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References from Germinal Center B cells provide essential IL-1β signals to TFH cells via canonical NLRP3 inflammasome activity post influenza infection. Local targets link to admitted publications; unresolved targets remain external evidence.
Mortality, morbidity, and hospitalisations due to influenza lower respiratory tract infections, 2017: an analysis for the Global Burden of Disease Study 2017
10.1016/s2213-2600(18)30496-x · 2019 · External reference
Evasion of influenza A viruses from innate and adaptive immune responses
10.3390/v4091438 · 2012 · External reference
Influenza vaccines: successes and continuing challenges
10.1093/infdis/jiab269 · 2021 · External reference
The establishment of resident memory B cells in the lung requires local antigen encounter
10.1038/s41590-018-0260-6 · 2019 · External reference
Germinal centers
10.1146/annurev-immunol-120419-022408 · 2022 · External reference
Regulated selection of germinal-center cells into the memory B cell compartment
10.1038/ni.3460 · 2016 · External reference
Germinal center-dependent and -independent memory B cells produced throughout the immune response
10.1084/jem.20202489 · 2021 · External reference
Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers
10.4049/jimmunol.155.2.556 · 1995 · External reference
IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses
10.1084/jem.20091738 · 2010 · External reference
The concerted change in the distribution of cell cycle phases and zone composition in germinal centers is regulated by IL-21
10.1038/s41467-021-27477-0 · 2021 · External reference
IL-21 shapes germinal center polarization via light zone B cell selection and cyclin D3 upregulation
10.1084/jem.20221653 · 2023 · External reference
The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation
10.1016/1074-7613(94)90095-7 · 1994 · External reference
CD40, but not CD154, expression on B cells is necessary for optimal primary B cell responses
10.4049/jimmunol.171.11.5707 · 2003 · External reference
CD40 signaling promotes CXCR5 expression in B cells via noncanonical NF-κB pathway activation
2020 · External reference
Bcl-x rather than Bcl-2 mediates CD40-dependent centrocyte survival in the germinal center
10.1182/blood.v88.4.1359.bloodjournal8841359 · 1996 · External reference
The quantity of CD40 signaling determines the differentiation of B cells into functionally distinct memory cell subsets
10.7554/elife.44245 · 2019 · External reference
IL-21R signal reprogramming cooperates with CD40 and BCR signals to select and differentiate germinal center B cells
2023 · External reference
B cell receptor and CD40 signaling are rewired for synergistic induction of the c-Myc transcription factor in Germinal center B cells
2018 · External reference
B and T cells collaborate in antiviral responses via IL-6, IL-21, and transcriptional activator and coactivator, Oct2 and OBF-1
10.1084/jem.20111504 · 2012 · External reference
B cell-derived IL-6 initiates spontaneous germinal center formation during systemic autoimmunity
10.1084/jem.20170580 · 2017 · External reference
Tfr cells lack IL-2Rα but express decoy IL-1R2 and IL-1Ra and suppress the IL-1-dependent activation of Tfh cells
2017 · External reference
Interleukin-1 regulates follicular T cells during the germinal center reaction
10.3389/fimmu.2024.1393096 · 2024 · External reference
Loss of T follicular regulatory cell-derived IL-1R2 augments germinal centre reactions via increased IL-1
2024 · External reference
IL-1 enhances T cell-dependent antibody production through induction of CD40 ligand and OX40 on T cells
10.4049/jimmunol.167.1.90 · 2001 · External reference
The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases)
10.1074/jbc.272.12.7727 · 1997 · External reference
IL-1R3 blockade broadly attenuates the functions of six members of the IL-1 family, revealing their contribution to models of disease
10.1038/s41590-019-0467-1 · 2019 · External reference
Interleukin-1 as innate mediator of T cell immunity
10.3389/fimmu.2020.621931 · 2021 · External reference
Persistent germinal center responses: slow-growing trees bear the best fruits
10.1016/j.coi.2023.102332 · 2023 · External reference
Transcriptional regulation of Tfh dynamics and the formation of immunological synapses
10.1038/s12276-024-01254-7 · 2024 · External reference
Distinction of virgin and memory T lymphocytes. Stable acquisition of the Pgp-1 glycoprotein concomitant with antigenic stimulation
10.4049/jimmunol.138.10.3120 · 1987 · External reference
Follicular helper T cells
10.1146/annurev-immunol-041015-055605 · 2016 · External reference
Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock
10.1016/0092-8674(95)90490-5 · 1995 · External reference
The inflammasome
10.1016/s1097-2765(02)00599-3 · 2002 · External reference
Unresolved reference
2011 · External reference
Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity
10.1084/jem.20172222 · 2018 · External reference
The NLRP3 inflammasome: an overview of mechanisms of activation and regulation
10.3390/ijms20133328 · 2019 · External reference
Germinal center hypoxia potentiates immunoglobulin class switch recombination
10.4049/jimmunol.1601401 · 2016 · External reference
Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system
10.1038/nature19334 · 2016 · External reference
CD73 expression is dynamically regulated in the germinal center and bone marrow plasma cells are diminished in its absence
10.1371/journal.pone.0092009 · 2014 · External reference
Inflammasome activation by viral infection: mechanisms of activation and regulation
10.3389/fmicb.2023.1247377 · 2023 · External reference
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
10.1038/nature07725 · 2009 · External reference
Maturation of germinal center B cells after influenza virus vaccination in humans
10.1084/jem.20240668 · 2024 · External reference
BAFF-driven NLRP3 inflammasome activation in B cells
10.1038/s41419-020-03035-2 · 2020 · External reference
IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation
10.1073/pnas.0902745106 · 2009 · External reference
T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells
10.1038/s41467-018-05489-7 · 2018 · External reference
IL-1 receptor 1 signaling shapes the development of viral antigen-specific CD4+ T cell responses following COVID-19 mRNA vaccination
10.1016/j.ebiom.2024.105114 · 2024 · External reference
Sensing microbial viability through bacterial RNA augments T follicular helper cell and antibody responses
10.1016/j.immuni.2018.02.015 · 2018 · External reference
Nitric oxide sustains IL-1β expression in human dendritic cells enhancing their capacity to induce IL-17-producing T-cells
10.1371/journal.pone.0120134 · 2015 · External reference
Cytokines in the germinal center niche
10.3390/antib5010005 · 2016 · External reference
The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation
10.1038/s41467-021-22979-3 · 2021 · External reference
Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes
10.1016/j.cell.2014.02.008 · 2014 · External reference
Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion
10.1038/cr.2015.139 · 2015 · External reference
The microanatomic segregation of selection by apoptosis in the germinal center
10.1126/science.aao2602 · 2017 · External reference
Interleukin-1β maturation triggers its relocation to the plasma Membrane for gasdermin-D-dependent and -independent secretion
10.1016/j.celrep.2018.07.027 · 2018 · External reference
Uncoupled pyroptosis and IL-1β secretion downstream of inflammasome signaling
10.3389/fimmu.2023.1128358 · 2023 · External reference
Inflammasomes
10.1101/cshperspect.a016287 · 2014 · External reference
Inflammasomes: mechanism of action, role in disease, and therapeutics
10.1038/nm.3893 · 2015 · External reference
Reactive oxygen species: the signal regulator of B cell
10.1016/j.freeradbiomed.2019.06.004 · 2019 · External reference
Prolonged production of reactive oxygen species in response to B cell receptor stimulation promotes B cell activation and proliferation
10.4049/jimmunol.1201433 · 2012 · External reference
STIM-mediated calcium influx regulates maintenance and selection of germinal center B cells
10.1084/jem.20222178 · 2024 · External reference
Oxidative phosphorylation regulates B cell effector cytokines and promotes inflammation in multiple sclerosis
2024 · External reference
The P2X7 receptor in autoimmunity
10.3390/ijms241814116 · 2023 · External reference
NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux
10.1038/nature16959 · 2016 · External reference
Dynamic mitochondrial transcription and translation in B cells control germinal center entry and lymphomagenesis
10.1038/s41590-023-01484-3 · 2023 · External reference
Mitochondrial DNA release in innate immune signaling
10.1146/annurev-biochem-032620-104401 · 2023 · External reference
AURKA facilitates the psoriasis-related inflammation by impeding autophagy-mediated AIM2 inflammasome suppression
10.1016/j.imlet.2021.10.004 · 2021 · External reference
Interferon-γ production by Tfh cells is required for CXCR3+ pre-memory B cell differentiation and subsequent lung-resident memory B cell responses
2023 · External reference
Correction: a novel function of NLRP3 independent of inflammasome as a key transcription factor of IL-33 in epithelial cells of atopic dermatitis
10.1038/s41419-024-06605-w · 2024 · External reference
Corrigendum: the receptor NLRP3 is a transcriptional regulator of TH2 differentiation
10.1038/ni1215-1292a · 2015 · External reference
B cell-derived IL-1β and IL-6 drive T cell reconstitution following lymphoablation
10.1111/ajt.15960 · 2020 · External reference
Phenotypic and functional characteristics of murine CD11c+ B cells which is suppressed by metformin
10.3389/fimmu.2023.1241531 · 2023 · External reference
Genetic dissection of TLR9 reveals complex regulatory and cryptic proinflammatory roles in mouse lupus
10.1038/s41590-022-01310-2 · 2022 · External reference
