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References from Age-associated immune dysregulation and B cell dysfunction drive severe outcomes in SFTSV infection. Local targets link to admitted publications; unresolved targets remain external evidence.
World Health Organization Methodology to Prioritize Emerging Infectious Diseases in Need of Research and Development
10.3201/eid2409.171427 · 2018 · External reference
Severe Fever with Thrombocytopenia Syndrome, Japan, 2013-2017
10.3201/eid2604.191011 · 2020 · External reference
Fever with thrombocytopenia associated with a novel bunyavirus in China
10.1056/nejmoa1010095 · 2011 · External reference
Severe fever with thrombocytopenia syndrome, South Korea, 2012
2013 · External reference
The first identification and retrospective study of Severe Fever with Thrombocytopenia Syndrome in Japan
10.1093/infdis/jit603 · 2014 · External reference
Epidemiological and clinical features of laboratory-diagnosed severe fever with thrombocytopenia syndrome in China, 2011-17: a prospective observational study
10.1016/s1473-3099(18)30293-7 · 2018 · External reference
Endemic Severe Fever with Thrombocytopenia Syndrome, Vietnam
10.3201/eid2505.181463 · 2019 · External reference
Severe Fever with Thrombocytopenia Syndrome Virus: The First Case Report in Thailand
10.31524/bkkmedj.2020.22.001 · 2020 · External reference
Genotypic Heterogeneity of Orientia tsutsugamushi in Scrub Typhus Patients and Thrombocytopenia Syndrome Co-infection, Myanmar
10.3201/eid2608.200135 · 2020 · External reference
Serologic Evidence of Severe Fever with Thrombocytopenia Syndrome Virus and Related Viruses in Pakistan
10.3201/eid2607.190611 · 2020 · External reference
Genetic and pathogenic diversity of severe fever with thrombocytopenia syndrome virus (SFTSV) in South Korea
2020 · External reference
Aging and Options to Halt Declining Immunity to Virus Infections
10.3389/fimmu.2021.681449 · 2021 · External reference
Unresolved reference
External reference
Infection in an aging population
10.1016/j.mib.2015.11.003 · 2016 · External reference
Infectious disease in an era of global change
10.1038/s41579-021-00639-z · 2022 · External reference
Deficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infection
10.1038/s41467-018-05746-9 · 2018 · External reference
Severe fever with thrombocytopenia syndrome virus targets B cells in lethal human infections
10.1172/jci129171 · 2020 · External reference
Molecular Signatures of Inflammatory Profile and B-Cell Function in Patients with Severe Fever with Thrombocytopenia Syndrome
10.1128/mbio.02583-20 · 2021 · External reference
Single-cell landscape of peripheral immune responses to fatal SFTS
10.1016/j.celrep.2021.110039 · 2021 · External reference
Haemophagocytic lymphohistiocytosis: A fulminant syndrome associated with multiorgan failure and high mortality that frequently masquerades as sepsis and shock
10.7196/samj.7810 · 2014 · External reference
Cytokine Storm and Sepsis-Induced Multiple Organ Dysfunction Syndrome
10.1007/978-3-031-59815-9_30 · 2024 · External reference
Infections in the Elderly Critically-Ill Patients
10.3389/fmed.2019.00118 · 2019 · External reference
Update in Viral Infections in the Intensive Care Unit
10.3389/fmed.2021.575580 · 2021 · External reference
Host cytokine storm is associated with disease severity of severe fever with thrombocytopenia syndrome
10.1093/infdis/jis452 · 2012 · External reference
Downregulation of Interferon-β and Inhibition of TLR3 Expression are associated with Fatal Outcome of Severe Fever with Thrombocytopenia Syndrome
10.1038/s41598-017-06921-6 · 2017 · External reference
SFTSV Infection Induces BAK/BAX-Dependent Mitochondrial DNA Release to Trigger NLRP3 Inflammasome Activation
2020 · External reference
Ferret animal model of severe fever with thrombocytopenia syndrome phlebovirus for human lethal infection and pathogenesis
10.1038/s41564-018-0317-1 · 2019 · External reference
Ferreting out viral pathogenesis
10.1038/s41564-019-0390-0 · 2019 · External reference
Severe fever with thrombocytopenia syndrome, an emerging tick-borne zoonosis
10.1016/s1473-3099(14)70718-2 · 2014 · External reference
Infection Route Impacts the Pathogenesis of Severe Fever with Thrombocytopenia Syndrome Virus in Ferrets
10.3390/v14061184 · 2022 · External reference
Clinical Update of Severe Fever with Thrombocytopenia Syndrome
10.3390/v13071213 · 2021 · External reference
Animal Model of Severe Fever With Thrombocytopenia Syndrome Virus Infection
10.3389/fmicb.2021.797189 · 2022 · External reference
The senior ferret (Mustela putorius furo)
10.1016/j.cvex.2009.12.002 · 2010 · External reference
Human Ageing Genomic Resources: updates on key databases in ageing research
2024 · External reference
Plasma cells: finding new light at the end of B cell development
10.1038/ni1201-1103 · 2001 · External reference
Age-Associated B Cells
10.1146/annurev-immunol-092419-031130 · 2020 · External reference
Single-Cell Transcriptomic Analyses Define Distinct Peripheral B Cell Subsets and Discrete Development Pathways
10.3389/fimmu.2021.602539 · 2021 · External reference
Single-cell analysis of germinal-center B cells informs on lymphoma cell of origin and outcome
10.1084/jem.20200483 · 2020 · External reference
Unraveling B cell trajectories at single cell resolution
10.1016/j.it.2022.01.003 · 2022 · External reference
Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion
10.1126/science.1067308 · 2002 · External reference
Activation-induced Cytidine Deaminase in B Cell Immunity and Cancers
10.4110/in.2012.12.6.230 · 2012 · External reference
B-cells in pulmonary arterial hypertension: friend, foe or bystander?
10.1183/13993003.01949-2023 · 2024 · External reference
Necroptosis, pyroptosis and apoptosis: an intricate game of cell death
10.1038/s41423-020-00630-3 · 2021 · External reference
Type I interferon signaling regulates Ly6C(hi) monocytes and neutrophils during acute viral pneumonia in mice
2011 · External reference
Engagement of CD44 up-regulates Fas ligand expression on T cells leading to activation-induced cell death
10.1007/s10495-006-0488-8 · 2007 · External reference
Immune escape mechanisms of severe fever with thrombocytopenia syndrome virus
10.3389/fimmu.2022.937684 · 2022 · External reference
Cytokine storm and targeted therapy in hemophagocytic lymphohistiocytosis
10.1007/s12026-022-09285-w · 2022 · External reference
Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte
10.1016/j.cell.2005.08.032 · 2005 · External reference
Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47
2010 · External reference
Advanced Age Alters Monocyte and Macrophage Responses
10.1089/ars.2016.6691 · 2016 · External reference
Understanding of cytokines and targeted therapy in macrophage activation syndrome
10.1016/j.semarthrit.2020.12.007 · 2021 · External reference
Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19
10.1038/s41590-020-00814-z · 2020 · External reference
Activation-induced cytidine deaminase mediates central tolerance in B cells
10.1073/pnas.1102571108 · 2011 · External reference
Single-Cell Profiling of Ebola Virus Disease In Vivo Reveals Viral and Host Dynamics
10.1016/j.cell.2020.10.002 · 2020 · External reference
The Role of Non-Structural Protein NSs in the Pathogenesis of Severe Fever with Thrombocytopenia Syndrome
10.3390/v13050876 · 2021 · External reference
Nonstructural Protein of Severe Fever with Thrombocytopenia Syndrome Phlebovirus Inhibits TBK1 to Evade Interferon-Mediated Response
10.4014/jmb.2008.08048 · 2021 · External reference
Human pDCs Are Superior to cDC2s in Attracting Cytolytic Lymphocytes in Melanoma Patients Receiving DC Vaccination
2020 · External reference
QuPath: Open source software for digital pathology image analysis
10.1038/s41598-017-17204-5 · 2017 · External reference
Integrated analysis of multimodal single-cell data
2021 · External reference
SoupX removes ambient RNA contamination from droplet-based single-cell RNA sequencing data
10.1093/gigascience/giaa151 · 2020 · External reference
COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets
10.1038/s41586-021-03570-8 · 2021 · External reference
DoubletFinder: Doublet Detection in Single-Cell RNA Sequencing Data Using Artificial Nearest Neighbors
2019 · External reference
Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression
10.1186/s13059-019-1874-1 · 2019 · External reference
Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes
10.1371/journal.pbio.3001143 · 2021 · External reference
Reversed graph embedding resolves complex single-cell trajectories
10.1038/nmeth.4402 · 2017 · External reference
Fast gene set enrichment analysis
2021 · External reference
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
10.1073/pnas.0506580102 · 2005 · External reference
