Research graph
References from TRIM28 is a target for paramyxovirus V proteins. Local targets link to admitted publications; unresolved targets remain external evidence.
An integrated encyclopedia of DNA elements in the human genome
10.1038/nature11247 · 2012 · External reference
Mobile elements and the human genome
10.1038/35038572 · 2000 · External reference
How retrotransposons shape genome regulation
10.1016/j.gde.2016.01.001 · 2016 · External reference
Origins and evolutionary consequences of ancient endogenous retroviruses
10.1038/s41579-019-0189-2 · 2019 · External reference
Regulatory evolution of innate immunity through co-option of endogenous retroviruses
10.1126/science.aad5497 · 2016 · External reference
Switching sides: how endogenous retroviruses protect us from viral infections
10.1128/jvi.02299-20 · 2021 · External reference
Endogenous double-stranded RNA
2021 · External reference
Inhibiting DNA methylation causes an interferon response in cancer via dsRNA including endogenous retroviruses
10.1016/j.cell.2015.07.011 · 2015 · External reference
Silencing of retrotransposons by SETDB1 inhibits the interferon response in acute myeloid leukemia
10.1083/jcb.201612160 · 2017 · External reference
The immunological conundrum of endogenous retroelements
10.1146/annurev-immunol-101721-033341 · 2023 · External reference
Enhanced transcription of human endogenous retroviruses and TRIM28 downregulation in patients with inflammatory bowel disease
10.3390/v16101570 · 2024 · External reference
KAP1 controls endogenous retroviruses in embryonic stem cells
10.1038/nature08674 · 2010 · External reference
Interplay of TRIM28 and DNA methylation in controlling human endogenous retroelements
10.1101/gr.172833.114 · 2014 · External reference
Transposable elements and their KRAB-ZFP controllers regulate gene expression in adult tissues
10.1016/j.devcel.2016.02.024 · 2016 · External reference
DNA-demethylating agents target colorectal cancer cells by inducing viral mimicry by endogenous transcripts
10.1016/j.cell.2015.07.056 · 2015 · External reference
Antiviral immunity triggered by infection-induced host transposable elements
10.1016/j.coviro.2021.12.006 · 2022 · External reference
An influenza virus-triggered SUMO switch orchestrates co-opted endogenous retroviruses to stimulate host antiviral immunity
10.1073/pnas.1907031116 · 2019 · External reference
Regulated localization of transposable element RNA during influenza A virus infection
10.1038/s44319-025-00498-2 · 2025 · External reference
Virus-induced transposable element expression up-regulation in human and mouse host cells
10.26508/lsa.201900536 · 2020 · External reference
Chronic HCV infection is associated with overexpression of human endogenous retroviruses that persists after drug-induced viral clearance
10.3390/ijms21113980 · 2020 · External reference
Identification and characterization of endogenous retroviruses upon SARS-CoV-2 infection
10.3389/fimmu.2024.1294020 · 2024 · External reference
KAP1 Is a host restriction factor that promotes human adenovirus E1B-55K SUMO modification
10.1128/jvi.01836-15 · 2015 · External reference
Kruppel-associated box domain-associated protein-1 as a latency regulator for Kaposi’s sarcoma-associated herpesvirus and its modulation by the viral protein kinase
10.1158/0008-5472.can-08-4570 · 2009 · External reference
Kaposi’s sarcoma-associated herpesvirus-encoded LANA interacts with host KAP1 to facilitate establishment of viral latency
10.1128/jvi.00596-14 · 2014 · External reference
A unique SUMO-2-interacting motif within LANA is essential for KSHV latency
2013 · External reference
Adeno-associated virus Rep proteins antagonize phosphatase PP1 to counteract KAP1 repression of the latent viral genome
10.1073/pnas.1721883115 · 2018 · External reference
Release of human cytomegalovirus from latency by a KAP1/TRIM28 phosphorylation switch
10.7554/elife.06068 · 2015 · External reference
Viral immune modulators perturb the human molecular network by common and unique strategies
10.1038/nature11289 · 2012 · External reference
Degradation of STAT1 and STAT2 by the V proteins of simian virus 5 and human parainfluenza virus type 2, respectively: consequences for virus replication in the presence of alpha/beta and gamma interferons
10.1128/jvi.76.5.2159-2167.2002 · 2002 · External reference
The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter
10.1073/pnas.0407639101 · 2004 · External reference
Paramyxovirus V proteins interact with the RNA Helicase LGP2 to inhibit RIG-I-dependent interferon induction
10.1128/jvi.06405-11 · 2012 · External reference
Human parainfluenza virus type 2 V protein inhibits TRAF6-mediated ubiquitination of IRF7 to prevent TLR7- and TLR9-dependent interferon induction
10.1128/jvi.03525-12 · 2013 · External reference
Role for KAP1 serine 824 phosphorylation and sumoylation/desumoylation switch in regulating KAP1-mediated transcriptional repression
10.1074/jbc.m706912200 · 2007 · External reference
The ATM substrate KAP1 controls DNA repair in heterochromatin: regulation by HP1 proteins and serine 473/824 phosphorylation
10.1158/1541-7786.mcr-11-0134 · 2012 · External reference
Recovery of paramyxovirus simian virus 5 with a V protein lacking the conserved cysteine-rich domain: the multifunctional V protein blocks both interferon-beta induction and interferon signaling
10.1006/viro.2002.1738 · 2002 · External reference
Identification of the sequences responsible for nuclear targeting of the V protein of human parainfluenza virus type 2
10.1099/0022-1317-77-2-327 · 1996 · External reference
Nipah virus V protein evades alpha and gamma interferons by preventing STAT1 and STAT2 activation and nuclear accumulation
10.1128/jvi.76.22.11476-11483.2002 · 2002 · External reference
Inhibition of interferon regulatory factor 3 activation by paramyxovirus V protein
10.1128/jvi.06705-11 · 2012 · External reference
STAT protein interference and suppression of cytokine signal transduction by measles virus V protein
10.1128/jvi.77.13.7635-7644.2003 · 2003 · External reference
The paramyxovirus SV5 V protein binds two atoms of zinc and is a structural component of virions
10.1006/viro.1995.1135 · 1995 · External reference
Mapuera virus, a rubulavirus that inhibits interferon signalling in a wide variety of mammalian cells without degrading STATs
10.1099/vir.0.82579-0 · 2007 · External reference
Inducible expression of the P, V, and NP genes of the paramyxovirus simian virus 5 in cell lines and an examination of NP-P and NP-V interactions
10.1128/jvi.69.12.8001-8010.1995 · 1995 · External reference
Identification of paramyxovirus V protein residues essential for STAT protein degradation and promotion of virus replication
10.1128/jvi.79.13.8591-8601.2005 · 2005 · External reference
The V protein of the paramyxovirus SV5 interacts with damage-specific DNA binding protein
10.1006/viro.1998.9317 · 1998 · External reference
The complexity of TRIM28 contribution to cancer
10.1186/s12929-017-0374-4 · 2017 · External reference
TIF1 proteins in genome stability and cancer
10.3390/cancers12082094 · 2020 · External reference
Transcription cofactors TRIM24, TRIM28, and TRIM33 associate to form regulatory complexes that suppress murine hepatocellular carcinoma
10.1073/pnas.1101544108 · 2011 · External reference
PHD domain-mediated E3 ligase activity directs intramolecular sumoylation of an adjacent bromodomain required for gene silencing
10.1016/j.molcel.2007.11.012 · 2007 · External reference
KAP1 protein: an enigmatic master regulator of the genome
10.1074/jbc.r111.252569 · 2011 · External reference
TRIM28 regulates RNA polymerase II promoter-proximal pausing and pause release
10.1038/nsmb.2878 · 2014 · External reference
HIF-1 Interacts with TRIM28 and DNA-PK to release paused RNA polymerase II and activate target gene transcription in response to hypoxia
10.1038/s41467-021-27944-8 · 2022 · External reference
SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1
2010 · External reference
Phosphorylation of TRIM28 enhances the expression of IFN-β and proinflammatory cytokines during HPAIV infection of human lung epithelial cells
10.3389/fimmu.2018.02229 · 2018 · External reference
An arginine-rich motif of ring finger protein 4 (RNF4) oversees the recruitment and degradation of the phosphorylated and SUMOylated Krüppel-associated box domain-associated protein 1 (KAP1)/TRIM28 protein during genotoxic stress
10.1074/jbc.m114.555672 · 2014 · External reference
Global reprogramming of host SUMOylation during influenza virus infection
10.1016/j.celrep.2015.10.001 · 2015 · External reference
KAP1-mediated epigenetic suppression in anti-RNA viral responses by direct targeting RIG-I and MDA5
10.4049/jimmunol.2100342 · 2021 · External reference
XAF1 promotes anti-RNA virus immune responses by regulating chromatin accessibility
10.1126/sciadv.adg5211 · 2023 · External reference
KAP1 regulates endogenous retroviruses in adult human cells and contributes to innate immune control
2018 · External reference
SUMO-specific proteases/isopeptidases: SENPs and beyond
10.1186/s13059-014-0422-2 · 2014 · External reference
Trim24 targets endogenous p53 for degradation
10.1073/pnas.0813177106 · 2009 · External reference
TRIM24 is a p53-induced E3-ubiquitin ligase that undergoes ATM-mediated phosphorylation and autodegradation during DNA damage
10.1128/mcb.01705-12 · 2014 · External reference
Trim24-repressed VL30 retrotransposons regulate gene expression by producing noncoding RNA
10.1038/nsmb.2496 · 2013 · External reference
Tripartite Motif-containing 33 (TRIM33) protein functions in the poly(ADP-ribose) polymerase (PARP)-dependent DNA damage response through interaction with Amplified in Liver Cancer 1 (ALC1) protein
10.1074/jbc.m113.459164 · 2013 · External reference
TRIM66 reads unmodified H3R2K4 and H3K56ac to respond to DNA damage in embryonic stem cells
10.1038/s41467-019-12126-4 · 2019 · External reference
The E3 ubiquitin ligase tripartite motif 33 is essential for cytosolic RNA-induced NLRP3 inflammasome activation
10.4049/jimmunol.1401448 · 2014 · External reference
TRIM28 SUMOylates and stabilizes NLRP3 to facilitate inflammasome activation
10.1038/s41467-021-25033-4 · 2021 · External reference
Nucleocytoplasmic shuttling of the human parainfluenza virus type 2 phosphoprotein
10.1016/j.virol.2018.12.005 · 2019 · External reference
Nipah virus V and W proteins have a common STAT1-binding domain yet inhibit STAT1 activation from the cytoplasmic and nuclear compartments, respectively
10.1128/jvi.78.11.5633-5641.2004 · 2004 · External reference
mda-5, but not RIG-I, is a common target for paramyxovirus V proteins
10.1016/j.virol.2006.09.023 · 2007 · External reference
ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity
10.1038/s41564-021-00884-1 · 2021 · External reference
TRIM28 interacts with EZH2 and SWI/SNF to activate genes that promote mammosphere formation
10.1038/onc.2016.453 · 2017 · External reference
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
10.1006/meth.2001.1262 · 2001 · External reference
Structure of DDB1 in complex with a paramyxovirus V protein: viral hijack of a propeller cluster in ubiquitin ligase
10.1016/j.cell.2005.10.033 · 2006 · External reference
