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References from A novel combination therapy with Uridine and Praziquantel effectively alleviates schistosomiasis-induced hepatic fibrosis through promoting adipogenic differentiation. Local targets link to admitted publications; unresolved targets remain external evidence.
Schistosomiasis
10.1007/978-3-031-60121-7_3 · 2024 · External reference
Exploring the immune interactions between Oncomelania hupensis and Schistosoma japonicum, with a cross-comparison of immunological research progress in other intermediate host snails
10.1186/s13071-023-06011-9 · 2023 · External reference
Review of 2022 WHO guidelines on the control and elimination of schistosomiasis
2022 · External reference
Prevalence and incidence of advanced schistosomiasis and risk factors for case fatality in Hunan Province, China
10.1016/j.actatropica.2021.105862 · 2021 · External reference
Mass spectrometry imaging reveals spatial metabolic variation and the crucial role of uridine metabolism in liver injury caused by Schistosoma japonicum
2025 · External reference
Uridine and its role in metabolic diseases, tumors, and neurodegenerative diseases
10.3389/fphys.2024.1360891 · 2024 · External reference
Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor
10.1038/s41421-021-00361-3 · 2022 · External reference
Uridine alleviates carbon tetrachloride-induced liver fibrosis by regulating the activity of liver-related cells
10.1111/jcmm.17131 · 2022 · External reference
Schistosome-Induced Fibrotic Disease: The Role of Hepatic Stellate Cells
10.1016/j.pt.2018.02.005 · 2018 · External reference
Origin of myofibroblasts in the fibrotic liver in mice
10.1073/pnas.1400062111 · 2014 · External reference
Purification and Isolation of Hepatic Stellate Cells
10.1007/978-1-0716-2128-8_9 · 2022 · External reference
New Perspectives on Chinese Medicine in Treating Hepatic Fibrosis: Lipid Droplets in Hepatic Stellate Cells
10.1142/s0192415x23500647 · 2023 · External reference
Aramchol downregulates stearoyl CoA-desaturase 1 in hepatic stellate cells to attenuate cellular fibrogenesis
10.1016/j.jhepr.2021.100237 · 2021 · External reference
p38 mitogen-activated protein kinase and liver X receptor-α mediate the leptin effect on sterol regulatory element binding protein-1c expression in hepatic stellate cells
10.2119/molmed.2011.00243 · 2012 · External reference
Morphogens and hepatic stellate cell fate regulation in chronic liver disease
10.1111/j.1440-1746.2011.07022.x · 2012 · External reference
Adenosine signaling in diabetes mellitus and associated cardiovascular and renal complications
10.1016/j.mam.2016.12.001 · 2017 · External reference
c-Abl Tyrosine Kinase Is Required for BDNF-Induced Dendritic Branching and Growth
10.3390/ijms24031944 · 2023 · External reference
Ameliorating effect offluoxetine on tamoxifen-induced memory loss: The role of corticolimbic NMDA receptors and CREB/BDNF/cFos signaling pathways in rats
10.1016/j.brainres.2022.148058 · 2022 · External reference
Vascular smooth muscle cell c-Fos is critical for foam cell formation and atherosclerosis
10.1016/j.metabol.2022.155213 · 2022 · External reference
Effect of Chinese herbal compound on liver fibrosis in rabbits with schistosomiasis by B-ultrasound
10.1016/s1995-7645(13)60114-5 · 2013 · External reference
The Role of Praziquantel in the Prevention and Treatment of Fibrosis Associated with Schistosomiasis: A Review
2022 · External reference
Status and challenges of mass drug administration for neglected tropical diseases in Africa
2023 · External reference
Impact of treatment with a Protein Tyrosine Kinase Inhibitor (Genistein) on acute and chronic experimental Schistosoma mansoni infection
10.1016/j.exppara.2018.01.013 · 2018 · External reference
TGF-β/SMAD Pathway and Its Regulation in Hepatic Fibrosis
10.1369/0022155415627681 · 2016 · External reference
Biochemistry of uridine in plasma
10.1016/j.cca.2011.06.006 · 2011 · External reference
Effect of uridine on mitochondrial function
2023 · External reference
Uridine Administration Promotes Normalization of Heart Mitochondrial Function in Dystrophin-Deficient Mice and Decreases Tissue Fibrosis
10.1007/s10517-023-05966-0 · 2023 · External reference
Therapeutic effect of uridine phosphorylase 1 (UPP1) inhibitor on liver fibrosis in vitro and in vivo
10.1016/j.ejphar.2020.173670 · 2021 · External reference
Uridine metabolism and its role in glucose, lipid, and amino acid homeostasis
10.1155/2020/7091718 · 2020 · External reference
Uridine attenuates obesity, ameliorates hepatic lipid accumulation and modifies the gut microbiota composition in mice fed with a high-fat diet
10.1039/d0fo02533j · 2021 · External reference
Acetyl-CoA carboxylase inhibition disrupts metabolic reprogramming during hepatic stellate cell activation
10.1016/j.jhep.2020.04.037 · 2020 · External reference
Circulating uridine dynamically and adaptively regulates food intake in humans
10.1016/j.xcrm.2022.100897 · 2023 · External reference
Hepatic stereology of Schistosomiasis mansoni infected-mice fed a high-fat diet
10.1590/s0074-02762006000900039 · 2006 · External reference
The cyclic AMP signaling pathway: Exploring targets for successful drug discovery (Review)
10.3892/mmr.2016.5005 · 2016 · External reference
P2RY14 cAMP signaling regulates Schwann cell precursor self-renewal, proliferation, and nerve tumor initiation in a mouse model of neurofibromatosis
10.7554/elife.73511 · 2022 · External reference
Involvement of cAMP-PKA pathway in adenosine A1 and A2A receptor-mediated regulation of acetaldehyde-induced activation of HSCs
10.1016/j.biochi.2015.04.019 · 2015 · External reference
Gs protein-coupled adenosine receptor signaling and lytic function of activated NK cells
10.4049/jimmunol.175.7.4383 · 2005 · External reference
PFOA regulate adenosine receptors and downstream concentration-response cAMP-PKA pathway revealed by integrated omics and molecular dynamics analyses
10.1016/j.scitotenv.2021.149910 · 2022 · External reference
The cellular thermal shift assay for evaluating drug target interactions in cells
10.1038/nprot.2014.138 · 2014 · External reference
Hypotensive effects of intravenously administered uridine and cytidine in conscious rats: involvement of adenosine receptors
10.1016/j.ejphar.2008.01.044 · 2008 · External reference
Physiology and effects of nucleosides in mice lacking all four adenosine receptors
10.1371/journal.pbio.3000161 · 2019 · External reference
The current status of neglected tropical diseases and the coping strategy exploration of China
2022 · External reference
Electrophysiological characterization of a schistosome transient receptor potential channel activated by praziquantel
10.1016/j.ijpara.2022.11.005 · 2023 · External reference
Dandelion (Taraxacum officinale) improves the therapeutic efficiency of praziquantel in experimental schistosomiasis
10.1007/s11686-021-00513-1 · 2022 · External reference
Schistosome Egg Migration: Mechanisms, Pathogenesis and Host Immune Responses
10.3389/fimmu.2018.03042 · 2018 · External reference
Uridine alleviates sepsis-induced acute lung injury by inhibiting ferroptosis of macrophage
2023 · External reference
