Research graph
References from Immune signatures of SARS-CoV-2 infection resolution in human lung tissues. Local targets link to admitted publications; unresolved targets remain external evidence.
A molecular single-cell lung atlas of lethal COVID-19
10.1038/s41586-021-03569-1 · 2021 · External reference
The spatial landscape of lung pathology during COVID-19 progression
10.1038/s41586-021-03475-6 · 2021 · External reference
Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages
10.1038/s41422-020-00455-9 · 2021 · External reference
Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia
10.1038/s41586-020-03148-w · 2021 · External reference
COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets
10.1038/s41586-021-03570-8 · 2021 · External reference
Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19
10.1038/s41591-020-0901-9 · 2020 · External reference
COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas
10.1016/j.cell.2021.10.023 · 2021 · External reference
Longitudinal profiling of respiratory and systemic immune responses reveals myeloid cell-driven lung inflammation in severe COVID-19
10.1016/j.immuni.2021.03.005 · 2021 · External reference
Pulmonary pathology of ARDS in COVID-19: A pathological review for clinicians
10.1016/j.rmed.2020.106239 · 2021 · External reference
Animal models for COVID-19: advances, gaps and perspectives
10.1038/s41392-022-01087-8 · 2022 · External reference
Single-cell multi-omics analysis of the immune response in COVID-19
10.1038/s41591-021-01329-2 · 2021 · External reference
COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas
2021 · External reference
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity
10.1038/s41588-023-01375-1 · 2023 · External reference
Human SARS-CoV-2 challenge uncovers local and systemic response dynamics
2024 · External reference
A common allele of HLA is associated with asymptomatic SARS-CoV-2 infection
10.1038/s41586-023-06331-x · 2023 · External reference
Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19
2021 · External reference
Less severe course of COVID-19 is associated with elevated levels of antibodies against seasonal human coronaviruses OC43 and HKU1 (HCoV OC43, HCoV HKU1)
10.1016/j.ijid.2021.02.085 · 2021 · External reference
Recent endemic coronavirus infection is associated with less-severe COVID-19
10.1172/jci143380 · 2021 · External reference
Standing on the shoulders of mice
10.1016/j.immuni.2022.07.008 · 2022 · External reference
Human hemato-lymphoid system mice: current use and future potential for medicine
10.1146/annurev-immunol-032712-095921 · 2013 · External reference
Precision mouse models with expanded tropism for human pathogens
10.1038/s41587-019-0225-9 · 2019 · External reference
SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801
10.1038/s41586-021-03312-w · 2021 · External reference
Humanized mice reveal a macrophage-enriched gene signature defining human lung tissue protection during SARS-CoV-2 infection
10.1016/j.celrep.2022.110714 · 2022 · External reference
SARS-CoV-2 Variant-Specific Infectivity and Immune Profiles Are Detectable in a Humanized Lung Mouse Model
10.3390/v14102272 · 2022 · External reference
Humanized mice for investigating SARS-CoV-2 lung infection and associated human immune responses
10.1002/eji.202249804 · 2022 · External reference
Single-cell RNA sequencing unveils the shared and the distinct cytotoxic hallmarks of human TCRVdelta1 and TCRVdelta2 gammadelta T lymphocytes
10.1073/pnas.1818488116 · 2019 · External reference
Unresolved reference
2021 · External reference
SARS-CoV-2 infection, neuropathogenesis and transmission among deer mice: implications for spillback to New World rodents
10.1371/journal.ppat.1009585 · 2021 · External reference
Development and differentiation of early innate lymphoid progenitors
10.1084/jem.20170832 · 2018 · External reference
SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response
10.1016/j.stem.2020.09.013 · 2020 · External reference
Regulation of alveolar type 2 stem/progenitor cells in lung injury and regeneration
10.1093/abbs/gmaa052 · 2020 · External reference
CD3( ) macrophages deliver proinflammatory cytokines by a CD3- and transmembrane TNF-dependent pathway and are increased at the BCG-infection site
10.3389/fimmu.2019.02550 · 2019 · External reference
SARS-CoV-2 disrupts splicing, translation, and protein trafficking to suppress host defenses
10.1016/j.cell.2020.10.004 · 2020 · External reference
SARS-CoV-2 uses a multipronged strategy to impede host protein synthesis
10.1038/s41586-021-03610-3 · 2021 · External reference
A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2
2021 · External reference
Fibrinogen-like protein 2 in inflammatory diseases: A future therapeutic target
10.1016/j.intimp.2023.109799 · 2023 · External reference
Mitochondrial protein C15ORF48 is a stress-independent inducer of autophagy that regulates oxidative stress and autoimmunity
10.1038/s41467-024-45206-1 · 2024 · External reference
Inflammation causes remodeling of mitochondrial cytochrome c oxidase mediated by the bifunctional gene C15orf48
10.1126/sciadv.abl5182 · 2021 · External reference
FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation
10.1038/s41586-022-04702-4 · 2022 · External reference
Chemokine receptors in human endothelial cells. Functional expression of CXCR4 and its transcriptional regulation by inflammatory cytokines
1998 · External reference
CD146 (Cluster of Differentiation 146)
10.1161/atvbaha.119.312653 · 2019 · External reference
Endothelial dysfunction in Covid-19 infection
10.1016/j.amjms.2021.12.010 · 2022 · External reference
Endothelial cell infection and dysfunction, immune activation in severe COVID-19
10.7150/thno.61810 · 2021 · External reference
Role of endothelial dysfunction in the severity of COVID‑19 infection (Review)
10.3892/mmr.2022.12867 · 2022 · External reference
Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies
10.1038/s41401-022-00998-0 · 2023 · External reference
CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection
10.1128/jvi.00616-14 · 2014 · External reference
Rapid detection of dendritic cell and monocyte disorders using CD4 as a lineage marker of the human peripheral blood antigen-presenting cell compartment
10.3389/fimmu.2013.00495 · 2013 · External reference
SARS-CoV-2 accessory proteins ORF7a and ORF3a use distinct mechanisms to down-regulate MHC-I surface expression
10.1073/pnas.2208525120 · 2023 · External reference
SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis
10.1038/s41467-021-26910-8 · 2021 · External reference
Homeostatic chemokines CCL19 and CCL21 promote inflammation in human immunodeficiency virus-infected patients with ongoing viral replication
10.1111/j.1365-2249.2009.03976.x · 2009 · External reference
Innate and Adaptive Immune Regulation During Chronic Viral Infections
10.1146/annurev-virology-100114-055226 · 2015 · External reference
Immune surveillance of the lung by migrating tissue monocytes
10.7554/elife.07847 · 2015 · External reference
Non-classical tissue monocytes and two functionally distinct populations of interstitial macrophages populate the mouse lung
10.1038/s41467-019-11843-0 · 2019 · External reference
Pulmonary monocytes interact with effector T cells in the lung tissue to drive TRM differentiation following viral infection
10.1038/s41385-019-0224-7 · 2020 · External reference
SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis
10.1016/j.cell.2021.11.033 · 2021 · External reference
Distinct developmental pathways from blood monocytes generate human lung macrophage diversity
10.1016/j.immuni.2020.12.003 · 2021 · External reference
Severe Acute Respiratory Syndrome Coronavirus 2-Induced Immune Activation and Death of Monocyte-Derived Human Macrophages and Dendritic Cells
10.1093/infdis/jiaa753 · 2021 · External reference
Monocytes and macrophages, targets of severe acute respiratory syndrome coronavirus 2: the clue for coronavirus disease 2019 immunoparalysis
10.1093/infdis/jiab044 · 2021 · External reference
Attenuated interferon and proinflammatory response in SARS-CoV-2-infected human dendritic cells is associated with viral antagonism of STAT1 phosphorylation
10.1093/infdis/jiaa356 · 2020 · External reference
Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infection
10.1038/s41590-021-01035-8 · 2021 · External reference
Inflammasome activation in infected macrophages drives COVID-19 pathology
10.1038/s41586-022-04802-1 · 2022 · External reference
Trained immunity - basic concepts and contributions to immunopathology
10.1038/s41581-022-00633-5 · 2023 · External reference
NF-κB in monocytes and macrophages - an inflammatory master regulator in multitalented immune cells
10.3389/fimmu.2023.1134661 · 2023 · External reference
Myeloid molecular characteristics of human γδ T cells support their acquisition of tumor antigen-presenting capacity
10.1007/s00262-015-1700-x · 2015 · External reference
SARS-CoV-2 uses CD4 to infect T helper lymphocytes
10.7554/elife.84790 · 2023 · External reference
Persistent SARS-CoV-2 infection in immunocompromised patients facilitates rapid viral evolution: Retrospective cohort study and literature review
10.1016/j.clinpr.2022.100210 · 2022 · External reference
The Longest Persistence of Viable SARS-CoV-2 With Recurrence of Viremia and Relapsing Symptomatic COVID-19 in an Immunocompromised Patient-A Case Study
10.1093/ofid/ofab217 · 2021 · External reference
A patient infected with SARS-CoV-2 over 100 days
10.1093/qjmed/hcaa296 · 2021 · External reference
Evolution of the SARS-CoV-2 omicron variants BA.1 to BA.5: Implications for immune escape and transmission
10.1002/rmv.2381 · 2022 · External reference
Differential desensitization, receptor phosphorylation, beta-arrestin recruitment, and ERK1/2 activation by the two endogenous ligands for the CC chemokine receptor 7
10.1074/jbc.m402125200 · 2004 · External reference
