Research graph
References from E2F1 suppresses Epstein-Barr virus lytic reactivation through cellular and viral transcriptional networks. Local targets link to admitted publications; unresolved targets remain external evidence.
Mechanisms of B-Cell Oncogenesis Induced by Epstein-Barr Virus
10.1128/jvi.00238-19 · 2019 · External reference
Epstein-Barr virus: more than 50 years old and still providing surprises
10.1038/nrc.2016.92 · 2016 · External reference
EBV epigenetically suppresses the B cell-to-plasma cell differentiation pathway while establishing long-term latency
10.1371/journal.pbio.2001992 · 2017 · External reference
Differential carbonic anhydrase activities control EBV-induced B-cell transformation and lytic cycle reactivation
10.1371/journal.ppat.1011998 · 2024 · External reference
Epstein-Barr virus-associated lymphomas
10.1098/rstb.2016.0271 · 2017 · External reference
Epstein-Barr virus oncoprotein-driven B cell metabolism remodeling
10.1371/journal.ppat.1010254 · 2022 · External reference
Epstein-Barr virus perpetuates B cell germinal center dynamics and generation of autoimmune-associated phenotypes in vitro
10.3389/fimmu.2022.1001145 · 2022 · External reference
Terminal differentiation into plasma cells initiates the replicative cycle of Epstein-Barr virus in vivo
10.1128/jvi.79.2.1296-1307.2005 · 2005 · External reference
Functional Implications of Epstein-Barr Virus Lytic Genes in Carcinogenesis
10.3390/cancers14235780 · 2022 · External reference
Identifying the key regulators orchestrating Epstein-Barr virus reactivation
10.3389/fmicb.2024.1505191 · 2024 · External reference
MYC Controls the Epstein-Barr Virus Lytic Switch
2020 · External reference
Structural basis of DNA methylation-dependent site selectivity of the Epstein-Barr virus lytic switch protein ZEBRA/Zta/BZLF1
10.1093/nar/gkab1183 · 2022 · External reference
Strategies of Epstein-Barr virus to evade innate antiviral immunity of its human host
10.3389/fmicb.2022.955603 · 2022 · External reference
Lytic Induction Therapy against Epstein-Barr Virus-Associated Malignancies: Past, Present, and Future
10.3390/cancers12082142 · 2020 · External reference
The Epstein-Barr virus (EBV)-encoded protein kinase, EBV-PK, but not the thymidine kinase (EBV-TK), is required for ganciclovir and acyclovir inhibition of lytic viral production
10.1128/jvi.02487-09 · 2010 · External reference
X-box-binding protein 1 activates lytic Epstein-Barr virus gene expression in combination with protein kinase D
10.1128/jvi.00154-07 · 2007 · External reference
Cellular differentiation regulator BLIMP1 induces Epstein-Barr virus lytic reactivation in epithelial and B cells by activating transcription from both the R and Z promoters
10.1128/jvi.02781-14 · 2015 · External reference
Proteasomal inhibition triggers viral oncoprotein degradation via autophagy-lysosomal pathway
10.1371/journal.ppat.1008105 · 2020 · External reference
E2F1 facilitates DNA break repair by localizing to break sites and enhancing the expression of homologous recombination factors
10.1038/s12276-019-0307-2 · 2019 · External reference
An E2F1-mediated DNA damage response contributes to the replication of human cytomegalovirus
2011 · External reference
Selectively replicating adenoviruses targeting deregulated E2F activity are potent, systemic antitumor agents
10.1016/s1535-6108(02)00060-0 · 2002 · External reference
E2F1 mediated apoptosis induced by the DNA damage response is blocked by EBV nuclear antigen 3C in lymphoblastoid cells
10.1371/journal.ppat.1002573 · 2012 · External reference
E2F1, ARID3A/Bright and Oct-2 factors bind to the Epstein-Barr virus C promoter, EBNA1 and oriP, participating in long-distance promoter-enhancer interactions
10.1099/vir.0.038752-0 · 2012 · External reference
EBV Nuclear Antigen 3C Mediates Regulation of E2F6 to Inhibit E2F1 Transcription and Promote Cell Proliferation
2016 · External reference
The Epstein-Barr virus immediate-early protein BZLF1 induces expression of E2F-1 and other proteins involved in cell cycle progression in primary keratinocytes and gastric carcinoma cells
10.1128/jvi.76.24.12543-12552.2002 · 2002 · External reference
Identification of a negative regulatory element in the Epstein-Barr virus Zta transactivation domain that is regulated by the cell cycle control factors c-Myc and E2F1
10.1128/jvi.78.21.11962-11971.2004 · 2004 · External reference
Regulation of E2F1-induced apoptosis by poly(ADP-ribosyl)ation
10.1038/cdd.2014.146 · 2015 · External reference
Expression level is a key determinant of E2F1-mediated cell fate
10.1038/cdd.2017.12 · 2017 · External reference
Extensive co-operation between the Epstein-Barr virus EBNA3 proteins in the manipulation of host gene expression and epigenetic chromatin modification
10.1371/journal.pone.0013979 · 2010 · External reference
B Cell Receptor Activation and Chemical Induction Trigger Caspase-Mediated Cleavage of PIAS1 to Facilitate Epstein-Barr Virus Reactivation
10.1016/j.celrep.2017.11.071 · 2017 · External reference
Epstein-Barr virus reactivation induces divergent abortive, reprogrammed, and host shutoff states by lytic progression
10.1371/journal.ppat.1012341 · 2024 · External reference
EBV LMP1: New and shared pathways to NF-κB activation
10.1073/pnas.1121357109 · 2012 · External reference
Epstein-Barr virus inactivates the transcriptome and disrupts the chromatin architecture of its host cell in the first phase of lytic reactivation
10.1093/nar/gkab099 · 2021 · External reference
JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles
10.1093/nar/gkad1059 · 2024 · External reference
The ZIIR element of the Epstein-Barr virus BZLF1 promoter plays a central role in establishment and maintenance of viral latency
10.1128/jvi.02615-10 · 2011 · External reference
G1/S Cell Cycle Induction by Epstein-Barr Virus BORF2 Is Mediated by P53 and APOBEC3B
10.1128/jvi.00660-22 · 2022 · External reference
Genetic dissection of cell growth arrest functions mediated by the Epstein-Barr virus lytic gene product, Zta
10.1128/jvi.73.11.9029-9038.1999 · 1999 · External reference
Epstein-Barr virus Rta-mediated transactivation of p21 and 14-3-3σ arrests cells at the G1/S transition by reducing cyclin E/CDK2 activity
10.1099/vir.0.034405-0 · 2012 · External reference
Identification of herpesvirus proteins that contribute to G1/S arrest
10.1128/jvi.00059-14 · 2014 · External reference
EBNA2-deleted Epstein-Barr virus (EBV) isolate, P3HR1, causes Hodgkin-like lymphomas and diffuse large B cell lymphomas with type II and Wp-restricted latency types in humanized mice
2020 · External reference
Molecular basis of Epstein-Barr virus latency establishment and lytic reactivation
10.3390/v13122344 · 2021 · External reference
“Myc’ed messages”: myc induces transcription of E2F1 while inhibiting its translation via a microRNA polycistron
10.1371/journal.pgen.0030146 · 2007 · External reference
Genomic targets of the human c-Myc protein
10.1101/gad.1067003 · 2003 · External reference
E2F1 inhibits c-Myc-driven apoptosis via PIK3CA/Akt/mTOR and COX-2 in a mouse model of human liver cancer
10.1053/j.gastro.2008.07.012 · 2008 · External reference
E2F1 acts as a negative feedback regulator of c-Myc‑induced hTERT transcription during tumorigenesis
10.3892/or.2014.3287 · 2014 · External reference
A role for Myc in facilitating transcription activation by E2F1
10.1038/onc.2008.55 · 2008 · External reference
E2F1 and c-Myc in cell growth and death
10.4161/cc.2.4.428 · 2003 · External reference
E2F-1 up-regulates c-Myc and p14(ARF) and induces apoptosis in colon cancer cells
2001 · External reference
Contribution of Epstein-Barr Virus Lytic Proteins to Cancer Hallmarks and Implications from Other Oncoviruses
10.3390/cancers15072120 · 2023 · External reference
Epstein-Barr virus lytic infection contributes to lymphoproliferative disease in a SCID mouse model
10.1128/jvi.79.22.13993-14003.2005 · 2005 · External reference
SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene
10.1016/0092-8674(88)90559-4 · 1988 · External reference
Cyclin-dependent kinases phosphorylate the adenovirus E1A protein, enhancing its ability to bind pRb and disrupt pRb-E2F complexes
10.1128/jvi.70.5.2911-2921.1996 · 1996 · External reference
Human papillomavirus type 16 E7 binds to E2F1 and activates E2F1-driven transcription in a retinoblastoma protein-independent manner
10.1074/jbc.m109113200 · 2002 · External reference
Epstein-Barr virus latent antigen 3C can mediate the degradation of the retinoblastoma protein through an SCF cellular ubiquitin ligase
10.1073/pnas.0503886102 · 2005 · External reference
PI3Kδ activates E2F1 synthesis in response to mRNA translation stress
10.1038/s41467-017-02282-w · 2017 · External reference
Replication stress and cancer
10.1038/nrc3916 · 2015 · External reference
An ATM/Chk2-mediated DNA damage-responsive signaling pathway suppresses Epstein-Barr virus transformation of primary human B cells
10.1016/j.chom.2010.11.004 · 2010 · External reference
The EBV lytic switch protein, Z, preferentially binds to and activates the methylated viral genome
10.1038/ng1424 · 2004 · External reference
CpG-methylation regulates a class of Epstein-Barr virus promoters
10.1371/journal.ppat.1001114 · 2010 · External reference
Viral genome methylation differentially affects the ability of BZLF1 versus BRLF1 to activate Epstein-Barr virus lytic gene expression and viral replication
10.1128/jvi.01790-12 · 2013 · External reference
Methylation profiling of Epstein-Barr virus immediate-early gene promoters, BZLF1 and BRLF1 in tumors of epithelial, NK- and B-cell origins
10.1186/1471-2407-12-125 · 2012 · External reference
Epigenetic histone modification of Epstein-Barr virus BZLF1 promoter during latency and reactivation in Raji cells
10.1128/jvi.06768-11 · 2012 · External reference
DNA methylation enzymes and PRC1 restrict B-cell Epstein-Barr virus oncoprotein expression
10.1038/s41564-020-0724-y · 2020 · External reference
Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation
10.1038/s41467-020-15006-4 · 2020 · External reference
Chromatin remodelers HELLS and UHRF1 mediate the epigenetic deregulation of genes that drive retinoblastoma tumor progression
10.18632/oncotarget.2468 · 2014 · External reference
Regulation of DNA methyltransferase 1 by the pRb/E2F1 pathway
10.1158/0008-5472.can-04-2158 · 2005 · External reference
Activated MEK/ERK Pathway Drives Widespread and Coordinated Overexpression of UHRF1 and DNMT1 in Cancer cells
10.1038/s41598-018-37258-3 · 2019 · External reference
Discovery of small molecules targeting the tandem tudor domain of the epigenetic factor UHRF1 using fragment-based ligand discovery
10.1038/s41598-020-80588-4 · 2021 · External reference
Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program
10.1016/s1074-7613(02)00335-7 · 2002 · External reference
Transcription of the NKG2D ligand MICA is suppressed by the IRE1/XBP1 pathway of the unfolded protein response through the regulation of E2F1
10.1096/fj.201801350rr · 2019 · External reference
Repression of CIITA by the Epstein-Barr virus transcription factor Zta is independent of its dimerization and DNA binding
10.1099/jgv.0.000369 · 2016 · External reference
Epstein-Barr virus transcription factor Zta acts through distal regulatory elements to directly control cellular gene expression
10.1093/nar/gkv212 · 2015 · External reference
Oncogenic Properties of the EBV ZEBRA Protein
10.3390/cancers12061479 · 2020 · External reference
The Epstein-Barr virus BZLF1 protein inhibits tumor necrosis factor receptor 1 expression through effects on cellular C/EBP proteins
10.1128/jvi.00712-10 · 2010 · External reference
Epstein-Barr-virus-induced one-carbon metabolism drives B cell transformation
2019 · External reference
Protein array identification of substrates of the Epstein-Barr virus protein kinase BGLF4
10.1128/jvi.02378-08 · 2009 · External reference
S-Like-Phase Cyclin-Dependent Kinases Stabilize the Epstein-Barr Virus BDLF4 Protein To Temporally Control Late Gene Transcription
10.1128/jvi.01707-18 · 2019 · External reference
Advancing therapeutic strategies for Epstein-Barr virus-associated malignancies through lytic reactivation
10.1016/j.biopha.2023.114916 · 2023 · External reference
Early events associated with infection of Epstein-Barr virus infection of primary B-cells
10.1371/journal.pone.0007214 · 2009 · External reference
Epstein-Barr virus quantitation by real-time PCR targeting multiple gene segments: a novel approach to screen for the virus in paraffin-embedded tissue and plasma
10.1016/s1525-1578(10)60535-1 · 2004 · External reference
POH1 deubiquitylates and stabilizes E2F1 to promote tumour formation
10.1038/ncomms9704 · 2015 · External reference
AlphaFold Protein Structure Database in 2024: providing structure coverage for over 214 million protein sequences
10.1093/nar/gkad1011 · 2024 · External reference