Research graph
References from Chimeric PRR T-cell-engager targeting cell surface β-1,3-glucan for invasive candidiasis. Local targets link to admitted publications; unresolved targets remain external evidence.
Global guideline for the diagnosis and management of candidiasis: an initiative of the ECMM in cooperation with ISHAM and ASM
10.1016/s1473-3099(24)00749-7 · 2025 · External reference
Hidden killers: human fungal infections
10.1126/scitranslmed.3004404 · 2012 · External reference
Nosocomial bloodstream infections in pediatric patients in United States hospitals: epidemiology, clinical features and susceptibilities
10.1097/01.inf.0000078159.53132.40 · 2003 · External reference
Candida albicans - Biology, molecular characterization, pathogenicity, and advances in diagnosis and control - An update
10.1016/j.micpath.2018.02.028 · 2018 · External reference
Invasive Candidiasis
10.1056/nejmra1315399 · 2015 · External reference
The Landscape of Candidemia During the Coronavirus Disease 2019 (COVID-19) Pandemic
10.1093/cid/ciab562 · 2022 · External reference
Mechanism of Candida pathogenesis: revisiting the vital drivers
10.1007/s10096-020-03912-w · 2020 · External reference
Changes in Prevalence of Health Care-Associated Infections in U.S. Hospitals
10.1056/nejmoa1801550 · 2018 · External reference
Invasive candidiasis
10.1038/s41572-024-00503-3 · 2024 · External reference
WHO publish fungal priority pathogens list
10.1016/s2666-5247(23)00003-4 · 2023 · External reference
Invasive candidiasis
10.1038/nrdp.2018.26 · 2018 · External reference
The Kallikrein-Kinin System: A Novel Mediator of IL-17-Driven Anti-Candida Immunity in the Kidney
10.1371/journal.ppat.1005952 · 2016 · External reference
Activation of HIF-1α and LL-37 by commensal bacteria inhibits Candida albicans colonization
10.1038/nm.3871 · 2015 · External reference
Immune defence against Candida fungal infections
10.1038/nri3897 · 2015 · External reference
Interferon-gamma as adjunctive immunotherapy for invasive fungal infections: a case series
10.1186/1471-2334-14-166 · 2014 · External reference
IL-17 regulates systemic fungal immunity by controlling the functional competence of NK cells
10.1016/j.immuni.2013.12.002 · 2014 · External reference
Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice
10.1086/422329 · 2004 · External reference
Differential effects of IL-17 pathway in disseminated candidiasis and zymosan-induced multiple organ failure
10.1097/shk.0b013e3181d67041 · 2010 · External reference
Prospects for adoptive T-cell therapy for invasive fungal disease
10.1097/qco.0000000000000403 · 2017 · External reference
Immunotherapeutic approaches to treatment of fungal diseases
10.1016/s1473-3099(17)30442-5 · 2017 · External reference
Bispecific antibodies: a mechanistic review of the pipeline
10.1038/s41573-019-0028-1 · 2019 · External reference
Programming a serial killer: CAR T cells form non-classical immune synapses
10.18632/oncoscience.406 · 2018 · External reference
Induction of regular cytolytic T cell synapses by bispecific single-chain antibody constructs on MHC class I-negative tumor cells
10.1016/j.molimm.2005.03.007 · 2006 · External reference
Serial killing of tumor cells by cytotoxic T cells redirected with a CD19-/CD3-bispecific single-chain antibody construct
10.1002/ijc.20908 · 2005 · External reference
T-cell engager antibodies enable T cells to control HBV infection and to target HBsAg-positive hepatoma in mice
10.1016/j.jhep.2021.06.022 · 2021 · External reference
Targeting HIV Reservoir in Infected CD4 T Cells by Dual-Affinity Re-targeting Molecules (DARTs) that Bind HIV Envelope and Recruit Cytotoxic T Cells
10.1371/journal.ppat.1005233 · 2015 · External reference
In Situ Liver Expression of HBsAg/CD3-Bispecific Antibodies for HBV Immunotherapy
10.1016/j.omtm.2017.08.006 · 2017 · External reference
Dectin-1 mediates macrophage recognition of Candida albicans yeast but not filaments
10.1038/sj.emboj.7600594 · 2005 · External reference
An integrated model of the recognition of Candida albicans by the innate immune system
10.1038/nrmicro1815 · 2008 · External reference
Identification of a novel, dendritic cell-associated molecule, dectin-1, by subtractive cDNA cloning
10.1074/jbc.m909512199 · 2000 · External reference
The beta-glucan receptor, dectin-1, is predominantly expressed on the surface of cells of the monocyte/macrophage and neutrophil lineages
10.4049/jimmunol.169.7.3876 · 2002 · External reference
Identification of a human homologue of the dendritic cell-associated C-type lectin-1, dectin-1
10.1016/s0378-1119(01)00528-5 · 2001 · External reference
Antibody glycosylation: impact on antibody drug characteristics and quality control
10.1007/s00253-020-10368-7 · 2020 · External reference
Characterization of the human beta -glucan receptor and its alternatively spliced isoforms
10.1074/jbc.m107715200 · 2001 · External reference
Mnn10 Maintains Pathogenicity in Candida albicans by Extending α-1,6-Mannose Backbone to Evade Host Dectin-1 Mediated Antifungal Immunity
10.1371/journal.ppat.1005617 · 2016 · External reference
Effector function activities of a panel of mutants of a broadly neutralizing antibody against human immunodeficiency virus type 1
10.1128/jvi.75.24.12161-12168.2001 · 2001 · External reference
Antifungal Th Immunity: Growing up in Family
10.3389/fimmu.2014.00506 · 2014 · External reference
Fungal dysbiosis: immunity and interactions at mucosal barriers
10.1038/nri.2017.55 · 2017 · External reference
IL-17 family cytokines and the expanding diversity of effector T cell lineages
10.1146/annurev.immunol.25.022106.141557 · 2007 · External reference
Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells
10.1038/s41591-018-0036-4 · 2018 · External reference
Quantifying antigen-specific CD4 T cells during a viral infection: CD4 T cell responses are larger than we think
10.4049/jimmunol.1102104 · 2011 · External reference
CD11a and CD49d enhance the detection of antigen-specific T cells following human vaccination
10.1016/j.vaccine.2017.06.013 · 2017 · External reference
Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage Plasmodium infection
10.1038/ni.2180 · 2011 · External reference
The T3/T cell receptor complex: antigenic distinction between the two 20-kd T3 (T3-delta and T3-epsilon) subunits
10.1002/j.1460-2075.1985.tb03634.x · 1985 · External reference
New immune cell engagers for cancer immunotherapy
10.1038/s41577-023-00982-7 · 2024 · External reference
Optimizing anti-CD3 affinity for effective T cell targeting against tumor cells
10.1002/1521-4141(200211)32:11<3102::aid-immu3102>3.0.co;2-c · 2002 · External reference
Biodistribution studies with tumor-targeting bispecific antibodies reveal selective accumulation at the tumor site
10.4161/mabs.22271 · 2012 · External reference
Relative Target Affinities of T-Cell-Dependent Bispecific Antibodies Determine Biodistribution in a Solid Tumor Mouse Model
10.1158/1535-7163.mct-17-0657 · 2018 · External reference
Optimizing Outcomes in Immunocompromised Hosts: Understanding the Role of Immunotherapy in Invasive Fungal Diseases
10.3389/fmicb.2015.01322 · 2015 · External reference
T cell-engaging therapies - BiTEs and beyond
10.1038/s41571-020-0347-5 · 2020 · External reference
T-cell-engaging bispecific antibodies in cancer
10.1016/s0140-6736(23)00521-4 · 2023 · External reference
Dectin-1 intracellular domain determines species-specific ligand spectrum by modulating receptor sensitivity
10.1074/jbc.m117.800847 · 2017 · External reference
Protein Glycosylation Investigated by Mass Spectrometry: An Overview
10.3390/cells9091986 · 2020 · External reference
Immunity to fungal infections
10.1038/nri2939 · 2011 · External reference
Adaptive immunity to fungi
10.1146/annurev-immunol-020711-074958 · 2012 · External reference
IL-10 Family Cytokines IL-10 and IL-22: from Basic Science to Clinical Translation
10.1016/j.immuni.2019.03.020 · 2019 · External reference
Cutting edge: Failure of antigen-specific CD4+ T cell recruitment to the kidney during systemic candidiasis
10.4049/jimmunol.1401675 · 2014 · External reference
Long-term antibiotic exposure promotes mortality after systemic fungal infection by driving lymphocyte dysfunction and systemic escape of commensal bacteria
10.1016/j.chom.2022.04.013 · 2022 · External reference
Microbiota-driven interleukin-17 production provides immune protection against invasive candidiasis
10.1186/s13054-020-02977-5 · 2020 · External reference
Mucosal damage and neutropenia are required for Candida albicans dissemination
2008 · External reference
Candida albicans strain maintenance, replacement, and microvariation demonstrated by multilocus sequence typing
10.1128/jcm.00934-06 · 2006 · External reference
High-resolution mycobiota analysis reveals dynamic intestinal translocation preceding invasive candidiasis
10.1038/s41591-019-0709-7 · 2020 · External reference
Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis
10.1126/science.1221789 · 2012 · External reference
Enhanced defense against Pneumocystis carinii mediated by a novel dectin-1 receptor Fc fusion protein
10.4049/jimmunol.178.6.3702 · 2007 · External reference
Bioengineering T cells to target carbohydrate to treat opportunistic fungal infection
10.1073/pnas.1312789111 · 2014 · External reference
Cytokine release syndrome
10.1186/s40425-018-0343-9 · 2018 · External reference
An anti-CD3/anti-CLL-1 bispecific antibody for the treatment of acute myeloid leukemia
10.1182/blood-2016-08-735365 · 2017 · External reference
T cell engaging bispecific antibody (T-BsAb): From technology to therapeutics
10.1016/j.pharmthera.2017.08.005 · 2018 · External reference
Interdomain spacing and spatial configuration drive the potency of IgG-[L]-scFv T cell bispecific antibodies
10.1126/scitranslmed.aax1315 · 2020 · External reference
