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References from Convergent mechanisms of epithelial cell structure manipulation by intestinal pathogens. Local targets link to admitted publications; unresolved targets remain external evidence.
Surfing on membrane waves: microvilli, curved membranes, and immune signaling
10.3389/fimmu.2020.02187 · 2020 · External reference
Mechanisms of cell polarity-controlled epithelial homeostasis and immunity in the intestine
10.1101/cshperspect.a027888 · 2017 · External reference
Inflammation and disintegration of intestinal villi in an experimental model for Vibrio parahaemolyticus-induced diarrhea
10.1371/journal.ppat.1002593 · 2012 · External reference
Manipulation of microvillar proteins during Salmonella enterica invasion results in brush border effacement and actin remodeling
10.3389/fcimb.2023.1137062 · 2023 · External reference
Attachment and penetration of Escherichia coli into intestinal epithelium of the ileum in newborn pigs
1969 · External reference
Insights into the pathogenesis of enteropathogenic E. coli using an improved intestinal enterocyte model
10.1371/journal.pone.0055284 · 2013 · External reference
The enteropathogenic Escherichia coli type III secretion system effector Map binds EBP50/NHERF1: implication for cell signalling and diarrhoea
10.1111/j.1365-2958.2006.05109.x · 2006 · External reference
Morphological characterization of Cryptosporidium parvum life-cycle stages in an in vitro model system
10.1017/s0031182009990837 · 2010 · External reference
Modelling Cryptosporidium infection in human small intestinal and lung organoids
10.1038/s41564-018-0177-8 · 2018 · External reference
Spontaneous cryptosporidiosis in an adult female rabbit
10.1177/030098587901600109 · 1979 · External reference
Targeting of an enteropathogenic Escherichia coli (EPEC) effector protein to host mitochondria
10.1046/j.1462-5822.2000.00082.x · 2000 · External reference
Identification of a bacterial type III effector family with G protein mimicry functions
10.1016/j.cell.2005.10.031 · 2006 · External reference
Identification of F-actin as the dynamic hub in a microbial-induced GTPase polarity circuit
10.1016/j.cell.2011.11.063 · 2012 · External reference
The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly
10.1016/s0092-8674(00)80732-1 · 1999 · External reference
Unresolved reference
2025 · External reference
Salmonella Typhimurium discreet-invasion of the murine gut absorptive epithelium
10.1371/journal.ppat.1008503 · 2020 · External reference
SARS-CoV-2 replication in airway epithelia requires motile cilia and microvillar reprogramming
2023 · External reference
Intimate host attachment: enteropathogenic and enterohaemorrhagic Escherichia coli
2013 · External reference
Why put yourself on a pedestal? The pathogenic role of the A/E pedestal
10.1128/iai.00489-23 · 2024 · External reference
Enteropathogenic and enterohemorrhagic E. coli: ecology, pathogenesis, and evolution
10.3389/fcimb.2013.00015 · 2013 · External reference
Enteropathogenic and enterohemorrhagic Escherichia coli virulence gene regulation
10.1128/iai.01927-06 · 2007 · External reference
Enteropathogenic E. coli (EPEC) transfers its receptor for intimate adherence into mammalian cells
10.1016/s0092-8674(00)80437-7 · 1997 · External reference
Binding of intimin from enteropathogenic Escherichia coli to Tir and to host cells
10.1046/j.1365-2958.1999.01338.x · 1999 · External reference
IRSp53 links the enterohemorrhagic E. coli effectors Tir and EspFU for actin pedestal formation
10.1016/j.chom.2009.02.003 · 2009 · External reference
Insulin receptor tyrosine kinase substrate links the E. coli O157:H7 actin assembly effectors Tir and EspF(U) during pedestal formation
10.1073/pnas.0809131106 · 2009 · External reference
Enteropathogenic E. coli Tir binds Nck to initiate actin pedestal formation in host cells
10.1038/ncb0901-856 · 2001 · External reference
A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization
10.1038/35017080 · 2000 · External reference
Enteropathogenic E. coli acts through WASP and Arp2/3 complex to form actin pedestals
10.1038/14087 · 1999 · External reference
The enteropathogenic E. coli effector EspH promotes actin pedestal formation and elongation via WASP-interacting protein (WIP)
10.1111/j.1462-5822.2012.01778.x · 2012 · External reference
The EHEC type III effector NleL is an E3 ubiquitin ligase that modulates pedestal formation
10.1371/journal.pone.0019331 · 2011 · External reference
Cryptosporidium parvum induces host cell actin accumulation at the host-parasite interface
10.1128/iai.68.4.2315-2322.2000 · 2000 · External reference
Cryptosporidiosis of the human small intestine: a light and electron microscopic study
10.1016/s0046-8177(84)80165-3 · 1984 · External reference
Cryptosporidium parvum infection requires host cell actin polymerization
10.1128/iai.69.9.5940-5942.2001 · 2001 · External reference
Gliding motility leads to active cellular invasion by Cryptosporidium parvum sporozoites
10.1128/iai.73.9.5379-5387.2005 · 2005 · External reference
Cryptosporidium rhoptry effector protein ROP1 injected during invasion targets the host cytoskeletal modulator LMO7
10.1016/j.chom.2021.07.002 · 2021 · External reference
The role of the eaeA gene in diarrhea and neurological complications in a gnotobiotic piglet model of enterohemorrhagic Escherichia coli infection
10.1128/iai.63.9.3621-3627.1995 · 1995 · External reference
Citrobacter rodentium translocated intimin receptor (Tir) is an essential virulence factor needed for actin condensation, intestinal colonization and colonic hyperplasia in mice
10.1046/j.1365-2958.2003.03429.x · 2003 · External reference
The ability of an attaching and effacing pathogen to trigger localized actin assembly contributes to virulence by promoting mucosal attachment
10.1111/cmi.12302 · 2014 · External reference
Extracellular motility and cell-to-cell transmission of enterohemorrhagic E. coli is driven by EspFU-mediated actin assembly
10.1371/journal.ppat.1006501 · 2017 · External reference
Actin pedestal formation by enterohemorrhagic Escherichia coli enhances bacterial host cell attachment and concomitant type III translocation
10.1128/iai.01523-13 · 2014 · External reference
Targeting of the apical junctional complex by bacterial pathogens
10.1016/j.bbamem.2020.183237 · 2020 · External reference
Virus-associated disruption of mucosal epithelial tight junctions and its role in viral transmission and spread
10.1080/21688370.2021.1943274 · 2021 · External reference
The Escherichia coli heat shock protease HtrA participates in defense against oxidative stress
10.1007/s004380051092 · 1999 · External reference
Identification, characterization, and mapping of the Escherichia coli htrA gene, whose product is essential for bacterial growth only at elevated temperatures
10.1128/jb.171.3.1574-1584.1989 · 1989 · External reference
Campylobacter jejuni surface-bound protease HtrA, but not the secreted protease nor protease in shed membrane vesicles, disrupts epithelial cell-to-cell junctions
10.3390/cells13030224 · 2024 · External reference
Distinct roles of secreted HtrA proteases from gram-negative pathogens in cleaving the junctional protein and tumor suppressor E-cadherin
10.1074/jbc.c111.333419 · 2012 · External reference
Campylobacter jejuni enters gut epithelial cells and impairs intestinal barrier function through cleavage of occludin by serine protease HtrA
10.1186/s13099-019-0283-z · 2019 · External reference
The HtrA family of serine proteases
10.1046/j.1365-2958.1997.5601928.x · 1997 · External reference
Serine protease PKF of Acinetobacter baumannii results in serum resistance and suppression of biofilm formation
10.1093/infdis/jis939 · 2013 · External reference
Proteomic analysis of Vibrio cholerae outer membrane vesicles
10.1073/pnas.1403683111 · 2014 · External reference
Extracellular HtrA serine proteases: an emerging new strategy in bacterial pathogenesis
10.1111/cmi.12845 · 2018 · External reference
HtrA-mediated E-cadherin cleavage is limited to DegP and DegQ homologs expressed by gram-negative pathogens
10.1186/s12964-016-0153-y · 2016 · External reference
Helicobacter pylori HtrA is a new secreted virulence factor that cleaves |E-cadherin to disrupt intercellular adhesion
10.1038/embor.2010.114 · 2010 · External reference
Adherens junctions and desmosomes are damaged by Entamoeba histolytica: participation of EhCPADH complex and EhCP112 protease
10.1111/cmi.12761 · 2017 · External reference
Aeromonas hydrophila Ssp1: a secretory serine protease that disrupts tight junction integrity and is essential for host infection
10.1016/j.fsi.2022.06.068 · 2022 · External reference
Secreted Giardia intestinalis cysteine proteases disrupt intestinal epithelial cell junctional complexes and degrade chemokines
10.1080/21505594.2018.1451284 · 2018 · External reference
Distinct effects of Vibrio cholerae haemagglutinin/protease on the structure and localization of the tight junction-associated proteins occludin and ZO-1
10.1046/j.1462-5822.2000.00025.x · 2000 · External reference
Actin dynamics in host-pathogen interaction
10.1002/1873-3468.13173 · 2018 · External reference
Cadherin-actin interactions at adherens junctions
10.1016/j.ceb.2011.07.001 · 2011 · External reference
A weak link with actin organizes tight junctions to control epithelial permeability
10.1016/j.devcel.2020.07.022 · 2020 · External reference
Novel bacterial ADP-ribosylating toxins: structure and function
10.1038/nrmicro3310 · 2014 · External reference
Bacterial guanine nucleotide exchange factors SopE-like and WxxxE effectors
10.1128/iai.01250-09 · 2010 · External reference
Identification of Salmonella SPI-2 secretion system components required for SpvB-mediated cytotoxicity in macrophages and virulence in mice
10.1111/j.1574-695x.2007.00364.x · 2008 · External reference
Aeromonas hydrophila AH-3 AexT is an ADP-ribosylating toxin secreted through the type III secretion system
10.1016/j.micpath.2007.06.004 · 2008 · External reference
Translocation of a Vibrio cholerae type VI secretion effector requires bacterial endocytosis by host cells
10.1016/j.chom.2009.02.005 · 2009 · External reference
Salmonella effector SpvB disrupts intestinal epithelial barrier integrity for bacterial translocation
10.3389/fcimb.2020.606541 · 2020 · External reference
Clostridium difficile toxins disrupt epithelial barrier function by altering membrane microdomain localization of tight junction proteins
10.1128/iai.69.3.1329-1336.2001 · 2001 · External reference
Intracellular expression of the Salmonella plasmid virulence protein, SpvB, causes apoptotic cell death in eukaryotic cells
10.1016/s0882-4010(03)00066-4 · 2003 · External reference
The long-lived nature of clostridium perfringens iota toxin in mammalian cells induces delayed apoptosis
10.1128/iai.00710-09 · 2009 · External reference
ADP-ribosylation of actin by the Clostridium botulinum C2 toxin in mammalian cells results in delayed caspase-dependent apoptotic cell death
10.1128/iai.00651-08 · 2008 · External reference
The Salmonella spvB virulence gene encodes an enzyme that ADP-ribosylates actin and destabilizes the cytoskeleton of eukaryotic cells
10.1046/j.1365-2958.2001.02360.x · 2001 · External reference
Co-ordinate regulation of distinct host cell signalling pathways by multifunctional enteropathogenic Escherichia coli effector molecules
10.1046/j.1365-2958.2002.02952.x · 2002 · External reference
Intestinal barrier dysfunction by enteropathogenic Escherichia coli is mediated by two effector molecules and a bacterial surface protein
10.1111/j.1365-2958.2004.04308.x · 2004 · External reference
Citrobacter rodentium infection causes both mitochondrial dysfunction and intestinal epithelial barrier disruption in vivo: role of mitochondrial associated protein (Map)
10.1111/j.1462-5822.2006.00741.x · 2006 · External reference
SopE and SopE2 from Salmonella typhimurium activate different sets of RhoGTPases of the host cell
10.1074/jbc.m100609200 · 2001 · External reference
Salmonella enterica serovar Typhimurium effectors SopB, SopE, SopE2 and SipA disrupt tight junction structure and function
10.1111/j.1462-5822.2006.00762.x · 2006 · External reference
Rac1, but not RhoA, signaling protects epithelial adherens junction assembly during ATP depletion
10.1152/ajpcell.00604.2001 · 2002 · External reference
Epithelial junctions and Rho family GTPases: the zonular signalosome
10.4161/21541248.2014.973760 · 2014 · External reference
Cryptosporidium parvum infection of Caco-2 cell monolayers induces an apical monolayer defect, selectively increases transmonolayer permeability, and causes epithelial cell death
10.1128/iai.62.10.4506-4514.1994 · 1994 · External reference
Infection of human and bovine epithelial cells with Cryptosporidium andersoni induces apoptosis and disrupts tight junctional ZO-1: effects of epidermal growth factor
10.1016/s0020-7519(03)00138-3 · 2003 · External reference
Differential response to the course of Cryptosporidium parvum infection and its impact on epithelial integrity in differentiated versus undifferentiated human intestinal enteroids
10.1128/iai.00397-22 · 2022 · External reference
Signalling to and from tight junctions
10.1038/nrm1055 · 2003 · External reference
Tight junctions: from simple barriers to multifunctional molecular gates
10.1038/nrm.2016.80 · 2016 · External reference
The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction
10.1073/pnas.261452898 · 2001 · External reference
The coxsackie- and adenovirus receptor (CAR) is an in vivo marker for epithelial tight junctions, with a potential role in regulating permeability and tissue homeostasis
10.1016/j.yexcr.2006.01.025 · 2006 · External reference
Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5
10.1126/science.275.5304.1320 · 1997 · External reference
The coxsackie-adenovirus receptor (CAR) is used by reference strains and clinical isolates representing all six serotypes of coxsackievirus group B and by swine vesicular disease virus
10.1006/viro.2000.0324 · 2000 · External reference
Virus-induced Abl and Fyn kinase signals permit coxsackievirus entry through epithelial tight junctions
10.1016/j.cell.2005.10.035 · 2006 · External reference
Coxsackievirus entry across epithelial tight junctions requires occludin and the small GTPases Rab34 and Rab5
10.1016/j.chom.2007.07.003 · 2007 · External reference
The coxsackievirus and adenovirus receptor, a required host factor for recovirus infection, is a putative enteric calicivirus receptor
10.1128/jvi.00869-19 · 2019 · External reference
Elucidating pathways of Toxoplasma gondii invasion in the gastrointestinal tract: involvement of the tight junction protein occludin
10.1016/j.micinf.2015.07.001 · 2015 · External reference
SARS-CoV-2 productively infects human gut enterocytes
10.1126/science.abc1669 · 2020 · External reference
Tight junction protein occludin is an internalization factor for SARS-CoV-2 infection and mediates virus cell-to-cell transmission
10.1073/pnas.2218623120 · 2023 · External reference
The tight junction protein JAM-A functions as coreceptor for rotavirus entry into MA104 cells
10.1016/j.virol.2014.11.016 · 2015 · External reference
The rotavirus surface protein VP8 modulates the gate and fence function of tight junctions in epithelial cells
10.1242/jcs.01425 · 2004 · External reference
Rotavirus-induced early activation of the RhoA/ROCK/MLC signaling pathway mediates the disruption of tight junctions in polarized MDCK cells
10.1038/s41598-018-32352-y · 2018 · External reference
A protein kinase A-dependent mechanism by which rotavirus affects the distribution and mRNA level of the functional tight junction-associated protein, occludin, in human differentiated intestinal Caco-2 cells
10.1128/jvi.00263-07 · 2007 · External reference
Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo
10.1172/jci24970 · 2005 · External reference
Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure
10.1242/jcs.02915 · 2006 · External reference
Tight junctions as targets and effectors of mucosal immune homeostasis
10.1016/j.jcmgh.2020.04.001 · 2020 · External reference
Listeria adhesion protein induces intestinal epithelial barrier dysfunction for bacterial translocation
10.1016/j.chom.2018.03.004 · 2018 · External reference
Enteropathogenic Escherichia coli-induced myosin light chain phosphorylation alters intestinal epithelial permeability
10.1016/s0016-5085(97)70006-4 · 1997 · External reference
Helicobacter pylori activates myosin light-chain kinase to disrupt claudin-4 and claudin-5 and increase epithelial permeability
10.1128/iai.73.12.7844-7852.2005 · 2005 · External reference
Helicobacter pylori dysregulation of gastric epithelial tight junctions by urease-mediated myosin II activation
10.1053/j.gastro.2008.10.011 · 2009 · External reference
Intestinal infection with Giardia spp. reduces epithelial barrier function in a myosin light chain kinase-dependent fashion
10.1053/gast.2002.36002 · 2002 · External reference
The PAR-aPKC system: lessons in polarity
10.1242/jcs.02898 · 2006 · External reference
aPKC: the kinase that phosphorylates cell polarity
10.12688/f1000research.14427.1 · 2018 · External reference
EPEC effector EspF promotes Crumbs3 endocytosis and disrupts epithelial cell polarity
10.1111/cmi.12757 · 2017 · External reference
Enteropathogenic Escherichia coli (EPEC) recruitment of PAR polarity protein atypical PKCζ to pedestals and cell-cell contacts precedes disruption of tight junctions in intestinal epithelial cells
10.3390/ijms21020527 · 2020 · External reference
Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA
10.1126/science.1081919 · 2003 · External reference
Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity
10.1038/nature05765 · 2007 · External reference
CagA-ASPP2 complex mediates loss of cell polarity and favors H. pylori colonization of human gastric organoids
10.1073/pnas.1908787117 · 2020 · External reference
Salmonella type III effector AvrA stabilizes cell tight junctions to inhibit inflammation in intestinal epithelial cells
2008 · External reference
Epithelial cells expressing EhADH, an entamoeba histolytica adhesin, exhibit increased tight junction proteins
10.3389/fcimb.2018.00340 · 2018 · External reference
Entamoeba histolytica EhCP112 dislocates and degrades claudin-1 and claudin-2 at tight junctions of the intestinal epithelium
10.3389/fcimb.2017.00372 · 2017 · External reference
Interaction of enteropathogenic Escherichia coli with human intestinal mucosa: role of effector proteins in brush border remodeling and formation of attaching and effacing lesions
10.1128/iai.73.2.1243-1251.2005 · 2005 · External reference