Research graph
References from VapC toxins promote the pathogenesis of Rickettsia heilongjiangensis by cleaving essential RNAs from both Rickettsia and its host. Local targets link to admitted publications; unresolved targets remain external evidence.
Recent Research Milestones in the Pathogenesis of Human Rickettsioses and Opportunities Ahead
10.2217/fmb-2019-0266 · 2020 · External reference
Rocky Mountain spotted fever
10.1016/s1473-3099(07)70261-x · 2007 · External reference
Mediterranean Spotted Fever
10.1016/j.idc.2008.03.003 · 2008 · External reference
Complete genome sequencing and comparative genomic analyses of a new spotted-fever Rickettsia heilongjiangensis strain B8
2023 · External reference
Emerging and re-emerging rickettsioses: endothelial cell infection and early disease events
10.1038/nrmicro1866 · 2008 · External reference
Inducible lung epithelial resistance requires multisource reactive oxygen species generation to protect against bacterial infections
2019 · External reference
Inducible Lung Epithelial Resistance Requires Multisource Reactive Oxygen Species Generation To Protect against Viral Infections
10.1128/mbio.00696-18 · 2018 · External reference
The Role of Reactive Oxygen Species in Antibiotic-Mediated Killing of Bacteria
10.1016/j.tim.2016.12.008 · 2017 · External reference
Infection of Endothelial Cells by Dengue Virus Induces ROS Production by Different Sources Affecting Virus Replication, Cellular Activation, Death and Vascular Permeability
10.3389/fimmu.2022.810376 · 2022 · External reference
Host-Cell Interactions with Pathogenic Rickettsia Species
10.2217/fmb.09.6 · 2009 · External reference
Reactive oxygen species and the bacterial response to lethal stress
10.1016/j.mib.2014.06.008 · 2014 · External reference
Oxidation of the Guanine Nucleotide Pool Underlies Cell Death by Bactericidal Antibiotics
10.1126/science.1219192 · 2012 · External reference
ROS-triggered endothelial cell death mechanisms: Focus on pyroptosis, parthanatos, and ferroptosis
10.3389/fimmu.2022.1039241 · 2022 · External reference
Rickettsia rickettsii-induced cellular injury of human vascular endothelium in vitro
10.1128/iai.44.3.545-553.1984 · 1984 · External reference
Toxins, Targets, and Triggers: An Overview of Toxin-Antitoxin Biology
10.1016/j.molcel.2018.01.003 · 2018 · External reference
A Type VI Secretion System of Pseudomonas aeruginosa Targets a Toxin to Bacteria
10.1016/j.chom.2009.12.007 · 2010 · External reference
Bacterial toxin RelE induces apoptosis in human cells
10.1016/s0014-5793(02)02764-3 · 2002 · External reference
The spirochetal chpK-chromosomal toxin-antitoxin locus induces growth inhibition of yeast and mycobacteria
10.1016/s0378-1097(03)00848-6 · External reference
Effect of Rickettsial Toxin VapC on Its Eukaryotic Host
10.1371/journal.pone.0026528 · 2011 · External reference
Toxin–antitoxin modules as bacterial metabolic stress managers
10.1016/j.tibs.2005.10.004 · 2005 · External reference
Cut to the chase–Regulating translation through RNA cleavage
10.1016/j.biochi.2015.01.009 · 2015 · External reference
VapCs of Mycobacterium tuberculosis cleave RNAs essential for translation
10.1093/nar/gkw781 · 2016 · External reference
Structural Variations and Rearrangements in Bacterial Type II Toxin-Antitoxin Systems
10.1007/978-3-031-58843-3_11 · 2024 · External reference
Toxin-antitoxin loci are highly abundant in free-living but lost from host-associated prokaryotes
10.1093/nar/gki201 · 2005 · External reference
Crystal Structure of the VapBC Toxin–Antitoxin Complex from Shigella flexneri Reveals a Hetero-Octameric DNA-Binding Assembly
10.1016/j.jmb.2011.10.024 · 2011 · External reference
A VapBC Toxin-Antitoxin Module Is a Posttranscriptional Regulator of Metabolic Flux in Mycobacteria
10.1128/jb.06790-11 · 2012 · External reference
Toxin inhibition inC. crescentusVapBC1 is mediated by a flexible pseudo-palindromic protein motif and modulated by DNA binding
2016 · External reference
Improved protein structure prediction using potentials from deep learning
10.1038/s41586-019-1923-7 · 2020 · External reference
Crystal Structures of Phd-Doc, HigA, and YeeU Establish Multiple Evolutionary Links between Microbial Growth-Regulating Toxin-Antitoxin Systems
10.1016/j.str.2010.04.018 · 2010 · External reference
Crystal structure of proteolyzed VapBC and DNA‐bound VapBC from Salmonella enterica Typhimurium LT2 and VapC as a putative Ca 2+ ‐dependent ribonuclease
10.1096/fj.201901989r · 2019 · External reference
Structure of FitAB from Neisseria gonorrhoeae Bound to DNA Reveals a Tetramer of Toxin-Antitoxin Heterodimers Containing Pin Domains and Ribbon-Helix-Helix Motifs
10.1074/jbc.m605198200 · 2006 · External reference
A homozygous Keap1-knockout human embryonic stem cell line generated using CRISPR/Cas9 mediates gene targeting
10.1016/j.scr.2016.12.028 · 2017 · External reference
The Key Role of GSH in Keeping the Redox Balance in Mammalian Cells: Mechanisms and Significance of GSH in Detoxification via Formation of Conjugates
10.3390/antiox12111953 · 2023 · External reference
Regulation of Enteric vapBC Transcription: Induction by VapC Toxin Dimer-Breaking
10.1093/nar/gks029 · 2012 · External reference
Addiction protein Phd of plasmid prophage P1 is a substrate of the ClpXP serine protease of Escherichia coli
10.1073/pnas.92.8.3274 · 1995 · External reference
Proteolysis in the SOS response and metal homeostasis in Escherichia coli
10.1016/j.resmic.2009.08.012 · 2009 · External reference
Temperature-dependent proteolysis as a control element in Escherichia coli metabolism
10.1016/j.resmic.2009.08.015 · 2009 · External reference
Targeted Knockout of the Rickettsia rickettsii OmpA Surface Antigen Does Not Diminish Virulence in a Mammalian Model System
10.1128/mbio.00323-15 · 2015 · External reference
The Pathogenesis of Severe Fever with Thrombocytopenia Syndrome Virus Infection in Alpha/Beta Interferon Knockout Mice: Insights into the Pathologic Mechanisms of a New Viral Hemorrhagic Fever
10.1128/jvi.02277-13 · 2014 · External reference
The Rickettsial Ankyrin Repeat Protein 2 Is a Type IV Secreted Effector That Associates with the Endoplasmic Reticulum
10.1128/mbio.00975-18 · 2018 · External reference
VapC20 of Mycobacterium tuberculosis cleaves the Sarcin–Ricin loop of 23S rRNA
10.1038/ncomms3796 · 2013 · External reference
An RNA-seq method for defining endoribonuclease cleavage specificity identifies dual rRNA substrates for toxin MazF-mt3
10.1038/ncomms4538 · 2014 · External reference
Measurement of Effector Protein Injection by Type III and Type IV Secretion Systems by Using a 13-Residue Phosphorylatable Glycogen Synthase Kinase Tag
10.1128/iai.00690-06 · 2006 · External reference
Functions of ROS in Macrophages and Antimicrobial Immunity
10.3390/antiox10020313 · 2021 · External reference
NF-?B activation suppresses host cell apoptosis during Rickettsia rickettsii infection via regulatory effects on intracellular localization or levels of apoptogenic and anti-apoptotic proteins
2004 · External reference
Rickettsia rickettsiiInfection Protects Human Microvascular Endothelial Cells against Staurosporine‐Induced Apoptosis by a cIAP2‐Independent Mechanism
10.1086/597805 · 2009 · External reference
System-Wide Analysis Unravels the Differential Regulation and In Vivo Essentiality of Virulence-Associated Proteins B and C Toxin-Antitoxin Systems of Mycobacterium tuberculosis
10.1093/infdis/jiy109 · 2018 · External reference
Regulation and quality control by Lon-dependent proteolysis
10.1016/j.resmic.2009.08.021 · 2009 · External reference
Toxin-Antitoxin Modules Are Pliable Switches Activated by Multiple Protease Pathways
10.3390/toxins8070214 · 2016 · External reference
Enteric virulence associated protein VapC inhibits translation by cleavage of initiator tRNA
10.1073/pnas.1019587108 · 2011 · External reference
Homologous VapC Toxins Inhibit Translation and Cell Growth by Sequence-Specific Cleavage of tRNA fMet
10.1128/jb.00582-17 · 2018 · External reference
Secretome of obligate intracellularRickettsia
2014 · External reference
Disruption of theRickettsia rickettsiiSca2 Autotransporter Inhibits Actin-Based Motility
10.1128/iai.00100-10 · 2010 · External reference
