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References from Cell type differences in human cytomegalovirus transcription and epigenetic regulation with insights into major immediate-early enhancer-promoter control. Local targets link to admitted publications; unresolved targets remain external evidence.
Cytomegalovirus cell tropism
2008 · External reference
Neuropathogenesis of congenital cytomegalovirus infection: disease mechanisms and prospects for intervention
10.1128/cmr.00023-08 · 2009 · External reference
Human cytomegalovirus transcriptome activity differs during replication in human fibroblast, epithelial and astrocyte cell lines
10.1099/vir.0.038083-0 · 2012 · External reference
Molecular characterization of human cytomegalovirus infection with single-cell transcriptomics
10.1038/s41564-023-01325-x · 2023 · External reference
Transcriptome-wide characterization of human cytomegalovirus in natural infection and experimental latency
10.1073/pnas.1710522114 · 2017 · External reference
Precise maps of RNA polymerase reveal how promoters direct initiation and pausing
10.1126/science.1229386 · 2013 · External reference
Thiol-linked alkylation of RNA to assess expression dynamics
10.1038/nmeth.4435 · 2017 · External reference
scSLAM-seq reveals core features of transcription dynamics in single cells
10.1038/s41586-019-1369-y · 2019 · External reference
Nucleotide resolution comparison of transcription of human cytomegalovirus and host genomes reveals universal use of RNA polymerase II elongation control driven by dissimilar core promoter elements
10.1128/mbio.02047-18 · 2019 · External reference
Herpes simplex virus 1 dramatically alters loading and positioning of RNA polymerase II on host genes early in infection
10.1128/jvi.02184-17 · 2018 · External reference
Reactivation of epstein-barr virus from latency involves increased RNA polymerase activity at CTCF binding sites on the viral genome
2023 · External reference
Decoding murine cytomegalovirus
10.1371/journal.ppat.1010992 · 2023 · External reference
HSV-1 infection induces a downstream shift of promoter-proximal pausing for host genes
10.1128/jvi.00381-23 · 2023 · External reference
Human cytomegalovirus IE2 drives transcription initiation from a select subset of late infection viral promoters by host RNA polymerase II
2020 · External reference
Cytomegalovirus late transcription factor target sequence diversity orchestrates viral early to late transcription
2021 · External reference
Human cytomegalovirus IE2 both activates and represses initiation and modulates elongation in a context-dependent manner
2022 · External reference
Immediate-early viral gene regulation and function.
10.1017/cbo9780511545313.018 · 2007 · External reference
Herpesvirus late gene expression: a viral-specific pre-initiation complex is key
10.3389/fmicb.2016.00869 · 2016 · External reference
Differences in RNA polymerase II complexes and their interactions with surrounding chromatin on human and cytomegalovirus genomes
10.1038/s41467-022-29739-x · 2022 · External reference
Human cytomegalovirus infection elicits global changes in host transcription by RNA polymerases I, II, and III
10.3390/v14040779 · 2022 · External reference
DFF-ChIP: a method to detect and quantify complex interactions between RNA polymerase II, transcription factors, and chromatin
10.1093/nar/gkae760 · 2024 · External reference
A unified view of the sequence and functional organization of the human RNA polymerase II promoter
2020 · External reference
Cytomegalovirus replicates in differentiated but not in undifferentiated human embryonal carcinoma cells
10.1126/science.6322309 · 1984 · External reference
Reactivation of the human cytomegalovirus major immediate-early regulatory region and viral replication in embryonal NTera2 cells: role of trichostatin A, retinoic acid, and deletion of the 21-base-pair repeats and modulator
10.1128/jvi.75.4.1581-1593.2001 · 2001 · External reference
Differentiation-coupled induction of human cytomegalovirus replication by union of the major enhancer retinoic acid, cyclic AMP, and NF-κB response elements
10.1128/jvi.00965-15 · 2015 · External reference
Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo
10.1074/jbc.m102306200 · 2001 · External reference
Phorbol ester-induced human cytomegalovirus major immediate-early (MIE) enhancer activation through PKC-delta, CREB, and NF-kappaB desilences MIE gene expression in quiescently infected human pluripotent NTera2 cells
10.1128/jvi.00416-10 · 2010 · External reference
Differential dependencies of human RNA polymerase II promoters on TBP, TAF1, TFIIB and XPB
10.1093/nar/gkac678 · 2022 · External reference
Two Sp1/Sp3 binding sites in the major immediate-early proximal enhancer of human cytomegalovirus have a significant role in viral replication
10.1128/jvi.79.15.9597-9607.2005 · 2005 · External reference
Decoding human cytomegalovirus
10.1126/science.1227919 · 2012 · External reference
Canonical and variant forms of histone h3 are deposited onto the human cytomegalovirus genome during lytic and latent infections
10.1128/jvi.01220-16 · 2016 · External reference
Regulation of human cytomegalovirus immediate-early gene expression
10.1159/000150504 · 1996 · External reference
Major immediate-early enhancer and its gene products.
2006 · External reference
Critical role for the human cytomegalovirus major immediate early proteins in recruitment of RNA polymerase II and H3K27Ac to an enhancer-like element in oriLyt
10.1128/spectrum.03144-22 · 2023 · External reference
Epigenetic reprogramming of host and viral genes by Human Cytomegalovirus infection in Kasumi-3 myeloid progenitor cells at early times post-infection
10.1128/jvi.00183-21 · 2021 · External reference
Autorepression of the human cytomegalovirus major immediate-early promoter/enhancer at late times of infection is mediated by the recruitment of chromatin remodeling enzymes by IE86
10.1128/jvi.01297-06 · 2006 · External reference
Chromatin control of human cytomegalovirus infection
2023 · External reference
Control of immediate early gene expression for human cytomegalovirus reactivation
10.3389/fcimb.2020.00476 · 2020 · External reference
Temporal dynamics of cytomegalovirus chromatin assembly in productively infected human cells
10.1128/jvi.01218-08 · 2008 · External reference
Histone H3 lysine 4 methylation marks postreplicative human cytomegalovirus chromatin
10.1128/jvi.00581-12 · 2012 · External reference
Characteristics of immediate-Early 2 (IE2) and UL84 proteins in UL84-independent strains of human cytomegalovirus (HCMV)
10.1128/spectrum.00539-21 · 2021 · External reference
Breaking human cytomegalovirus major immediate-early gene silence by vasoactive intestinal peptide stimulation of the protein kinase A-CREB-TORC2 signaling cascade in human pluripotent embryonal NTera2 cells
10.1128/jvi.00061-09 · 2009 · External reference
Effect of a modulator deletion on transcription of the human cytomegalovirus major immediate-early genes in infected undifferentiated and differentiated cells
10.1128/jvi.71.2.1246-1255.1997 · 1997 · External reference
Human cytomegalovirus with IE-2 (UL122) deleted fails to express early lytic genes
10.1128/jvi.75.4.1870-1878.2001 · 2001 · External reference
Simple and highly efficient BAC recombineering using galK selection
10.1093/nar/gni035 · 2005 · External reference
Oxidative stress rapidly stabilizes promoter-proximal paused Pol II across the human genome
10.1093/nar/gkx724 · 2017 · External reference
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome
10.1186/gb-2009-10-3-r25 · 2009 · External reference
BEDTools: a flexible suite of utilities for comparing genomic features
10.1093/bioinformatics/btq033 · 2010 · External reference
The human genome browser at UCSC
10.1101/gr.229102 · 2002 · External reference
Use of the nuclear walk-on methodology to determine sites of RNA polymerase II initiation and pausing and quantify nascent RNAs in cells
10.1016/j.ymeth.2019.02.003 · 2019 · External reference
Data quality aware analysis of differential expression in RNA-seq with NOISeq R/Bioc package
2015 · External reference
