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References from The multifaceted role of the viral 2A protease in enterovirus replication and antagonism of host antiviral responses. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
External reference
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Tinkering with translation: protein synthesis in virus-infected cells
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Nucleocytoplasmic Trafficking Perturbation Induced by Picornaviruses
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Inhibition of nuclear import and alteration of nuclear pore complex composition by rhinovirus
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La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate
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A cytoplasmic 57-kDa protein that is required for translation of picornavirus RNA by internal ribosomal entry is identical to the nuclear pyrimidine tract-binding protein
10.1073/pnas.90.16.7642 · 1993 · External reference
RNA nuclear export is blocked by poliovirus 2A protease and is concomitant with nucleoporin cleavage
10.1242/jcs.055988 · 2009 · External reference
ISG15 overexpression compensates the defect of Crimean-Congo hemorrhagic fever virus polymerase bearing a protease-inactive ovarian tumor domain
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Picornavirus 2A protease regulates stress granule formation to facilitate viral translation
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2A protease is not a prerequisite for poliovirus replication
10.1128/jvi.02575-09 · 2010 · External reference
Translation and replication dynamics of single RNA viruses
10.1016/j.cell.2020.10.019 · 2020 · External reference
Increased gelatinase B/matrix metalloproteinase 9 (MMP-9) activity in a murine model of acute coxsackievirus B4-induced pancreatitis
10.1016/j.virol.2008.08.046 · 2008 · External reference
Fitness and virulence of a coxsackievirus mutant that can circumnavigate the need for phosphatidylinositol 4-kinase class III beta
10.1128/jvi.03177-13 · 2014 · External reference
Proteomic elucidation of the targets and primary functions of the picornavirus 2A protease
10.1016/j.jbc.2022.101882 · 2022 · External reference
Differential targeting of nuclear pore complex proteins in poliovirus-infected cells
10.1128/jvi.01670-07 · 2008 · External reference
Selective removal of FG repeat domains from the nuclear pore complex by enterovirus 2Apro
10.1128/jvi.00956-15 · 2015 · External reference
Rhinovirus 3C protease facilitates specific nucleoporin cleavage and mislocalisation of nuclear proteins in infected host cells
10.1371/journal.pone.0071316 · 2013 · External reference
Defining the proteolytic landscape during enterovirus infection
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Differential processing of nuclear pore complex proteins by rhinovirus 2A proteases from different species and serotypes
10.1128/jvi.00718-11 · 2011 · External reference
Differential disruption of nucleocytoplasmic trafficking pathways by rhinovirus 2A proteases
10.1128/jvi.02472-16 · 2017 · External reference
Specific cleavage of the nuclear pore complex protein Nup62 by a viral protease
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Cleavage and Sub-Cellular Redistribution of Nuclear Pore Protein 98 by Coxsackievirus B3 Protease 2A Impairs Cardioprotection
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Rhinovirus 3C protease can localize in the nucleus and alter active and passive nucleocytoplasmic transport
10.1128/jvi.01748-08 · 2009 · External reference
Poliovirus proteinase 2A induces cleavage of eucaryotic initiation factor 4F polypeptide p220
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Inhibition of HeLa cell protein synthesis following poliovirus infection correlates with the proteolysis of a 220,000-dalton polypeptide associated with eucaryotic initiation factor 3 and a cap binding protein complex
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Proteolysis of human eukaryotic translation initiation factor eIF4GII, but not eIF4GI, coincides with the shutoff of host protein synthesis after poliovirus infection
10.1073/pnas.95.19.11089 · 1998 · External reference
Eukaryotic initiation factor 4GII (eIF4GII), but not eIF4GI, cleavage correlates with inhibition of host cell protein synthesis after human rhinovirus infection
10.1128/jvi.73.4.3467-3472.1999 · 1999 · External reference
Differential cleavage of eIF4GI and eIF4GII in mammalian cells. Effects on translation
10.1074/jbc.m604340200 · 2006 · External reference
Mapping of functional domains in eukaryotic protein synthesis initiation factor 4G (eIF4G) with picornaviral proteases. Implications for cap-dependent and cap-independent translational initiation
10.1074/jbc.270.37.21975 · 1995 · External reference
Direct functional interaction of initiation factor eIF4G with type 1 internal ribosomal entry sites
10.1073/pnas.0900153106 · 2009 · External reference
The mammalian host protein DAP5 facilitates the initial round of translation of Coxsackievirus B3 RNA
10.1074/jbc.ra119.009000 · 2019 · External reference
Cleavage of DAP5 by coxsackievirus B3 2A protease facilitates viral replication and enhances apoptosis by altering translation of IRES-containing genes
10.1038/cdd.2015.145 · 2016 · External reference
THRONCAT: metabolic labeling of newly synthesized proteins using a bioorthogonal threonine analog
10.1038/s41467-023-39063-7 · 2023 · External reference
Poliovirus unlinks TIA1 aggregation and mRNA stress granule formation
10.1128/jvi.05888-11 · 2011 · External reference
Translation without eIF2 promoted by poliovirus 2A protease
10.1371/journal.pone.0025699 · 2011 · External reference
Endoplasmic reticulum stress is induced and modulated by enterovirus 71
10.1111/j.1462-5822.2010.01434.x · 2010 · External reference
Coxsackievirus B3 infection activates the unfolded protein response and induces apoptosis through downregulation of p58IPK and activation of CHOP and SREBP1
10.1128/jvi.01416-09 · 2010 · External reference
Coxsackievirus B3 Infection Triggers Autophagy through 3 Pathways of Endoplasmic Reticulum Stress
2018 · External reference
A heat-sensitive inhibitor in poliovirus-infected cells which selectively blocks phosphorylation of the alpha subunit of eucaryotic initiation factor 2 by the double-stranded RNA-activated protein kinase
10.1128/jvi.62.10.3551-3557.1988 · 1988 · External reference
The cellular 68,000-Mr protein kinase is highly autophosphorylated and activated yet significantly degraded during poliovirus infection: implications for translational regulation
10.1128/jvi.63.5.2244-2251.1989 · 1989 · External reference
Inhibition of translation in cells infected with a poliovirus 2Apro mutant correlates with phosphorylation of the alpha subunit of eucaryotic initiation factor 2
10.1128/jvi.63.12.5069-5075.1989 · 1989 · External reference
Different effect of proteasome inhibition on vesicular stomatitis virus and poliovirus replication
10.1371/journal.pone.0001887 · 2008 · External reference
Protease 2A induces stress granule formation during coxsackievirus B3 and enterovirus 71 infections
10.1186/s12985-014-0192-1 · 2014 · External reference
Essential Role of Enterovirus 2A Protease in Counteracting Stress Granule Formation and the Induction of Type I Interferon
10.1128/jvi.00222-19 · 2019 · External reference
Inhibition of cytoplasmic mRNA stress granule formation by a viral proteinase
10.1016/j.chom.2007.08.006 · 2007 · External reference
Encephalomyocarditis virus disrupts stress granules, the critical platform for triggering antiviral innate immune responses
10.1128/jvi.03248-12 · 2013 · External reference
SG formation relies on eIF4GI-G3BP interaction which is targeted by picornavirus stress antagonists
10.1038/s41421-018-0068-4 · 2019 · External reference
Enteroviral protease 2A cleaves dystrophin: evidence of cytoskeletal disruption in an acquired cardiomyopathy
10.1038/6543 · 1999 · External reference
2A proteinase of human rhinovirus cleaves cytokeratin 8 in infected HeLa cells
10.1074/jbc.275.26.20084 · 2000 · External reference
Poliovirus 2A protease induces apoptotic cell death
10.1128/mcb.20.4.1271-1277.2000 · 2000 · External reference
MDA5 detects the double-stranded RNA replicative form in picornavirus-infected cells
10.1016/j.celrep.2012.10.005 · 2012 · External reference
Visualisation of direct interaction of MDA5 and the dsRNA replicative intermediate form of positive strand RNA viruses
2012 · External reference
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
10.1038/nature04734 · 2006 · External reference
Cell-type specificity and functional redundancy of RIG-I-like receptors in innate immune sensing of Coxsackievirus B3 and encephalomyocarditis virus
10.1016/j.virol.2018.12.003 · 2019 · External reference
RIG-I is cleaved during picornavirus infection
10.1016/j.virol.2009.06.045 · 2009 · External reference
Cleavage of IPS-1 in cells infected with human rhinovirus
10.1128/jvi.01490-09 · 2009 · External reference
The Coxsackievirus B 3Cpro Protease Cleaves MAVS and TRIF to Attenuate Host Type I Interferon and Apoptotic Signaling
10.1371/journal.ppat.1001311 · 2011 · External reference
Enterovirus 71 protease 2Apro targets MAVS to inhibit anti-viral type I interferon responses
10.1371/journal.ppat.1003231 · 2013 · External reference
Enterovirus 2Apro targets MDA5 and MAVS in infected cells
10.1128/jvi.02712-13 · 2014 · External reference
The suppression of innate immune response by human rhinovirus C
10.1016/j.bbrc.2017.05.169 · 2017 · External reference
Proteinase 2Apro is essential for enterovirus replication in type I interferon-treated cells
10.1128/jvi.02177-08 · 2009 · External reference
Viral security proteins: counteracting host defences
10.1038/nrmicro2452 · 2010 · External reference
Cleavage of poly(A)-binding protein by enterovirus proteases concurrent with inhibition of translation in vitro
10.1128/jvi.73.1.718-727.1999 · 1999 · External reference
Efficient cleavage of ribosome-associated poly(A)-binding protein by enterovirus 3C protease
10.1128/jvi.76.5.2062-2074.2002 · 2002 · External reference
Modulation of enteroviral proteinase cleavage of poly(A)-binding protein (PABP) by conformation and PABP-associated factors
10.1016/j.virol.2008.02.002 · 2008 · External reference
TDRD3 functions as a selective autophagy receptor with dual roles in autophagy and modulation of stress granule stability
2024 · External reference
TDRD3 is an antiviral restriction factor that promotes IFN signaling with G3BP1
10.1371/journal.ppat.1010249 · 2022 · External reference
Critical role of an antiviral stress granule containing RIG-I and PKR in viral detection and innate immunity
10.1371/journal.pone.0043031 · 2012 · External reference
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
10.1038/34112 · 1998 · External reference
Poliovirus 2A(Pro) increases viral mRNA and polysome stability coordinately in time with cleavage of eIF4G
10.1128/jvi.01514-07 · 2008 · External reference
Enteroviral proteases: structure, host interactions and pathogenicity
10.1002/rmv.1883 · 2016 · External reference
A proline-rich region in the coxsackievirus 3A protein is required for the protein to inhibit endoplasmic reticulum-to-Golgi transport
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Fiji: an open-source platform for biological-image analysis
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Antiviral responses are shaped by heterogeneity in viral replication dynamics
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