Research graph
References from Glycosylphosphatidylinositol biosynthesis functions as a conserved host defense pathway against coronaviruses via regulation of LY6E. Local targets link to admitted publications; unresolved targets remain external evidence.
SARS-CoV-2 pathogenesis
10.1038/s41579-022-00713-0 · 2022 · External reference
Coronavirus biology and replication: implications for SARS-CoV-2
10.1038/s41579-020-00468-6 · 2021 · External reference
A Novel Coronavirus from Patients with Pneumonia in China, 2019
10.1056/nejmoa2001017 · 2020 · External reference
SARS-CoV-2 variant biology: immune escape, transmission and fitness
2023 · External reference
Drawing Comparisons between SARS-CoV-2 and the Animal Coronaviruses
10.3390/microorganisms8111840 · 2020 · External reference
Porcine epidemic diarrhea virus (PEDV): An update on etiology, transmission, pathogenesis, and prevention and control
10.1016/j.virusres.2020.198045 · 2020 · External reference
Comparison of Infectious Bronchitis Virus (IBV) Pathogenesis and Host Responses in Young Male and Female Chickens
10.3390/v15122285 · 2023 · External reference
Independent infections of porcine deltacoronavirus among Haitian children
10.1038/s41586-021-04111-z · 2021 · External reference
Origin and evolution of pathogenic coronaviruses
10.1038/s41579-018-0118-9 · 2019 · External reference
Novel Canine Coronavirus Isolated from a Hospitalized Patient With Pneumonia in East Malaysia
10.1093/cid/ciab456 · 2022 · External reference
Structure, receptor recognition, and antigenicity of the human coronavirus CCoV-HuPn-2018 spike glycoprotein
10.1016/j.cell.2022.05.019 · 2022 · External reference
CRISPR Screening: Molecular Tools for Studying Virus-Host Interactions
10.3390/v13112258 · 2021 · External reference
A CRISPR toolbox to study virus-host interactions
10.1038/nrmicro.2017.29 · 2017 · External reference
Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection
2021 · External reference
Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses
10.1016/j.cell.2020.12.004 · 2021 · External reference
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks
10.1016/j.cell.2020.12.006 · 2021 · External reference
Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells
10.1016/j.cell.2020.10.030 · 2021 · External reference
Genome-wide CRISPR screening identifies TMEM106B as a proviral host factor for SARS-CoV-2
10.1038/s41588-021-00805-2 · 2021 · External reference
A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry
10.1038/s41467-021-21213-4 · 2021 · External reference
Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs
10.1038/s41588-022-01110-2 · 2022 · External reference
Identification of DAXX as a restriction factor of SARS-CoV-2 through a CRISPR/Cas9 screen
10.1038/s41467-022-30134-9 · 2022 · External reference
Functional landscape of SARS-CoV-2 cellular restriction
10.1016/j.molcel.2021.04.008 · 2021 · External reference
A prenylated dsRNA sensor protects against severe COVID-19
10.1126/science.abj3624 · 2021 · External reference
Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection
10.1038/s41588-022-01131-x · 2022 · External reference
Host proviral and antiviral factors for SARS-CoV-2
10.1007/s11262-021-01869-2 · 2021 · External reference
PLSCR1 is a cell-autonomous defence factor against SARS-CoV-2 infection
10.1038/s41586-023-06322-y · 2023 · External reference
Integrated multi-omics analyses identify anti-viral host factors and pathways controlling SARS-CoV-2 infection
10.1038/s41467-023-44175-1 · 2024 · External reference
Unresolved reference
2025 · External reference
Biosynthesis and biology of mammalian GPI-anchored proteins
10.1098/rsob.190290 · 2020 · External reference
The GPI-anchor biosynthesis pathway is critical for syncytiotrophoblast differentiation and placental development
10.1007/s00018-024-05284-2 · 2024 · External reference
A knockout cell library of GPI biosynthetic genes for functional studies of GPI-anchored proteins
10.1038/s42003-021-02337-1 · 2021 · External reference
A novel cell culture system modeling the SARS-CoV-2 life cycle
2021 · External reference
LY6E is a pan-coronavirus restriction factor in the respiratory tract
10.1038/s41564-023-01431-w · 2023 · External reference
LY6E impairs coronavirus fusion and confers immune control of viral disease
10.1038/s41564-020-0769-y · 2020 · External reference
Rescue of Glycosylphosphatidylinositol-Anchored Protein Biosynthesis Using Synthetic Glycosylphosphatidylinositol Oligosaccharides
10.1021/acschembio.1c00465 · 2021 · External reference
Inference of CRISPR Edits from Sanger Trace Data
10.1089/crispr.2021.0113 · 2022 · External reference
Dual Split Protein (DSP) Assay to Monitor Cell-Cell Membrane Fusion
10.1007/978-1-4939-2703-6_17 · 2015 · External reference
Cell-type-specific, multicolor labeling of endogenous proteins with split fluorescent protein tags in Drosophila
10.1073/pnas.2024690118 · 2021 · External reference
Prediction of GPI-anchored proteins with pointer neural networks
10.1016/j.crbiot.2021.01.001 · 2021 · External reference
Unresolved reference
2010 · External reference
A Cell Fusion-Based Screening Method Identifies Glycosylphosphatidylinositol-Anchored Protein Ly6e as the Receptor for Mouse Endogenous Retroviral Envelope Syncytin-A
10.1128/jvi.00832-17 · 2017 · External reference
Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding
10.1016/s0140-6736(20)30251-8 · 2020 · External reference
Genome-scale CRISPR screen identifies TMEM41B as a multi-function host factor required for coronavirus replication
2021 · External reference
A CRISPR activation screen identifies genes that enhance SARS-CoV-2 infection
2022 · External reference
A genome-wide CRISPR screen identifies interactors of the autophagy pathway as conserved coronavirus targets
10.1371/journal.pbio.3001490 · 2021 · External reference
Sorting GPI-anchored proteins
10.1038/nrm1309 · 2004 · External reference
Decay-accelerating factor (CD55), a glycosylphosphatidylinositol-anchored complement regulatory protein, is a receptor for several echoviruses
10.1073/pnas.91.13.6245 · 1994 · External reference
The HeLa cell receptor for enterovirus 70 is decay-accelerating factor (CD55)
10.1128/jvi.70.8.5143-5152.1996 · 1996 · External reference
Hantavirus causing hemorrhagic fever with renal syndrome enters from the apical surface and requires decay-accelerating factor (DAF/CD55)
10.1128/jvi.02210-07 · 2008 · External reference
Folate receptor-alpha is a cofactor for cellular entry by Marburg and Ebola viruses
10.1016/s0092-8674(01)00418-4 · 2001 · External reference
Role of GPI-anchored NCAM-120 in rabies virus infection
10.1016/j.micinf.2006.11.003 · 2007 · External reference
LY6E mediates an evolutionarily conserved enhancement of virus infection by targeting a late entry step
10.1038/s41467-018-06000-y · 2018 · External reference
Flavivirus internalization is regulated by a size-dependent endocytic pathway
10.1073/pnas.1720032115 · 2018 · External reference
Interferon-inducible LY6E Protein Promotes HIV-1 Infection
10.1074/jbc.m116.755819 · 2017 · External reference
CD4-Dependent Modulation of HIV-1 Entry by LY6E
2019 · External reference
BST-2/tetherin: structural biology, viral antagonism, and immunobiology of a potent host antiviral factor
10.1016/j.molimm.2012.11.008 · 2013 · External reference
Relating GPI-Anchored Ly6 Proteins uPAR and CD59 to Viral Infection
10.3390/v11111060 · 2019 · External reference
Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria
10.1016/0092-8674(93)90250-t · 1993 · External reference
Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
10.1038/nbt.3437 · 2016 · External reference
The single amino acid change of R516K enables efficient generation of vesicular stomatitis virus-based Crimean-Congo hemorrhagic fever reporter virus
2025 · External reference
