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References from Cytotoxic CX3CR1+ Vδ1 T cells clonally expand in an interplay of CMV, microbiota, and HIV-1 persistence in people on antiretroviral therapy. Local targets link to admitted publications; unresolved targets remain external evidence.
CD4 T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract
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Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract
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Altered CD4+ T cell homing to the gut impairs mucosal immune reconstitution in treated HIV-infected individuals
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Lack of mucosal immune reconstitution during prolonged treatment of acute and early HIV-1 infection
2006 · External reference
An altered intestinal mucosal microbiome in HIV-1 infection is associated with mucosal and systemic immune activation and endotoxemia
10.1038/mi.2013.116 · 2014 · External reference
Microbial translocation is a cause of systemic immune activation in chronic HIV infection
10.1038/nm1511 · 2006 · External reference
Intact proviruses are enriched in the colon and associated with PD-1+TIGIT- mucosal CD4+ T cells of people with HIV-1 on antiretroviral therapy
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Defective HIV-1 proviruses are expressed and can be recognized by Cytotoxic T lymphocytes, which shape the proviral landscape
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Defective HIV-1 proviruses produce viral proteins
10.1073/pnas.1917876117 · 2020 · External reference
Long-term persistence of transcriptionally active “defective” HIV-1 proviruses: implications for persistent immune activation during antiretroviral therapy
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CD8 T-cell expansion and inflammation linked to CMV coinfection in ART-treated HIV infection
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10.1111/imr.12823 · 2019 · External reference
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Regional specialization within the intestinal immune system
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Regional variations in the distributions of small intestinal intraepithelial lymphocytes in germ-free and specific pathogen-free mice
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γδ T cells in homeostasis and host defence of epithelial barrier tissues
10.1038/nri.2017.101 · 2017 · External reference
Recasting human Vδ1 lymphocytes in an adaptive role
10.1016/j.it.2018.03.003 · 2018 · External reference
Diversity in recognition and function of human γδ T cells
10.1111/imr.12930 · 2020 · External reference
Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance
10.1038/ncomms14760 · 2017 · External reference
Repeated Plasmodium falciparum infection in humans drives the clonal expansion of an adaptive γδ T cell repertoire
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Cytomegalovirus drives Vδ1+ γδ T cell expansion and clonality in common variable immunodeficiency
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Skewed T cell receptor repertoire of Vdelta1(+) gammadelta T lymphocytes after human allogeneic haematopoietic stem cell transplantation and the potential role for Epstein-Barr virus-infected B cells in clonal restriction
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Human liver infiltrating γδ T cells are composed of clonally expanded circulating and tissue-resident populations
10.1016/j.jhep.2018.05.007 · 2018 · External reference
TCR-Vγδ usage distinguishes protumor from antitumor intestinal γδ T cell subsets.
10.1126/science.abj8695 · 2022 · External reference
Human immunodeficiency virus type 1 induces persistent changes in mucosal and blood gammadelta T cells despite suppressive therapy
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Primary and chronic HIV infection differently modulates mucosal Vδ1 and Vδ2 T-Cells differentiation profile and effector functions
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Increased frequency of systemic pro-inflammatory Vδ1+ γδ T cells in HIV elite controllers correlates with gut viral load
10.1038/s41598-018-34576-4 · 2018 · External reference
Vδ1 Effector and Vδ2 γδ T-Cell subsets shift in frequency and are linked to plasma inflammatory markers during antiretroviral therapy-suppressed HIV infection
10.1093/infdis/jiae091 · 2024 · External reference
CD16 and CD57 expressing gamma delta T cells in acute HIV-1 infection are associated with the development of neutralization breadth
10.1371/journal.ppat.1012916 · 2025 · External reference
Dysregulation of IL-17/IL-22 effector functions in blood and gut mucosal gamma delta T cells correlates with increase in circulating leaky gut and inflammatory markers during cART-treated chronic SIV infection in macaques
10.3389/fimmu.2021.647398 · 2021 · External reference
Intraepithelial γδ T cells remain increased in the duodenum of AIDS patients despite antiretroviral treatment. Nixon DF, éditeur
10.1371/journal.pone.0029066 · 2012 · External reference
Mechanisms underlying γδ T-cell subset perturbations in SIV-infected Asian rhesus macaques
10.1182/blood-2010-05-283549 · 2010 · External reference
NKG2C is a major triggering receptor involved in the V[delta]1 T cell-mediated cytotoxicity against HIV-infected CD4 T cells
10.1097/qad.0b013e3282f46e7c · 2008 · External reference
γδ T cells mediate robust anti-HIV functions during antiretroviral therapy regardless of immune checkpoint expression
10.1002/cti2.1486 · 2024 · External reference
Asymptomatic CMV replication during early human immunodeficiency virus (HIV) infection is associated with lower CD4/CD8 ratio during HIV treatment
10.1093/cid/ciw612 · 2016 · External reference
Novel strategies to combat cmv-related cardiovascular disease
10.20411/pai.v5i1.382 · 2020 · External reference
Cytomegalovirus coinfection is associated with increased vascular-homing CD57 CD4 T cells in HIV infection
10.4049/jimmunol.1900734 · 2020 · External reference
Partners in crime: the role of CMV in immune dysregulation and clinical outcome during HIV infection
10.1007/s11904-016-0297-9 · 2016 · External reference
Determinants of a low CD4/CD8 ratio in HIV-1-infected individuals despite long-term viral suppression
10.1093/cid/ciw076 · 2016 · External reference
Cytomegalovirus seropositivity is associated with increased microbial translocation in people living with human immunodeficiency virus and uninfected controls
10.1093/cid/ciz1001 · 2020 · External reference
Incidence and sexual risk factors of cytomegalovirus seroconversion in HIV-infected subjects. The SEROCO Study Group
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Cytomegalovirus coinfection is associated with an increased risk of severe non-AIDS-defining events in a large cohort of HIV-infected patients
10.1093/infdis/jiu417 · 2015 · External reference
Assessment of coronary artery disease with computed tomography angiography and inflammatory and immune activation biomarkers among adults with HIV eligible for primary cardiovascular prevention
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Increased carotid intima-media thickness in HIV patients is associated with increased cytomegalovirus-specific T-cell responses
10.1097/qad.0b013e3280108704 · 2006 · External reference
Cytomegalovirus immunoglobulin G antibody is associated with subclinical carotid artery disease among HIV-infected women
10.1093/infdis/jis276 · 2012 · External reference
Shared reactivity of V{delta}2(neg) {gamma}{delta} T cells against cytomegalovirus-infected cells and tumor intestinal epithelial cells
10.1084/jem.20041851 · 2005 · External reference
γδ T cells exhibit multifunctional and protective memory in intestinal tissues
10.1016/j.immuni.2013.06.015 · 2013 · External reference
Tissue adaptations of memory and tissue-resident gamma delta T cells
10.3389/fimmu.2018.02636 · 2018 · External reference
Differential skewing of donor-unrestricted and γδ T cell repertoires in tuberculosis-infected human lungs
10.1172/jci130711 · 2020 · External reference
Inflammescent CX3CR1 CD57 CD8 T cells are generated and expanded by IL-15
2020 · External reference
Cytomegalovirus infection leads to development of high frequencies of cytotoxic virus-specific CD4+ T Cells targeted to vascular endothelium
10.1371/journal.ppat.1005832 · 2016 · External reference
Cytomegalovirus (CMV) epitope-specific CD4+ T cells are inflated in HIV+ CMV+ subjects
10.4049/jimmunol.1700851 · 2017 · External reference
CX3CL1 and IL-15 promote CD8 T cell chemoattraction in HIV and in atherosclerosis
10.1371/journal.ppat.1008885 · 2020 · External reference
Single-cell RNA sequencing unveils the shared and the distinct cytotoxic hallmarks of human TCRVδ1 and TCRVδ2 γδ T lymphocytes
10.1073/pnas.1818488116 · 2019 · External reference
Transcriptional profiling of human Vδ1 T cells reveals a pathogen-driven adaptive differentiation program
10.1016/j.celrep.2022.110858 · 2022 · External reference
Eomes expression reports the progressive differentiation of IFN-γ-producing Th1-like γδ T cells
10.1002/eji.201646753 · 2017 · External reference
Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection
10.1126/science.1229620 · 2012 · External reference
The chemokine receptor CX3CR1 defines three antigen-experienced CD8 T cell subsets with distinct roles in immune surveillance and homeostasis
10.1016/j.immuni.2016.10.018 · 2016 · External reference
Graded expression of the chemokine receptor CX3CR1 marks differentiation states of human and murine T cells and enables cross-species interpretation
10.1016/j.immuni.2023.06.025 · 2023 · External reference
Transforming growth factor-β signaling controls the formation and maintenance of gut-resident memory T cells by regulating migration and retention
10.1016/j.immuni.2013.08.019 · 2013 · External reference
Predominance of weakly cytotoxic, T-betLowEomesNeg CD8+ T-cells in human gastrointestinal mucosa: implications for HIV infection
10.1038/mi.2016.100 · 2017 · External reference
Detection of HIV-1-specific gastrointestinal tissue resident CD8+ T-cells in chronic infection
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10.1093/bioinformatics/btac582 · 2022 · External reference
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