Research graph
References from Identification of a Kingella kingae factor H binding protein that is the major determinant of serum resistance. Local targets link to admitted publications; unresolved targets remain external evidence.
Kingella kingae and osteoarticular infections
10.1542/peds.2019-1509 · 2019 · External reference
Outbreaks of Kingella kingae infections in daycare facilities
10.3201/eid2005.131633 · 2014 · External reference
Specific real-time polymerase chain reaction places Kingella kingae as the most common cause of osteoarticular infections in young children
10.1097/01.inf.0000259954.88139.f4 · 2007 · External reference
Kingella kingae: an emerging pathogen in young children
10.1542/peds.2010-1867 · 2011 · External reference
Prevalence of pharyngeal carriage of Kingella kingae in young children and risk factors for colonization
10.1097/inf.0b013e3182755779 · 2013 · External reference
Kingella kingae: Carriage, transmission, and disease
10.1128/cmr.00028-14 · 2015 · External reference
Identification and characterization of an RTX toxin in the emerging pathogen Kingella kingae
10.1128/jb.01319-06 · 2007 · External reference
Kingella kingae surface polysaccharides promote resistance to human serum and virulence in a juvenile rat model
10.1128/iai.00100-18 · 2018 · External reference
Immunobiology: The immune system in health and disease.
2001 · External reference
Complement and its role in innate and adaptive immune responses
10.1038/cr.2009.139 · 2010 · External reference
Assessment of the role of C3(H2O) in the alternative pathway
2020 · External reference
Looking back on the alternative complement pathway
10.1016/j.imbio.2018.02.001 · 2018 · External reference
The complement alternative pathway in health and disease-activation or amplification?
10.1111/imr.13172 · 2023 · External reference
Complement regulators and inhibitory proteins
10.1038/nri2620 · 2009 · External reference
Kingella kingae surface polysaccharides promote resistance to neutrophil phagocytosis and killing
10.1128/mbio.00631-19 · 2019 · External reference
The hijackers guide to escaping complement: lessons learned from pathogens
10.1016/j.molimm.2019.07.018 · 2019 · External reference
Human complement C3b inactivator: isolation, characterization, and demonstration of an absolute requirement for the serum protein beta1H for cleavage of C3b and C4b in solution
10.1084/jem.146.1.257 · 1977 · External reference
Modulation of the alternative complement pathways by beta 1 H globulin
10.1084/jem.144.5.1147 · 1976 · External reference
Structure of C3b-factor H and implications for host protection by complement regulators
10.1038/ni.1755 · 2009 · External reference
The binding of human complement proteins C5, factor B, beta 1H and properdin to complement fragment C3b on zymosan
10.1042/bj1990485 · 1981 · External reference
Human alternative complement pathway: membrane-associated sialic acid regulates the competition between B and beta1 H for cell-bound C3b
10.4049/jimmunol.122.1.75 · 1979 · External reference
Structural stability and heat-induced conformational change of two complement inhibitors: C4b-binding protein and factor H
10.1110/ps.03516504 · 2004 · External reference
Tuning the functionality by splicing: factor H and its alternative splice variant fhl-1 share a gene but not all functions
10.3389/fimmu.2020.596415 · 2020 · External reference
Structural and functional analysis of the complement component factor H with the use of different enzymes and monoclonal antibodies to factor H
10.1042/bj2320841 · 1985 · External reference
Monoclonal antibodies against the complement control protein factor H (beta 1 H)
10.1007/bf01120205 · 1983 · External reference
Surface anchoring of the Kingella kingae galactan is dependent on the lipopolysaccharide O-antigen
10.1128/mbio.02295-22 · 2022 · External reference
Characterization of the Kingella kingae polysaccharide capsule and exopolysaccharide
10.1371/journal.pone.0075409 · 2013 · External reference
Genetic and environmental factors influencing the human factor H plasma levels
10.1007/s00251-004-0660-7 · 2004 · External reference
Ontogeny of complement regulatory proteins - concentrations of factor h, factor I, c4b-binding protein, properdin and vitronectin in healthy children of different ages and in adults
10.1046/j.1365-3083.2003.01326.x · 2003 · External reference
Serum complement levels in infancy: age related changes
10.1203/00006450-197909000-00019 · 1979 · External reference
Function of the classical and alternate pathways of human complement in serum treated with ethylene glycol tetraacetic acid and MgCl2-ethylene glycol tetraacetic acid
10.1128/iai.11.6.1235-1243.1975 · 1975 · External reference
Multilocus sequence typing and rtxA toxin gene sequencing analysis of Kingella kingae isolates demonstrates genetic diversity and international clones
10.1371/journal.pone.0038078 · 2012 · External reference
RTX toxin plays a key role in Kingella kingae virulence in an infant rat model
10.1128/iai.01636-14 · 82 · External reference
Hijacking factor H for complement immune evasion
10.3389/fimmu.2021.602277 · 2021 · External reference
The (α2→8)-linked polysialic acid capsule and lipooligosaccharide structure both contribute to the ability of serogroup B Neisseria meningitidis to resist the bactericidal activity of normal human serum
10.1128/iai.66.12.5939-5947.1998 · 1998 · External reference
Complement factor C3 deposition and serum resistance in isogenic capsule and lipooligosaccharide sialic acid mutants of serogroup B Neisseria meningitidis
10.1128/iai.65.10.4022-4029.1997 · 1997 · External reference
The contrasting mechanisms of serum resistance of Neisseria gonorrhoeae and group B Neisseria meningitidis
10.1016/s0161-5890(99)00114-5 · 1999 · External reference
The capsule regulatory network of Klebsiella pneumoniae defined by density-traDISort
10.1128/mbio.01863-18 · 2018 · External reference
The Haemophilus influenzae Type b hcsA and hcsB gene products facilitate transport of capsular polysaccharide across the outer membrane and are essential for virulence
10.1128/jb.01968-05 · 2006 · External reference
Update on meningococcal disease with emphasis on pathogenesis and clinical management
10.1128/cmr.13.1.144 · 2000 · External reference
The host-pathogen interactions and epicellular lifestyle of Neisseria meningitidis
10.3389/fcimb.2022.862935 · 2022 · External reference
Novel hypercapsulation RNA thermosensor variants in Neisseria meningitidis and their association with invasive meningococcal disease: a genetic and phenotypic investigation and molecular epidemiological study
10.1016/s2666-5247(20)30146-4 · 2020 · External reference
Effect of amplification of the Cap b locus on complement-mediated bacteriolysis and opsonization of type b Haemophilus influenzae
10.1128/iai.64.11.4769-4775.1996 · 1996 · External reference
A novel virulence gene in Klebsiella pneumoniae strains causing primary liver abscess and septic metastatic complications
10.1084/jem.20030857 · 2004 · External reference
Hijacking complement regulatory proteins for bacterial immune evasion
2016 · External reference
Functional comparison of the binding of factor H short consensus repeat 6 (scr 6) to factor H binding protein from Neisseria meningitidis and the binding of factor H SCR 18 to 20 to Neisseria gonorrhoeae porin
10.1128/iai.01561-08 · 2009 · External reference
Binding of complement factor H to loop 5 of porin protein 1A: a molecular mechanism of serum resistance of nonsialylated Neisseria gonorrhoeae
10.1084/jem.188.4.671 · 1998 · External reference
Binding of C4b-binding protein to porin: a molecular mechanism of serum resistance of Neisseria gonorrhoeae
10.1084/jem.193.3.281 · 2001 · External reference
Nontypeable Haemophilus influenzae P5 binds human C4b-binding protein, promoting serum resistance
10.4049/jimmunol.2100105 · 2021 · External reference
Outer membrane protein P5 is required for resistance of nontypeable Haemophilus influenzae to both the classical and alternative complement pathways
10.1128/iai.01224-13 · 2014 · External reference
Nontypeable Haemophilus influenzae protein E binds vitronectin and is important for serum resistance
10.4049/jimmunol.0803226 · 2009 · External reference
The meningococcal vaccine candidate GNA1870 binds the complement regulatory protein factor H and enhances serum resistance
10.4049/jimmunol.177.1.501 · 2006 · External reference
The meningococcal vaccine candidate neisserial surface protein A (NspA) binds to factor H and enhances meningococcal resistance to complement
10.1371/journal.ppat.1001027 · 2010 · External reference
Factor H-dependent alternative pathway inhibition mediated by porin B contributes to virulence of Neisseria meningitidis
10.1128/mbio.00339-13 · 2013 · External reference
Binding of complement factor H to PorB3 and NspA enhances resistance of Neisseria meningitidis to anti-factor H binding protein bactericidal activity
10.1128/iai.02984-14 · 2015 · External reference
The relative roles of factor H binding protein, neisserial surface protein A, and lipooligosaccharide sialylation in regulation of the alternative pathway of complement on meningococci
10.4049/jimmunol.1103748 · 2012 · External reference
The host immune regulator factor H interacts via two contact sites with the PspC protein of Streptococcus pneumoniae and mediates adhesion to host epithelial cells
10.4049/jimmunol.178.9.5848 · 2007 · External reference
PspC, a pneumococcal surface protein, binds human factor H
10.1128/iai.69.5.3435-3437.2001 · 2001 · External reference
Tuf of Streptococcus pneumoniae is a surface displayed human complement regulator binding protein
10.1016/j.molimm.2014.06.029 · 2014 · External reference
Pleiotropic effects of cell wall amidase LytA on Streptococcus pneumoniae sensitivity to the host immune response
10.1128/iai.02811-14 · 2015 · External reference
Hic, a novel surface protein of Streptococcus pneumoniae that interferes with complement function
10.1074/jbc.m004572200 · 2000 · External reference
Immune evasion of the human pathogenic yeast Candida albicans: Pra1 is a Factor H, FHL-1 and plasminogen binding surface protein
10.1016/j.molimm.2009.07.017 · 2009 · External reference
Gpm1p is a factor H-, FHL-1-, and plasminogen-binding surface protein of Candida albicans
10.1074/jbc.m707280200 · 2007 · External reference
Glycerol-3-phosphate dehydrogenase 2 is a novel factor H-, factor H-like protein 1-, and plasminogen-binding surface protein of Candida albicans
10.1093/infdis/jis718 · 2013 · External reference
Candida albicans Hgt1p, a multifunctional evasion molecule: complement inhibitor, CR3 analogue, and human immunodeficiency virus–binding molecule
10.1093/infdis/jir455 · 2011 · External reference
Candida albicans Factor H Binding Molecule Hgt1p – A Low Glucose-Induced Transmembrane Protein Is Trafficked to the Cell Wall and Impairs Phagocytosis and Killing by Human Neutrophils
10.3389/fmicb.2018.03319 · 2019 · External reference
Binding of human factor H to outer membrane protein P5 of non-typeable Haemophilus influenzae contributes to complement resistance
10.1111/mmi.12741 · 2014 · External reference
Defining the Binding Region in Factor H to Develop a Therapeutic Factor H-Fc Fusion Protein against Non-Typeable Haemophilus influenzae
2016 · External reference
Identification of a Haemophilus influenzae factor H-Binding lipoprotein involved in serum resistance
10.4049/jimmunol.1303449 · 2014 · External reference
Molecular characterization of the interaction between porins of Neisseria gonorrhoeae and C4b-binding protein
10.4049/jimmunol.179.1.540 · 2007 · External reference
Molecular characterization of the interaction between sialylated Neisseria gonorrhoeae and factor H
10.1074/jbc.m111.225516 · 2011 · External reference
Binding of vitronectin and Factor H to Hic contributes to immune evasion of Streptococcus pneumoniae serotype 3
10.1160/th14-06-0561 · 2015 · External reference
The choline-binding protein PspC of Streptococcus pneumoniae interacts with the c-terminal heparin-binding domain of vitronectin
10.1074/jbc.m112.443507 · 2013 · External reference
Clinical isolates of Streptococcus pneumoniae bind the complement inhibitor C4b-binding protein in a PspC allele-dependent fashion
10.4049/jimmunol.0802376 · 2009 · External reference
Complement activation on the nasal mucosal surface--a feature of the immediate allergic reaction in the nose
10.1111/j.1398-9995.1994.tb02656.x · 1994 · External reference
Local complement activation in nasal polyposis
10.1002/lary.20484 · 2009 · External reference
Neisseria gonorrhoeae co-opts C4b-binding protein to enhance complement-independent survival from neutrophils
10.1371/journal.ppat.1011055 · 2023 · External reference
Vaccine potential of the Neisseria meningitidis 2086 lipoprotein
10.1128/iai.72.4.2088-2100.2004 · 2004 · External reference
Vaccination against Neisseria meningitidis using three variants of the lipoprotein GNA1870
10.1084/jem.20021911 · 2003 · External reference
Conservation of meningococcal antigens in the genus Neisseria
10.1128/mbio.00163-13 · 2013 · External reference
Neisseria cinerea Expresses a Functional Factor H Binding Protein Which Is Recognized by Immune Responses Elicited by Meningococcal Vaccines
10.1128/iai.00305-17 · 2017 · External reference
Functional significance of factor H binding to Neisseria meningitidis
10.4049/jimmunol.176.12.7566 · 2006 · External reference
4CMenB breadth of immune response, immunogenicity, and safety: results from a phase 3 randomized, controlled, observer blind study in adolescents and young adults
10.1093/ofid/ofae638 · 2024 · External reference
A phase 3 study to assess the immunogenicity, safety, and tolerability of MenB-FHbp administered as a 2-dose schedule in adolescents and young adults
10.1016/j.vaccine.2021.11.053 · 2022 · External reference
Meningococcal factor H-binding protein: implications for disease susceptibility, virulence, and vaccines
10.1016/j.tim.2023.02.011 · 2023 · External reference
Vaccine potential of the Neisseria meningitidis 2086 lipoprotein
10.1128/iai.72.4.2088-2100.2004 · 2004 · External reference
Expression of factor H binding protein in meningococcal strains can vary at least 15-fold and is genetically determined
10.1073/pnas.1521142113 · 2016 · External reference
Factor H binding to PspC of Streptococcus pneumoniae increases adherence to human cell lines in vitro and enhances invasion of mouse lungs in vivo
10.1128/iai.00474-07 · 2007 · External reference
Complement regulator Factor H mediates a two-step uptake of Streptococcus pneumoniae by human cells
10.1074/jbc.m110.142703 · 2010 · External reference
Factor H facilitates adherence of Neisseria gonorrhoeae to complement receptor 3 on eukaryotic cells
10.4049/jimmunol.0904191 · 2010 · External reference
A fine-tuned interaction between trimeric autotransporter Haemophilus surface fibrils and vitronectin leads to serum resistance and adherence to respiratory epithelial cells
10.1128/iai.01636-13 · 2014 · External reference
Haemophilus influenzae Type f Hijacks Vitronectin Using Protein H To Resist Host Innate Immunity and Adhere to Pulmonary Epithelial Cells
10.4049/jimmunol.1501197 · 2015 · External reference
Binding of vitronectin to opa-expressing Neisseria gonorrhoeae mediates invasion of HeLa cells
10.1128/iai.65.9.3857-3866.1997 · 1997 · External reference
Vitronectin mediates internalization of Neisseria gonorrhoeae by Chinese hamster ovary cells
10.1128/iai.65.3.964-970.1997 · 1997 · External reference
Pseudomonas aeruginosa Uses Dihydrolipoamide Dehydrogenase (Lpd) to Bind to the Human Terminal Pathway Regulators Vitronectin and Clusterin to Inhibit Terminal Pathway Complement Attack
10.1371/journal.pone.0137630 · 2015 · External reference
Vitronectin in bacterial pathogenesis: a host protein used in complement escape and cellular invasion
10.1111/j.1365-2958.2010.07373.x · 2010 · External reference
Integrin-linked kinase is required for vitronectin-mediated internalization of Streptococcus pneumoniae by host cells
10.1242/jcs.035600 · 2009 · External reference
Modulation of Kingella kingae adherence to human epithelial cells by type IV Pili, capsule, and a novel trimeric autotransporter
10.1128/mbio.00372-12 · 2012 · External reference
Defining the Mechanical Determinants of Kingella kingae Adherence to Host Cells
2017 · External reference
Unresolved reference
2011 · External reference
Unresolved reference
1989 · External reference
Transposon mutagenesis of Campylobacter jejuni identifies a bipartite energy taxis system required for motility
10.1046/j.1365-2958.2001.02376.x · 2001 · External reference
Insertionally inactivated and inducible recA alleles for use in Neisseria
10.1016/s0378-1119(96)00810-4 · 1997 · External reference
Expression of Kingella kingae type IV pili is regulated by sigma54, PilS, and PilR
10.1128/jb.00123-09 · 2009 · External reference
Rapid microprocedure for isolating detergent-insoluble outer membrane proteins from Haemophilus species
10.1128/jcm.24.3.330-332.1986 · 1986 · External reference
The MaxQuant computational platform for mass spectrometry-based shotgun proteomics
10.1038/nprot.2016.136 · 2016 · External reference
Proteomics quality control: quality control software for maxquant results
10.1021/acs.jproteome.5b00780 · 2016 · External reference
Non-parametric estimation of posterior error probabilities associated with peptides identified by tandem mass spectrometry
10.1093/bioinformatics/btn294 · 2008 · External reference
A statistical model for identifying proteins by tandem mass spectrometry
10.1021/ac0341261 · 2003 · External reference
Genetic and Molecular Basis of Kingella kingae Encapsulation
10.1128/iai.00128-16 · 2016 · External reference
Haemophilus influenzae interacts with the human complement inhibitor factor H
10.4049/jimmunol.181.1.537 · 2008 · External reference
