External reference
X-ray crystal structure of IRF-3 and its functional implications
10.1038/nsb1001 · 2003 · External reference
The Structural Basis of IRF-3 Activation upon Phosphorylation
10.4049/jimmunol.2000026 · 2020 · External reference
Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction
10.1016/s1074-7613(00)00053-4 · 2000 · External reference
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10.1074/jbc.r600026200 · 2007 · External reference
Variola virus topoisomerase: DNA cleavage specificity and distribution of sites in Poxvirus genomes
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Monkeypox
10.1056/nejmra2208860 · 2022 · External reference
Virulent Poxviruses Inhibit DNA Sensing by Preventing STING Activation
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DNA-PK is a DNA sensor for IRF-3-dependent innate immunity
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IFI16 is an innate immune sensor for intracellular DNA
10.1038/ni.1932 · 2010 · External reference
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway
10.1038/ni921 · 2003 · External reference
Crystal structure of IRF-3 reveals mechanism of autoinhibition and virus-induced phosphoactivation
10.1038/nsb1002 · 2003 · External reference
The IRF family transcription factors at the interface of innate and adaptive immune responses
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Type I interferon [corrected] gene induction by the interferon regulatory factor family of transcription factors
10.1016/j.immuni.2006.08.009 · 2006 · External reference
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Molecular basis for the recognition of phosphorylated STAT1 by importin alpha5
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IPO3-mediated Nonclassical Nuclear Import of NF-κB Essential Modulator (NEMO) Drives DNA Damage-dependent NF-κB Activation
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Japanese Encephalitis Virus NS5 Inhibits Type I Interferon (IFN) Production by Blocking the Nuclear Translocation of IFN Regulatory Factor 3 and NF-κB
2017 · External reference
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10.1038/20367 · 1999 · External reference
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Host species-specific activity of the poxvirus PKR inhibitors E3 and K3 mediate host range function
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A short amino acid sequence able to specify nuclear location
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