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References from Human tonsil organoids reveal innate pathways modulating humoral and cellular responses to ChAdOx1. Local targets link to admitted publications; unresolved targets remain external evidence.
Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK
10.1016/s0140-6736(20)32661-1 · 2021 · External reference
Final efficacy analysis, interim safety analysis, and immunogenicity of a single dose of recombinant novel coronavirus vaccine (adenovirus type 5 vector) in adults 18 years and older: an international, multicentre, randomised, double-blinded, placebo-controlled phase 3 trial
10.1016/s0140-6736(21)02753-7 · 2022 · External reference
Final analysis of efficacy and safety of single-dose Ad26.COV2.S
10.1056/nejmoa2117608 · 2022 · External reference
Adenovirus vector and mRNA vaccines: mechanisms regulating their immunogenicity
10.1002/eji.202250022 · 2023 · External reference
Tfh cells and the germinal center are required for memory B cell formation & humoral immunity after ChAdOx1 nCoV-19 vaccination
10.1016/j.xcrm.2022.100845 · 2022 · External reference
Distinct requirements for CD4+ T cell help for immune responses induced by mRNA and adenovirus-vector SARS-CoV-2 vaccines
10.1002/eji.202451142 · 2025 · External reference
Transient CD4+ T cell depletion results in delayed development of functional vaccine-elicited antibody responses
10.1128/jvi.00039-16 · 2016 · External reference
Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination
10.1038/s41590-022-01329-5 · 2022 · External reference
Transcriptional atlas of the human immune response to 13 vaccines reveals a common predictor of vaccine-induced antibody responses
10.1038/s41590-022-01328-6 · 2022 · External reference
Toll-like receptor 4 signalling regulates antibody response to adenoviral vector-based vaccines by imprinting germinal centre quality
10.1111/imm.12957 · 2018 · External reference
Type I IFN signaling on both B and CD4 T cells is required for protective antibody response to adenovirus
10.4049/jimmunol.178.6.3505 · 2007 · External reference
A homologous or variant booster vaccine after Ad26.COV2.S immunization enhances SARS-CoV-2-specific immune responses in rhesus macaques
2022 · External reference
Modeling human adaptive immune responses with tonsil organoids
10.1038/s41591-020-01145-0 · 2021 · External reference
Influenza vaccine format mediates distinct cellular and antibody responses in human immune organoids
10.1016/j.immuni.2023.06.019 · 2023 · External reference
A TLR7-nanoparticle adjuvant promotes a broad immune response against heterologous strains of influenza and SARS-CoV-2
2023 · External reference
Tissue-specific sex differences in pediatric and adult immune cell composition and function
10.3389/fimmu.2024.1373537 · 2024 · External reference
Defining T cell subsets in human tonsils using ChipCytometry
10.4049/jimmunol.2100063 · 2021 · External reference
Rapid and stable mobilization of CD8+ T cells by SARS-CoV-2 mRNA vaccine
10.1038/s41586-021-03841-4 · 2021 · External reference
Spontaneous immunoglobulin production by adenoidal and tonsillar lymphocytes in relation to age and otitis media with effusion
10.1016/0165-5876(95)01298-2 · 1996 · External reference
Metabolic regulation of the immune humoral response
10.1016/j.immuni.2017.04.009 · 2017 · External reference
Naive human B cells engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses
10.1126/sciimmunol.abl5842 · 2021 · External reference
Challenges and opportunities for consistent classification of human B cell and plasma cell populations
10.3389/fimmu.2019.02458 · 2019 · External reference
Increased expression of CD27 on activated human memory B cells correlates with their commitment to the plasma cell lineage
10.4049/jimmunol.174.7.4034 · 2005 · External reference
MAIT cell activation augments adenovirus vector vaccine immunogenicity
10.1126/science.aax8819 · 2021 · External reference
COVID-19 adenovirus vector vaccine induces higher interferon and pro-inflammatory responses than mRNA vaccines in human PBMCs, macrophages and moDCs
10.1016/j.vaccine.2023.04.049 · 2023 · External reference
Vaccination with adenovirus serotypes 35, 26, and 48 elicits higher levels of innate cytokine responses than adenovirus serotype 5 in rhesus monkeys
10.1128/jvi.00740-12 · 2012 · External reference
B cells responses and cytokine production are regulated by their immune microenvironment
10.1016/j.cyto.2015.02.007 · 2015 · External reference
Interleukin-6 is a growth factor for nonmalignant human plasmablasts
10.1182/blood.v97.6.1817 · 2001 · External reference
Production of hybridoma growth factor by human monocytes
10.1002/eji.1830171004 · 1987 · External reference
T follicular helper cell differentiation, function, and roles in disease
10.1016/j.immuni.2014.10.004 · 2014 · External reference
Role of IL-6 in the commitment of T cell subsets
10.1016/j.cyto.2021.155654 · 2021 · External reference
Germinal centers
10.1146/annurev-immunol-120419-022408 · 2022 · External reference
A systems immunology study comparing innate and adaptive immune responses in adults to COVID-19 mRNA and adenovirus vectored vaccines
10.1016/j.xcrm.2023.100971 · 2023 · External reference
IFN-α as an adjuvant for adenovirus-vectored FMDV subunit vaccine through improving the generation of T follicular helper cells
2013 · External reference
1IFN-α modulates memory Tfh cells and memory B cells in mice, following recombinant FMDV adenoviral challenge
10.3389/fimmu.2020.00701 · 2020 · External reference
Plasmacytoid dendritic cells control TLR7 sensitivity of naive B cells via type I IFN
10.4049/jimmunol.174.7.4043 · 2005 · External reference
Type I interferons promote the survival and proinflammatory properties of transitional B cells in systemic lupus erythematosus patients
10.1038/s41423-018-0010-6 · 2019 · External reference
Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6
10.1016/s1074-7613(03)00208-5 · 2003 · External reference
A critical role of T follicular helper cells in human mucosal anti-influenza response that can be enhanced by immunological adjuvant CpG-DNA
10.1016/j.antiviral.2016.05.021 · 2016 · External reference
Type I interferon promotes humoral immunity in viral vector vaccination
10.1128/jvi.00925-21 · 2021 · External reference
Specialization, kinetics, and repertoire of type 1 interferon responses by human plasmacytoid predendritic cells
10.1182/blood-2005-07-2709 · 2006 · External reference
Interdependent and independent roles of type I interferons and IL-6 in innate immune, neuroinflammatory and sickness behaviour responses to systemic poly I:C
10.1016/j.bbi.2015.04.009 · 2015 · External reference
The role of IL-6 in host defence against infections: immunobiology and clinical implications
10.1038/nrrheum.2017.83 · 2017 · External reference
The accelerated waning of immunity and reduced effect of booster in patients treated with bDMARD and tsDMARD after SARS-CoV-2 mRNA vaccination
10.3389/fmed.2023.1049157 · 2023 · External reference
Immunomodulators and risk for breakthrough COVID-19 after third SARS-CoV-2 mRNA vaccine among patients with rheumatoid arthritis: a cohort study
10.1136/ard-2023-225162 · 2024 · External reference
Type I IFN induces binding of STAT1 to Bcl6: divergent roles of STAT family transcription factors in the T follicular helper cell genetic program
10.4049/jimmunol.1300675 · 2014 · External reference
Late interleukin-6 escalates T follicular helper cell responses and controls a chronic viral infection
10.1126/science.1208421 · 2011 · External reference
Type I interferons promote germinal centers through B cell intrinsic signaling and dendritic cell dependent Th1 and Tfh cell lineages
10.3389/fimmu.2022.932388 · 2022 · External reference
A distinct subset of plasmacytoid dendritic cells induces activation and differentiation of B and T lymphocytes
10.1073/pnas.1610630114 · 2017 · External reference
Diversification of human plasmacytoid predendritic cells in response to a single stimulus
10.1038/s41590-017-0012-z · 2018 · External reference
Plasmacytoid and conventional dendritic cells cooperate in crosspriming AAV capsid-specific CD8+ T cells
10.1182/blood-2016-11-751040 · 2017 · External reference
Plasmacytoid dendritic cells cross-prime naive CD8 T cells by transferring antigen to conventional dendritic cells through exosomes
10.1073/pnas.2002345117 · 2020 · External reference