Research graph
References from Sec10 suppresses antiviral innate immune response by facilitating STUB1-mediated STAT1 degradation. Local targets link to admitted publications; unresolved targets remain external evidence.
Pathogen recognition and innate immunity
10.1016/j.cell.2006.02.015 · 2006 · External reference
Innate immune pattern recognition: a cell biological perspective
10.1146/annurev-immunol-032414-112240 · 2015 · External reference
The regulation of JAKs in cytokine signaling and its breakdown in disease
10.1016/j.cyto.2018.03.041 · 2019 · External reference
STAT1 and its crucial role in the control of viral infections
10.3390/ijms23084095 · 2022 · External reference
The dynamic interface of viruses with STATs
10.1128/jvi.00856-20 · 2020 · External reference
Biologic consequences of Stat1-independent IFN signaling
10.1073/pnas.111163898 · 2001 · External reference
STAT1 knockout mice are highly susceptible to pulmonary mycobacterial infection
10.1620/tjem.202.41 · 2004 · External reference
Bta-miR-2890 up-regulates JAK-STAT pathway to inhibit BoHV-1 replication by targeting viral gene UL41
10.1016/j.vetmic.2020.108709 · 2020 · External reference
Bovine herpesvirus 1 tegument protein UL41 suppresses antiviral innate immune response via directly targeting STAT1
10.1016/j.vetmic.2019.108494 · 2019 · External reference
Human metapneumovirus inhibits IFN-alpha signaling through inhibition of STAT1 phosphorylation
10.1165/rcmb.2007-0285oc · 2008 · External reference
Nuclear RNF2 inhibits interferon function by promoting K33-linked STAT1 disassociation from DNA
10.1038/s41590-017-0003-0 · 2018 · External reference
RNF220 mediates K63-linked polyubiquitination of STAT1 and promotes host defense
10.1038/s41418-020-00609-7 · 2021 · External reference
Smurf1 protein negatively regulates interferon-γ signaling through promoting STAT1 protein ubiquitination and degradation
10.1074/jbc.m112.341198 · 2012 · External reference
Regulation of the linear ubiquitination of STAT1 controls antiviral interferon signaling
10.1038/s41467-020-14948-z · 2020 · External reference
Herpes simplex virus Type 2 inhibits Type I IFN signaling mediated by the novel E3 ubiquitin protein ligase activity of viral protein ICP22
10.4049/jimmunol.2000418 · 2020 · External reference
In vitro and in vivo specificity of ubiquitination and degradation of STAT1 and STAT2 by the V proteins of the paramyxoviruses simian virus 5 and human parainfluenza virus type 2
10.1099/vir.0.80263-0 · 2005 · External reference
Newcastle disease virus v protein targets phosphorylated STAT1 to block IFN-I signaling
2016 · External reference
N Protein of Viral Hemorrhagic Septicemia Virus Suppresses STAT1-Mediated MHC Class II Transcription to Impair Antigen Presentation in Sea Perch, Lateolabrax japonicus
10.4049/jimmunol.2100939 · 2022 · External reference
Identification and characterization of homologues of the Exocyst component Sec10p
10.1016/s0014-5793(97)00109-9 · 1997 · External reference
The exocyst complex associates with microtubules to mediate vesicle targeting and neurite outgrowth
10.1523/jneurosci.21-11-03839.2001 · 2001 · External reference
The exocyst protein Sec10 interacts with Polycystin-2 and knockdown causes PKD-phenotypes
10.1371/journal.pgen.1001361 · 2011 · External reference
Exocyst Sec10 is involved in basolateral protein translation and translocation in the endoplasmic reticulum
2012 · External reference
Exocyst Sec10 protects renal tubule cells from injury by EGFR/MAPK activation and effects on endocytosis
10.1152/ajprenal.00032.2014 · 2014 · External reference
Human Sec3 protein is a novel transcriptional and translational repressor of flavivirus
10.1111/j.1462-5822.2009.01407.x · 2010 · External reference
Exocyst complex component 2 is a potential host factor for SARS-CoV-2 infection
10.1016/j.isci.2022.105427 · 2022 · External reference
Molecular cloning, inducible expression and function analysis of Epinephelus coioides Sec6 response to SGIV infection
10.1016/j.fsi.2022.04.039 · 2022 · External reference
EXO70 protein influences dengue virus secretion
10.1016/j.micinf.2010.10.011 · 2011 · External reference
Interferon independent non-canonical STAT activation and virus induced inflammation
10.3390/v10040196 · 2018 · External reference
Mechanisms of mono- and poly-ubiquitination: Ubiquitination specificity depends on compatibility between the E2 catalytic core and amino acid residues proximal to the lysine
10.1186/1747-1028-5-19 · 2010 · External reference
The recognition of ubiquitinated proteins by the proteasome
10.1007/s00018-016-2255-5 · 2016 · External reference
African Swine Fever Virus Georgia Isolate Harboring Deletions of MGF360 and MGF505 Genes Is Attenuated in Swine and Confers Protection against Challenge with Virulent Parental Virus
10.1128/jvi.00554-15 · 2015 · External reference
Exocyst dynamics during vesicle tethering and fusion
10.1038/s41467-018-07467-5 · 2018 · External reference
Cryo-EM structure of the exocyst complex
10.1038/s41594-017-0016-2 · 2018 · External reference
Characterization of RalB-Sec5-TBK1 function in human oncogenesis
10.1016/s0076-6879(07)38022-1 · 2008 · External reference
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
10.1038/nature08476 · 2009 · External reference
Urothelial Defects from Targeted Inactivation of Exocyst Sec10 in Mice Cause Ureteropelvic Junction Obstructions
10.1371/journal.pone.0129346 · 2015 · External reference
JAK-STAT Pathway: A Novel Target to Tackle Viral Infections
10.3390/v13122379 · 2021 · External reference
Tick-borne encephalitis virus NS4A ubiquitination antagonizes type I interferon-stimulated STAT1/2 signalling pathway
10.1080/22221751.2020.1745094 · 2020 · External reference
INMI1 Zika Virus NS4B Antagonizes the Interferon Signaling by Suppressing STAT1 Phosphorylation
10.3390/v13122448 · 2021 · External reference
A triple gene mutant of BoHV-1 administered intranasally is significantly more efficacious than a BoHV-1 glycoprotein E-deleted virus against a virulent BoHV-1 challenge
10.1016/j.vaccine.2014.07.004 · 2014 · External reference
Cytoplasmic STAT4 Promotes Antiviral Type I IFN Production by Blocking CHIP-Mediated Degradation of RIG-I
10.4049/jimmunol.1501224 · 2016 · External reference
Carboxyl terminus of HSC70-interacting protein (CHIP) down-regulates NF-κB-inducing kinase (NIK) and suppresses NIK-induced liver injury
10.1074/jbc.m114.635086 · 2015 · External reference
Regulation of IL-4 receptor signaling by STUB1 in lung inflammation
10.1164/rccm.201305-0874oc · 2014 · External reference
Dimerization of the human E3 ligase CHIP via a coiled-coil domain is essential for its activity
10.1074/jbc.m311112200 · 2004 · External reference
Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA
10.1016/s0092-8674(00)81443-9 · 1998 · External reference
SARS-CoV-2 ORF10 suppresses the antiviral innate immune response by degrading MAVS through mitophagy
10.1038/s41423-021-00807-4 · 2022 · External reference
