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References from Fish TOLLIP manipulates ATG5 for autophagic degradation of STING to attenuate antiviral interferon responses. Local targets link to admitted publications; unresolved targets remain external evidence.
Pathogen recognition and innate immunity
10.1016/j.cell.2006.02.015 · 2006 · External reference
Innate immune recognition of viral infection
10.1038/ni1303 · 2006 · External reference
Pattern recognition receptors and inflammation
10.1016/j.cell.2010.01.022 · 2010 · External reference
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
10.1038/nature07317 · 2008 · External reference
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
10.1038/nature04734 · 2006 · External reference
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
10.1038/ni1243 · 2005 · External reference
The crosstalk between DNA-damage responses and innate immunity
10.1016/j.intimp.2024.112768 · 2024 · External reference
Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction
10.1016/s1074-7613(00)00053-4 · 2000 · External reference
Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation
2015 · External reference
Pattern recognition receptors in zebrafish provide functional and evolutionary insight into innate immune signaling pathways
10.1038/cmi.2016.50 · 2017 · External reference
Mitochondrial antiviral signaling protein plays a major role in induction of the fish innate immune response against RNA and DNA viruses
10.1128/jvi.00404-09 · 2009 · External reference
Molecular characterizations of grass carp (Ctenopharyngodon idella) TBK1 gene and its roles in regulating IFN-I pathway
10.1016/j.dci.2014.03.018 · 2014 · External reference
Fish MITA serves as a mediator for distinct fish IFN gene activation dependent on IRF3 or IRF7
10.4049/jimmunol.1100642 · 2011 · External reference
The LxIS motif is the language between virus and host RLRs: From fish to mammalian viruses
10.1016/j.watbs.2024.100246 · 2024 · External reference
Antiviral immune responses: triggers of or triggered by autoimmunity?
10.1038/nri2527 · 2009 · External reference
MITA/STING-mediated antiviral immunity and autoimmunity: the evolution, mechanism, and intervention
10.1016/j.coi.2022.102248 · 2022 · External reference
The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA
10.1016/j.immuni.2009.01.008 · 2009 · External reference
PELI2 is a negative regulator of STING signaling that is dynamically repressed during viral infection
10.1016/j.molcel.2024.06.001 · 2024 · External reference
Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins
10.1073/pnas.1603269113 · 2016 · External reference
Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation
10.1016/j.celrep.2019.03.098 · 2019 · External reference
The antiviral role of largemouth bass STING against iridovirus infection
10.1016/j.fsi.2024.109480 · 2024 · External reference
A zebrafish NLRX1 isoform downregulates fish IFN responses by targeting the adaptor STING
10.1128/jvi.01801-23 · 2024 · External reference
Fish female-biased gene cyp19a1a leads to female antiviral response attenuation between sexes by autophagic degradation of MITA
2022 · External reference
Grass carp cGASL negatively regulates fish IFN response by targeting MITA
10.1016/j.fsi.2019.10.010 · 2019 · External reference
An overview of autophagy: morphology, mechanism, and regulation
10.1089/ars.2013.5371 · 2014 · External reference
The mechanisms and roles of selective autophagy in mammals
10.1038/s41580-022-00542-2 · 2023 · External reference
The role of Atg proteins in autophagosome formation
10.1146/annurev-cellbio-092910-154005 · 2011 · External reference
Mechanisms of Selective Autophagy
10.1146/annurev-cellbio-120219-035530 · 2021 · External reference
A guide to the regulation of selective autophagy receptors
10.1111/febs.15824 · 2022 · External reference
Selective Autophagy: ATG8 Family Proteins, LIR Motifs and Cargo Receptors
10.1016/j.jmb.2019.07.016 · 2020 · External reference
Autophagy during viral infection - a double-edged sword
10.1038/s41579-018-0003-6 · 2018 · External reference
Tetherin Suppresses Type I Interferon Signaling by Targeting MAVS for NDP52-Mediated Selective Autophagic Degradation in Human Cells
2017 · External reference
UNC93B1 attenuates the cGAS-STING signaling pathway by targeting STING for autophagy-lysosome degradation
10.1002/jmv.27860 · 2022 · External reference
Zebrafish TMEM47 is an effective blocker of IFN production during RNA and DNA virus infection
2023 · External reference
Rethinking fish biology and biotechnologies in the challenge era for burgeoning genome resources and strengthening food security
10.1016/j.watbs.2021.11.001 · 2022 · External reference
Toll-interacting protein impacts on inflammation, autophagy, and vacuole trafficking in human disease
10.1007/s00109-020-01999-4 · 2021 · External reference
Negative regulation of toll-like receptor-mediated signaling by Tollip
10.1074/jbc.m109537200 · 2002 · External reference
Tom1, a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin
10.1074/jbc.m306740200 · 2003 · External reference
Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor
10.1038/35014038 · 2000 · External reference
Homeostatic regulation of STING protein at the resting state by stabilizer TOLLIP
10.1038/s41590-019-0569-9 · 2020 · External reference
Toll-interacting protein in the freshwater fish Labeo rohita exhibits conserved structural motifs of higher eukaryotes and is distinctly expressed in pathogen-associated molecular pattern stimulations and bacterial infections
10.1111/1348-0421.12792 · 2021 · External reference
Tollip suppresses MyD88-mediated NF-κB activation by enhancing MyD88 ubiquitination levels in large yellow croaker (Larimichthys crocea)
10.1016/j.fsi.2022.08.038 · 2022 · External reference
Molecular characterization, expression patterns, and functional analysis of toll-interacting protein (Tollip) in Japanese eel Anguilla japonica
10.1016/j.fsi.2019.04.053 · 2019 · External reference
Identification, characterization and the interaction of Tollip and IRAK-1 in grass carp (Ctenopharyngodon idellus)
10.1016/j.fsi.2012.05.025 · 2012 · External reference
Inhibitor analysis revealed that clathrin-mediated endocytosis is involed in cellular entry of type III grass carp reovirus
10.1186/s12985-018-0993-8 · 2018 · External reference
Comparison of the blood parameters and histopathology between grass carp infected with a virulent and avirulent isolates of genotype II grass carp reovirus
10.1016/j.micpath.2019.103859 · 2020 · External reference
Differences in responses of grass carp to different types of grass carp reovirus (GCRV) and the mechanism of hemorrhage revealed by transcriptome sequencing
10.1186/s12864-017-3824-1 · 2017 · External reference
Spring Viremia of Carp Virus N Protein Suppresses Fish IFNφ1 Production by Targeting the Mitochondrial Antiviral Signaling Protein
10.4049/jimmunol.1502038 · 2016 · External reference
Spring viraemia of carp virus modulates p53 expression using two distinct mechanisms
2019 · External reference
Grass Carp Reovirus (GCRV) Giving Its All to Suppress IFN Production by Countering MAVS Signaling Transduction
10.3389/fimmu.2020.545302 · 2020 · External reference
Interferon stimulated binding of ISRE is cell type specific and is predicted by homeostatic chromatin state
10.1016/j.cytox.2021.100056 · 2021 · External reference
Spring Viremia of Carp Virus N Protein Negatively Regulates IFN Induction through Autophagy-Lysosome-Dependent Degradation of STING
10.4049/jimmunol.2200477 · 2023 · External reference
GCRV NS38 counteracts SVCV proliferation by intracellular antagonization during co-infection
10.1016/j.virs.2022.12.003 · 2023 · External reference
Fe2+ inhibits spring viraemia of carp virus proliferation via ATG14-dependent autophagy
10.1016/j.aquaculture.2024.741858 · 2025 · External reference
Fine tuning type I interferon responses
10.1016/j.cytogfr.2013.04.002 · 2013 · External reference
Interferon-stimulated genes: a complex web of host defenses
10.1146/annurev-immunol-032713-120231 · 2014 · External reference
The alpha-coronavirus E protein inhibits the JAK-STAT pathway signaling by triggering STAT2 degradation through OPTN- and NBR1-mediated selective autophagy
10.1080/15548627.2025.2479671 · 2025 · External reference
Fish herpesvirus KLP manipulates Beclin1 to selectively degrade MITA through a precise autophagic manner for immune evasion
10.1016/j.watbs.2022.100092 · 2023 · External reference
Grass carp reovirus VP4 manipulates TOLLIP to degrade STING for inhibition of IFN production
2025 · External reference
Pseudorabies virus UL38 attenuates the cGAS-STING signaling pathway by recruiting Tollip to promote STING for autophagy degradation
10.1186/s12985-024-02379-x · 2024 · External reference
Tollip deficiency enhances mitophagy and reduces STING activation in influenza A virus-infected mice
10.1093/jimmun/vkaf058 · 2025 · External reference
Tollip coordinates Parkin-dependent trafficking of mitochondrial-derived vesicles
2020 · External reference
MARCH6 suppresses Tembusu virus replication by targeting viral NS5 protein for TOLLIP-mediated selective autophagic degradation
10.1128/jvi.00735-25 · 2025 · External reference
Autophagic clearance of polyQ proteins mediated by ubiquitin-Atg8 adaptors of the conserved CUET protein family
10.1016/j.cell.2014.05.048 · 2014 · External reference
