Research graph
References from Cross-kingdom dialogs in the gut: Integrating bacterial pathogens, helminths, and microbiota interactions for immune homeostasis. Local targets link to admitted publications; unresolved targets remain external evidence.
The intestinal epithelium at the forefront of host–helminth interactions
10.1016/j.pt.2020.07.002 · 2020 · External reference
Gut microbiota, metabolites and host immunity
10.1038/nri.2016.42 · 2016 · External reference
Gut inflammation provides a respiratory electron acceptor for Salmonella
10.1038/nature09415 · 2010 · External reference
Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens
10.1038/nm1720 · 2008 · External reference
Microbiota-mediated colonization resistance: mechanisms and regulation
10.1038/s41579-022-00833-7 · 2023 · External reference
Bifidobacteria can protect from enteropathogenic infection through production of acetate
10.1038/nature09646 · 2011 · External reference
Effect of helminth-induced immunity on infections with microbial pathogens
10.1038/ni.2736 · 2013 · External reference
Exploitation of the intestinal microflora by the parasitic nematode Trichuris muris
10.1126/science.1187703 · 2010 · External reference
Commensal-pathogen interactions in the intestinal tract: lactobacilli promote infection with, and are promoted by, helminth parasites
10.4161/gmic.32155 · 2014 · External reference
Corrigendum: the intestinal roundworm Ascaris suum releases antimicrobial factors which interfere with bacterial growth and biofilm formation
10.3389/fcimb.2018.00367 · 2018 · External reference
Parasitic nematodes exert antimicrobial activity and benefit from microbiota-driven support for host immune regulation
10.3389/fimmu.2018.02282 · 2018 · External reference
Trilateral relationship: ascaris, microbiota, and host cells
10.1016/j.pt.2020.09.002 · 2021 · External reference
Reciprocal interactions between nematodes and their microbial environments
10.3389/fcimb.2017.00144 · 2017 · External reference
Colonization of Ascaris lumbricoides by V. cholerae
10.2307/3278979 · 1976 · External reference
Intestinal epithelial cells: regulators of barrier function and immune homeostasis
10.1038/nri3608 · 2014 · External reference
Cytokine-mediated crosstalk between immune cells and epithelial cells in the gut
10.3390/cells10010111 · 2021 · External reference
Intestinal stromal cells in mucosal immunity and homeostasis
10.1038/mi.2012.125 · 2013 · External reference
Allergic host defences
10.1038/nature11047 · 2012 · External reference
Getting a taste for parasites in the gut
10.1016/j.immuni.2018.07.002 · 2018 · External reference
Immunomodulation by filarial nematodes
10.1111/j.1365-3024.2005.00792.x · 2005 · External reference
Protective immune mechanisms in helminth infection
10.1038/nri2199 · 2007 · External reference
Diversity and dialogue in immunity to helminths
10.1038/nri2992 · 2011 · External reference
Characterization of putative stem cells in isolated human colonic crypt epithelial cells and their interactions with myofibroblasts
10.1152/ajpcell.00383.2008 · 2009 · External reference
Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells
10.1053/j.gastro.2012.08.031 · 2012 · External reference
Myd88-dependent positioning of Ptgs2-expressing stromal cells maintains colonic epithelial proliferation during injury
10.1172/jci29159 · 2007 · External reference
Intestinal barrier function: molecular regulation and disease pathogenesis
10.1016/j.jaci.2009.05.038 · 2009 · External reference
Epithelial cells: liaisons of immunity
10.1016/j.coi.2019.11.004 · 2020 · External reference
A single-cell survey of the small intestinal epithelium
10.1038/nature24489 · 2017 · External reference
Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis
10.1038/s41467-018-07386-5 · 2018 · External reference
The NIH human microbiome project
10.1101/gr.096651.109 · 2009 · External reference
Gut microbiota: role in pathogen colonization, immune responses, and inflammatory disease
10.1111/imr.12567 · 2017 · External reference
Epithelial IL-18 equilibrium controls barrier function in colitis
10.1016/j.cell.2015.10.072 · 2015 · External reference
The interleukin (IL)-1 cytokine family—balance between agonists and antagonists in inflammatory diseases
10.1016/j.cyto.2015.06.017 · 2015 · External reference
Epithelial-derived IL-18 regulates Th17 cell differentiation and Foxp3⁺ Treg cell function in the intestine
10.1038/mi.2015.13 · 2015 · External reference
Interleukin-22 and intestinal homeostasis: protective or destructive?
10.1002/iub.2295 · 2020 · External reference
Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense
10.1016/j.immuni.2008.11.001 · 2008 · External reference
Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
10.1038/nature05505 · 2007 · External reference
Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides
10.1084/jem.20061308 · 2006 · External reference
Transcription factor c-Maf mediates the TGF-β-dependent suppression of IL-22 production in T(H)17 cells
10.1038/ni.2134 · 2011 · External reference
A T-bet gradient controls the fate and function of CCR6-RORγt+ innate lymphoid cells
10.1038/nature11813 · 2013 · External reference
Innate lymphoid cells: important regulators of host–bacteria interaction for border defense
10.3390/microorganisms8091342 · 2020 · External reference
IL-12 induces a B cell-intrinsic IL-12/IFNγ feed-forward loop promoting extrafollicular B cell responses
10.1038/s41590-024-01858-1 · 2024 · External reference
Gut microbiota regulation of T cells during inflammation and autoimmunity
10.1146/annurev-immunol-042718-041841 · 2019 · External reference
Understanding host immune responses in Clostridioides difficile infection: implications for pathogenesis and immunotherapy
10.1002/imt2.200 · 2024 · External reference
Networking between helminths, microbes, and mammals
10.1016/j.chom.2023.02.008 · 2023 · External reference
Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles
10.1126/science.1214914 · 2011 · External reference
Dysbiosis caused by vitamin D receptor deficiency confers colonization resistance to Citrobacter rodentium through modulation of innate lymphoid cells
10.1038/mi.2014.94 · 2015 · External reference
Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity
10.1038/s41467-020-18262-6 · 2020 · External reference
The role of the aryl hydrocarbon receptor (AhR) in modulating intestinal ILC3s to optimise gut pathogen resistance in lupus and benefits of nutritional AhR ligands
10.1016/j.clnu.2024.04.008 · 2024 · External reference
CX(3)CR1(+) macrophages support IL-22 production by innate lymphoid cells during infection with Citrobacter rodentium
10.1038/mi.2012.61 · 2013 · External reference
CX₃CR1⁺ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22
10.1084/jem.20140678 · 2014 · External reference
The chemokine receptor CXCR6 controls the functional topography of interleukin-22 producing intestinal innate lymphoid cells
10.1016/j.immuni.2014.10.007 · 2014 · External reference
IL-23 and IL-2 activation of STAT5 is required for optimal IL-22 production in ILC3s during colitis
10.1126/sciimmunol.aav1080 · 2020 · External reference
Enteric nematodes induce stereotypic STAT6-dependent alterations in intestinal epithelial cell function
10.4049/jimmunol.172.9.5616 · 2004 · External reference
Duodenal helminth infection alters barrier function of the colonic epithelium via adaptive immune activation
10.1128/iai.01123-10 · 2011 · External reference
Helminth-bacterial interactions: cause and consequence
10.1016/j.it.2018.06.002 · 2018 · External reference
Interleukin (IL)-33: an orchestrator of immunity from host defence to tissue homeostasis
10.1002/cti2.1146 · 2020 · External reference
Mast cells are crucial for induction of group 2 innate lymphoid cells and clearance of helminth infections
10.1016/j.immuni.2017.04.017 · 2017 · External reference
Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites
10.1038/nature16527 · 2016 · External reference
Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit
10.1038/nature16161 · 2016 · External reference
IL-33 drives biphasic IL-13 production for noncanonical Type 2 immunity against hookworms
10.1073/pnas.1206587110 · 2013 · External reference
Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract
10.1084/jem.20051496 · 2006 · External reference
IL-25 (IL-17E) in epithelial immunology and pathophysiology
10.1016/j.jaci.2020.12.628 · 2021 · External reference
BATF acts as an essential regulator of IL-25-responsive migratory ILC2 cell fate and function
10.1126/sciimmunol.aay3994 · 2020 · External reference
Molecular cloning and biological characterization of a novel murine lymphoid growth factor
10.1084/jem.192.5.671 · 2000 · External reference
Tuft cells: a new flavor in innate epithelial immunity
10.1016/j.pt.2016.04.016 · 2016 · External reference
Thymic stromal lymphopoietin-activated invariant natural killer T cells trigger an innate allergic immune response in atopic dermatitis
10.1016/j.jaci.2010.05.024 · 2010 · External reference
TSLP signaling in CD4+ T cells programs a pathogenic T helper 2 cell state
10.1126/scisignal.aam8858 · 2018 · External reference
Induction of IL-4 expression in CD4(+) T cells by thymic stromal lymphopoietin
10.4049/jimmunol.178.3.1396 · 2007 · External reference
TSLP enhances the function of helper type 2 cells
10.1002/eji.201041195 · 2011 · External reference
Increased prevalence of regulatory T cells in the lung cancer microenvironment: a role of thymic stromal lymphopoietin
10.1007/s00262-011-1059-6 · 2011 · External reference
Human thymic stromal lymphopoietin promotes dendritic cell-mediated CD4+ T cell homeostatic expansion
10.1038/ni1048 · 2004 · External reference
Thymic stromal lymphopoietin: a cytokine that promotes the development of IgM+ B cells in vitro and signals via a novel mechanism
10.4049/jimmunol.162.2.677 · 1999 · External reference
A thymic stromal cell line supports in vitro development of surface IgM+ B cells and produces a novel growth factor affecting B and T lineage cells
1994 · External reference
TSLP or IL-7 provide an IL-7Rα signal that is critical for human B lymphopoiesis
10.1002/eji.201646307 · 2016 · External reference
Thymic stromal lymphopoietin induces early human B-cell proliferation and differentiation
10.1002/eji.200939419 · 2010 · External reference
Colonization resistance of the digestive tract in conventional and antibiotic-treated mice
10.1017/s0022172400021653 · 1971 · External reference
Effect of streptomycin on susceptibility of intestinal tract to experimental Salmonella infection
10.3181/00379727-86-21030 · 1954 · External reference
An enteric pathogen subverts colonization resistance by evading competition for amino acids in the gut
10.1016/j.chom.2020.06.018 · 2020 · External reference
Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infection
10.1038/ncomms4114 · 2014 · External reference
Probiotic bacteria reduce Salmonella Typhimurium intestinal colonization by competing for iron
10.1016/j.chom.2013.06.007 · 2013 · External reference
Siderophore-mediated zinc acquisition enhances enterobacterial colonization of the inflamed gut
10.1038/s41467-021-27297-2 · 2021 · External reference
The microbiome-shaping roles of bacteriocins
10.1038/s41579-021-00569-w · 2021 · External reference
Persistence of colicinogenic Escherichia coli in the mouse gastrointestinal tract
10.1186/1471-2180-9-165 · 2009 · External reference
Cooperating commensals restore colonization resistance to vancomycin-resistant Enterococcus faecium
10.1016/j.chom.2017.04.002 · 2017 · External reference
Microbiota-derived lantibiotic restores resistance against vancomycin-resistant Enterococcus
10.1038/s41586-019-1501-z · 2019 · External reference
Mechanisms and biological roles of contact-dependent growth inhibition systems
10.1101/cshperspect.a010025 · 2014 · External reference
Type VI secretion systems of human gut Bacteroidales segregate into three genetic architectures, two of which are contained on mobile genetic elements
10.1186/s12864-016-2377-z · 2016 · External reference
Review: microbial transformations of human bile acids
10.1186/s40168-021-01101-1 · 2021 · External reference
In vitro antibacterial activity of unconjugated and conjugated bile salts on Staphylococcus aureus
10.3389/fmicb.2017.01581 · 2017 · External reference
Comprehensive evaluation of the bactericidal activities of free bile acids in the large intestine of humans and rodents
10.1194/jlr.m075143 · 2017 · External reference
Microbiota-derived metabolic factors reduce campylobacteriosis in mice
2018 · External reference
Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile
10.1038/nature13828 · 2015 · External reference
Inhibiting antibiotic-resistant Enterobacteriaceae by microbiota-mediated intracellular acidification
10.1084/jem.20181639 · 2019 · External reference
Resistance of the mouse’s intestinal tract to experimental Salmonella infection: II. Factors responsibie for its loss following streptomycin treatment
10.1084/jem.120.5.817 · 1964 · External reference
Influence of intestinal anaerobes and organic acids on the growth of enterohaemorrhagic Escherichia coli O157:H7
10.1099/0022-1317-51-3-201 · 2002 · External reference
Role of volatile fatty acids in colonization resistance to Clostridium difficile in gnotobiotic mice
10.1128/iai.55.7.1686-1691.1987 · 1987 · External reference
Variations in microbiota composition of laboratory mice influence Citrobacter rodentium infection via variable short-chain fatty acid production
10.1371/journal.ppat.1008448 · 2020 · External reference
Importance and regulation of the colonic mucus barrier in a mouse model of colitis
10.1152/ajpgi.00422.2010 · 2011 · External reference
Normalization of host intestinal mucus layers requires long-term microbial colonization
10.1016/j.chom.2015.10.007 · 2015 · External reference
Muc2 protects against lethal infectious colitis by disassociating pathogenic and commensal bacteria from the colonic mucosa
2010 · External reference
The mucin Muc2 limits pathogen burdens and epithelial barrier dysfunction during Salmonella enterica serovar Typhimurium colitis
10.1128/iai.00854-13 · 2013 · External reference
Increased Listeria monocytogenes dissemination and altered population dynamics in Muc2-deficient mice
10.1128/iai.00667-20 · 2021 · External reference
Microbiota-activated PPAR-γ signaling inhibits dysbiotic Enterobacteriaceae expansion
10.1126/science.aam9949 · 2017 · External reference
Crosstalk between microbiota-derived short-chain fatty acids and intestinal epithelial HIF augments tissue barrier function
10.1016/j.chom.2015.03.005 · 2015 · External reference
Depletion of butyrate-producing Clostridia from the gut microbiota drives an aerobic luminal expansion of Salmonella
10.1016/j.chom.2016.03.004 · 2016 · External reference
Dysbiotic Proteobacteria expansion: a microbial signature of epithelial dysfunction
10.1016/j.mib.2017.07.003 · 2017 · External reference
Modulation of Shigella virulence in response to available oxygen in vivo
10.1038/nature08970 · 2010 · External reference
Virulence factors enhance Citrobacter rodentium expansion through aerobic respiration
10.1126/science.aag3042 · 2016 · External reference
Commensal Enterobacteriaceae protect against Salmonella colonization through oxygen competition
10.1016/j.chom.2018.12.003 · 2019 · External reference
Host-derived nitrate boosts growth of E. coli in the inflamed gut
10.1126/science.1232467 · 2013 · External reference
Streptomycin-induced inflammation enhances Escherichia coli gut colonization through nitrate respiration
10.1128/mbio.00430-13 · 2013 · External reference
Mucispirillum schaedleri antagonizes Salmonella virulence to protect mice against colitis
10.1016/j.chom.2019.03.004 · 2019 · External reference
The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine
10.1126/science.1209791 · 2011 · External reference
Symbiotic bacteria direct expression of an intestinal bactericidal lectin
10.1126/science.1127119 · 2006 · External reference
Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits
10.1038/nature07250 · 2008 · External reference
TLR-7 activation enhances IL-22-mediated colonization resistance against vancomycin-resistant enterococcus
2016 · External reference
The regenerating family member 3 β instigates IL-17A-mediated neutrophil recruitment downstream of NOD1/2 signalling for controlling colonisation resistance independently of microbiota community structure
10.1136/gutjnl-2018-316757 · 2019 · External reference
The role of iron in host-microbiota crosstalk and its effects on systemic glucose metabolism
10.1038/s41574-022-00721-3 · 2022 · External reference
Microbiota-inducible innate immune siderophore binding protein lipocalin 2 is critical for intestinal homeostasis
10.1016/j.jcmgh.2016.03.007 · 2016 · External reference
Depletion of lipocalin 2 (LCN2) in mice leads to dysbiosis and persistent colonization with segmented filamentous bacteria
10.3390/ijms222313156 · 2021 · External reference
Transition metal sequestration by the host-defense protein calprotectin
10.1146/annurev-biochem-062917-012312 · 2018 · External reference
Induction of intestinal Th17 cells by segmented filamentous bacteria
10.1016/j.cell.2009.09.033 · 2009 · External reference
An enteric virus can replace the beneficial function of commensal bacteria
10.1038/nature13960 · 2014 · External reference
IFN-I and IL-22 mediate protective effects of intestinal viral infection
10.1038/s41564-019-0470-1 · 2019 · External reference
A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria
10.1126/science.288.5474.2222 · 2000 · External reference
Innate and adaptive humoral responses coat distinct commensal bacteria with immunoglobulin A
10.1016/j.immuni.2015.08.007 · 2015 · External reference
Natural polyreactive IgA antibodies coat the intestinal microbiota
10.1126/science.aan6619 · 2017 · External reference
Phage-mediated acquisition of a type III secreted effector protein boosts growth of Salmonella by nitrate respiration
10.1128/mbio.00143-12 · 2012 · External reference
Host-mediated sugar oxidation promotes post-antibiotic pathogen expansion
10.1038/nature18597 · 2016 · External reference
Antagonism toward the intestinal microbiota and its effect on Vibrio cholerae virulence
10.1126/science.aap8775 · 2018 · External reference
Salmonella Typhimurium utilizes a T6SS-mediated antibacterial weapon to establish in the host gut
2016 · External reference
Shigella sonnei encodes a functional T6SS used for interbacterial competition and niche occupancy
10.1016/j.chom.2017.05.004 · 2017 · External reference
Type VI secretion systems of pathogenic and commensal bacteria mediate niche occupancy in the gut
10.1016/j.celrep.2022.110731 · 2022 · External reference
Induction of ferroptosis: a new strategy for the control of bacterial infections
10.1016/j.micres.2024.127728 · 2024 · External reference
Mucin glycan foraging in the human gut microbiome
10.3389/fgene.2015.00081 · 2015 · External reference
10.4161/gmic.1.4.12778 · 2010 · Admitted local publication
Altered expression of goblet cell- and mucin glycosylation-related genes in the intestinal epithelium during infection with the nematode Nippostrongylus brasiliensis in rat
10.1111/j.1600-0463.2006.apm_353.x · 2006 · External reference
Alteration of the expression profiles of acidic mucin, sialytransferase, and sulfotransferases in the intestinal epithelium of rats infected with the nematode Nippostrongylus brasiliensis
10.1007/s00436-008-1152-8 · 2008 · External reference
Immune-driven alterations in mucin sulphation is an important mediator of Trichuris muris helminth expulsion
10.1371/journal.ppat.1006218 · 2017 · External reference
Helminth infection promotes colonization resistance via type 2 immunity
10.1126/science.aaf3229 · 2016 · External reference
Small proline-rich protein 2A is a gut bactericidal protein deployed during helminth infection
2021 · External reference
Resistin-like molecule β is a bactericidal protein that promotes spatial segregation of the microbiota and the colonic epithelium
10.1073/pnas.1711395114 · 2017 · External reference
Microbial byproducts determine reproductive fitness of free-living and parasitic nematodes
10.1016/j.chom.2022.03.015 · 2022 · External reference
Colonic transit time is related to bacterial metabolism and mucosal turnover in the gut
10.1038/nmicrobiol.2016.93 · 2016 · External reference
Manipulation of host and parasite microbiotas: survival strategies during chronic nematode infection
10.1126/sciadv.aap7399 · 2018 · External reference
Effect of chito-oligosaccharide on growth performance, intestinal barrier function, intestinal morphology and cecal microflora in weaned pigs
10.2527/jas.2011-4699 · 2012 · External reference
Dietary chitosan supplementation increases microbial diversity and attenuates the severity of Citrobacter rodentium infection in mice
10.1155/2016/9236196 · 2016 · External reference
Acetate formation in the energy metabolism of parasitic helminths and protists
10.1016/j.ijpara.2009.12.006 · 2010 · External reference
Macrobiota—helminths as active participants and partners of the microbiota in host intestinal homeostasis
10.1016/j.mib.2016.04.004 · 2016 · External reference
Microbial regulation of intestinal motility provides resistance against helminth infection
10.1038/s41385-022-00498-8 · 2022 · External reference
Recent advances in type-2-cell-mediated immunity: insights from helminth infection
10.1016/j.immuni.2017.11.015 · 2017 · External reference
