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References from The calcineurin pathway regulates extreme thermotolerance, cell membrane and wall integrity, antifungal resistance, and virulence in Candida auris. Local targets link to admitted publications; unresolved targets remain external evidence.
Global incidence and mortality of severe fungal disease
10.1016/s1473-3099(23)00692-8 · 2024 · External reference
Candida auris‒associated hospitalizations, United States, 2017-2022
10.3201/eid2907.230540 · 2023 · External reference
Worsening spread of Candida auris in the United States, 2019 to 2021
10.7326/m22-3469 · 2023 · External reference
Calcium-calcineurin signaling pathway in Candida albicans: A potential drug target
10.1016/j.micres.2021.126786 · 2021 · External reference
Calcineurin-Crz1 signaling in lower eukaryotes
10.1128/ec.00038-14 · 2014 · External reference
Elucidation of the calcineurin-Crz1 stress response transcriptional network in the human fungal pathogen Cryptococcus neoformans
2017 · External reference
Calcineurin acts through the CRZ1/TCN1-encoded transcription factor to regulate gene expression in yeast
10.1101/gad.11.24.3432 · 1997 · External reference
Calcineurin is essential for Candida albicans survival in serum and virulence
10.1128/ec.2.3.422-430.2003 · 2003 · External reference
Calcineurin signaling: lessons from Candida species
2015 · External reference
Convergent evolution of calcineurin pathway roles in thermotolerance and virulence in Candida glabrata
10.1534/g3.112.002279 · 2012 · External reference
The Crz1/Sp1 transcription factor of Cryptococcus neoformans is activated by calcineurin and regulates cell wall integrity
2012 · External reference
Calcineurin targets involved in stress survival and fungal virulence
2016 · External reference
Highly accurate protein structure prediction with AlphaFold
10.1038/s41586-021-03819-2 · 2021 · External reference
Accurate structure prediction of biomolecular interactions with AlphaFold 3
10.1038/s41586-024-07487-w · 2024 · External reference
Genome-wide identification for genes involved in sodium dodecyl sulfate toxicity in Saccharomyces cerevisiae
10.1186/s12866-020-1721-2 · 2020 · External reference
Fungal tolerance to Congo red, a cell wall integrity stress, as a promising indicator of ecological niche
10.1016/j.funbio.2021.03.007 · 2021 · External reference
The importance of connections between the cell wall integrity pathway and the unfolded protein response in filamentous fungi
10.1093/bfgp/elu027 · 2014 · External reference
Effect of cadmium on essential metals and their impact on lipid metabolism in Saccharomyces cerevisiae
10.1007/s12192-019-01058-z · 2020 · External reference
Azole combinations and multi-targeting drugs that synergistically inhibit Candidozyma auris
10.3390/jof10100698 · 2024 · External reference
Candida auris genetics and emergence
10.1146/annurev-micro-032521-015858 · 2023 · External reference
Candida auris: a review of the literature
10.1128/cmr.00029-17 · 2017 · External reference
The many faces of Candida auris: phenotypic and strain variation in an emerging pathogen
10.1371/journal.ppat.1012011 · 2024 · External reference
Candida auris undergoes adhesin-dependent and -independent cellular aggregation
10.1371/journal.ppat.1012076 · 2024 · External reference
The Fungal Cell Wall: Candida, Cryptococcus, and Aspergillus Species
10.3389/fmicb.2019.02993 · 2020 · External reference
Cell aggregation mediated by ACE2 deletion in Candida auris modulates fungal colonization and host immune responses in the skin
10.1128/msphere.00734-24 · 2024 · External reference
Analysis of chitin at the hyphal tip of Candida albicans using calcofluor white
10.1271/bbb.69.1798 · 2005 · External reference
A role for the MAP kinase gene MKC1 in cell wall construction and morphological transitions in Candida albicans
10.1099/00221287-144-2-411 · 1998 · External reference
Pseudohyphal growth of the emerging pathogen Candida auris is triggered by genotoxic stress through the S phase checkpoint
10.1128/msphere.00151-20 · 2020 · External reference
Discovery of the diploid form of the emerging fungal pathogen Candida auris
10.1021/acsinfecdis.0c00282 · 2020 · External reference
The utility of Drosophila melanogaster as a fungal infection model
10.3389/fimmu.2024.1349027 · 2024 · External reference
Adenylyl cyclase and protein kinase A play redundant and distinct roles in growth, differentiation, antifungal drug resistance, and pathogenicity of Candida auris
2021 · External reference
Calcineurin controls growth, morphology, and pathogenicity in Aspergillus fumigatus
10.1128/ec.00139-06 · 2006 · External reference
Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin
10.1371/journal.ppat.1000532 · 2009 · External reference
Calcineurin is essential for virulence in Candida albicans
10.1128/iai.71.9.5344-5354.2003 · 2003 · External reference
Calcineurin is required for virulence of Cryptococcus neoformans
10.1093/emboj/16.10.2576 · 1997 · External reference
Cryptococcus neoformans Rim101 is associated with cell wall remodeling and evasion of the host immune responses
2013 · External reference
Synergistic effect of calcineurin inhibitors and fluconazole against Candida albicans biofilms
10.1128/aac.01397-07 · 2008 · External reference
The calcineruin inhibitor cyclosporine a synergistically enhances the susceptibility of Candida albicans biofilms to fluconazole by multiple mechanisms
10.1186/s12866-016-0728-1 · 2016 · External reference
Synergistic antifungal activities of bafilomycin A1, fluconazole, and the pneumocandin MK-0991/caspofungin acetate (L-743,873) with calcineurin inhibitors FK506 and L-685,818 against Cryptococcus neoformans
10.1128/aac.44.3.739-746.2000 · 2000 · External reference
In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus
10.1128/aac.48.5.1664-1669.2004 · 2004 · External reference
Functional genomic analysis of fluconazole susceptibility in the pathogenic yeast Candida glabrata: roles of calcium signaling and mitochondria
10.1128/aac.48.5.1600-1613.2004 · 2004 · External reference
Structure-guided synthesis of FK506 and FK520 analogs with increased selectivity exhibit in vivo therapeutic efficacy against Cryptococcus
2022 · External reference
In vitro and in vivo assessment of FK506 analogs as novel antifungal drug candidates
2018 · External reference
Sre1p, a regulator of oxygen sensing and sterol homeostasis, is required for virulence in Cryptococcus neoformans
10.1111/j.1365-2958.2007.05676.x · 2007 · External reference
Systematic functional profiling of transcription factor networks in Cryptococcus neoformans
10.1038/ncomms7757 · 2015 · External reference
Functional redundancy in Candida auris cell surface adhesins crucial for cell-cell interaction and aggregation
10.1038/s41467-024-53588-5 · 2024 · External reference
