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References from A non-canonical activation of the host’s ESCRT machinery is required for the scission of parasitophorous vacuoles and the replication of Leishmania donovani. Local targets link to admitted publications; unresolved targets remain external evidence.
Comprehensive insights into leishmaniasis: From etiopathogenesis to a novel therapeutic approach
10.1016/j.micpath.2025.107535 · 2025 · External reference
Leishmaniasis: clinical syndromes and treatment
10.1093/qjmed/hct116 · 2014 · External reference
Dual-scRNA-seq analysis reveals rare and uncommon parasitized cell populations in chronic L. donovani infection
10.1016/j.celrep.2023.113097 · 2023 · External reference
Leishmania species: models of intracellular parasitism
10.1242/jcs.112.18.2993 · 1999 · External reference
Interactions of pathogen-containing compartments with the secretory pathway
10.1111/cmi.12000 · 2012 · External reference
Leishmania parasitophorous vacuoles interact continuously with the host cell’s endoplasmic reticulum; parasitophorous vacuoles are hybrid compartments
10.1111/j.1462-5822.2010.01483.x · 2010 · External reference
Inhibition of phagolysosomal biogenesis by the Leishmania lipophosphoglycan
10.1084/jem.185.12.2061 · 1997 · External reference
The biogenesis and properties of the parasitophorous vacuoles that harbour Leishmania in murine macrophages
10.1016/s0966-842x(98)01324-9 · 1998 · External reference
Quantitative single-cell analysis of Leishmania major amastigote differentiation demonstrates variably extended expression of the lipophosphoglycan (LPG) virulence factor in different host cell types
10.1371/journal.pntd.0010893 · 2022 · External reference
Regulation dynamics of Leishmania differentiation: deconvoluting signals and identifying phosphorylation trends
10.1074/mcp.m114.037705 · 2014 · External reference
ER-mitochondria contacts couple mtDNA synthesis with mitochondrial division in human cells
10.1126/science.aaf5549 · 2016 · External reference
Cell biology: The organelle replication connection
10.1038/538326b · 2016 · External reference
Prazoles Targeting Tsg101 Inhibit Release of Epstein-Barr Virus following Reactivation from Latency
10.1128/jvi.02466-20 · 2021 · External reference
The Protein Network of HIV Budding
10.1016/s0092-8674(03)00714-1 · 2003 · External reference
Dynamics of endosomal sorting complex required for transport (ESCRT) machinery during cytokinesis and its role in abscission
10.1073/pnas.1102714108 · 2011 · External reference
ESCRT-dependent control of membrane remodelling during cell division
10.1016/j.semcdb.2017.08.035 · 2018 · External reference
STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes
10.1074/jbc.m210843200 · 2003 · External reference
The ESCRT complexes
10.3109/10409238.2010.502516 · 2010 · External reference
Structure of the ESCRT-II endosomal trafficking complex
10.1038/nature02914 · 2004 · External reference
Structure and function of ESCRT-III
10.1042/bst0370156 · 2009 · External reference
ALIX- and ESCRT-III-dependent sorting of tetraspanins to exosomes
10.1083/jcb.201904113 · 2020 · External reference
Dynamic subunit turnover in ESCRT-III assemblies is regulated by Vps4 to mediate membrane remodelling during cytokinesis
10.1038/ncb3559 · 2017 · External reference
Endosome-associated complex, ESCRT-II, recruits transport machinery for protein sorting at the multivesicular body
10.1016/s1534-5807(02)00219-8 · 2002 · External reference
Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I
10.1016/s0092-8674(01)00434-2 · 2001 · External reference
Novel ESCRT functions in cell biology: spiraling out of control?
10.1016/j.ceb.2016.03.008 · 2016 · External reference
ALIX and ESCRT-I/II function as parallel ESCRT-III recruiters in cytokinetic abscission
10.1083/jcb.201507009 · 2016 · External reference
Differential requirements for Alix and ESCRT-III in cytokinesis and HIV-1 release
10.1073/pnas.0802008105 · 2008 · External reference
Midbody Targeting of the ESCRT Machinery by a Noncanonical Coiled Coil in CEP55
10.1126/science.1162042 · 2008 · External reference
Centrosomal ALIX regulates mitotic spindle orientation by modulating astral microtubule dynamics
10.15252/embj.201797741 · 2018 · External reference
ESCRT machinery is required for plasma membrane repair
10.1126/science.1247136 · 2014 · External reference
IST1 regulates select recycling pathways
10.1111/tra.12921 · 2024 · External reference
A chemical inhibitor of IST1-CHMP1B interaction impairs endosomal recycling and induces noncanonical LC3 lipidation
10.1073/pnas.2317680121 · 2024 · External reference
Nuclear and degradative functions of the ESCRT-III pathway: implications for neurodegenerative disease
10.1080/19491034.2024.2349085 · 2024 · External reference
The multifaceted interactions between pathogens and host ESCRT machinery
10.1371/journal.ppat.1011344 · 2023 · External reference
The ESCRT Machinery: Remodeling, Repairing, and Sealing Membranes
10.3390/membranes12060633 · 2022 · External reference
The many functions of ESCRTs
10.1038/s41580-019-0177-4 · 2019 · External reference
Mycobacterium tuberculosis activates the DNA-dependent cytosolic surveillance pathway within macrophages
10.1016/j.chom.2012.03.007 · 2012 · External reference
Mycobacterium tuberculosis Type VII Secretion System Effectors Differentially Impact the ESCRT Endomembrane Damage Response
10.1128/mbio.01765-18 · 2018 · External reference
Galectin-3 Coordinates a Cellular System for Lysosomal Repair and Removal
2020 · External reference
The ESCRT and autophagy machineries cooperate to repair ESX-1-dependent damage at the Mycobacterium-containing vacuole but have opposite impact on containing the infection
2018 · External reference
A TRAF-like E3 ubiquitin ligase TrafE coordinates ESCRT and autophagy in endolysosomal damage response and cell-autonomous immunity to Mycobacterium marinum
10.7554/elife.85727 · 2023 · External reference
Role of the ESCRT-III complex in controlling integrity of the Salmonella-containing vacuole
10.1111/cmi.13176 · 2020 · External reference
ESCRT ‐mediated lysosome repair precedes lysophagy and promotes cell survival
10.15252/embj.201899753 · 2018 · External reference
Proximity-Labeling Reveals Novel Host and Parasite Proteins at the Toxoplasma Parasitophorous Vacuole Membrane
10.1128/mbio.00260-21 · 2021 · External reference
Toxoplasma gondii exploits the host ESCRT machinery for parasite uptake of host cytosolic proteins
10.1371/journal.ppat.1010138 · 2021 · External reference
Cytokinetic Abscission: Phosphoinositides and ESCRTs Direct the Final Cut
10.1002/jcb.26066 · 2017 · External reference
PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation
10.1126/science.abk0410 · 2021 · External reference
Inhibition of PIKFYVE kinase interferes ESCRT pathway to suppress RNA virus replication
2023 · External reference
Leishmania-infected macrophages release extracellular vesicles that can promote lesion development
10.26508/lsa.202000742 · 2020 · External reference
ATPase-defective mammalian VPS4 localizes to aberrant endosomes and impairs cholesterol trafficking
10.1091/mbc.11.1.227 · 2000 · External reference
Phagocytosis: latex leads the way
10.1016/s0955-0674(03)00083-8 · 2003 · External reference
Leishmania parasitophorous vacuole membranes display phosphoinositides that create conditions for continuous Akt activation and a target for miltefosine in Leishmania infections
10.1111/cmi.12889 · 2018 · External reference
Designed proteins induce the formation of nanocage-containing extracellular vesicles
10.1038/nature20607 · 2016 · External reference
Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury
10.1038/emboj.2013.171 · 2013 · External reference
Phosphoinositides as membrane organizers
10.1038/s41580-022-00490-x · 2022 · External reference
The PI3 Kinase Complex II-PI3P-Vps27 Axis on Vacuolar Membranes is Critical for Microautophagy Induction and Nutrient Stress Adaptation
10.1016/j.jmb.2021.167360 · 2022 · External reference
ALIX Catches HIV
10.1016/j.chom.2007.02.006 · 2007 · External reference
Negative membrane curvature catalyzes nucleation of endosomal sorting complex required for transport (ESCRT)-III assembly
10.1073/pnas.1518765113 · 2015 · External reference
Identification and overexpression of the A2 amastigote-specific protein in Leishmania donovani
10.1016/s0166-6851(96)02612-6 · 1996 · External reference
Restoration of lysosomal function after damage is accompanied by recycling of lysosomal membrane proteins
10.1038/s41419-020-2527-8 · 2020 · External reference
Mechanism of L-leucyl-L-leucine methyl ester-mediated killing of cytotoxic lymphocytes: dependence on a lysosomal thiol protease, dipeptidyl peptidase I, that is enriched in these cells
10.1073/pnas.87.1.83 · 1990 · External reference
MERIT, a cellular system coordinating lysosomal repair, removal and replacement
10.1080/15548627.2020.1779451 · 2020 · External reference
Alix-Mediated Rescue of Feline Immunodeficiency Virus Budding Differs from That Observed with Human Immunodeficiency Virus
10.1128/jvi.02019-19 · 2020 · External reference
Structural and Functional Study of Apoptosis-linked Gene-2·Heme-binding Protein 2 Interactions in HIV-1 Production
10.1074/jbc.m116.752444 · 2016 · External reference
The ESCRT pathway and HIV-1 budding
10.1042/bst0370181 · 2009 · External reference
A parasite rescue and transformation assay for antileishmanial screening against intracellular Leishmania donovani amastigotes in THP1 human acute monocytic leukemia cell line
2012 · External reference
