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References from Regulation of host immunity by a novel Legionella pneumophila E3 ubiquitin ligase. Local targets link to admitted publications; unresolved targets remain external evidence.
The ubiquitin system
10.1146/annurev.biochem.67.1.425 · 1998 · External reference
Exploitation of the host ubiquitin system by human bacterial pathogens
10.1038/nrmicro3259 · 2014 · External reference
Bacterial interference of ubiquitination and deubiquitination
10.1016/j.chom.2007.02.003 · 2007 · External reference
Hijacking of the host ubiquitin network by Legionella pneumophila
10.3389/fcimb.2017.00487 · 2017 · External reference
Formation of a pathogen vacuole according to Legionella pneumophila: how to kill one bird with many stones
10.1111/cmi.12450 · 2015 · External reference
Legionella pneumophila, armed to the hilt: justifying the largest arsenal of effectors in the bacterial world
10.1016/j.mib.2015.11.002 · 2016 · External reference
Legionella and Coxiella effectors: strength in diversity and activity
10.1038/nrmicro.2017.67 · 2017 · External reference
Exploitation of the host ubiquitin system: means by Legionella pneumophila
10.3389/fmicb.2021.790442 · 2021 · External reference
Molecular mimicry by an F-box effector of Legionella pneumophila hijacks a conserved polyubiquitination machinery within macrophages and protozoa
10.1371/journal.ppat.1000704 · 2009 · External reference
A Warburg shakeup
10.1038/nchembio.751 · 2011 · External reference
E3 ubiquitin ligase activity and targeting of BAT3 by multiple Legionella pneumophila translocated substrates
10.1128/iai.00344-10 · 2010 · External reference
The Legionella pneumophila F-box protein Lpp2082 (AnkB) modulates ubiquitination of the host protein parvin B and promotes intracellular replication
10.1111/j.1462-5822.2010.01467.x · 2010 · External reference
Legionella translocates an E3 ubiquitin ligase that has multiple U-boxes with distinct functions
10.1111/j.1365-2958.2008.06124.x · 2008 · External reference
Legionella metaeffector exploits host proteasome to temporally regulate cognate effector
10.1371/journal.ppat.1001216 · 2010 · External reference
Host cell-catalyzed S-Palmitoylation mediates Golgi targeting of the Legionella Ubiquitin Ligase GobX
10.1074/jbc.m115.637397 · 2015 · External reference
Structural mimicry by a bacterial F Box Effector Hijacks the Host Ubiquitin-Proteasome System
10.1016/j.str.2016.12.015 · 2017 · External reference
Systematic identification of host cell regulators of Legionella pneumophila pathogenesis using a genome-wide CRISPR screen
2019 · External reference
Ubiquitination of Sec22b by a novel Legionella pneumophila ubiquitin E3 ligase
2023 · External reference
RavN is a member of a previously unrecognized group of Legionella pneumophila E3 ubiquitin ligases
2018 · External reference
DUBs at a glance
10.1242/jcs.041046 · 2009 · External reference
Structural basis of substrate recognition by a bacterial deubiquitinase important for dynamics of phagosome ubiquitination
10.1073/pnas.1514568112 · 2015 · External reference
LotA, a Legionella deubiquitinase, has dual catalytic activity and contributes to intracellular growth
10.1111/cmi.12840 · 2018 · External reference
The bacterial deubiquitinase Ceg23 regulates the association of Lys-63-linked polyubiquitin molecules on the Legionella phagosome
10.1074/jbc.ra119.011758 · 2020 · External reference
Identification and characterization of diverse OTU deubiquitinases in bacteria
10.15252/embj.2020105127 · 2020 · External reference
Bacterial OTU deubiquitinases regulate substrate ubiquitination upon Legionella infection
10.7554/elife.58277 · 2020 · External reference
Interplay between bacterial deubiquitinase and ubiquitin E3 ligase regulates ubiquitin dynamics on Legionella phagosomes
2020 · External reference
Otubains: a new family of cysteine proteases in the ubiquitin pathway
10.1038/sj.embor.embor824 · 2003 · External reference
Legionella manipulates non-canonical SNARE pairing using a bacterial deubiquitinase
10.1016/j.celrep.2020.108107 · 2020 · External reference
A bacterial effector deubiquitinase specifically hydrolyses linear ubiquitin chains to inhibit host inflammatory signalling
10.1038/s41564-019-0454-1 · 2019 · External reference
The UBE2D ubiquitin conjugating enzymes: Potential regulatory hubs in development, disease and evolution
10.3389/fcell.2022.1058751 · 2022 · External reference
Legionella effector MavC targets the Ube2N~Ub conjugate for noncanonical ubiquitination
10.1038/s41467-020-16211-x · 2020 · External reference
Legionella pneumophila inhibits immune signalling via MavC-mediated transglutaminase-induced ubiquitination of UBE2N
10.1038/s41564-018-0282-8 · 2019 · External reference
Discovery of ubiquitin deamidases in the pathogenic arsenal of Legionella pneumophila
10.1016/j.celrep.2018.03.060 · 2018 · External reference
Legionella pneumophila regulates the activity of UBE2N by deamidase-mediated deubiquitination
2020 · External reference
Multiple substrates of the Legionella pneumophila Dot/Icm system identified by interbacterial protein transfer
10.1073/pnas.0304916101 · 2004 · External reference
Ubiquitination independent of E1 and E2 enzymes by bacterial effectors
10.1038/nature17657 · 2016 · External reference
Phosphoribosylation of ubiquitin promotes serine ubiquitination and impairs conventional ubiquitination
10.1016/j.cell.2016.11.019 · 2016 · External reference
A single Legionella effector catalyzes a multistep ubiquitination pathway to rearrange tubular endoplasmic reticulum for replication
10.1016/j.chom.2016.12.007 · 2017 · External reference
Legionella hijacks the host Golgi-to-ER retrograde pathway for the association of Legionella-containing vacuole with the ER
10.1371/journal.ppat.1009437 · 2021 · External reference
Regulation of phosphoribosyl-linked serine ubiquitination by deubiquitinases DupA and DupB
10.1016/j.molcel.2019.10.019 · 2020 · External reference
Deubiquitination of phosphoribosyl-ubiquitin conjugates by phosphodiesterase-domain-containing Legionella effectors
10.1073/pnas.1916287116 · 2019 · External reference
Inhibition of bacterial ubiquitin ligases by SidJ-calmodulin catalysed glutamylation
10.1038/s41586-019-1440-8 · 2019 · External reference
Bacterial pseudokinase catalyzes protein polyglutamylation to inhibit the SidE-family ubiquitin ligases
10.1126/science.aaw7446 · 2019 · External reference
Regulation of phosphoribosyl ubiquitination by a calmodulin-dependent glutamylase
10.1038/s41586-019-1439-1 · 2019 · External reference
Protein polyglutamylation catalyzed by the bacterial calmodulin-dependent pseudokinase SidJ
10.7554/elife.51162 · 2019 · External reference
The Legionella pneumophila effector SidJ is required for efficient recruitment of endoplasmic reticulum proteins to the bacterial phagosome
10.1128/iai.01278-06 · 2007 · External reference
Legionella effector LnaB is a phosphoryl-AMPylase that impairs phosphosignalling
10.1038/s41586-024-07573-z · 2024 · External reference
Legionella maintains host cell ubiquitin homeostasis by effectors with unique catalytic mechanisms
10.1038/s41467-024-50311-2 · 2024 · External reference
A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells
10.1083/jcb.201112098 · 2012 · External reference
Enhanced Purification of Ubiquitinated Proteins by Engineered Tandem Hybrid Ubiquitin-binding Domains (ThUBDs)
10.1074/mcp.o115.051839 · 2016 · External reference
Proximity labeling in mammalian cells with TurboID and split-TurboID
10.1038/s41596-020-0399-0 · 2020 · External reference
The Legionella effector SidC defines a unique family of ubiquitin ligases important for bacterial phagosomal remodeling
10.1073/pnas.1402605111 · 2014 · External reference
Structural insights into the catalysis and regulation of E3 ubiquitin ligases
10.1038/nrm.2016.91 · 2016 · External reference
E2 enzymes: more than just middle men
10.1038/cr.2016.35 · 2016 · External reference
The HHpred interactive server for protein homology detection and structure prediction
10.1093/nar/gki408 · 2005 · External reference
Highly accurate protein structure prediction with AlphaFold
10.1038/s41586-021-03819-2 · 2021 · External reference
The Legionella pneumophila replication vacuole: making a cosy niche inside host cells
10.1038/nrmicro1967 · 2008 · External reference
Intracellular growth of Legionella pneumophila in Dictyostelium discoideum, a system for genetic analysis of host-pathogen interactions
10.1128/iai.68.5.2939-2947.2000 · 2000 · External reference
Two distinct defects in intracellular growth complemented by a single genetic locus in Legionella pneumophila
10.1111/j.1365-2958.1993.tb01092.x · 1993 · External reference
Altered intracellular targeting properties associated with mutations in the Legionella pneumophila dotA gene
10.1111/j.1365-2958.1994.tb01317.x · 1994 · External reference
Legionella pneumophila, a Rosetta stone to understanding bacterial pathogenesis
10.1128/jb.00324-24 · 2024 · External reference
Ubiquitin-Activated Interaction Traps (UBAITs) identify E3 ligase binding partners
10.15252/embr.201540620 · 2015 · External reference
The giant E3 ligase HUWE1 is linked to tumorigenesis, spermatogenesis, intellectual disability, and inflammatory diseases
10.3389/fcimb.2022.905906 · 2022 · External reference
Actin remodeling mediates ROS production and JNK activation to drive apoptosis-induced proliferation
10.1371/journal.pgen.1010533 · 2022 · External reference
The role of cullin 5-containing ubiquitin ligases
10.1186/s13008-016-0016-3 · 2016 · External reference
TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes
10.1038/emboj.2013.209 · 2013 · External reference
ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection
10.1016/j.chom.2019.05.008 · 2019 · External reference
ARIH2 ubiquitinates NLRP3 and negatively regulates NLRP3 inflammasome activation in macrophages
10.4049/jimmunol.1700184 · 2017 · External reference
Shigella ubiquitin ligase IpaH7.8 targets gasdermin D for degradation to prevent pyroptosis and enable infection
10.1016/j.chom.2021.08.010 · 2021 · External reference
Ubiquitination and degradation of GBPs by a Shigella effector to suppress host defence
10.1038/nature24467 · 2017 · External reference
Ubiquitin chain diversity at a glance
10.1242/jcs.183954 · 2016 · External reference
Legionella effectors SidC/SdcA ubiquitinate multiple small GTPases and SNARE proteins to promote phagosomal maturation
10.1007/s00018-024-05271-7 · 2024 · External reference
The inflammation-associated Salmonella SopA is a HECT-like E3 ubiquitin ligase
10.1111/j.1365-2958.2006.05407.x · 2006 · External reference
The Salmonella Effector Protein SopA modulates innate immune responses by targeting TRIM E3 ligase family members
10.1371/journal.ppat.1005552 · 2016 · External reference
Bacterial effector modulation of host E3 ligase activity suppresses PAMP-triggered immunity in rice
10.1038/ncomms6430 · 2014 · External reference
A Legionella type IV effector activates the NF-κB pathway by phosphorylating the IκB family of inhibitors
10.1073/pnas.0907200106 · 2009 · External reference
LnaB: a Legionella pneumophila activator of NF-kappaB
10.1111/j.1462-5822.2010.01452.x · 2010 · External reference
Ubiquitin ligases: structure, function, and regulation
10.1146/annurev-biochem-060815-014922 · 2017 · External reference
NLRP3 inflammasome in cancer and metabolic diseases
10.1038/s41590-021-00886-5 · 2021 · External reference
Canonical and non-canonical functions of NLRP3
10.1016/j.jare.2023.01.001 · 2023 · External reference
NLRP3 deficiency protects from type 1 diabetes through the regulation of chemotaxis into the pancreatic islets
10.1073/pnas.1513509112 · 2015 · External reference
An inflammasome-independent role for epithelial-expressed Nlrp3 in renal ischemia-reperfusion injury
10.4049/jimmunol.1002330 · 2010 · External reference
Legionella and mitochondria, an intriguing relationship
10.1016/bs.ircmb.2022.10.001 · 2023 · External reference
Identification of the ubiquitin ligase Triad1 as a regulator of endosomal transport
10.1242/bio.2012778 · 2012 · External reference
Bacteria make surgical strikes on host ubiquitin signaling
10.1371/journal.ppat.1009341 · 2021 · External reference
Inhibition of host vacuolar H+-ATPase activity by a Legionella pneumophila Effector
2010 · External reference
