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References from Persistent type I interferon signaling within the brain of people with HIV on ART with cognitive impairment. Local targets link to admitted publications; unresolved targets remain external evidence.
Current understanding of HIV-associated neurocognitive disorders pathogenesis
10.1097/wco.0b013e32834695fb · 2011 · External reference
HIV-Associated Neurocognitive Impairment in the Modern ART Era: Are We Close to Discovering Reliable Biomarkers in the Setting of Virological Suppression?
10.3389/fnagi.2019.00187 · 2019 · External reference
Lentiviral Infections Persist in Brain despite Effective Antiretroviral Therapy and Neuroimmune Activation
10.1128/mbio.02784-21 · 2021 · External reference
Immune activation of the central nervous system is still present after >4 years of effective highly active antiretroviral therapy
10.1086/523648 · 2007 · External reference
Persistent central nervous system immune activation following more than 10 years of effective HIV antiretroviral treatment
10.1097/qad.0000000000001950 · 2018 · External reference
Brain microglia serve as a persistent HIV reservoir despite durable antiretroviral therapy
10.1172/jci167417 · 2023 · External reference
Lessons for Understanding Central Nervous System HIV Reservoirs from the Last Gift Program
10.1007/s11904-022-00628-8 · 2022 · External reference
Tandem mass tags: a novel quantification strategy for comparative analysis of complex protein mixtures by MS/MS
10.1021/ac0262560 · 2003 · External reference
The mitochondrial ubiquitin ligase MARCH5 resolves MAVS aggregates during antiviral signalling
10.1038/ncomms8910 · 2015 · External reference
Emerging roles for angiomotin in the nervous system
10.1126/scisignal.abc0635 · 2020 · External reference
The brain-specific RasGEF very-KIND is required for normal dendritic growth in cerebellar granule cells and proper motor coordination
10.1371/journal.pone.0173175 · 2017 · External reference
MPP3 is required for maintenance of the apical junctional complex, neuronal migration, and stratification in the developing cortex
10.1523/jneurosci.5627-12.2013 · 2013 · External reference
CD81 regulates neuron-induced astrocyte cell-cycle exit
10.1006/mcne.2000.0955 · 2001 · External reference
SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse
10.1016/j.neuron.2019.05.002 · 2019 · External reference
Regulation of tissue iron homeostasis: the macrophage “ferrostat”
2020 · External reference
Endosomal Recycling Defects and Neurodevelopmental Disorders
10.3390/cells11010148 · 2022 · External reference
HIV influences microtubule associated protein-2: potential marker of HIV-associated neurocognitive disorders
10.1097/qad.0000000000002509 · 2020 · External reference
Central nervous system (CNS) transcriptomic correlates of human immunodeficiency virus (HIV) brain RNA load in HIV-infected individuals
10.1038/s41598-021-88052-7 · 2021 · External reference
Type I IFNs Regulate Inflammation, Vasculopathy, and Fibrosis in Chronic Cutaneous Graft-versus-Host Disease
10.4049/jimmunol.1502190 · 2016 · External reference
Phenotypic changes on hairy cells exposed in vitro to interferons: a quantitative FACS study
10.1111/j.1365-2141.1989.tb07719.x · 1989 · External reference
Tetraspanin Tspan8 restrains interferon signaling to stabilize intestinal epithelium by directing endocytosis of interferon receptor
10.1007/s00018-023-04803-x · 2023 · External reference
Systemic Inflammation Leads to Changes in the Intracellular Localization of KLK6 in Oligodendrocytes in Spinal Cord White Matter
10.1007/s11064-023-03929-5 · 2023 · External reference
Enhanced CD9 expression in the mouse and human brains infected with transmissible spongiform encephalopathies
10.1093/jnen/59.9.774 · 2000 · External reference
Type-I Interferon Responses: From Friend to Foe in the Battle against Chronic Viral Infection
10.3389/fimmu.2016.00609 · 2016 · External reference
Interferons and HIV Infection: The Good, the Bad, and the Ugly
10.20411/pai.v1i1.125 · 2016 · External reference
Interferons: cell signalling, immune modulation, antiviral response and virus countermeasures
10.1099/0022-1317-81-10-2341 · 2000 · External reference
Type I interferons as ambiguous modulators of chronic inflammation in the central nervous system
10.3389/fimmu.2012.00067 · 2012 · External reference
Single-cell RNA-seq analysis reveals compartment-specific heterogeneity and plasticity of microglia
10.1016/j.isci.2021.102186 · 2021 · External reference
OP 1.4 – 00053 Definitive evidence of a persistent HIV reservoir in human brain myeloid cells despite ART
10.1016/j.jve.2022.100099 · 2022 · External reference
HIV infection of non-classical cells in the brain
10.1186/s12977-023-00616-9 · 2023 · External reference
Senescent-like microglia limit remyelination through the senescence associated secretory phenotype
10.1038/s41467-025-57632-w · 2025 · External reference
Novel scalable and simplified system to generate microglia-containing cerebral organoids from human induced pluripotent stem cells
10.3389/fncel.2021.682272 · 2021 · External reference
Characterization of HIV-1 Infection in Microglia-Containing Human Cerebral Organoids
10.3390/v14040829 · 2022 · External reference
Type I Interferon Responses by HIV-1 Infection: Association with Disease Progression and Control
10.3389/fimmu.2017.01823 · 2018 · External reference
Pathogenic Role of Type I Interferons in HIV-Induced Immune Impairments in Humanized Mice
10.1007/s11904-019-00444-7 · 2019 · External reference
HIV infection and HERV expression: a review
10.1186/1742-4690-9-6 · 2012 · External reference
HIV Tat acts on endogenous retroviruses of the W family and this occurs via Toll-like receptor 4: inference for neuroAIDS
10.1097/qad.0000000000000477 · 2014 · External reference
HIV-associated neurocognitive disorder - pathogenesis and prospects for treatment
10.1038/nrneurol.2016.53 · 2016 · External reference
Neuroinflammation in treated HIV-positive individuals: A TSPO PET study
10.1212/wnl.0000000000002485 · 2016 · External reference
Can antiretroviral therapy prevent HIV-associated cognitive disorders?
10.1097/coh.0000000000000016 · 2014 · External reference
HIV infection and immune activation: the role of coinfections
10.1097/coh.0000000000000241 · 2016 · External reference
Neurocognitive impairment in human immunodeficiency virus infection is correlated with sexually transmitted disease history
10.1097/00007435-199708000-00003 · 1997 · External reference
An overview of the biological and psychosocial context surrounding neurocognition in HIV
10.1177/1078390314527549 · 2014 · External reference
Regulatory evolution of innate immunity through co-option of endogenous retroviruses
10.1126/science.aad5497 · 2016 · External reference
Activation of Endogenous Retrovirus, Brain Infections and Environmental Insults in Neurodegeneration and Alzheimer’s Disease
10.3390/ijms22147263 · 2021 · External reference
Viruses and endogenous retroviruses as roots for neuroinflammation and neurodegenerative diseases
10.3389/fnins.2021.648629 · 2021 · External reference
Human Endogenous Retroviral Envelope Protein Syncytin-1 and Inflammatory Abnormalities in Neuropsychological Diseases
10.3389/fpsyt.2018.00422 · 2018 · External reference
The aliens inside human DNA: HERV-W/MSRV/syncytin-1 endogenous retroviruses and neurodegeneration
10.3855/jidc.6916 · 2015 · External reference
Controlling Trophoblast Cell Fusion in the Human Placenta-Transcriptional Regulation of Suppressyn, an Endogenous Inhibitor of Syncytin-1
10.3390/biom13111627 · 2023 · External reference
HERV-W ENV Induces Innate Immune Activation and Neuronal Apoptosis via linc01930/cGAS Axis in Recent-Onset Schizophrenia
2023 · External reference
The human endogenous retrovirus envelope glycoprotein, syncytin-1, regulates neuroinflammation and its receptor expression in multiple sclerosis: a role for endoplasmic reticulum chaperones in astrocytes
10.4049/jimmunol.179.2.1210 · 2007 · External reference
Regulation of the syncytin-1 promoter in human astrocytes by multiple sclerosis-related cytokines
10.1016/j.virol.2006.12.019 · 2007 · External reference
Type I Interferons in NeuroHIV
10.1089/vim.2018.0085 · 2019 · External reference
Cerebrospinal fluid interferon alpha levels correlate with neurocognitive impairment in ambulatory HIV-Infected individuals
10.1007/s13365-016-0466-z · 2017 · External reference
Immune activation in the central nervous system throughout the course of HIV infection
10.1097/coh.0000000000000243 · 2016 · External reference
Blocking type I interferon signaling enhances T cell recovery and reduces HIV-1 reservoirs
10.1172/jci90745 · 2017 · External reference
Differential type 1 interferon-regulated gene expression in the brain during AIDS: interactions with viral diversity and neurovirulence
10.1096/fj.13-227868 · 2013 · External reference
Global genomic analysis reveals rapid control of a robust innate response in SIV-infected sooty mangabeys
2009 · External reference
Downregulation of robust acute type I interferon responses distinguishes nonpathogenic simian immunodeficiency virus (SIV) infection of natural hosts from pathogenic SIV infection of rhesus macaques
10.1128/jvi.02612-09 · 2010 · External reference
Breaking down the cellular responses to type I interferon neurotoxicity in the brain
10.3389/fimmu.2023.1110593 · 2023 · External reference
Interferon-Alpha Reduces Human Hippocampal Neurogenesis and Increases Apoptosis via Activation of Distinct STAT1-Dependent Mechanisms
10.1093/ijnp/pyx083 · 2018 · External reference
Interferon-beta: mechanism of action and dosing issues
10.1212/01.wnl.0000277703.74115.d2 · 2007 · External reference
Mechanism for the establishment of transcriptional HIV latency in the brain in a simian immunodeficiency virus-macaque model
10.1086/500983 · 2006 · External reference
IFNβ Protects Neurons from Damage in a Murine Model of HIV-1 Associated Brain Injury
10.1038/srep46514 · 2017 · External reference
Blockade of interferon Beta, but not interferon alpha, signaling controls persistent viral infection
10.1016/j.chom.2015.04.005 · 2015 · External reference
Dysregulation of protein modification by ISG15 results in brain cell injury
10.1101/gad.1010202 · 2002 · External reference
Not only myelination: the immune-inflammatory functions of oligodendrocytes
10.4103/1673-5374.342678 · 2022 · External reference
The interferon-induced gene ISG15 blocks retrovirus release from cells late in the budding process
10.1128/jvi.02478-09 · 2010 · External reference
Kaposi’s Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 1 Interacts with a Member of the Interferon-Stimulated Gene 15 Pathway
10.1128/jvi.01482-15 · 2015 · External reference
Type I interferon responses are impaired in latently HIV infected cells
10.1186/s12977-016-0302-9 · 2016 · External reference
IFN-α blockade during ART-treated SIV infection lowers tissue vDNA, rescues immune function, and improves overall health
10.1172/jci.insight.153046 · 2022 · External reference
Targeting type I interferon-mediated activation restores immune function in chronic HIV infection
10.1172/jci89488 · 2017 · External reference
Suppressor of cytokine signaling 3 inhibits antiviral IFN-beta signaling to enhance HIV-1 replication in macrophages
10.4049/jimmunol.0903563 · 2010 · External reference
Blockade of IFN-beta Reactivates HIV Reservoir in ART-Suppressed HIV-Infected BLT Humanized Mice
2024 · External reference
Simian immunodeficiency virus infection in the brain and lung leads to differential type I IFN signaling during acute infection
10.4049/jimmunol.1003757 · 2011 · External reference
Enhanced human immunodeficiency virus Type 1 expression and neuropathogenesis in knockout mice lacking Type I interferon responses
10.1097/nen.0000000000000026 · 2014 · External reference
Monocyte activation and differentiation augment human endogenous retrovirus expression: implications for inflammatory brain diseases
10.1002/ana.1131 · 2001 · External reference
Human endogenous retrovirus glycoprotein-mediated induction of redox reactants causes oligodendrocyte death and demyelination
10.1038/nn1319 · 2004 · External reference
The neutralizing antibody GNbAC1 abrogates HERV-W envelope protein-mediated oligodendroglial maturation blockade
10.1177/1352458514560926 · 2015 · External reference
Endogenous retroviruses in neurodevelopmental, psychotic and cognitive disorders
10.1016/j.micinf.2025.105479 · 2025 · External reference
Endogenous Retroviral Envelope Syncytin Induces HIV-1 Spreading and Establishes HIV Reservoirs in Placenta
10.1016/j.celrep.2020.03.016 · 2020 · External reference
Integrated analysis of multimodal single-cell data
2021 · External reference
A survey of human brain transcriptome diversity at the single cell level
10.1073/pnas.1507125112 · 2015 · External reference
