Research graph
References from HBV capsid assembly modulators differentially modulate the assembly of wild-type and drug-resistant core protein chimeric nucleocapsids and empty capsids. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
External reference
Interferon alpha induces sustained changes in NK cell responsiveness to Hepatitis B viral load suppression in vivo
2016 · External reference
Clearance of pegylated interferon by Kupffer cells limits NK cell activation and therapy response of patients with HBV infection
10.1126/scitranslmed.aba6322 · 2021 · External reference
Alpha-interferon suppresses hepadnavirus transcription by altering epigenetic modification of cccDNA minichromosomes
2013 · External reference
Persistent low level of Hepatitis B virus promotes fibrosis progression during therapy
2020 · External reference
Benefits and risks of nucleoside analog therapy for Hepatitis B
10.1002/hep.22920 · 2009 · External reference
Present and future therapies of hepatitis B: from discovery to cure
10.1002/hep.28025 · 2015 · External reference
Chronic hepatitis B: what should be the goal for new therapies?
10.1016/j.antiviral.2013.01.006 · 2013 · External reference
Mechanism of interferon alpha therapy for chronic hepatitis B and potential approaches to improve its therapeutic efficacy
10.1016/j.antiviral.2023.105782 · 2024 · External reference
Benefits and risks of interferon therapy for hepatitis B
10.1002/hep.22956 · 2009 · External reference
The current status and future directions of hepatitis B antiviral drug discovery
10.1080/17460441.2017.1255195 · 2017 · External reference
Restoration of a functional antiviral immune response to chronic HBV infection by reducing viral antigen load: if not sufficient, is it necessary?
10.1080/22221751.2021.1952851 · 2021 · External reference
Therapeutic strategies for a functional cure of chronic hepatitis B virus infection
10.1016/j.apsb.2014.05.002 · 2014 · External reference
Virological basis for the cure of chronic hepatitis B
10.1021/acsinfecdis.8b00081 · 2019 · External reference
Molecular virology of hepatitis B virus for clinicians
10.1016/j.cld.2007.08.002 · 2007 · External reference
Phenotypic mixing between different hepadnavirus nucleocapsid proteins reveals C protein dimerization to be cis preferential
10.1128/jvi.68.8.5225-5231.1994 · 1994 · External reference
Visualization of a 4-helix bundle in the hepatitis B virus capsid by cryo-electron microscopy
10.1038/386091a0 · 1997 · External reference
The crystal structure of the human hepatitis B virus capsid
10.1016/s1097-2765(01)80009-5 · 1999 · External reference
Weak protein-protein interactions are sufficient to drive assembly of hepatitis B virus capsids
10.1021/bi0261645 · 2002 · External reference
The HBV capsid modulators derived from sulfamoylbenzamides and benzamides: an overview of the progress of patents
10.1007/s00044-023-03095-x · 2023 · External reference
Recent advances in the development of HBV capsid assembly modulators
10.1016/j.cbpa.2019.02.009 · 2019 · External reference
Hepatitis B virus capsids have diverse structural responses to small-molecule ligands bound to the heteroaryldihydropyrimidine pocket
10.1128/jvi.03058-15 · 2016 · External reference
Assembly-directed antivirals differentially bind quasiequivalent pockets to modify hepatitis B virus capsid tertiary and quaternary structure
10.1016/j.str.2013.06.013 · 2013 · External reference
Local stabilization of subunit-subunit contacts causes global destabilization of hepatitis B virus capsids
10.1021/acschembio.0c00320 · 2020 · External reference
High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein
10.1073/pnas.1513803112 · 2015 · External reference
Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) inhibit Hepatitis B virus replication by different molecular mechanisms
10.1038/srep42374 · 2017 · External reference
Nomenclature of HBV core protein-targeting antivirals
10.1038/s41575-022-00700-z · 2022 · External reference
Sulfamoylbenzamide derivatives inhibit the assembly of hepatitis B virus nucleocapsids
10.1128/jvi.00582-13 · 2013 · External reference
Interferons accelerate decay of replication-competent nucleocapsids of hepatitis B virus
10.1128/jvi.00918-10 · 2010 · External reference
Discovery and mechanistic study of benzamide derivatives that modulate hepatitis B virus capsid assembly
2017 · External reference
CpAMs induce assembly of HBV capsids with altered electrophoresis mobility: implications for mechanism of inhibiting pgRNA packaging
10.1016/j.antiviral.2018.09.001 · 2018 · External reference
Identification of hepatitis B virus core protein residues critical for capsid assembly, pgRNA encapsidation and resistance to capsid assembly modulators
10.1016/j.antiviral.2021.105080 · 2021 · External reference
Amino acid residues at core protein dimer-dimer interface modulate multiple steps of hepatitis B virus replication and HBeAg biogenesis
2021 · External reference
The interface between hepatitis B virus capsid proteins affects self-assembly, pregenomic RNA packaging, and reverse transcription
10.1128/jvi.03545-14 · 2015 · External reference
Alteration of mature nucleocapsid and enhancement of covalently closed circular DNA formation by hepatitis b virus core mutants defective in complete-virion formation
10.1128/jvi.01481-15 · 2015 · External reference
Preclinical profile and characterization of the hepatitis B virus core protein inhibitor ABI-H0731
10.1128/aac.01463-20 · 2020 · External reference
Preclinical characterization of AB-506, an inhibitor of HBV replication targeting the viral core protein
10.1016/j.antiviral.2021.105211 · 2022 · External reference
Assembly properties of hepatitis B virus core protein mutants correlate with their resistance to assembly-directed antivirals
10.1128/jvi.01082-18 · 2018 · External reference
The premise of capsid assembly modulators towards eliminating HBV persistence
10.1080/17460441.2023.2239701 · 2023 · External reference
Targeting the multifunctional HBV core protein as a potential cure for chronic hepatitis B
10.1016/j.antiviral.2020.104917 · 2020 · External reference
Safety, pharmacokinetics, and antiviral activity of the capsid inhibitor AB-506 from Phase 1 studies in healthy subjects and those with hepatitis B
10.1002/hep4.2095 · 2022 · External reference
Viral sequence analysis of chronic hepatitis B patients treated with the capsid assembly modulator JNJ-56136379 in the JADE phase 2a study
10.1016/j.antiviral.2023.105660 · 2023 · External reference
Randomised phase 2 study (JADE) of the HBV capsid assembly modulator JNJ-56136379 with or without a nucleos(t)ide analogue in patients with chronic hepatitis B infection
10.1136/gutjnl-2022-328041 · 2023 · External reference
Computational approaches to predict hepatitis B virus capsid protein mutations that confer resistance to capsid assembly modulators
10.3390/v17030332 · 2025 · External reference
Deep mutational scanning of hepatitis B virus reveals a mechanism for cis-preferential reverse transcription
2024 · External reference
A mutant hepatitis B virus core protein mimics inhibitors of icosahedral capsid self-assembly
10.1021/bi801814y · 2009 · External reference
Pregenomic RNA launch hepatitis B virus replication system facilitates the mechanistic study of antiviral agents and drug-resistant variants on covalently closed circular DNA synthesis
10.1128/jvi.01150-22 · 2022 · External reference
An RNA-based system to study hepatitis B virus replication and evaluate antivirals
2023 · External reference
Bay41-4109-induced aberrant polymers of hepatitis b capsid proteins are removed via STUB1-promoted p62-mediated macroautophagy
2022 · External reference
Selective depletion of HBV-infected hepatocytes by class A capsid assembly modulators requires high levels of intrahepatic HBV core protein
10.1128/aac.00420-24 · 2024 · External reference
Class A capsid assembly modulator RG7907 clears HBV-infected hepatocytes through core-dependent hepatocyte death and proliferation
10.1097/hep.0000000000000428 · 2023 · External reference
Novel non-HAP class A HBV capsid assembly modulators have distinct in vitro and in vivo profiles
10.1128/jvi.00722-23 · 2023 · External reference
Class A capsid assembly modulator apoptotic elimination of hepatocytes with high HBV core antigen level in vivo is dependent on de novo core protein translation
10.1128/jvi.01502-23 · 2024 · External reference
CAM-A-dependent HBV core aggregation induces apoptosis through ANXA1
10.1016/j.jhepr.2024.101134 · 2024 · External reference
Global structural changes in hepatitis B virus capsids induced by the assembly effector HAP1
10.1128/jvi.00933-06 · 2006 · External reference
HBV core protein allosteric modulators differentially alter cccDNA biosynthesis from de novo infection and intracellular amplification pathways
2017 · External reference
Antiviral properties and mechanism of action studies of the hepatitis B virus capsid assembly modulator JNJ-56136379
10.1128/aac.02439-19 · 2020 · External reference
Hepatitis B virus nucleocapsid uncoating: biological consequences and regulation by cellular nucleases
10.1080/22221751.2021.1919034 · 2021 · External reference
A southern blot assay for detection of hepatitis B virus covalently closed circular DNA from cell cultures
10.1007/978-1-62703-484-5_13 · 2013 · External reference
Direct inhibition of hepatitis B e antigen by core protein allosteric modulator
10.1002/hep.30514 · 2019 · External reference
Capsids of hepatitis B virus e antigen with authentic C termini are stabilized by electrostatic interactions
10.1002/1873-3468.13706 · 2020 · External reference
Multiple pathways in capsid assembly
10.1021/jacs.8b01804 · 2018 · External reference
Core protein: a pleiotropic keystone in the HBV lifecycle
10.1016/j.antiviral.2015.06.020 · 2015 · External reference
BAY 41-4109 has multiple effects on Hepatitis B virus capsid assembly
10.1002/jmr.801 · 2006 · External reference
Trapping of hepatitis B virus capsid assembly intermediates by phenylpropenamide assembly accelerators
10.1021/cb100275b · 2010 · External reference
Protein phosphatase 1 catalyzes HBV core protein dephosphorylation and is co-packaged with viral pregenomic RNA into nucleocapsids
2020 · External reference
Dimorphism of hepatitis B virus capsids is strongly influenced by the C-terminus of the capsid protein
10.1021/bi9604800 · 1996 · External reference
A dimorphism shift of hepatitis B virus capsids in response to ionic conditions
10.1039/c8nr03370f · 2018 · External reference
Secretion of genome-free hepatitis B virus--single strand blocking model for virion morphogenesis of para-retrovirus
10.1371/journal.ppat.1002255 · 2011 · External reference
Hepatitis B virus core protein dephosphorylation occurs during pregenomic RNA encapsidation
10.1128/jvi.02139-17 · 2018 · External reference
Common and distinct capsid and surface protein requirements for secretion of complete and genome-free hepatitis B virions
10.1128/jvi.00272-18 · 2018 · External reference
Hepatitis B virus e antigen variants
10.7150/ijms.2.2 · 2005 · External reference
Is the function of the HBeAg really unknown?
10.1080/21645515.2019.1607132 · 2019 · External reference
Precore and basal core promoter hepatitis B virus (HBV) variants are present from a young age and differ across HBV genotypes
10.1002/hep.31506 · 2021 · External reference
Novel potent capsid assembly modulators regulate multiple steps of the hepatitis B virus life cycle
10.1128/aac.00835-18 · 2018 · External reference
Characterization of the intracellular deproteinized relaxed circular DNA of hepatitis B virus: an intermediate of covalently closed circular DNA formation
10.1128/jvi.01123-07 · 2007 · External reference
Reversal of fulminant hepatic failure using an extracorporeal liver assist device
10.1002/hep.1840160112 · 1992 · External reference
Activation of stimulator of interferon genes in hepatocytes suppresses the replication of hepatitis B virus
2017 · External reference
Highly permissive cell lines for subgenomic and genomic hepatitis C virus RNA replication
10.1128/jvi.76.24.13001-13014.2002 · 2002 · External reference
Indoleamine 2,3-dioxygenase mediates the antiviral effect of gamma interferon against hepatitis B virus in human hepatocyte-derived cells
10.1128/jvi.01998-10 · 2011 · External reference
Regulation of hepatitis B virus replication by the phosphatidylinositol 3-kinase-akt signal transduction pathway
10.1128/jvi.00541-07 · 2007 · External reference
A putative amphipathic alpha helix in hepatitis B virus small envelope protein plays a critical role in the morphogenesis of subviral particles
10.1128/jvi.02399-20 · 2021 · External reference
In vitro screening for molecules that affect virus capsid assembly (and other protein association reactions)
10.1038/nprot.2007.60 · 2007 · External reference
Hepatitis core antigen produced in Escherichia coli: subunit composition, conformational analysis, and in vitro capsid assembly
10.1021/bi00015a003 · 1995 · External reference
Assembly properties of hepatitis B virus core protein mutants correlate with their resistance to assembly-directed antivirals
10.1128/jvi.01082-18 · 2018 · External reference
Engineering metastability into a virus-like particle to enable triggered dissociation
10.1021/jacs.2c10937 · 2023 · External reference
Hepatitis B virus virions produced under nucleos(t)ide analogue treatment are mainly not infectious because of irreversible DNA chain termination
10.1002/hep.30844 · 2020 · External reference
Analyses of HBV cccDNA quantification and modification
10.1007/978-1-4939-6700-1_6 · 2017 · External reference