Research graph
References from Differential tropisms of old and new world hantaviruses influence virulence and developing host-directed antiviral candidates. Local targets link to admitted publications; unresolved targets remain external evidence.
Hantavirus infections
2019 · External reference
Epidemiology of Hantavirus infections in humans: a comprehensive, global overview
10.3109/1040841x.2013.783555 · 2014 · External reference
Hantaviruses
10.1016/j.cll.2010.01.004 · 2010 · External reference
Isolation of the etiologic agent of Korean Hemorrhagic fever
10.1093/infdis/137.3.298 · 1978 · External reference
Genetic identification of a hantavirus associated with an outbreak of acute respiratory illness
10.1126/science.8235615 · 1993 · External reference
Genetically distinct hantavirus in deer mice
10.1016/0140-6736(93)92917-i · 1993 · External reference
Differential pathogenesis between Andes virus strains CHI-7913 and Chile-9717869in Syrian Hamsters
10.1128/jvi.00108-21 · 2021 · External reference
Diversity and distribution of hantaviruses in South America
10.1128/jvi.02341-12 · 2012 · External reference
Nephropathia epidemica: detection of antigen in bank voles and serologic diagnosis of human infection
10.1093/infdis/141.2.131 · 1980 · External reference
Hantavirus reservoir hosts associated with peridomestic habitats in Argentina
10.3201/eid0506.990608 · 1999 · External reference
Hantavirus cardiopulmonary syndrome
2024 · External reference
Interactions of Viral Proteins from Pathogenic and Low or Non-Pathogenic Orthohantaviruses with Human Type I Interferon Signaling
10.3390/v13010140 · 2021 · External reference
A global perspective on hantavirus ecology, epidemiology, and disease
10.1128/cmr.00062-09 · 2010 · External reference
“Super-Spreaders” and Person-to-Person Transmission of Andes Virus in Argentina
10.1056/nejmoa2009040 · 2020 · External reference
Hantavirus pulmonary syndrome in Argentina. Possibility of person to person transmission
1996 · External reference
An unusual hantavirus outbreak in southern Argentina: person-to-person transmission? Hantavirus Pulmonary Syndrome Study Group for Patagonia
10.3201/eid0302.970210 · 1997 · External reference
Unresolved reference
External reference
Unresolved reference
External reference
Molecular biology of the Bunyaviridae
10.1099/0022-1317-71-3-501 · 1990 · External reference
Genetic depletion studies inform receptor usage by virulent hantaviruses in human endothelial cells
10.7554/elife.69708 · 2021 · External reference
beta3 Integrins mediate the cellular entry of hantaviruses that cause respiratory failure
10.1073/pnas.95.12.7074 · 1998 · External reference
Protocadherin-1 is essential for cell entry by New World hantaviruses
10.1038/s41586-018-0702-1 · 2018 · External reference
Orthohantavirus Pathogenesis and Cell Tropism
10.3389/fcimb.2020.00399 · 2020 · External reference
Hantavirus Pulmonary Syndrome
1995 · External reference
Tissue distribution of hantavirus antigen in naturally infected humans and deer mice
10.1086/515325 · 1998 · External reference
An outbreak of hantavirus pulmonary syndrome, Chile, 1997
10.3201/eid0404.980425 · 1998 · External reference
Hantavirus pulmonary syndrome in the United States: a pathological description of a disease caused by a new agent
10.1016/0046-8177(95)90123-x · 1995 · External reference
Hantavirus infection induces a typical myocarditis that may be responsible for myocardial depression and shock in hantavirus pulmonary syndrome
10.1086/513874 · 2007 · External reference
Seoul virus enhances regulatory and reduces proinflammatory responses in male Norway rats
10.1002/jmv.21213 · 2008 · External reference
Experimental infection with Puumala virus, the etiologic agent of nephropathia epidemica, in bank voles (Clethrionomys glareolus)
10.1128/jvi.55.1.34-38.1985 · 1985 · External reference
Seoul Virus Tropism and Pathology in Naturally Infected Feeder Rats
10.3390/v11060531 · 2019 · External reference
Susceptibility of human cells to Puumala virus infection
10.1099/0022-1317-74-3-515 · 1993 · External reference
A lethal disease model for hantavirus pulmonary syndrome
10.1006/viro.2001.1133 · 2001 · External reference
Seoul virus-infected rat lung endothelial cells and alveolar macrophages differ in their ability to support virus replication and induce regulatory T cell phenotypes
10.1128/jvi.01233-12 · 2012 · External reference
Hantavirus infection: an emerging infectious disease causing acute renal failure
10.1038/ki.2012.360 · 2013 · External reference
Progress on the Prevention and Treatment of Hantavirus Disease
10.3390/v11070610 · 2019 · External reference
Effect of Vandetanib on Andes virus survival in the hamster model of Hantavirus pulmonary syndrome
10.1016/j.antiviral.2016.05.014 · 2016 · External reference
The Syrian hamster model of hantavirus pulmonary syndrome
10.1016/j.antiviral.2012.06.002 · 2012 · External reference
Synergistic antiviral effects of ribavirin and the C-nucleoside analogs tiazofurin and selenazofurin against togaviruses, bunyaviruses, and arenaviruses
10.1128/aac.26.4.476 · 1984 · External reference
Ribavirin therapy for Hantaan virus infection in suckling mice
10.1093/infdis/153.3.489 · 1986 · External reference
Ribavirin protects Syrian hamsters against lethal hantavirus pulmonary syndrome--after intranasal exposure to Andes virus
10.3390/v5112704 · 2013 · External reference
Insufficient efficacy and safety of intravenous ribavirin in treatment of haemorrhagic fever with renal syndrome caused by Puumala virus
10.1080/23744235.2017.1293841 · 2017 · External reference
Intravenous ribavirin for hantavirus pulmonary syndrome: safety and tolerance during 1 year of open-label experience. Ribavirin Study Group
10.1177/135965359900400404 · 1999 · External reference
Placebo-controlled, double-blind trial of intravenous ribavirin for the treatment of hantavirus cardiopulmonary syndrome in North America
10.1086/425007 · 2004 · External reference
In vitro and in vivo activities of T-705 against arenavirus and bunyavirus infections
10.1128/aac.00356-07 · 2007 · External reference
Hantavirus regulation of endothelial cell functions
2009 · External reference
Endothelial cell permeability during hantavirus infection involves factor XII-dependent increased activation of the kallikrein-kinin system
10.1371/journal.ppat.1003470 · 2013 · External reference
Hantavirus Infection Suppresses Thrombospondin-1 Expression in Cultured Endothelial Cells in a Strain-Specific Manner
10.3389/fmicb.2016.01077 · 2016 · External reference
Novel infection of pericytes by Andes virus enhances endothelial cell permeability
10.1016/j.virusres.2021.198584 · 2021 · External reference
Experimental infection of human vascular endothelial cells by pathogenic and nonpathogenic hantaviruses
10.1007/bf01311063 · 1990 · External reference
Hantavirus pulmonary syndrome. Pathogenesis of an emerging infectious disease
1995 · External reference
Andes virus disrupts the endothelial cell barrier by induction of vascular endothelial growth factor and downregulation of VE-cadherin
10.1128/jvi.01405-10 · 2010 · External reference
Andes Virus Infection of Lymphatic Endothelial Cells Causes Giant Cell and Enhanced Permeability Responses That Are Rapamycin and Vascular Endothelial Growth Factor C Sensitive
10.1128/jvi.00817-12 · 2012 · External reference
SARS-CoV-2 infection of primary human lung epithelium for COVID-19 modeling and drug discovery
10.1016/j.celrep.2021.109055 · 2021 · External reference
Elevated cerebrospinal fluid neopterin concentration is associated with disease severity in acute Puumala hantavirus infection
10.1155/2013/634632 · 2013 · External reference
Heterozygous TLR3 Mutation in Patients with Hantavirus Encephalitis
10.1007/s10875-020-00834-2 · 2020 · External reference
Case report: severe neurological manifestation of Dobrava hantavirus infection
10.1002/jmv.21021 · 2007 · External reference
Hantavirus pulmonary syndrome: encephalitis caused by virus Andes
10.1007/s13365-010-0011-4 · 2011 · External reference
Hantaviruses induce antiviral and pro-inflammatory innate immune responses in astrocytic cells and the brain
10.1089/vim.2014.0019 · 2014 · External reference
Specific interference shRNA-expressing plasmids inhibit Hantaan virus infection in vitro and in vivo
10.1038/aps.2015.165 · 2016 · External reference
Cellular entry of hantaviruses which cause hemorrhagic fever with renal syndrome is mediated by beta3 integrins
10.1128/jvi.73.5.3951-3959.1999 · 1999 · External reference
Distinct ligand-binding modes for integrin alpha(v)beta(3)-mediated adhesion to fibronectin versus vitronectin
10.1074/jbc.m103997200 · 2001 · External reference
A hantavirus causing hemorrhagic fever with renal syndrome requires gC1qR/p32 for efficient cell binding and infection
10.1016/j.virol.2008.08.035 · 2008 · External reference
Hantaviruses direct endothelial cell permeability by sensitizing cells to the vascular permeability factor VEGF, while angiopoietin 1 and sphingosine 1-phosphate inhibit hantavirus-directed permeability
10.1128/jvi.02397-07 · 2008 · External reference
Hantavirus causing hemorrhagic fever with renal syndrome enters from the apical surface and requires decay-accelerating factor (DAF/CD55)
10.1128/jvi.02210-07 · 2008 · External reference
β2 integrin mediates hantavirus-induced release of neutrophil extracellular traps
10.1084/jem.20131092 · 2014 · External reference
Structural basis for pure antagonism of integrin αVβ3 by a high-affinity form of fibronectin
10.1038/nsmb.2797 · 2014 · External reference
Hantavirus entry: Perspectives and recent advances
10.1016/bs.aivir.2019.07.002 · 2019 · External reference
Macropinocytosis contributes to hantavirus entry into human airway epithelial cells
10.1016/j.virol.2019.02.013 · 2019 · External reference
Macropinocytosis and Clathrin-Dependent Endocytosis Play Pivotal Roles for the Infectious Entry of Puumala Virus
10.1128/jvi.00184-20 · 2020 · External reference
General awareness on hantavirus infection: A brief review
10.4103/bbrj.bbrj_110_20 · 2020 · External reference
Hantavirus Replication Cycle-An Updated Structural Virology Perspective
10.3390/v13081561 · 2021 · External reference
Antiviral drug screen identifies DNA-damage response inhibitor as potent blocker of SARS-CoV-2 replication
10.1016/j.celrep.2021.108940 · 2021 · External reference
Innate immune pathway modulator screen identifies STING pathway activation as a strategy to inhibit multiple families of arbo and respiratory viruses
10.1016/j.xcrm.2023.101024 · 2023 · External reference
Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease
10.1038/s41467-020-18233-x · 2020 · External reference
Favipiravir (T-705), a broad spectrum inhibitor of viral RNA polymerase
10.2183/pjab.93.027 · 2017 · External reference
Differential Susceptibility of Fetal Retinal Pigment Epithelial Cells, hiPSC- Retinal Stem Cells, and Retinal Organoids to Zika Virus Infection
10.3390/v15010142 · 2023 · External reference
Antiviral Activities of Silymarin and Derivatives
10.3390/molecules24081552 · 2019 · External reference
Recent Advances and Perspectives on the Health Benefits of Urolithin B, A Bioactive Natural Product Derived From Ellagitannins
10.3389/fphar.2022.917266 · 2022 · External reference
6-Azauridine Induces Autophagy-Mediated Cell Death via a p53- and AMPK-Dependent Pathway
10.3390/ijms22062947 · 2021 · External reference
Unresolved reference
External reference
Category C Diseases and Agents
10.1016/b978-0-12-802029-6.00005-0 · 2016 · External reference
Regulation of cellular gene expression in endothelial cells by sin nombre and prospect hill viruses
10.1089/0882824041310504 · 2004 · External reference
The role of endothelial activation in dengue hemorrhagic fever and hantavirus pulmonary syndrome
10.4161/viru.25569 · 2013 · External reference
Endothelial Cells in Emerging Viral Infections
10.3389/fcvm.2021.619690 · 2021 · External reference
Hantavirus
10.1055/s-0041-1733803 · 2021 · External reference
Differential antiviral response of endothelial cells after infection with pathogenic and nonpathogenic hantaviruses
10.1128/jvi.78.12.6143-6150.2004 · 2004 · External reference
The Andes Virus Nucleocapsid Protein Directs Basal Endothelial Cell Permeability by Activating RhoA
10.1128/mbio.01747-16 · 2016 · External reference
More than half of the patients with acute Puumala hantavirus infection have abnormal cardiac findings
10.1080/00365540802502629 · 2009 · External reference
Encephalitis due to a hantavirus infection
10.1053/jinf.2002.1014 · 2002 · External reference
Diagnosis of hantavirus infection in humans
10.1586/14787210.2015.1047825 · 2015 · External reference
Central Nervous System and Ocular Manifestations in Puumala Hantavirus Infection
10.3390/v13061040 · 2021 · External reference
Acute Hantavirus Infection Presenting With Fever and Altered Mentation in the Absence of Pulmonary or Renal Manifestations
10.1093/ofid/ofac430 · 2022 · External reference
Two point mutations in protocadherin-1 disrupt hantavirus recognition and afford protection against lethal infection
10.1038/s41467-023-40126-y · 2023 · External reference
Orthohantavirus Replication in the Context of Innate Immunity
10.3390/v15051130 · 2023 · External reference
Innate immune responses elicited by Sin Nombre virus or type I IFN agonists protect hamsters from lethal Andes virus infections
2018 · External reference
Comparison of transcriptional responses between pathogenic and nonpathogenic hantavirus infections in Syrian hamsters using NanoString
10.1371/journal.pntd.0009592 · 2021 · External reference
The NY-1 hantavirus Gn cytoplasmic tail coprecipitates TRAF3 and inhibits cellular interferon responses by disrupting TBK1-TRAF3 complex formation
10.1128/jvi.00290-08 · 2008 · External reference
NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase
10.1093/emboj/18.23.6694 · 1999 · External reference
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway
10.1038/ni921 · 2003 · External reference
Are the IKKs and IKK-related kinases TBK1 and IKK-epsilon similarly activated?
10.1016/j.tibs.2008.01.002 · 2008 · External reference
Hantaan virus nucleocapsid protein binds to importin alpha proteins and inhibits tumor necrosis factor alpha-induced activation of nuclear factor kappa B
10.1128/jvi.00986-08 · 2009 · External reference
Inhibition of TNF-alpha-induced activation of NF-kappaB by hantavirus nucleocapsid proteins
2009 · External reference
TAX1BP1 and A20 inhibit antiviral signaling by targeting TBK1-IKKi kinases
10.1074/jbc.m110.109819 · 2010 · External reference
Hantavirus regulation of type I interferon responses
10.1155/2012/524024 · 2012 · External reference
Hantaan virus inhibits type I interferon response by targeting RLR signaling pathways through TRIM25
10.1016/j.virol.2023.109942 · 2024 · External reference
RIPK3 promotes hantaviral replication by restricting JAK-STAT signaling without triggering necroptosis
10.1016/j.virs.2023.08.006 · 2023 · External reference
Antagonism of type I interferon responses by new world hantaviruses
10.1128/jvi.00916-10 · 2010 · External reference
The Andes Orthohantavirus NSs Protein Antagonizes the Type I Interferon Response by Inhibiting MAVS Signaling
10.1128/jvi.00454-20 · 2020 · External reference
RIG-I-like receptor activation drives type I IFN and antiviral signaling to limit Hantaan orthohantavirus replication
2020 · External reference
The major cellular sterol regulatory pathway is required for Andes virus infection
10.1371/journal.ppat.1003911 · 2014 · External reference
LncRNA NEAT1 Potentiates SREBP2 Activity to Promote Inflammatory Macrophage Activation and Limit Hantaan Virus Propagation
10.3389/fmicb.2022.849020 · 2022 · External reference
Haploid Genetic Screen Reveals a Profound and Direct Dependence on Cholesterol for Hantavirus Membrane Fusion
10.1128/mbio.00801-15 · 2015 · External reference
Endocytic Pathways Used by Andes Virus to Enter Primary Human Lung Endothelial Cells
2016 · External reference
Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells
10.1016/j.cell.2020.10.030 · 2021 · External reference
Lipids and flaviviruses, present and future perspectives for the control of dengue, Zika, and West Nile viruses
10.1016/j.plipres.2016.09.005 · 2016 · External reference
Determination of system level alterations in host transcriptome due to Zika virus (ZIKV) Infection in retinal pigment epithelium
10.1038/s41598-018-29329-2 · 2018 · External reference
DENV up-regulates the HMG-CoA reductase activity through the impairment of AMPK phosphorylation: A potential antiviral target
10.1371/journal.ppat.1006257 · 2017 · External reference
Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection
10.1038/s41598-017-09536-z · 2017 · External reference
Large-Scale Plasma Analysis Revealed New Mechanisms and Molecules Associated with the Host Response to SARS-CoV-2
10.3390/ijms21228623 · 2020 · External reference
Plasma lipid profiles discriminate bacterial from viral infection in febrile children
10.1038/s41598-019-53721-1 · 2019 · External reference
Localization of Hantaan viral envelope glycoproteins by monoclonal antibodies in renal tissues from patients with Korean hemorrhagic fever H
10.1093/ajcp/100.4.398 · 1993 · External reference
Hypophyseal hemorrhage and panhypopituitarism during Puumala Virus Infection: Magnetic Resonance Imaging and detection of viral antigen in the hypophysis
10.1086/340859 · 2002 · External reference
Pharmacological activation of STING blocks SARS-CoV-2 infection
2021 · External reference
STING strengthens host anti-hantaviral immunity through an interferon-independent pathway
10.1016/j.virs.2023.06.006 · 2023 · External reference
Antiviral Efficacy of Ribavirin and Favipiravir against Hantaan Virus
10.3390/microorganisms9061306 · 2021 · External reference
Antiviral efficacy of favipiravir against two prominent etiological agents of hantavirus pulmonary syndrome
10.1128/aac.00886-13 · 2013 · External reference
Favipiravir, an anti-influenza drug against life-threatening RNA virus infections
10.1016/j.pharmthera.2020.107512 · 2020 · External reference
First human isolate of Hantavirus (Andes virus) in the Americas
10.3201/eid0807.010277 · 2002 · External reference
GFAP Mutations in Astrocytes Impair Oligodendrocyte Progenitor Proliferation and Myelination in an hiPSC Model of Alexander Disease
2018 · External reference
ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response
10.1016/j.stem.2020.12.018 · 2021 · External reference
Isolation and Enrichment of Human Lung Epithelial Progenitor Cells for Organoid Culture
10.3791/61541 · 2020 · External reference
Complete nucleotide sequence of a Chilean hantavirus
10.1016/s0168-1702(02)00129-6 · 2002 · External reference
Experimental infection model for Sin Nombre hantavirus in the deer mouse (Peromyscus maniculatus)
10.1073/pnas.180197197 · 2000 · External reference
Hemorrhagic fever with renal syndrome in Yugoslavia: antigenic characterization of hantaviruses isolated from Apodemus flavicollis and Clethrionomys glareolus
10.4269/ajtmh.1989.41.109 · 1989 · External reference
Toll-Like Receptors Induce Signal-Specific Reprogramming of the Macrophage Lipidome
2020 · External reference
A DMS Shotgun Lipidomics Workflow Application to Facilitate High-Throughput, Comprehensive Lipidomics
10.1021/jasms.1c00203 · 2021 · External reference
Profiling of mouse macrophage lipidome using direct infusion shotgun mass spectrometry
10.1016/j.xpro.2020.100235 · 2021 · External reference
MAFFT online service: multiple sequence alignment, interactive sequence choice and visualization
10.1093/bib/bbx108 · 2019 · External reference
ModelFinder: fast model selection for accurate phylogenetic estimates
10.1038/nmeth.4285 · 2017 · External reference
IQ-TREE 2: New Models and Efficient Methods for Phylogenetic Inference in the Genomic Era
10.1093/molbev/msaa015 · 2020 · External reference
Interactive Tree Of Life (iTOL) v5: an online tool for phylogenetic tree display and annotation
10.1093/nar/gkab301 · 2021 · External reference
ORAI1 Limits SARS-CoV-2 Infection by Regulating Tonic Type I IFN Signaling
10.4049/jimmunol.2100742 · 2022 · External reference