Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Research graph
References from An invertebrate NLR recognizes viral nucleic acids and balances the antiviral signaling pathway through interaction with STING and Cyclophilin A. Local targets link to admitted publications; unresolved targets remain external evidence.
Toll-like receptors and their crosstalk with other innate receptors in infection and immunity
10.1016/j.immuni.2011.05.006 · 2011 · External reference
Immune signaling by RIG-I-like receptors
10.1016/j.immuni.2011.05.003 · 2011 · External reference
Viral RNA detection by RIG-I-like receptors
10.1016/j.coi.2014.12.012 · 2015 · External reference
Pattern recognition receptors and inflammation
10.1016/j.cell.2010.01.022 · 2010 · External reference
CqToll participates in antiviral response against white spot syndrome virus via induction of anti-lipopolysaccharide factor in red claw crayfish Cherax quadricarinatus
10.1016/j.dci.2017.04.020 · 2017 · External reference
RNAi screening identifies a new Toll from shrimp Litopenaeus vannamei that restricts WSSV infection through activating Dorsal to induce antimicrobial peptides
2018 · External reference
Scavenger receptor C mediates phagocytosis of white spot syndrome virus and restricts virus proliferation in shrimp
2016 · External reference
The DExD/H-box helicase Dicer-2 mediates the induction of antiviral activity in Drosophila
10.1038/ni.1664 · 2008 · External reference
Secreted Vago restricts West Nile virus infection in Culex mosquito cells by activating the Jak-STAT pathway
10.1073/pnas.1205231109 · 2012 · External reference
Activation of Vago by interferon regulatory factor (IRF) suggests an interferon system-like antiviral mechanism in shrimp
10.1038/srep15078 · 2015 · External reference
Interferon functional analog activates antiviral Jak/Stat signaling through integrin in an arthropod
10.1016/j.celrep.2021.109761 · 2021 · External reference
MD-2 homologue recognizes the white spot syndrome virus lipid component and induces antiviral molecule expression in shrimp
10.4049/jimmunol.1900268 · 2019 · External reference
Functional elucidation of LvToll3 receptor from P. vannamei through RNA interference and its potential role in the shrimp antiviral response
10.1016/j.dci.2018.01.020 · 2018 · External reference
A cytosolic sensor, PmDDX41, binds double stranded-dna and triggers the activation of an innate antiviral response in the shrimp Penaeus monodon via the STING-dependent signaling pathway
10.3389/fimmu.2019.02069 · 2019 · External reference
Cellular entry of white spot syndrome virus and antiviral immunity mediated by cellular receptors in crustaceans
10.1016/j.fsi.2019.08.011 · 2019 · External reference
The NLR family of innate immune and cell death sensors
10.1016/j.immuni.2024.03.012 · 2024 · External reference
Role of NLRs in the regulation of type I interferon signaling, host defense and tolerance to inflammation
10.3390/ijms22031301 · 2021 · External reference
Defining the origins of the NOD-like receptor system at the base of animal evolution
10.1093/molbev/msq349 · 2011 · External reference
Responding to threats both foreign and domestic: NOD-like receptors in corals
10.1093/icb/icz111 · 2019 · External reference
A newly identified NLR-like gene participates in bacteria and virus infection possibly through regulating hemocytes apoptosis in shrimp
10.1016/j.dci.2022.104395 · 2022 · External reference
The emerging roles of NOD-like receptors in antiviral innate immune signaling pathways
10.1016/j.ijbiomac.2020.12.127 · 2021 · External reference
NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-κB signaling pathways
10.1016/j.immuni.2011.03.026 · 2011 · External reference
NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens
10.1038/nature11250 · 2012 · External reference
NLRP12 regulates Anti-viral RIG-I activation via interaction with TRIM25
2019 · External reference
NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways
10.1016/j.cell.2010.03.040 · 2010 · External reference
Do Type I interferons link systemic autoimmunities and metabolic syndrome in a pathogenetic continuum?
10.1016/j.it.2017.07.001 · 2018 · External reference
NOD-like receptors in infection, immunity, and diseases
10.3349/ymj.2016.57.1.5 · 2016 · External reference
Viral DNA binding to NLRC3, an inhibitory nucleic acid sensor, unleashes STING, a cyclic dinucleotide receptor that activates Type I interferon
2019 · External reference
NLRX1 sequesters STING to negatively regulate the interferon response, thereby facilitating the replication of HIV-1 and DNA viruses
10.1016/j.chom.2016.03.001 · 2016 · External reference
NLRX1 negatively regulates TLR-induced NF-κB signaling by targeting TRAF6 and IKK
10.1016/j.immuni.2011.02.022 · 2011 · External reference
An invertebrate gene encoding a Mab21-containing protein involves in antiviral response through regulating the STING pathway
10.1016/j.dci.2021.104101 · 2021 · External reference
NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING
10.1016/j.immuni.2014.01.010 · 2014 · External reference
Cyclophilin A: a key player for etiological agent infection
10.1007/s00253-021-11115-2 · 2021 · External reference
Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses
2017 · External reference
Repurposing of cyclophilin A inhibitors as broad-spectrum antiviral agents
10.1016/j.drudis.2022.05.016 · 2022 · External reference
Transcriptome analysis reveals the activation of neuroendocrine-immune system in shrimp hemocytes at the early stage of WSSV infection
10.1186/s12864-019-5614-4 · 2019 · External reference
W-IQ-TREE: a fast online phylogenetic tool for maximum likelihood analysis
10.1093/nar/gkw256 · 2016 · External reference
Analysis on the dynamic changes of the amount of WSSV in Chinese shrimp Fenneropenaeus chinensis during infection
10.1016/j.aquaculture.2012.11.014 · 2013 · External reference
Autophagy and white spot syndrome virus infection in crustaceans
10.1016/j.fsirep.2021.100047 · 2021 · External reference