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References from Transcriptome profiling of L. infantum-infected human macrophages reveals sex-specific type I interferon induction. Local targets link to admitted publications; unresolved targets remain external evidence.
Sex differences in immune responses
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Regulation of macrophage subsets and cytokine production in leishmaniasis
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Who is a typical patient with visceral leishmaniasis? Characterizing the demographic and nutritional profile of patients in Brazil, East Africa, and South Asia
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Changing epidemiology of visceral leishmaniasis in northeastern Brazil: a 25-year follow-up of an urban outbreak
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Leishmania panamensis transmission in the domestic environment: the results of a prospective epidemiological survey in Santander, Colombia
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American tegumentary leishmaniasis: epidemiological and molecular characterization of prevalent Leishmania species in the State of Tocantins, Brazil, 2011-2015
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Sex-associated susceptibility in humans with chiclero’s ulcer: resistance in females is associated with increased serum-levels of GM-CSF
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Sex bias in infectious disease epidemiology: patterns and processes
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Epidemiology of cutaneous leishmaniasis in central Amazonia: a comparison of sex-biased incidence among rural settlers and field biologists
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Epidemiological and Experimental Evidence for Sex-Dependent Differences in the Outcome of Leishmania infantum Infection
10.4269/ajtmh.17-0563 · 2018 · External reference
Sex-Related Differences in Immune Response and Symptomatic Manifestations to Infection with Leishmania Species
10.1155/2019/4103819 · 2019 · External reference
Gender and cutaneous leishmaniasis in Israel
10.3390/tropicalmed7080179 · 2022 · External reference
Sex bias in the outcome of human tropical infectious diseases: influence of steroid hormones
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Gene-specific sex effects on eosinophil infiltration in leishmaniasis
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10.1038/icb.2008.39 · 2008 · External reference
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Image based Machine Learning for identification of macrophage subsets
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Macrophage activation switching: an asset for the resolution of inflammation
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Cytokines: Key Determinants of Resistance or Disease Progression in Visceral Leishmaniasis: Opportunities for Novel Diagnostics and Immunotherapy
10.3389/fimmu.2019.00670 · 2019 · External reference
Chemokines in Leishmaniasis: Map of cell movements highlights the landscape of infection and pathogenesis
10.1016/j.cyto.2020.155339 · 2021 · External reference
Estradiol regulates expression of estrogen receptor ERalpha46 in human macrophages
10.1371/journal.pone.0005539 · 2009 · External reference
Testosterone signaling through internalizable surface receptors in androgen receptor-free macrophages
10.1091/mbc.10.10.3113 · 1999 · External reference
Localization of androgen receptor expression in human bone marrow
10.1002/1096-9896(0000)9999:9999<::aid-path803>3.0.co;2-w · 2001 · External reference
Sex hormones and modulation of immunity against leishmaniasis
10.1159/000180265 · 2009 · External reference
High Content Analysis of Macrophage-Targeting EhPIb-Compounds against Cutaneous and Visceral Leishmania Species
10.3390/microorganisms9020422 · 2021 · External reference
Male predominance in reported Visceral Leishmaniasis cases: Nature or nurture? A comparison of population-based with health facility-reported data
10.1371/journal.pntd.0007995 · 2020 · External reference
Linking in vitro and in vivo survival of clinical Leishmania donovani strains
10.1371/journal.pone.0012211 · 2010 · External reference
In vitro infectivity and differential gene expression of Leishmania infantum metacyclic promastigotes: negative selection with peanut agglutinin in culture versus isolation from the stomodeal valve of Phlebotomus perniciosus
10.1186/s12864-016-2672-8 · 2016 · External reference
Visceral leishmaniasis: experimental models for drug discovery
2011 · External reference
Infection of Human Neutrophils With Leishmania infantum or Leishmania major Strains Triggers Activation and Differential Cytokines Release
10.3389/fcimb.2019.00153 · 2019 · External reference
Neutrophil kinetics in health and disease
10.1016/j.it.2010.05.006 · 2010 · External reference
Modulation of multiple neutrophil functions by preparative methods or trace concentrations of bacterial lipopolysaccharide
1985 · External reference
Leishmania lipophosphoglycan (LPG) activates NK cells through toll-like receptor-2
10.1016/s0166-6851(03)00160-9 · 2003 · External reference
Gene expression during the generation and activation of mouse neutrophils: implication of novel functional and regulatory pathways
10.1371/journal.pone.0108553 · 2014 · External reference
Gender difference in the non-specific and specific immune response in humans
10.1111/j.1600-0897.2004.00177.x · 2004 · External reference
Sex differences in neutrophil biology modulate response to type I interferons and immunometabolism
10.1073/pnas.2003603117 · 2020 · External reference
Testosterone affects type I/type II interferon response of neutrophils during hepatic amebiasis
10.3389/fimmu.2023.1279245 · 2023 · External reference
Leishmania: manipulation of signaling pathways to inhibit host cell apoptosis
2021 · External reference
Apoptosis: a review of programmed cell death
10.1080/01926230701320337 · 2007 · External reference
Leishmania donovani promastigotes evade the activation of mitogen-activated protein kinases p38, c-Jun N-terminal kinase, and extracellular signal-regulated kinase-1/2 during infection of naive macrophages
10.1002/1521-4141(2000)30:8<2235::aid-immu2235>3.0.co;2-9 · 2000 · External reference
Simultaneous gene expression profiling in human macrophages infected with Leishmania major parasites using SAGE
10.1186/1471-2164-9-238 · 2008 · External reference
Infection of neutrophil granulocytes with Leishmania major activates ERK 1/2 and modulates multiple apoptotic pathways to inhibit apoptosis
10.1007/s00430-012-0246-1 · 2013 · External reference
The PI3K/AKT signalling pathway in inflammation, cell death and glial scar formation after traumatic spinal cord injury: Mechanisms and therapeutic opportunities
2022 · External reference
Leishmania promastigotes activate PI3K/Akt signalling to confer host cell resistance to apoptosis
10.1111/j.1462-5822.2006.00769.x · 2007 · External reference
PI3K signaling in Leishmania infections
10.1016/j.cellimm.2016.09.004 · 2016 · External reference
High-throughput phenotypic screen and transcriptional analysis identify new compounds and targets for macrophage reprogramming
10.1038/s41467-021-21066-x · 2021 · External reference
Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression
10.4049/jimmunol.177.10.7303 · 2006 · External reference
Role of human macrophage polarization in inflammation during infectious diseases
10.3390/ijms19061801 · 2018 · External reference
M2 Polarization of Human Macrophages Favors Survival of the Intracellular Pathogen Chlamydia pneumoniae
10.1371/journal.pone.0143593 · 2015 · External reference
Transcriptional Profiling of Immune-Related Genes in Leishmania infantum-Infected Mice: Identification of Potential Biomarkers of Infection and Progression of Disease
10.3389/fcimb.2018.00197 · 2018 · External reference
Arginase activity - a marker of disease status in patients with visceral leishmaniasis in ethiopia
10.1371/journal.pntd.0002134 · 2013 · External reference
sCD163 levels as a biomarker of disease severity in leprosy and visceral leishmaniasis
2017 · External reference
An IL-10 dominant polarization of monocytes is a feature of Indian Visceral Leishmaniasis
2018 · External reference
Polarized M2 macrophages in dogs with visceral leishmaniasis
10.1016/j.vetpar.2016.06.032 · 2016 · External reference
Nucleosides present on phlebotomine saliva induce immunossuppression and promote the infection establishment
10.1371/journal.pntd.0003600 · 2015 · External reference
Unravelling the unsolved paradoxes of cytokine families in host resistance and susceptibility to Leishmania infection
10.1016/j.cytox.2020.100043 · 2020 · External reference
Hormonal and immunological mechanisms mediating sex differences in parasite infection
10.1111/j.0141-9838.2004.00710.x · 2004 · External reference
TNF-Mediated Restriction of Arginase 1 Expression in Myeloid Cells Triggers Type 2 NO Synthase Activity at the Site of Infection
10.1016/j.celrep.2016.04.001 · 2016 · External reference
Absence of Tumor Necrosis Factor Supports Alternative Activation of Macrophages in the Liver after Infection with Leishmania major
10.3389/fimmu.2018.00001 · 2018 · External reference
Role and effect of TNF-alpha in experimental visceral leishmaniasis
10.4049/jimmunol.153.2.768 · 1994 · External reference
Tissue granuloma structure-function in experimental visceral leishmaniasis
10.1046/j.1365-2613.2001.00199.x · 2001 · External reference
Anti-parasite therapy drives changes in human visceral leishmaniasis-associated inflammatory balance
10.1038/s41598-017-04595-8 · 2017 · External reference
Leishmaniasis and tumor necrosis factor alpha antagonists in the Mediterranean basin. A switch in clinical expression
10.1371/journal.pntd.0007708 · 2019 · External reference
Tumor necrosis factor (cachectin) in human visceral leishmaniasis
10.1093/infdis/163.4.853 · 1991 · External reference
Sex-determined susceptibility and differential IFN-gamma and TNF-alpha mRNA expression in DBA/2 mice infected with Leishmania mexicana
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Androgens predispose males to monocyte-mediated immunopathology by inducing the expression of leukocyte recruitment factor CXCL1
10.1038/s41467-020-17260-y · 2020 · External reference
Interleukin 8 elicits rapid physiological changes in neutrophils that are altered by inflammatory conditions
10.1159/000514885 · 2021 · External reference
Evaluation of interleukin 8 +2767 A/T polymorphism in visceral leishmaniasis
10.1016/j.apjtm.2016.09.010 · 2016 · External reference
Evaluation of IL-8, nitric oxide and macrophage inhibitory factor as clinical circulatory markers in patients with cutaneous leishmaniasis, before and during sodium stibogluconate treatment
10.1016/j.cyto.2023.156450 · 2024 · External reference
The role of IL-10 in promoting disease progression in leishmaniasis
10.4049/jimmunol.166.2.1141 · 2001 · External reference
Cytokine regulation of female-macrophage resistance to Leishmania mexicana parasites. Role of IL-12p70
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Endogenous interleukin-18 is involved in immunity to Leishmania donovani but its absence does not adversely influence the therapeutic activity of sodium stibogluconate
10.1111/j.1365-2567.2006.02438.x · 2006 · External reference
IL-18 contributes to susceptibility to Leishmania amazonensis infection by macrophage-independent mechanisms
10.1016/j.cyto.2015.01.021 · 2015 · External reference
ImmGen report: sexual dimorphism in the immune system transcriptome
10.1038/s41467-019-12348-6 · 2019 · External reference
Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures
10.1128/mbio.00027-16 · 2016 · External reference
Simultaneous transcriptional profiling of Leishmania major and its murine macrophage host cell reveals insights into host-pathogen interactions
10.1186/s12864-015-2237-2 · 2015 · External reference
Transcriptional profiling of macrophages reveals distinct parasite stage-driven signatures during early infection by Leishmania donovani
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Macrophage and T-cell gene expression in a model of early infection with the protozoan Leishmania chagasi
10.1371/journal.pntd.0000252 · 2008 · External reference
Metallothionein 1: A New Spotlight on Inflammatory Diseases
10.3389/fimmu.2021.739918 · 2021 · External reference
Metallothioneins: emerging modulators in immunity and infection
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Heme oxygenase-1 is an anti-inflammatory host factor that promotes murine plasmodium liver infection
10.1016/j.chom.2008.04.003 · 2008 · External reference
Heme oxygenase-1-derived carbon monoxide enhances the host defense response to microbial sepsis in mice
10.1172/jci32730 · 2008 · External reference
Leishmania donovani Targets Host Transcription Factor NRF2 To Activate Antioxidant Enzyme HO-1 and Transcriptional Repressor ATF3 for Establishing Infection
10.1128/iai.00764-20 · 2021 · External reference
Heme oxygenase-1 promotes the persistence of Leishmania chagasi infection
10.4049/jimmunol.1103072 · 2012 · External reference
Transcriptional Profiling in Experimental Visceral Leishmaniasis Reveals a Broad Splenic Inflammatory Environment that Conditions Macrophages toward a Disease-Promoting Phenotype
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Sustained parasite burden in the spleen of Leishmania infantum-infected BALB/c mice is accompanied by expression of MCP-1 transcripts and lack of protection against challenge
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CXC Chemokine–Mediated Protection against Visceral Leishmaniasis: Involvement of the Proinflammatory Response
10.1086/605895 · 2009 · External reference
Interferon-Stimulated Genes: What Do They All Do?
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Type I interferon signaling, regulation and gene stimulation in chronic virus infection
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Protozoan parasites and type I IFNs
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Innate killing of Leishmania donovani by macrophages of the splenic marginal zone requires IRF-7
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