Research graph
References from Uukuniemi virus infection causes a pervasive remodelling of the RNA-binding proteome in tick cells. Local targets link to admitted publications; unresolved targets remain external evidence.
Isolation of some viruses other than typical tick-borne encephalitis viruses from ixodes ricinus ticks In Finland
1964 · External reference
Uukuniemi Virus as a Tick-Borne Virus Model
10.1128/jvi.00095-16 · 2016 · External reference
Generation of mutant Uukuniemi viruses lacking the nonstructural protein NSs by reverse genetics indicates that NSs is a weak interferon antagonist
10.1128/jvi.03511-14 · 2015 · External reference
The genome of Uukuniemi virus consists of three unique RNA segments
10.1016/0092-8674(77)90316-6 · 1977 · External reference
Uukuniemi virus contains an RNA polymerase
10.1128/jvi.16.6.1420-1425.1975 · 1975 · External reference
Insights into bunyavirus architecture from electron cryotomography of Uukuniemi virus
10.1073/pnas.0708738105 · 2008 · External reference
DC-SIGN as a receptor for phleboviruses
10.1016/j.chom.2011.06.007 · 2011 · External reference
Entry of bunyaviruses into mammalian cells
10.1016/j.chom.2010.05.007 · 2010 · External reference
Genome-wide small interfering RNA screens reveal VAMP3 as a novel host factor required for Uukuniemi virus late penetration
10.1128/jvi.00388-14 · 2014 · External reference
Emerging phleboviruses
10.1016/j.coviro.2014.01.011 · 2014 · External reference
The mechanism of genome replication and transcription in bunyaviruses
10.1371/journal.ppat.1011060 · 2023 · External reference
Mutational analysis of the Bunyamwera orthobunyavirus nucleocapsid protein gene
10.1128/jvi.01460-09 · 2009 · External reference
Mutational analysis of Rift Valley fever phlebovirus nucleocapsid protein indicates novel conserved, functional amino acids
10.1371/journal.pntd.0006155 · 2017 · External reference
Differential Antagonism of Human Innate Immune Responses by Tick-Borne Phlebovirus Nonstructural Proteins
10.1128/msphere.00234-17 · 2017 · External reference
Characterization of the Uukuniemi virus group (Phlebovirus: Bunyaviridae): evidence for seven distinct species
10.1128/jvi.02719-12 · 2013 · External reference
How relevant are in vitro culture models for study of tick-pathogen interactions?
10.1080/20477724.2021.1944539 · 2021 · External reference
A draft genome sequence for the Ixodes scapularis cell line, ISE6
10.12688/f1000research.13635.1 · 2018 · External reference
Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities
2020 · External reference
Genomic insights into the Ixodes scapularis tick vector of Lyme disease
10.1038/ncomms10507 · 2016 · External reference
Tick cell lines: tools for tick and tick-borne disease research
10.1016/j.pt.2007.07.009 · 2007 · External reference
Induction and suppression of tick cell antiviral RNAi responses by tick-borne flaviviruses
10.1093/nar/gku657 · 2014 · External reference
Ixodes scapularis and Ixodes ricinus tick cell lines respond to infection with tick-borne encephalitis virus: transcriptomic and proteomic analysis
10.1186/s13071-015-1210-x · 2015 · External reference
RNAi reveals proteins for metabolism and protein processing associated with Langat virus infection in Ixodes scapularis (black-legged tick) ISE6 cells
10.1186/s13071-016-1944-0 · 2017 · External reference
Differential salivary gland transcript expression profile in Ixodes scapularis nymphs upon feeding or flavivirus infection
10.1016/j.ttbdis.2011.09.003 · 2012 · External reference
Tick-borne pathogens induce differential expression of genes promoting cell survival and host resistance in Ixodes ricinus cells
10.1186/s13071-017-2011-1 · 2017 · External reference
Immune-responsive lysozymes from hemocytes of the American dog tick, Dermacentor variabilis and an embryonic cell line of the Rocky Mountain wood tick, D. andersoni
10.1016/j.ibmb.2004.07.003 · 2004 · External reference
The Unfolded-Protein Response Triggers the Arthropod Immune Deficiency Pathway
2022 · External reference
Quantitative Proteomics of Uukuniemi Virus-host Cell Interactions Reveals GBF1 as Proviral Host Factor for Phleboviruses
10.1074/mcp.ra119.001631 · 2019 · External reference
Viral RNA Is a Hub for Critical Host-Virus Interactions
10.1007/978-3-031-40086-5_13 · 2023 · External reference
A Balancing Act: The Viral-Host Battle over RNA Binding Proteins
10.3390/v16030474 · 2024 · External reference
System-wide Profiling of RNA-Binding Proteins Uncovers Key Regulators of Virus Infection
10.1016/j.molcel.2019.01.017 · 2019 · External reference
Global analysis of protein-RNA interactions in SARS-CoV-2-infected cells reveals key regulators of infection
10.1016/j.molcel.2021.05.023 · 2021 · External reference
RNA Binding Proteins as Pioneer Determinants of Infection: Protective, Proviral, or Both?
10.3390/v13112172 · 2021 · External reference
System-wide identification of RNA-binding proteins by interactome capture
10.1038/nprot.2013.020 · 2013 · External reference
Tick cell culture isolation of an intracellular prokaryote from the tick Ixodes scapularis
10.1006/jipa.1996.0050 · 1996 · External reference
Uncovering viral RNA-host cell interactions on a proteome-wide scale
10.1016/j.tibs.2021.08.002 · 2022 · External reference
Global analysis of RNA-binding protein dynamics by comparative and enhanced RNA interactome capture
10.1038/s41596-020-00404-1 · 2021 · External reference
The Cap-Snatching Mechanism of Bunyaviruses
10.1016/j.tim.2019.12.006 · 2020 · External reference
XRN1 supplies free nucleotides to feed alphavirus replication
2024 · External reference
Bunyamwera orthobunyavirus S-segment untranslated regions mediate poly(A) tail-independent translation
10.1128/jvi.02201-08 · 2009 · External reference
Characterization of the 5’ and 3’ ends of viral messenger RNAs isolated from BHK21 cells infected with Germiston virus (Bunyavirus)
10.1016/0042-6822(90)90185-t · 1990 · External reference
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins
10.1016/j.cell.2012.04.031 · 2012 · External reference
Global changes of the RNA-bound proteome during the maternal-to-zygotic transition in Drosophila
10.1038/ncomms12128 · 2016 · External reference
The mRNA-bound proteome of the early fly embryo
10.1101/gr.200386.115 · 2016 · External reference
Antiviral RNAi in Insects and Mammals: Parallels and Differences
10.3390/v11050448 · 2019 · External reference
The interplay between virus infection and the cellular RNA interference machinery
10.1016/j.febslet.2006.02.070 · 2006 · External reference
RNA Encapsidation and Packaging in the Phleboviruses
10.3390/v8070194 · 2016 · External reference
Multi-omics analysis of SFTS virus infection in Rhipicephalus microplus cells reveals antiviral tick factors
10.1038/s41467-025-59565-w · 2025 · External reference
An Aedes aegypti-Derived Ago2 Knockout Cell Line to Investigate Arbovirus Infections
10.3390/v13061066 · 2021 · External reference
Antiviral RNA interference in disease vector (Asian longhorned) ticks
2021 · External reference
Attacked from All Sides: RNA Decay in Antiviral Defense
10.3390/v9010002 · 2017 · External reference
New Cell Lines Derived from European Tick Species
10.3390/microorganisms10061086 · 2022 · External reference
A high-quality Ixodes scapularis genome advances tick science
10.1038/s41588-022-01275-w · 2023 · External reference
The RNA-binding protein repertoire of embryonic stem cells
10.1038/nsmb.2638 · 2013 · External reference
Dynamic RNA-protein interactions underlie the zebrafish maternal-to-zygotic transition
10.1101/gr.215954.116 · 2017 · External reference
Comprehensive Identification of mRNA-Binding Proteins of Leishmania donovani by Interactome Capture
10.1371/journal.pone.0170068 · 2017 · External reference
Proteome-wide search reveals unexpected RNA-binding proteins in Saccharomyces cerevisiae
10.1371/journal.pone.0012671 · 2010 · External reference
The RNA-binding protein repertoire of Arabidopsis thaliana
10.1038/srep29766 · 2016 · External reference
ISG20 inhibits bluetongue virus replication
10.1016/j.virs.2022.04.010 · 2022 · External reference
Bcl-2 expression and p38MAPK activity in cells infected with influenza A virus: impact on virally induced apoptosis and viral replication
10.1074/jbc.m900146200 · 2009 · External reference
Nucleocapsids of the Rift Valley fever virus ambisense S segment contain an exposed RNA element in the center that overlaps with the intergenic region
10.1038/s41467-024-52058-2 · 2024 · External reference
HIV- 1 protease inhibits Cap- and poly(A)-dependent translation upon eIF4GI and PABP cleavage
10.1371/journal.pone.0007997 · 2009 · External reference
Nuclear relocalization of polyadenylate binding protein during rift valley fever virus infection involves expression of the NSs gene
10.1128/jvi.01434-13 · 2013 · External reference
Regulation of translation initiation in eukaryotes: mechanisms and biological targets
10.1016/j.cell.2009.01.042 · 2009 · External reference
Embraced by eIF3: structural and functional insights into the roles of eIF3 across the translation cycle
10.1093/nar/gkx805 · 2017 · External reference
Two RNA-binding motifs in eIF3 direct HCV IRES-dependent translation
10.1093/nar/gkt510 · 2013 · External reference
Molecular analysis of the factorless internal ribosome entry site in Cricket Paralysis virus infection
10.1038/srep37319 · 2016 · External reference
Bunyaviral cap-snatching vs. decapping: recycling cell cycle mRNAs
10.4161/cc.26878 · 2013 · External reference
Hybrid Gene Origination Creates Human-Virus Chimeric Proteins during Infection
2020 · External reference
The viral nucleocapsid protein and the human RNA-binding protein Mex3A promote translation of the Andes orthohantavirus small mRNA
10.1371/journal.ppat.1009931 · 2021 · External reference
Identification and structural analysis of human RBM8A and RBM8B: two highly conserved RNA-binding motif proteins that interact with OVCA1, a candidate tumor suppressor
10.1006/geno.2000.6315 · 2000 · External reference
Transcriptional regulation of the small nuclear ribonucleoprotein E protein gene. Identification of cis-acting sequences with homology to genes encoding ribosomal proteins
10.1016/s0021-9258(18)54495-1 · 1991 · External reference
SND1, a component of RNA-induced silencing complex, is up-regulated in human colon cancers and implicated in early stage colon carcinogenesis
10.1158/0008-5472.can-06-2707 · 2007 · External reference
Exploring the expanding universe of host-virus interactions mediated by viral RNA
10.1016/j.molcel.2024.08.027 · 2024 · External reference
SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9
10.1016/j.cell.2023.09.002 · 2023 · External reference
Human topoisomerases and their roles in genome stability and organization
10.1038/s41580-022-00452-3 · 2022 · External reference
Topoisomerase 3β is the major topoisomerase for mRNAs and linked to neurodevelopment and mental dysfunction
2017 · External reference
DNA and RNA topoisomerase activities of Top3β are promoted by mediator protein Tudor domain-containing protein 3
2016 · External reference
Highly accurate protein structure prediction with AlphaFold
10.1038/s41586-021-03819-2 · 2021 · External reference
Comprehensive Identification of RNA-Binding Domains in Human Cells
10.1016/j.molcel.2016.06.029 · 2016 · External reference
Role of RNA-binding proteins during the late stages of Flavivirus replication cycle
10.1186/s12985-020-01329-7 · 2020 · External reference
Top3β is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation
10.1038/nn.3479 · 2013 · External reference
An Ixodes scapularis cell line with a predominantly neuron-like phenotype
10.1007/s10493-015-9908-1 · 2015 · External reference
Enlisting the Ixodes scapularis Embryonic ISE6 Cell Line to Investigate the Neuronal Basis of Tick-Pathogen Interactions
10.3390/pathogens10010070 · 2021 · External reference
A little less aggregation a little more replication: Viral manipulation of stress granules
10.1002/wrna.1741 · 2023 · External reference
Plaque formation of herpes virus hominis type 2 and rubella virus in variants isolated from the colonies of BHK21/WI-2 cells formed in soft agar
10.1007/bf01314672 · 1977 · External reference
Generation of bovine respiratory syncytial virus (BRSV) from cDNA: BRSV NS2 is not essential for virus replication in tissue culture, and the human RSV leader region acts as a functional BRSV genome promoter
10.1128/jvi.73.1.251-259.1999 · 1999 · External reference
Invasion and intracellular development of the human granulocytic ehrlichiosis agent in tick cell culture
10.1128/jcm.37.8.2518-2524.1999 · 1999 · External reference
Formation and intracellular transport of a heterodimeric viral spike protein complex
10.1083/jcb.112.2.257 · 1991 · External reference
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
10.1006/meth.2001.1262 · 2001 · External reference
InParanoid-DIAMOND: faster orthology analysis with the InParanoid algorithm
10.1093/bioinformatics/btac194 · 2022 · External reference
ReactomePA: an R/Bioconductor package for reactome pathway analysis and visualization
10.1039/c5mb00663e · 2016 · External reference
ColabFold: making protein folding accessible to all
10.1038/s41592-022-01488-1 · 2022 · External reference
UCSF ChimeraX: Tools for structure building and analysis
2023 · External reference
The InterPro protein families and domains database: 20 years on
10.1093/nar/gkaa977 · 2021 · External reference
The EMBL-EBI Job Dispatcher sequence analysis tools framework in 2024
10.1093/nar/gkae241 · 2024 · External reference
