Research graph
References from Coronavirus M protein impairs cilium during early infection by enhancing the AurA-HDAC6 axis. Local targets link to admitted publications; unresolved targets remain external evidence.
Coronavirus biology and replication: implications for SARS-CoV-2
10.1038/s41579-020-00468-6 · 2021 · External reference
SARS-CoV-2 biology and host interactions
10.1038/s41579-023-01003-z · 2024 · External reference
IBV QX affects the antigen presentation function of BMDCs through nonstructural protein16
10.1016/j.psj.2023.102620 · 2023 · External reference
Adaptive truncation of the S gene in IBV during chicken embryo passaging plays a crucial role in its attenuation
10.1371/journal.ppat.1012415 · 2024 · External reference
Virus-derived siRNA: Coronavirus and influenza virus trigger antiviral RNAi immunity in birds
2025 · External reference
Mini-review: microbiota have potential to prevent PEDV infection by improved intestinal barrier
10.3389/fimmu.2023.1230937 · 2023 · External reference
Effective inhibition of PDCoV infection in chimeric APN gene-edited neonatal pigs
2024 · External reference
Recombinant bivalent subunit vaccine combining truncated VP4 from P[7] and P[23] induces protective immunity against prevalent porcine rotaviruses
10.1128/jvi.00212-24 · 2024 · External reference
Structural specializations of the sperm tail
10.1016/j.cell.2023.05.026 · 2023 · External reference
Structure of the Decorated Ciliary Doublet Microtubule
2019 · External reference
The dynamic and structural properties of axonemal tubulins support the high length stability of cilia
10.1038/s41467-019-09779-6 · 2019 · External reference
Cellular signalling by primary cilia in development, organ function and disease
10.1038/s41581-019-0116-9 · 2019 · External reference
Hedgehog pathway, cell cycle, and primary cilium
10.1038/s41420-025-02605-7 · 2025 · External reference
Ciliogenesis: building the cell’s antenna
10.1038/nrm3085 · 2011 · External reference
Porcine epidemic diarrhea virus M protein blocks cell cycle progression at S-phase and its subcellular localization in the porcine intestinal epithelial cells
10.4149/av_2015_03_265 · 2015 · External reference
Up-regulated 60S ribosomal protein L18 in PEDV N protein-induced S-phase arrested host cells promotes viral replication
10.1016/j.virusres.2022.198916 · 2022 · External reference
SARS-CoV-2 ORF10 impairs cilia by enhancing CUL2ZYG11B activity
10.1083/jcb.202108015 · 2022 · External reference
SARS-CoV-2 Infection Dysregulates Cilia and Basal Cell Homeostasis in the Respiratory Epithelium of Hamsters
10.3390/ijms23095124 · 2022 · External reference
SARS-CoV-2 infection induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance
10.1038/s41467-021-24521-x · 2021 · External reference
Recombinant live attenuated avian coronavirus vaccines with deletions in the accessory genes 3ab and/or 5ab protect against infectious bronchitis in chickens
10.1016/j.vaccine.2018.01.017 · 2018 · External reference
Erasers of histone acetylation: the histone deacetylase enzymes
10.1101/cshperspect.a018713 · 2014 · External reference
HDAC6 is a microtubule-associated deacetylase
10.1038/417455a · 2002 · External reference
HEF1-dependent Aurora A activation induces disassembly of the primary cilium
10.1016/j.cell.2007.04.035 · 2007 · External reference
Cleavage of HDAC6 to dampen its antiviral activity by nsp5 is a common strategy of swine enteric coronaviruses
2024 · External reference
The ZIKV NS5 Protein Aberrantly Alters the Tubulin Cytoskeleton, Induces the Accumulation of Autophagic p62 and Affects IFN Production: HDAC6 Has Emerged as an Anti-NS5/ZIKV Factor
10.3390/cells13070598 · 2024 · External reference
Curriculum vitae of HDAC6 in solid tumors
10.1016/j.ijbiomac.2023.123219 · 2023 · External reference
miR449 Protects Airway Regeneration by Controlling AURKA/HDAC6-Mediated Ciliary Disassembly
10.3390/ijms23147749 · 2022 · External reference
HDAC6 Degrades nsp8 of Porcine Deltacoronavirus through Deacetylation and Ubiquitination to Inhibit Viral Replication
2023 · External reference
Sufu negatively regulates both initiations of centrosome duplication and DNA replication
10.1073/pnas.2026421118 · 2021 · External reference
The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation
10.1038/sj.onc.1203847 · 2000 · External reference
Nek2 activation of Kif24 ensures cilium disassembly during the cell cycle
10.1038/ncomms9087 · 2015 · External reference
Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib
10.1016/j.ebiom.2024.105368 · 2024 · External reference
The gE/gI complex is necessary for kinesin-1 recruitment during alphaherpesvirus egress from neurons
2024 · External reference
HDAC6 at Crossroads of Infection and Innate Immunity
10.1016/j.it.2018.05.004 · 2018 · External reference
The HDOCK server for integrated protein-protein docking
10.1038/s41596-020-0312-x · 2020 · External reference
HawkDock: a web server to predict and analyze the protein-protein complex based on computational docking and MM/GBSA
10.1093/nar/gkz397 · 2019 · External reference
A resource database for protein kinase substrate sequence-preference motifs based on large-scale mass spectrometry data
10.1186/s12964-023-01436-2 · 2024 · External reference
The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation
10.1371/journal.ppat.1009412 · 2021 · External reference
High-sensitivity profiling of SARS-CoV-2 noncoding region-host protein interactome reveals the potential regulatory role of negative-sense viral RNA
2023 · External reference
Origin and evolution of pathogenic coronaviruses
10.1038/s41579-018-0118-9 · 2019 · External reference
Efficacy evaluation of a bivalent subunit vaccine against epidemic PEDV heterologous strains with low cross-protection
10.1128/jvi.01309-24 · 2024 · External reference
PEDV-spike-protein-expressing mRNA vaccine protects piglets against PEDV challenge
10.1128/mbio.02958-23 · 2024 · External reference
A spike-based mRNA vaccine that induces durable and broad protection against porcine deltacoronavirus in piglets
2024 · External reference
Marek’s disease virus Meq oncoprotein interacts with chicken HDAC 1 and 2 and mediates their degradation via proteasome dependent pathway
10.1038/s41598-020-80792-2 · 2021 · External reference
Knockout of HDAC9 Gene Enhances Foot-and-Mouth Disease Virus Replication
10.3389/fmicb.2022.805606 · 2022 · External reference
Histone deacetylase 6 inhibits influenza A virus release by downregulating the trafficking of viral components to the plasma membrane via its substrate, acetylated microtubules
10.1128/jvi.00727-14 · 2014 · External reference
HDAC6 Triggers the ATM-Dependent DNA Damage Response To Promote PRV Replication
2023 · External reference
Deacetylation of α-tubulin and cortactin is required for HDAC6 to trigger ciliary disassembly
10.1038/srep12917 · 2015 · External reference
Sub-toxic levels of cobalt ions impair chondrocyte mechanostranduction via HDAC6-dependent primary cilia shortening
10.1016/j.bbrc.2021.01.041 · 2021 · External reference
Overexpression of Histone Deacetylase 6 Enhances Resistance to Porcine Reproductive and Respiratory Syndrome Virus in Pigs
2017 · External reference
PCV2 targets cGAS to inhibit type I interferon induction to promote other DNA virus infection
10.1371/journal.ppat.1009940 · 2021 · External reference
Histone acetylation regulates BMMCs recognition of foot-and-mouth disease virus-like particles
10.1016/j.intimp.2023.110428 · 2023 · External reference
Life in lockdown: Orchestrating endoplasmic reticulum and lysosome homeostasis for quiescent cells
10.1016/j.molcel.2022.08.005 · 2022 · External reference
Centromeres as universal hotspots of DNA breakage, driving RAD51-mediated recombination during quiescence
2023 · External reference
Trichoplein and Aurora A block aberrant primary cilia assembly in proliferating cells
10.1083/jcb.201106101 · 2012 · External reference
Nuclear localisation of Aurora-A: its regulation and significance for Aurora-A functions in cancer
10.1038/s41388-021-01766-w · 2021 · External reference
Can cilia provide an entry gateway for SARS-CoV-2 to human ciliated cells?
10.1152/physiolgenomics.00015.2021 · 2021 · External reference
Dynamic Dissection of Dynein and Kinesin-1 Cooperatively Mediated Intercellular Transport of Porcine Epidemic Diarrhea Coronavirus along Microtubule Using Single Virus Tracking
10.1080/21505594.2021.1878748 · 2021 · External reference
The Role of HDAC6 in Autophagy and NLRP3 Inflammasome
10.3389/fimmu.2021.763831 · 2021 · External reference
SWISS-MODEL: homology modelling of protein structures and complexes
10.1093/nar/gky427 · 2018 · External reference
AlphaFold Protein Structure Database in 2024: providing structure coverage for over 214 million protein sequences
10.1093/nar/gkad1011 · 2024 · External reference
Accurate structure prediction of biomolecular interactions with AlphaFold 3
10.1038/s41586-024-07487-w · 2024 · External reference
