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References from Hnf4α integrates AIF and caspase 3/9 signaling to restrict single and coinfecting pathogens in teleosts. Local targets link to admitted publications; unresolved targets remain external evidence.
Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily
10.1101/gad.4.12b.2353 · 1990 · External reference
Control of pancreas and liver gene expression by HNF transcription factors
10.1126/science.1089769 · 2004 · External reference
Structural insights into the HNF4 biology
10.3389/fendo.2023.1197063 · 2023 · External reference
Hepatocyte nuclear factor 4α multiple isoforms, their functions, and their interactomes
2023 · External reference
Dysregulated expression of P1 and P2 promoter-driven hepatocyte nuclear factor-4alpha in the pathogenesis of human cancer
10.1002/path.1928 · 2006 · External reference
Developmental and tissue-specific regulation of hepatocyte nuclear factor 4-alpha (HNF4-alpha) isoforms in rodents
10.3727/105221610x12717040569901 · 2010 · External reference
HNF4α in Hepatocyte Health and Disease
10.1055/a-2097-0660 · 2023 · External reference
Role of Hepatocyte Nuclear Factor 4 Alpha in Liver Cancer
10.1055/a-2349-7236 · 2024 · External reference
Sirtuin 2 Prevents Liver Steatosis and Metabolic Disorders by Deacetylation of Hepatocyte Nuclear Factor 4alpha
10.1002/hep.31773 · 2021 · External reference
LncRNA Hnf4αos exacerbates liver ischemia/reperfusion injury in mice via Hnf4αos/Hnf4α duplex-mediated PGC1α suppression
10.1016/j.redox.2022.102498 · 2022 · External reference
Hepatocyte Nuclear Factor 4 alpha 2 Messenger RNA Reprograms Liver-Enriched Transcription Factors and Functional Proteins in End-Stage Cirrhotic Human Hepatocytes
10.1002/hep4.1763 · 2021 · External reference
Mechanism and Effect of HNF4α Decrease in a Rat Model of Cirrhosis and Liver Failure
10.1016/j.jcmgh.2023.11.009 · 2024 · External reference
Deregulation of hepatocyte nuclear factor 4 (HNF4)as a marker of epithelial tumors progression
2010 · External reference
Decreased expression of hepatocyte nuclear factor 4α (Hnf4α)/microRNA-122 (miR-122) axis in hepatitis B virus-associated hepatocellular carcinoma enhances potential oncogenic GALNT10 protein activity
10.1074/jbc.m114.601203 · 2015 · External reference
Hepatocyte Nuclear Factor 4α (HNF4α) Is a Transcription Factor of Vertebrate Fatty Acyl Desaturase Gene as Identified in Marine Teleost Siganus canaliculatus
10.1371/journal.pone.0160361 · 2016 · External reference
Hnf4α Is Involved in LC-PUFA Biosynthesis by Up-Regulating Gene Transcription of Elongase in Marine Teleost Siganus canaliculatus
10.3390/ijms19103193 · 2018 · External reference
Hnf4α is involved in the regulation of vertebrate LC-PUFA biosynthesis: insights into the regulatory role of Hnf4α on expression of liver fatty acyl desaturases in the marine teleost Siganus canaliculatus
10.1007/s10695-018-0470-8 · 2018 · External reference
Hepatocyte nuclear factor 4α (Hnf4α) is involved in transcriptional regulation of Δ6/Δ5 fatty acyl desaturase (Fad) gene expression in marine teleost Siganus canaliculatus
10.1016/j.cbpb.2019.110353 · 2020 · External reference
Regulation of long-chain polyunsaturated fatty acid biosynthesis in teleost fish
10.1016/j.plipres.2021.101095 · 2021 · External reference
Hepatocyte nuclear factor 4α transactivates the mitochondrial alanine aminotransferase gene in the kidney of Sparus aurata
10.1007/s10126-011-9386-3 · 2012 · External reference
Microbiota regulate intestinal epithelial gene expression by suppressing the transcription factor Hepatocyte nuclear factor 4 alpha
10.1101/gr.220111.116 · 2017 · External reference
Structure, function and immune evasion strategies of aquareoviruses, with focus on grass carp reovirus
10.1111/raq.12844 · 2024 · External reference
Identification and characterization of a novel reovirus strain isolated from grass carp (Ctenopharyngodon idella)
10.1186/s12985-025-02716-8 · 2025 · External reference
CRISPR/Cas9 mutagenesis reveals an essential role of PI4KB in promoting growth and resisting hemorrhagic disease caused by GCRV-II infection in juvenile grass carp
10.1016/j.watbs.2024.100323 · 2025 · External reference
Isolation, identification and characterization of Aeromonas hydrophila from hemorrhagic grass carp
2009 · External reference
Prevention and control strategies for common diseases of grass carp
2018 · External reference
Grass carp Hnf4β orchestrates antibacterial defense via the AIF/Hnf4α/caspase 3 signaling axis
10.1016/j.fsi.2025.110534 · 2025 · External reference
Conserved roles for Hnf4 family transcription factors in zebrafish development and intestinal function
10.1093/genetics/iyac133 · 2022 · External reference
NS38 is required for aquareovirus replication via interaction with viral core proteins and host eIF3A
10.1016/j.virol.2019.01.029 · 2019 · External reference
Grass carp reovirus VP56 and VP35 induce formation of viral inclusion bodies for replication
10.1016/j.isci.2023.108684 · 2023 · External reference
Integrated approach for the identification of human hepatocyte nuclear factor 4alpha target genes using protein binding microarrays
10.1002/hep.23357 · 2010 · External reference
Aeromonas salmonicida-secreted protein AopP is a potent inducer of apoptosis in a mammalian and a Drosophila model
10.1111/j.1462-5822.2011.01717.x · 2012 · External reference
Grass carp reovirus induces apoptosis and oxidative stress in grass carp (Ctenopharyngodon idellus) kidney cell line
10.1016/j.virusres.2014.03.021 · 2014 · External reference
GCRV-II invades monocytes/macrophages and induces macrophage polarization and apoptosis in tissues to facilitate viral replication and dissemination
2024 · External reference
Caspases disrupt the nuclear-cytoplasmic barrier
10.1083/jcb.151.5.951 · 2000 · External reference
Nuclear localization of procaspase-9 and processing by a caspase-3-like activity in mammary epithelial cells
10.1078/s0171-9335(04)70040-0 · 2000 · External reference
Apoptosis-inducing factor (AIF): key to the conserved caspase-independent pathways of cell death?
10.1242/jcs.00210 · 2002 · External reference
Study on the apoptosis mediated by apoptosis-inducing-factor and influencing factors of bovine muscle during postmortem aging
10.1016/j.foodchem.2018.06.032 · 2018 · External reference
Hepatocyte Nuclear Factor 4α Prevents the Steatosis-to-NASH Progression by Regulating p53 and Bile Acid Signaling (in mice)
10.1002/hep.31604 · 2021 · External reference
The hepatitis B virus core promoter is strongly activated by the liver nuclear receptor fetoprotein transcription factor or by ectopically expressed steroidogenic factor 1
10.1128/jvi.74.11.5032-5039.2000 · 2000 · External reference
Interleukin-35 stimulates hepatitis B virus transcription and replication by targeting transcription factor HNF4α
10.1099/jgv.0.001050 · 2018 · External reference
The nuclear hormone receptor NHR-86 controls anti-pathogen responses in C. elegans
10.1371/journal.pgen.1007935 · 2019 · External reference
A critical role for HNF4α in polymicrobial sepsis-associated metabolic reprogramming and death
10.1038/s44321-024-00130-1 · 2024 · External reference
Long-term oral administration of an HNF4α agonist prevents weight gain and hepatic steatosis by promoting increased mitochondrial mass and function
10.1038/s41419-022-04521-5 · 2022 · External reference
Recent Insights into Aeromonas salmonicida and Its Bacteriophages in Aquaculture: A Comprehensive Review
10.4014/jmb.2005.05040 · 2020 · External reference
Recombinant Baculovirus-Produced Grass Carp Reovirus Virus-Like Particles as Vaccine Candidate That Provides Protective Immunity against GCRV Genotype II Infection in Grass Carp
10.3390/vaccines9010053 · 2021 · External reference
Transcriptional regulation of hepatitis B virus by nuclear hormone receptors is a critical determinant of viral tropism
10.1073/pnas.98.4.1841 · 2001 · External reference
A concerted action of HNF4alpha and HNF1alpha links hepatitis B virus replication to hepatocyte differentiation
10.1111/j.1462-5822.2008.01141.x · 2008 · External reference
Hepatocyte nuclear factor 4α and downstream secreted phospholipase A2 GXIIB regulate production of infectious hepatitis C virus
10.1128/jvi.02068-13 · 2014 · External reference
Inhibition of EGFR signaling augments oridonin-induced apoptosis in human laryngeal cancer cells via enhancing oxidative stress coincident with activation of both the intrinsic and extrinsic apoptotic pathways
10.1016/j.canlet.2010.01.032 · 2010 · External reference
Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis
10.1016/s0014-5793(00)01731-2 · 2000 · External reference
Low-dose naltrexone inhibits colorectal cancer progression and promotes apoptosis by increasing M1-type macrophages and activating the Bax/Bcl-2/caspase-3/PARP pathway
10.1016/j.intimp.2020.106388 · 2020 · External reference
Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes
10.1128/mcb.16.3.925 · 1996 · External reference
Hepatocyte nuclear factor 4 gamma (HNF4G) is correlated with poor prognosis and promotes tumor cell growth by inhibiting caspase-dependent intrinsic apoptosis in colorectal cancer
10.1016/j.ejphar.2021.174727 · 2022 · External reference
p53 in health and disease
10.1038/nrm2147 · 2007 · External reference
The pro- or anti-apoptotic function of NF-kappaB is determined by the nature of the apoptotic stimulus
10.1046/j.1432-1327.2000.01421.x · 2000 · External reference
Pro-apoptotic role of NF-kappaB: implications for cancer therapy
2006 · External reference
Context-Dependent Regulation of Autophagy by IKK-NF-κB Signaling: Impact on the Aging Process
10.1155/2012/849541 · 2012 · External reference
Molecular characterization of mitochondrial apoptosis-inducing factor
10.1038/17135 · 1999 · External reference
Non-canonical pattern recognition of a pathogen-derived metabolite by a nuclear hormone receptor identifies virulent bacteria in C. elegans
10.1016/j.immuni.2023.01.027 · 2023 · External reference
Serine/threonine phosphorylation of orphan receptor hepatocyte nuclear factor 4
10.1006/abbi.1997.9914 · 1997 · External reference
Protein kinase A-dependent phosphorylation modulates DNA-binding activity of hepatocyte nuclear factor 4
10.1128/mcb.17.8.4208 · 1997 · External reference
Acetylation regulates transcription factor activity at multiple levels
10.1016/s1097-2765(00)80253-1 · 2000 · External reference
Two functional modes of a nuclear receptor-recruited arginine methyltransferase in transcriptional activation
10.1016/j.molcel.2006.09.020 · 2006 · External reference
Structural and functional analysis of the small GTPase ARF1 reveals a pivotal role of its GTP-binding domain in controlling of the generation of viral inclusion bodies and replication of grass carp reovirus
10.3389/fimmu.2022.956587 · 2022 · External reference
CD44a functions as a regulator of p53 signaling, apoptosis and autophagy in the antibacterial immune response
10.1038/s42003-022-03856-1 · 2022 · External reference
