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References from N460S in PB2 and I163T in nucleoprotein synergistically enhance the viral replication and pathogenicity of influenza B virus. Local targets link to admitted publications; unresolved targets remain external evidence.
Estimates of global seasonal influenza-associated respiratory mortality: a modelling study
10.1016/s0140-6736(17)33293-2 · 2018 · External reference
Influenza vaccines: challenges and solutions
10.1016/j.chom.2015.02.012 · 2015 · External reference
Unresolved reference
External reference
The rationale for quadrivalent influenza vaccines
10.4161/hv.8.1.17623 · 2012 · External reference
The burden of influenza B: a structured literature review
10.2105/ajph.2012.301137 · 2013 · External reference
A comprehensive review of the epidemiology and disease burden of Influenza B in 9 European countries
10.1080/21645515.2015.1111494 · 2016 · External reference
Distribution of influenza virus types by age using case-based global surveillance data from twenty-nine countries, 1999-2014
10.1186/s12879-018-3181-y · 2018 · External reference
Antigenic characterization of influenza and SARS-CoV-2 viruses
10.1007/s00216-021-03806-6 · 2022 · External reference
The epidemiological signature of influenza B virus and its B/Victoria and B/Yamagata lineages in the 21st century
10.1371/journal.pone.0222381 · 2019 · External reference
Burden of influenza B virus infection and considerations for clinical management
10.1016/j.antiviral.2020.104970 · 2021 · External reference
Epidemiological and clinical characteristics of children hospitalized due to influenza A and B in the south of Europe, 2010-2016
10.1038/s41598-019-49273-z · 2019 · External reference
Severe influenza virus infection in children admitted to the PICU: Comparison of influenza A and influenza B virus infection
10.1002/jmv.27400 · 2022 · External reference
Knowns and unknowns of influenza B viruses
10.2217/fmb.15.120 · 2016 · External reference
At the centre: influenza A virus ribonucleoproteins
10.1038/nrmicro3367 · 2015 · External reference
Structural insight into cap-snatching and RNA synthesis by influenza polymerase
10.1038/nature14009 · 2014 · External reference
Architecture of ribonucleoprotein complexes in influenza A virus particles
10.1038/nature04378 · 2006 · External reference
Morphology of influenza B/Lee/40 determined by cryo-electron microscopy
10.1371/journal.pone.0088288 · 2014 · External reference
Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD
10.1371/journal.ppat.1010328 · 2022 · External reference
Structures of influenza A and B replication complexes give insight into avian to human host adaptation and reveal a role of ANP32 as an electrostatic chaperone for the apo-polymerase
10.1038/s41467-024-51007-3 · 2024 · External reference
The crystal structure of the PB2 cap-binding domain of influenza B virus reveals a novel cap recognition mechanism
10.1074/jbc.m115.636464 · 2015 · External reference
The N terminus of the influenza B virus nucleoprotein is essential for virus viability, nuclear localization, and optimal transcription and replication of the viral genome
10.1128/jvi.01542-14 · 2014 · External reference
Structural analysis of the complex between influenza B nucleoprotein and human importin-α
10.1038/s41598-017-17458-z · 2017 · External reference
Transmission of influenza virus in a mammalian host is increased by PB2 amino acids 627K or 627E/701N
10.1371/journal.ppat.1000252 · 2009 · External reference
A single amino acid in the PB2 gene of influenza A virus is a determinant of host range
10.1128/jvi.67.4.1761-1764.1993 · 1993 · External reference
Molecular basis of replication of duck H5N1 influenza viruses in a mammalian mouse model
10.1128/jvi.79.18.12058-12064.2005 · 2005 · External reference
Mammalian-adaptive mutation NP-Q357K in Eurasian H1N1 Swine Influenza viruses determines the virulence phenotype in mice
10.1080/22221751.2019.1635873 · 2019 · External reference
An important amino acid in nucleoprotein contributes to influenza A virus replication by interacting with polymerase PB2
10.1016/j.virol.2014.06.033 · 2014 · External reference
Interaction of polymerase subunit PB2 and NP with importin alpha1 is a determinant of host range of influenza A virus
10.1371/journal.ppat.0040011 · 2008 · External reference
The viral polymerase mediates adaptation of an avian influenza virus to a mammalian host
10.1073/pnas.0507415102 · 2005 · External reference
A Single Amino Acid in the Polymerase Acidic Protein Determines the Pathogenicity of Influenza B Viruses
2018 · External reference
Development of an Alternative Modified Live Influenza B Virus Vaccine
2017 · External reference
A single amino acid change in the C-terminal domain of the matrix protein M1 of influenza B virus confers mouse adaptation and virulence
10.1016/j.virol.2005.03.028 · 2005 · External reference
A single N342D substitution in Influenza B Virus NA protein determines viral pathogenicity in mice
10.1080/22221751.2020.1806005 · 2020 · External reference
The tree shrew is a promising model for the study of influenza B virus infection
10.1186/s12985-019-1171-3 · 2019 · External reference
Influenza virus nucleoprotein interacts with influenza virus polymerase proteins
10.1128/jvi.72.7.5493-5501.1998 · 1998 · External reference
The structure of a biologically active influenza virus ribonucleoprotein complex
10.1371/journal.ppat.1000491 · 2009 · External reference
Ultrastructure of influenza virus ribonucleoprotein complexes during viral RNA synthesis
10.1038/s42003-021-02388-4 · 2021 · External reference
Host restriction of avian influenza viruses at the level of the ribonucleoproteins
10.1146/annurev.micro.62.081307.162746 · 2008 · External reference
PB2 residue 271 plays a key role in enhanced polymerase activity of influenza A viruses in mammalian host cells
10.1128/jvi.02642-09 · 2010 · External reference
Identification of PB2 mutations responsible for the efficient replication of H5N1 influenza viruses in human lung epithelial cells
10.1128/jvi.03328-14 · 2015 · External reference
The K526R substitution in viral protein PB2 enhances the effects of E627K on influenza virus replication
10.1038/ncomms6509 · 2014 · External reference
The PB2 I714S mutation influenced mammalian adaptation of the H3N2 canine influenza virus by interfering with nuclear import efficiency and RNP complex assembly
10.1080/22221751.2024.2387439 · 2024 · External reference
Role of influenza A virus NP acetylation on viral growth and replication
10.1038/s41467-017-01112-3 · 2017 · External reference
Mutations to PB2 and NP proteins of an avian influenza virus combine to confer efficient growth in primary human respiratory cells
10.1128/jvi.01093-14 · 2014 · External reference
Functional Genomics Reveals Linkers Critical for Influenza Virus Polymerase
10.1128/jvi.02400-15 · 2015 · External reference
Acute respiratory distress syndrome
10.1038/s41572-019-0069-0 · 2019 · External reference
Disease tolerance and immunity in host protection against infection
10.1038/nri.2016.136 · 2017 · External reference
The trinity of COVID-19: immunity, inflammation and intervention
10.1038/s41577-020-0311-8 · 2020 · External reference
Innate immunity and interferon in SARS-CoV-2 infection outcome
10.1016/j.immuni.2023.06.018 · 2023 · External reference
Exuberant fibroblast activity compromises lung function via ADAMTS4
10.1038/s41586-020-2877-5 · 2020 · External reference
Universal influenza B virus genomic amplification facilitates sequencing, diagnostics, and reverse genetics
10.1128/jcm.03265-13 · 2014 · External reference
Visualizing influenza virus infection in living mice
10.1038/ncomms3369 · 2013 · External reference
Influenza Virus Carrying a Codon-Reprogrammed Neuraminidase Gene as a Strategy for Live Attenuated Vaccine
10.3390/vaccines11020391 · 2023 · External reference
Rescue of influenza B virus from eight plasmids
10.1073/pnas.172393399 · 2002 · External reference
Unresolved reference
External reference
Genome-wide CRISPR screen identifies GNE as a key host factor that promotes influenza A virus adsorption and endocytosis
2023 · External reference
Time-Dependent Proinflammatory Responses Shape Virus Interference during Coinfections of Influenza A Virus and Influenza D Virus
10.3390/v14020224 · 2022 · External reference
RNA-Seq Analysis of Influenza A Virus-Induced Transcriptional Changes in Mice Lung and Its Possible Implications for the Virus Pathogenicity in Mice
10.3390/v13102031 · 2021 · External reference
Accurate structure prediction of biomolecular interactions with AlphaFold 3
10.1038/s41586-024-07487-w · 2024 · External reference
Contacts-based prediction of binding affinity in protein-protein complexes
10.7554/elife.07454 · 2015 · External reference
PRODIGY: a web server for predicting the binding affinity of protein-protein complexes
10.1093/bioinformatics/btw514 · 2016 · External reference
UCSF ChimeraX: Tools for structure building and analysis
2023 · External reference
