Research graph
References from Genome-wide phenotypic insights into mycobacterial virulence using Drosophila melanogaster. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
External reference
Anti-tuberculosis treatment strategies and drug development: challenges and priorities
10.1038/s41579-022-00731-y · 2022 · External reference
Tuberculosis treatment discontinuation and symptom persistence: an observational study of Bihar, India’s public care system covering >100,000,000 inhabitants
10.1186/1471-2458-14-418 · 2014 · External reference
Adverse drug reactions in tuberculosis and management
10.1016/j.ijtb.2019.11.005 · 2019 · External reference
Targeting virulence: can we make evolution-proof drugs?
10.1038/nrmicro3232 · 2014 · External reference
Pathogen-associated gene discovery workflows for novel antivirulence therapeutic development
10.1016/j.ebiom.2022.104429 · 2023 · External reference
Host-directed therapies for bacterial and viral infections
10.1038/nrd.2017.162 · 2018 · External reference
Host-Pathogen Interaction as a Novel Target for Host-Directed Therapies in Tuberculosis
10.3389/fimmu.2020.01553 · 2020 · External reference
Recombinant BCG Expressing ESX-1 of Mycobacterium marinum Combines Low Virulence with Cytosolic Immune Signaling and Improved TB Protection
10.1016/j.celrep.2017.02.057 · 2017 · External reference
Synthetic protein conjugate vaccines provide protection against Mycobacterium tuberculosis in mice
10.1073/pnas.2013730118 · 2021 · External reference
Introducing the ESAT-6 free IGRA, a companion diagnostic for TB vaccines based on ESAT-6
10.1038/srep45969 · 2017 · External reference
Reproducibility of animal research in light of biological variation
10.1038/s41583-020-0313-3 · 2020 · External reference
Heterogeneity in tuberculosis
10.1038/nri.2017.69 · 2017 · External reference
Drosophila versus Mycobacteria: A model for mycobacterial host-pathogen interactions
10.1111/mmi.14819 · 2022 · External reference
Drosophila as a Model Organism in Host-Pathogen Interaction Studies
10.3389/fcimb.2020.00214 · 2020 · External reference
Drosophila tools and assays for the study of human diseases
10.1242/dmm.023762 · 2016 · External reference
The immune response of Drosophila
10.1038/nature02021 · 2003 · External reference
The dorsoventral regulatory gene cassette spätzle/toll/cactus controls the potent antifungal response in Drosophila adults
10.1016/s0092-8674(00)80172-5 · 1996 · External reference
Unresolved reference
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Immune Response to Mycobacterium tuberculosis: A Narrative Review
10.3389/fped.2019.00350 · 2019 · External reference
Drosophila melanogaster is a genetically tractable model host for Mycobacterium marinum
10.1128/iai.71.6.3540-3550.2003 · 2003 · External reference
Mycobacterium marinum
10.1128/microbiolspec.tnmi7-0038-2016 · 2017 · External reference
Disseminated Invasive Mycobacterium marinum Infection Involving the Lung of a Patient with Diabetes Mellitus
10.3947/ic.2018.50.1.59 · 2018 · External reference
A mariner’s tale: Invasive endotracheal Mycobacterium marinum infection
2023 · External reference
The reproductive status determines tolerance and resistance to Mycobacterium marinum in Drosophila melanogaster
10.1093/emph/eoad029 · 2023 · External reference
Mycobacterium abscessus pathogenesis identified by phenogenomic analyses
10.1038/s41564-022-01204-x · 2022 · External reference
Mycobacterium abscessus Opsonization Allows an Escape from the Defensin Bactericidal Action in Drosophila
10.1128/spectrum.00777-23 · 2023 · External reference
Mycobacterium abscessus resists the innate cellular response by surviving cell lysis of infected phagocytes
10.1371/journal.ppat.1011257 · 2023 · External reference
Microbial metabolism disrupts cytokine activity to impact host immune response
2024 · External reference
ENaC is a host susceptibility factor to bacterial infections in cystic fibrosis context
10.1038/s42003-025-07877-4 · 2025 · External reference
Unresolved reference
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Mycobacterium marinum infection in Drosophila melanogaster for antimycobacterial activity assessment
10.1093/jac/dks425 · 2013 · External reference
Novel drug combination for Mycobacterium abscessus disease therapy identified in a Drosophila infection model
10.1093/jac/dku024 · 2014 · External reference
Mycobacteria, metals, and the macrophage
10.1111/imr.12265 · 2015 · External reference
Iron Acquisition in Mycobacterium tuberculosis
10.1021/acs.chemrev.8b00285 · 2019 · External reference
Structures of EccB1 and EccD1 from the core complex of the mycobacterial ESX-1 type VII secretion system
10.1186/s12900-016-0056-6 · 2016 · External reference
ESX secretion systems: mycobacterial evolution to counter host immunity
10.1038/nrmicro.2016.131 · 2016 · External reference
Global Assessment of Mycobacterium avium subsp. hominissuis Genetic Requirement for Growth and Virulence
10.1128/msystems.00402-19 · 2019 · External reference
Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice
10.7554/elife.74419 · 2022 · External reference
Disruption of Mycobacterium avium subsp. paratuberculosis-specific genes impairs in vivo fitness
10.1186/1471-2164-15-415 · 2014 · External reference
Tryptophan biosynthesis protects mycobacteria from CD4 T-cell-mediated killing
10.1016/j.cell.2013.10.045 · 2013 · External reference
Transposon libraries identify novel Mycobacterium bovis BCG genes involved in the dynamic interactions required for BCG to persist during in vivo passage in cattle
10.1186/s12864-019-5791-1 · 2019 · External reference
Identification of genes required for Mycobacterium abscessus growth in vivo with a prominent role of the ESX-4 locus
10.1073/pnas.1713195115 · 2018 · External reference
Genome-wide transposon mutagenesis indicates that Mycobacterium marinum customizes its virulence mechanisms for survival and replication in different hosts
10.1128/iai.03050-14 · 2015 · External reference
Temporal genome-wide fitness analysis of Mycobacterium marinum during infection reveals the genetic requirement for virulence and survival in amoebae and microglial cells
10.1128/msystems.01326-23 · 2024 · External reference
A decade of advances in transposon-insertion sequencing
10.1038/s41576-020-0244-x · 2020 · External reference
Comprehensive identification of conditionally essential genes in mycobacteria
10.1073/pnas.231275498 · 2001 · External reference
10.1128/mbio.02133-16
10.1128/mbio.02133-16 · External reference
Genes required for mycobacterial growth defined by high density mutagenesis
10.1046/j.1365-2958.2003.03425.x · 2003 · External reference
Analysis of gene essentiality from TnSeq data using Transit.
10.1007/978-1-0716-1720-5_22 · 2022 · External reference
Genome-wide Phenotypic Profiling Identifies and Categorizes Genes Required for Mycobacterial Low Iron Fitness
10.1038/s41598-019-47905-y · 2019 · External reference
A novel antimycobacterial compound acts as an intracellular iron chelator
10.1128/aac.05114-14 · 2015 · External reference
Mycobacterial Esx-3 requires multiple components for iron acquisition
10.1128/mbio.01073-14 · 2014 · External reference
The ATP-Binding Cassette (ABC) Transport Systems in Mycobacterium tuberculosis: Structure, Function, and Possible Targets for Therapeutics
10.3390/biology9120443 · 2020 · External reference
The ATP binding cassette (ABC) transport systems of Mycobacterium tuberculosis
10.1111/j.1574-6976.2000.tb00550.x · 2000 · External reference
Identification and characterization of metal uptake ABC transporters in Mycobacterium tuberculosis unveil their ligand specificity
10.1016/j.ijbiomac.2021.06.126 · 2021 · External reference
Metal ion transport and regulation in Mycobacterium tuberculosis
10.2741/1454 · 2004 · External reference
The MycoBrowser portal: a comprehensive and manually annotated resource for mycobacterial genomes
10.1016/j.tube.2010.09.006 · 2011 · External reference
Quantification of Natural Growth of Two Strains of Mycobacterium Marinum for Translational Antituberculosis Drug Development
10.1111/cts.12793 · 2020 · External reference
Interferon-gamma promotes iron export in human macrophages to limit intracellular bacterial replication
10.1371/journal.pone.0240949 · 2020 · External reference
Heparin inhibits intracellular Mycobacterium tuberculosis bacterial replication by reducing iron levels in human macrophages
10.1038/s41598-018-25480-y · 2018 · External reference
An iron-rich diet decreases the mycobacterial burden and correlates with hepcidin upregulation, lower levels of proinflammatory mediators, and increased T-cell recruitment in a model of Mycobacterium bovis bacille Calmette-Guerin infection
10.1093/infdis/jix366 · 2017 · External reference
The Cell Wall Lipid PDIM Contributes to Phagosomal Escape and Host Cell Exit of Mycobacterium tuberculosis
10.1128/mbio.00148-17 · 2017 · External reference
Type VII secretion systems: structure, functions and transport models
10.1038/s41579-021-00560-5 · 2021 · External reference
Impaired Succinate Oxidation Prevents Growth and Influences Drug Susceptibility in Mycobacterium tuberculosis
10.1128/mbio.01672-22 · 2022 · External reference
Dependency on host vitamin B12 has shaped
10.1038/s41467-024-46449-8 · 2023 · External reference
Cobalamin is present in cells of non-tuberculous mycobacteria, but not in
10.1038/s41598-021-91430-w · 2021 · External reference
A vitamin B. Transporter in
10.1098/rsob.120175 · 2013 · External reference
Vitamin B12 uptake across the mycobacterial outer membrane is influenced by membrane permeability in Mycobacterium marinum
2024 · External reference
Temporal genome-wide fitness analysis of Mycobacterium marinum during infection reveals the genetic requirement for virulence and survival in amoebae and microglial cells
10.1128/msystems.01326-23 · 2024 · External reference
EccA1, a component of the Mycobacterium marinum ESX-1 protein virulence factor secretion pathway, regulates mycolic acid lipid synthesis
10.1016/j.chembiol.2012.01.008 · 2012 · External reference
The C terminus of the mycobacterium ESX-1 secretion system substrate ESAT-6 is required for phagosomal membrane damage and virulence
10.1073/pnas.2122161119 · 2022 · External reference
The Mycobacterium tuberculosis TrcR response regulator represses transcription of the intracellularly expressed Rv1057 gene, encoding a seven-bladed beta-propeller
10.1128/jb.188.1.150-159.2006 · 2006 · External reference
Deletion of the β-Propeller Protein Gene Rv1057 Reduces ESAT-6 Secretion and Intracellular Growth of Mycobacterium tuberculosis
10.1007/s00284-017-1394-8 · 2018 · External reference
EspH is a hypervirulence factor for. And essential for the secretion of the ESX-1 substrates EspE and EspF
2018 · External reference
A Lysine Acetyltransferase Contributes to the Metabolic Adaptation to Hypoxia in Mycobacterium tuberculosis
2018 · External reference
Iron in infection and immunity
10.1016/j.chom.2013.04.010 · 2013 · External reference
Mycobacterial siderophore: A review on chemistry and biology of siderophore and its potential as a target for tuberculosis
10.1016/j.ejmech.2018.08.030 · 2018 · External reference
Identification of an ABC transporter required for iron acquisition and virulence in Mycobacterium tuberculosis
10.1128/jb.188.2.424-430.2006 · 2006 · External reference
Differentiating the roles of
2023 · External reference
The ABC exporter IrtAB imports and reduces mycobacterial siderophores
10.1038/s41586-020-2136-9 · 2020 · External reference
A uniform cloning platform for mycobacterial genetics and protein production
10.1038/s41598-018-27687-5 · 2018 · External reference
High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism
10.1371/journal.ppat.1002251 · 2011 · External reference
Reciprocal analysis of Francisella novicida infections of a Drosophila melanogaster model reveal host-pathogen conflicts mediated by reactive oxygen and imd-regulated innate immune response
10.1371/journal.ppat.1001065 · 2010 · External reference
Specialized transduction designed for precise high-throughput unmarked deletions in Mycobacterium tuberculosis
10.1128/mbio.01245-14 · 2014 · External reference
Efficient genome editing in pathogenic mycobacteria using Streptococcus thermophilus CRISPR1-Cas9
10.1016/j.tube.2020.101983 · 2020 · External reference
Unresolved reference
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Unresolved reference
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Unresolved reference
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Phylogeny to function: PE/PPE protein evolution and impact on Mycobacterium tuberculosis pathogenicity
10.1111/mmi.12981 · 2015 · External reference
Identifying essential genes in Mycobacterium tuberculosis by global phenotypic profiling.
10.1007/978-1-4939-2398-4_6 · 2015 · External reference
TRANSIT - A Software Tool for Himar1 TnSeq Analysis
10.1371/journal.pcbi.1004401 · 2015 · External reference
Normalization of transposon-mutant library sequencing datasets to improve identification of conditionally essential genes
10.1142/s021972001642004x · 2016 · External reference
10.7554/elife.78609
10.7554/elife.78609 · External reference
High-throughput screening of small molecules targeting Mycobacterium tuberculosis in human iPSC macrophages
2025 · External reference
