Research graph
References from Single-round infectious rotaviruses with deletions of VP7 or VP4 genes, based on SA11 and WC3 strain backbones, and their potential use as viral vectors. Local targets link to admitted publications; unresolved targets remain external evidence.
2008 estimate of worldwide rotavirus-associated mortality in children younger than 5 years before the introduction of universal rotavirus vaccination programmes: a systematic review and meta-analysis
10.1016/s1473-3099(11)70253-5 · 2012 · External reference
Safety and efficacy of a pentavalent human-bovine (WC3) reassortant rotavirus vaccine
10.1056/nejmoa052664 · 2006 · External reference
Safety and efficacy of an attenuated vaccine against severe rotavirus gastroenteritis
10.1056/nejmoa052434 · 2006 · External reference
Global impact of rotavirus vaccination on diarrhea hospitalizations and deaths among children <5 years old: 2006-2019
10.1093/infdis/jiaa081 · 2020 · External reference
Rotavirus vaccination and the global burden of rotavirus diarrhea among children younger than 5 years
10.1001/jamapediatrics.2018.1960 · 2018 · External reference
Rotavirus vaccines: viral shedding and risk of transmission
10.1016/s1473-3099(08)70231-7 · 2008 · External reference
Rotavirus vaccine-derived cases in Belgium: evidence for reversion of attenuating mutations and alternative causes of gastroenteritis
10.1016/j.vaccine.2022.06.082 · 2022 · External reference
ICTV virus taxonomy profile: sedoreoviridae 2022
10.1099/jgv.0.001782 · 2022 · External reference
Rotaviruses.
2013 · External reference
Atomic model of an infectious rotavirus particle
10.1038/emboj.2010.322 · 2011 · External reference
Genetic mapping indicates that VP4 is the rotavirus cell attachment protein in vitro and in vivo
10.1128/jvi.70.1.487-493.1996 · 1996 · External reference
Rotavirus contains integrin ligand sequences and a disintegrin-like domain that are implicated in virus entry into cells
10.1073/pnas.94.10.5389 · 1997 · External reference
VP4- and VP7-specific antibodies mediate heterotypic immunity to rotavirus in humans
10.1126/scitranslmed.aam5434 · 2017 · External reference
Location of the dsRNA-dependent polymerase, VP1, in rotavirus particles
10.1016/j.jmb.2012.10.011 · 2013 · External reference
2.7 Å cryo-EM structure of rotavirus core protein VP3, a unique capping machine with a helicase activity
10.1126/sciadv.aay6410 · 2020 · External reference
Rotavirus VP2 core shell regions critical for viral polymerase activation
10.1128/jvi.02360-10 · 2011 · External reference
Identification of rotavirus VP6 residues located at the interface with VP2 that are essential for capsid assembly and transcriptase activity
10.1128/jvi.76.15.7822-7831.2002 · 2002 · External reference
Two non-structural rotavirus proteins, NSP2 and NSP5, form viroplasm-like structures in vivo
10.1099/0022-1317-80-2-333 · 1999 · External reference
Generation of single-round infectious rotavirus with a mutation in the intermediate capsid protein VP6
10.1128/jvi.00762-24 · 2024 · External reference
Entirely plasmid-based reverse genetics system for rotaviruses
10.1073/pnas.1618424114 · 2017 · External reference
Structure of rotavirus outer-layer protein VP7 bound with a neutralizing Fab
10.1126/science.1170481 · 2009 · External reference
Development of stable rotavirus reporter expression systems
10.1128/jvi.01774-18 · 2019 · External reference
Generation of recombinant rotavirus expressing NSP3-UnaG fusion protein by a simplified reverse genetics system
10.1128/jvi.01616-19 · 2019 · External reference
A trans-complementation system for SARS-CoV-2 recapitulates authentic viral replication without virulence
10.1016/j.cell.2021.02.044 · 2021 · External reference
High-throughput neutralization assay for multiple flaviviruses based on single-round infectious particles using dengue virus type 1 reporter replicon
10.1038/s41598-018-34865-y · 2018 · External reference
Molecular and biological characterization of the 5 human-bovine rotavirus (WC3)-based reassortant strains of the pentavalent rotavirus vaccine, RotaTeq
10.1016/j.virol.2010.04.004 · 2010 · External reference
The development of multivalent bovine rotavirus (strain WC3) reassortant vaccine for infants
1996 · External reference
CRISPR-Csy4-mediated editing of rotavirus double-stranded RNA genome
10.1016/j.celrep.2020.108205 · 2020 · External reference
Genome rearrangements of rotaviruses
10.1016/s0065-3527(08)60070-6 · 1996 · External reference
What are the limits of the packaging capacity for genomic RNA in the cores of rotaviruses and of other members of the Reoviridae?
10.1016/j.virusres.2019.197822 · 2020 · External reference
Single-cell sequencing of rotavirus-infected intestinal epithelium reveals cell-type specific epithelial repair and tuft cell infection
10.1073/pnas.2112814118 · 2021 · External reference
Innate immune sensing of rotavirus by intestinal epithelial cells leads to diarrhea
2025 · External reference
Age-dependent diarrhea induced by a rotaviral nonstructural glycoprotein
10.1126/science.272.5258.101 · 1996 · External reference
The effects of host age, virus dose, and virus strain on heterologous rotavirus infection of suckling mice
10.1016/0882-4010(88)90069-1 · 1988 · External reference
Comparative growth of different rotavirus strains in differentiated cells (MA104, HepG2, and CaCo-2)
10.1016/0042-6822(91)90443-f · 1991 · External reference
Permissive replication of homologous murine rotavirus in the mouse intestine is primarily regulated by VP4 and NSP1
10.1128/jvi.00619-13 · 2013 · External reference
Roles of VP4 and NSP1 in determining the distinctive replication capacities of simian rotavirus RRV and bovine rotavirus UK in the mouse biliary tract
10.1128/jvi.02408-10 · 2011 · External reference
Extraintestinal spread and replication of a homologous EC rotavirus strain and a heterologous rhesus rotavirus in BALB/c mice
10.1128/jvi.02664-05 · 2006 · External reference
Molecular basis of age-dependent gastric inactivation of rhesus rotavirus in the mouse
10.1172/jci115776 · 1992 · External reference
Cultivation and characterization of three strains of murine rotavirus
10.1128/jvi.57.2.585-590.1986 · 1986 · External reference
A rotavirus VP4 or VP7 monoreassortant panel identifies genotypes that are less susceptible to neutralization by systemic antibodies induced by vaccination or natural infection
10.1128/mbio.00897-25 · 2025 · External reference
Human VP8* mAbs neutralize rotavirus selectively in human intestinal epithelial cells
10.1172/jci128382 · 2019 · External reference
Generation of recombinant authentic live attenuated human rotavirus vaccine strain RIX4414 (Rotarix®) from cloned cDNAs using reverse genetics
10.3390/v16081198 · 2024 · External reference
T7 expression plasmids for producing a recombinant human G1P[8] rotavirus comprising RIX4414 sequences of the RV1 (Rotarix , GSK) vaccine strain
10.1128/mra.00603-23 · 2023 · External reference
Vaccine-derived NSP2 segment in rotaviruses from vaccinated children with gastroenteritis in Nicaragua
10.1016/j.meegid.2012.03.007 · 2012 · External reference
Symptomatic infection and detection of vaccine and vaccine-reassortant rotavirus strains in 5 children: a case series
10.1093/infdis/jis490 · 2012 · External reference
Detection of rotateq vaccine-derived, double-reassortant rotavirus in a 7-year-old child with acute gastroenteritis
10.1097/inf.0000000000000221 · 2014 · External reference
Rewiring the RNAs of influenza virus to prevent reassortment
10.1073/pnas.0908897106 · 2009 · External reference
Receptor activity of rotavirus nonstructural glycoprotein NS28
10.1128/jvi.63.11.4553-4562.1989 · 1989 · External reference
Structural plasticity of the coiled-coil domain of rotavirus NSP4
10.1128/jvi.02227-14 · 2014 · External reference
Generation of recombinant rotaviruses encoding a split NanoLuc peptide tag
10.1016/j.bbrc.2020.11.007 · 2021 · External reference
N-glycosylation of rotavirus NSP4 protein affects viral replication and pathogenesis
10.1128/jvi.01861-22 · 2023 · External reference
Reverse genetics approach for developing rotavirus vaccine candidates carrying VP4 and VP7 genes cloned from clinical isolates of human rotavirus
10.1128/jvi.01374-20 · 2020 · External reference
Reverse genetics system for a human group A rotavirus
10.1128/jvi.00963-19 · 2020 · External reference
Rapid production of recombinant rotaviruses by overexpression of NSP2 and NSP5 genes with modified nucleotide sequences
10.1128/jvi.00996-24 · 2024 · External reference
Drebrin restricts rotavirus entry by inhibiting dynamin-mediated endocytosis
2017 · External reference
