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References from Activation of PD-1/PD-L1 immune checkpoint by Zika virus. Local targets link to admitted publications; unresolved targets remain external evidence.
The continued threat of emerging flaviviruses
10.1038/s41564-020-0714-0 · 2020 · External reference
An update on sexual transmission of Zika virus
10.3390/pathogens7030066 · 2018 · External reference
Researching Zika in pregnancy: lessons for global preparedness
2020 · External reference
Guillain-Barré syndrome
10.1016/s0140-6736(21)00517-1 · 2021 · External reference
Pathogenesis of Zika virus infection
10.1146/annurev-pathmechdis-031521-034739 · 2023 · External reference
Immune Response to Dengue and Zika
10.1146/annurev-immunol-042617-053142 · 2018 · External reference
Innate immune response in patients with acute Zika virus infection
10.1007/s00430-019-00588-8 · 2019 · External reference
The IFITMs Inhibit Zika Virus Replication
10.1016/j.celrep.2016.05.074 · 2016 · External reference
Mapping and Role of the CD8+ T Cell Response During Primary Zika Virus Infection in Mice
10.1016/j.chom.2016.12.010 · 2017 · External reference
Zika virus evades interferon-mediated antiviral response through the co-operation of multiple nonstructural proteins in vitro
10.1038/celldisc.2017.6 · 2017 · External reference
Zika virus elicits inflammation to evade antiviral response by cleaving cGAS via NS1-caspase-1 axis
10.15252/embj.201899347 · 2018 · External reference
Zika virus NS2A inhibits interferon signaling by degradation of STAT1 and STAT2
10.1080/21505594.2021.1935613 · 2021 · External reference
Species-specific disruption of STING-dependent antiviral cellular defenses by the Zika virus NS2B3 protease
10.1073/pnas.1803406115 · 2018 · External reference
Zika virus circumvents host innate immunity by targeting the adaptor proteins MAVS and MITA
10.1096/fj.201900260r · 2019 · External reference
Zika Virus NS3 Mimics a Cellular 14-3-3-Binding Motif to Antagonize RIG-I- and MDA5-Mediated Innate Immunity
10.1016/j.chom.2019.09.012 · 2019 · External reference
Zika virus antagonizes interferon response in patients and disrupts RIG-I-MAVS interaction through its CARD-TM domains
10.1186/s13578-019-0308-9 · 2019 · External reference
INMI1 Zika Virus NS4B Antagonizes the Interferon Signaling by Suppressing STAT1 Phosphorylation
10.3390/v13122448 · 2021 · External reference
Zika virus NS4B protein targets TANK-binding kinase 1 and inhibits type I interferon production
10.1016/j.bbagen.2023.130483 · 2023 · External reference
Zika virus targets human STAT2 to inhibit type I interferon signaling
10.1016/j.chom.2016.05.009 · 2016 · External reference
Selective Activation of Type II Interferon Signaling by Zika Virus NS5 Protein
10.1128/jvi.00163-17 · 2017 · External reference
Zika virus NS5 protein inhibits type I interferon signaling via CRL3 E3 ubiquitin ligase-mediated degradation of STAT2
2024 · External reference
Zika Virus Antagonizes Type I Interferon Responses during Infection of Human Dendritic Cells
10.1371/journal.ppat.1006164 · 2017 · External reference
Evolution of the innate and adaptive immune response in women with acute Zika virus infection
10.1038/s41564-019-0618-z · 2020 · External reference
Analysis of the T Cell Response to Zika Virus and Identification of a Novel CD8+ T Cell Epitope in Immunocompetent Mice
10.1371/journal.ppat.1006184 · 2017 · External reference
CD8+ T Cell Immune Response in Immunocompetent Mice during Zika Virus Infection
10.1128/jvi.00900-17 · 2017 · External reference
Cutting edge: Transcriptional profiling reveals multifunctional and cytotoxic antiviral responses of Zika virus-specific CD8 T cells
10.4049/jimmunol.1801090 · 2018 · External reference
Bystander activated CD8+ T cells mediate neuropathology during viral infection via antigen-independent cytotoxicity
10.1038/s41467-023-44667-0 · 2024 · External reference
A Mouse Model of Zika Virus Pathogenesis
10.1016/j.chom.2016.03.010 · 2016 · External reference
Antiviral CD8 T cells induce Zika-virus-associated paralysis in mice
10.1038/s41564-017-0060-z · 2018 · External reference
An epidemic Zika virus isolate suppresses antiviral immunity by disrupting antigen presentation pathways
10.1038/s41467-021-24340-0 · 2021 · External reference
Insights from a 30-year journey: function, regulation and therapeutic modulation of PD1
10.1038/s41577-023-00867-9 · 2023 · External reference
Immune checkpoint therapy-current perspectives and future directions
10.1016/j.cell.2023.03.006 · 2023 · External reference
The PD-1/PD-L1 Axis and Virus Infections: A Delicate Balance
10.3389/fcimb.2019.00207 · 2019 · External reference
CD4 T Helper Cells Instruct Lymphopenia-Induced Memory-Like CD8 T Cells for Control of Acute LCMV Infection
2016 · External reference
Viral acute lower respiratory infections impair CD8 T cells through PD-1
10.1172/jci62860 · 2012 · External reference
Highly pathological influenza A virus infection is associated with augmented expression of PD-1 by functionally compromised virus-specific CD8 T cells
10.1128/jvi.02851-13 · 2014 · External reference
Genetic absence of PD-L1 does not restore CD8+ T cell function during respiratory virus infection and delays virus clearance
10.1128/jvi.00797-24 · 2024 · External reference
Oncolytic Zika virus promotes intratumoral T cell infiltration and improves immunotherapy efficacy in glioblastoma
10.1016/j.omto.2022.01.011 · 2022 · External reference
Revealing the characteristics of ZIKV infection through tissue-specific transcriptome sequencing analysis
10.1186/s12864-022-08919-5 · 2022 · External reference
Immune-profiling of ZIKV-infected patients identifies a distinct function of plasmacytoid dendritic cells for immune cross-regulation
10.1038/s41467-020-16217-5 · 2020 · External reference
Lineage-dependent differences in the disease progression of Zika virus infection in type-I interferon receptor knockout (A129) mice
10.1371/journal.pntd.0005704 · 2017 · External reference
Programmed cell death-1/programmed cell death-ligand 1 inhibitors exert antiapoptosis and antiinflammatory activity in lipopolysaccharide stimulated murine alveolar macrophages
10.3892/etm.2021.9831 · 2021 · External reference
A mating mechanism to generate diversity for the Darwinian selection of DNA-encoded synthetic molecules
10.1038/s41557-021-00829-5 · 2022 · External reference
Relationship between CD107a expression and cytotoxic activity
10.1016/j.cellimm.2008.08.007 · 2009 · External reference
Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression
10.1016/j.celrep.2017.04.031 · 2017 · External reference
Zika virus infection induces endoplasmic reticulum stress and apoptosis in placental trophoblasts
10.1038/s41420-020-00379-8 · 2021 · External reference
Stress-induced unfolded protein response contributes to Zika virus-associated microcephaly
10.1038/s41593-017-0038-4 · 2018 · External reference
The stabilization of PD-L1 by the endoplasmic reticulum stress protein GRP78 in triple-negative breast cancer
2020 · External reference
Inhibition of SFTSV replication in humanized mice by a subcutaneously administered anti-PD1 nanobody
10.1038/s44321-024-00026-0 · 2024 · External reference
Upregulation of PD-L1 by SARS-CoV-2 promotes immune evasion
2023 · External reference
Mechanisms Controlling PD-L1 Expression in Cancer
10.1016/j.molcel.2019.09.030 · 2019 · External reference
Regulation and function of the PD-L1 checkpoint
10.1016/j.immuni.2018.03.014 · 2018 · External reference
The MLL1-H3K4me3 Axis-Mediated PD-L1 Expression and Pancreatic Cancer Immune Evasion
2017 · External reference
Characterization of dengue virus NS4A and NS4B protein interaction
10.1128/jvi.03453-14 · 2015 · External reference
An Hsp70-like protein in the ER: identity with the 78 kd glucose-regulated protein and immunoglobulin heavy chain binding protein
10.1016/0092-8674(86)90746-4 · 1986 · External reference
Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium
10.1073/pnas.0807691105 · 2008 · External reference
Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha
10.1128/mcb.22.21.7405-7416.2002 · 2002 · External reference
The interaction of Grp78 and Zika virus E and NS1 proteins occurs in a chaperone-client manner
10.1038/s41598-024-61195-z · 2024 · External reference
Flavivirus NS4B protein: Structure, function, and antiviral discovery
10.1016/j.antiviral.2022.105423 · 2022 · External reference
The stress-inducible ER chaperone GRP78/BiP is upregulated during SARS-CoV-2 infection and acts as a pro-viral protein
10.1038/s41467-022-34065-3 · 2022 · External reference
Glucose-Regulated Protein 78 Interacts with Zika Virus Envelope Protein and Contributes to a Productive Infection
10.3390/v12050524 · 2020 · External reference
Placental alkaline phosphatase promotes Zika virus replication by stabilizing viral proteins through BIP
10.1128/mbio.01716-20 · 2020 · External reference
A functional interaction between GRP78 and Zika virus E protein
10.1038/s41598-020-79803-z · 2021 · External reference
An attenuated Zika virus NS4B protein mutant is a potent inducer of antiviral immune responses
10.1038/s41541-019-0143-3 · 2019 · External reference
Zika virus research models
10.1016/j.virusres.2017.07.025 · 2018 · External reference
From mosquito bites to sexual transmission: evaluating mouse models of Zika virus infection
10.3390/v13112244 · 2021 · External reference
Characterization of a novel murine model to study Zika virus
10.4269/ajtmh.16-0111 · 2016 · External reference
Characterization of Lethal Zika Virus Infection in AG129 Mice
10.1371/journal.pntd.0004682 · 2016 · External reference
The importance of type I interferon in orchestrating the cytotoxic T-cell response to cancer
10.1016/j.imlet.2024.106938 · 2024 · External reference
Zika Virus Infection of Pregnant Ifnar1-/- Mice Triggers Strain-Specific Differences in Fetal Outcomes
2021 · External reference
Zika virus-induced fetal demise is triggered by strain- and dose-specific RLR-driven activation of the interferon response in the decidua, placenta, and fetus in Ifnar1-/- mice
2025 · External reference
Cross-reactive Dengue virus-specific CD8+ T cells protect against Zika virus during pregnancy
10.1038/s41467-018-05458-0 · 2018 · External reference
Recent advances in understanding the adaptive immune response to Zika virus and the effect of previous flavivirus exposure
10.1016/j.virusres.2017.06.019 · 2018 · External reference
Japanese Encephalitis Vaccine Generates Cross-Reactive Memory T Cell Responses to Zika Virus in Humans
10.1155/2022/8379286 · 2022 · External reference
Vaccination reshapes the virus-specific T cell repertoire in unexposed adults
2021 · External reference
Vaccine-induced T cell responses control Orthoflavivirus challenge infection without neutralizing antibodies in humans
10.1038/s41564-024-01903-7 · 2025 · External reference
Characterization of CD8+ T cells in immune-privileged organs of ZIKV-infected Ifnar1-/- mice
10.1128/jvi.00789-23 · 2024 · External reference
Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells
10.1074/jbc.ra118.001897 · 2018 · External reference
Inhibition of AIM2 inflammasome activation by a novel transcript isoform of IFI16
2018 · External reference
Enhanced stability of M1 protein mediated by a phospho-resistant mutation promotes the replication of prevailing avian influenza virus in mammals
10.1371/journal.ppat.1010645 · 2022 · External reference
Intranasal administration of a single dose of a candidate live attenuated vaccine derived from an NSP16-deficient SARS-CoV-2 strain confers sterilizing immunity in animals
10.1038/s41423-022-00855-4 · 2022 · External reference
The celecoxib derivative kinase inhibitor AR-12 (OSU-03012) inhibits Zika virus via down-regulation of the PI3K/Akt pathway and protects Zika virus-infected A129 mice: A host-targeting treatment strategy
10.1016/j.antiviral.2018.10.007 · 2018 · External reference
Zika Virus Infection Alters Gene Expression and Poly-Adenylation Patterns in Placental Cells
10.3390/pathogens11080936 · 2022 · External reference
