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References from Tac1 deficiency reduces the severity of enteric bacterial infection. Local targets link to admitted publications; unresolved targets remain external evidence.
Mice lacking T and B lymphocytes develop transient colitis and crypt hyperplasia yet suffer impaired bacterial clearance during Citrobacter rodentium infection
10.1128/iai.70.4.2070-2081.2002 · 2002 · External reference
CD4(+) lymphoid tissue-inducer cells promote innate immunity in the gut
10.1016/j.immuni.2010.12.009 · 2011 · External reference
Th22 cells are an important source of IL-22 for host protection against enteropathogenic bacteria
10.1016/j.immuni.2012.08.024 · 2012 · External reference
Utility of the Citrobacter rodentium infection model in laboratory mice
10.1097/mog.0b013e3282f2b0fb · 2008 · External reference
Citrobacter rodentium: infection, inflammation and the microbiota
10.1038/nrmicro3315 · 2014 · External reference
Neuroimmune Communication in Health and Disease
10.1152/physrev.00035.2017 · 2018 · External reference
Neuroimmune Interactions in the Intestine
10.1146/annurev-immunol-101921-042929 · 2024 · External reference
The enteric nervous system
10.1152/physrev.00018.2022 · 2023 · External reference
The enteric nervous system and gastrointestinal innervation: integrated local and central control
10.1007/978-1-4939-0897-4_3 · 2014 · External reference
The capsaicin receptor: a heat-activated ion channel in the pain pathway
10.1038/39807 · 1997 · External reference
Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection
10.1016/j.cell.2022.09.008 · 2022 · External reference
Glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide stimulate release of substance P from TRPV1- and TRPA1-expressing sensory nerves
10.1152/ajpgi.00189.2019 · 2020 · External reference
Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens
10.1016/j.immuni.2020.10.001 · 2020 · External reference
C. difficile intoxicates neurons and pericytes to drive neurogenic inflammation
10.1038/s41586-023-06607-2 · 2023 · External reference
TRPV1 controls innate immunity during Citrobacter rodentium enteric infection
10.1371/journal.ppat.1011576 · 2023 · External reference
Sensory Nociceptive Neurons Contribute to Host Protection During Enteric Infection With Citrobacter rodentium
10.1093/infdis/jiaa014 · 2020 · External reference
Substance P receptor signaling contributes to host maladaptive responses during enteric bacterial infection
10.1073/pnas.2415287122 · 2025 · External reference
Substance P in sensory nerve fibres contributes to the development of oedema in the rat hind paw after thermal injury
10.1111/j.1476-5381.1984.tb16461.x · 1984 · External reference
Neuropeptides induce rapid expression of endothelial cell adhesion molecules and elicit granulocytic infiltration in human skin
10.4049/jimmunol.151.6.3274 · 1993 · External reference
Substance P induces the expression of intercellular adhesion molecule-1 on vascular endothelial cells and enhances neutrophil transendothelial migration
10.1016/0196-9781(95)00037-k · 1995 · External reference
Scratching promotes allergic inflammation and host defense via neurogenic mast cell activation
2025 · External reference
Characterization of putative interneurons in the myenteric plexus of human colon
10.1111/nmo.13964 · 2021 · External reference
Localisation and activation of the neurokinin 1 receptor in the enteric nervous system of the mouse distal colon
10.1007/s00441-014-1822-z · 2014 · External reference
Spatial differentiation of the intestinal epithelium: analysis of enteroendocrine cells containing immunoreactive serotonin, secretin, and substance P in normal and transgenic mice
10.1073/pnas.87.16.6408 · 1990 · External reference
Enteroendocrine cell types revisited
10.1016/j.coph.2013.09.018 · 2013 · External reference
A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin
10.1210/en.2012-1595 · 2012 · External reference
Dictamnine ameliorates chronic itch in DNFB-induced atopic dermatitis mice via inhibiting MrgprA3
10.1016/j.bcp.2022.115368 · 2023 · External reference
PrimerBank: a resource of human and mouse PCR primer pairs for gene expression detection and quantification
10.1093/nar/gkp1005 · 2010 · External reference
Enteric neuroimmune interactions coordinate intestinal responses in health and disease
10.1038/s41385-021-00443-1 · 2022 · External reference
Neuro-Immune Interactions at Barrier Surfaces
10.1016/j.cell.2016.04.041 · 2016 · External reference
Cellular Organization of Neuroimmune Interactions in the Gastrointestinal Tract
10.1016/j.it.2016.05.003 · 2016 · External reference
Gut-Innervating Nociceptor Neurons Regulate Peyer’s Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense
10.1016/j.cell.2019.11.014 · 2020 · External reference
Role of Substance P Neuropeptide in Inflammation, Wound Healing, and Tissue Homeostasis
10.4049/jimmunol.1601751 · 2017 · External reference
Hemokinin 1 is a full agonist at the substance P receptor
10.1038/ni1201-1088 · 2001 · External reference
Local effect of substance P on colonic motor activity in different experimental states
1989 · External reference
Effects of substance P on human colonic mucosa in vitro
1999 · External reference
Substance P induces ion secretion in mouse small intestine through effects on enteric nerves and mast cells
1995 · External reference
Role of Bacterial Intimin in Colonic Hyperplasia and Inflammation
10.1126/science.285.5427.588 · 1999 · External reference
Mice lacking T and B lymphocytes develop transient colitis and crypt hyperplasia yet suffer impaired bacterial clearance during Citrobacter rodentium infection
10.1128/iai.70.4.2070-2081.2002 · 2002 · External reference
CD4+ T cells drive goblet cell depletion during Citrobacter rodentium infection
10.1128/iai.00655-13 · 2013 · External reference
Modulation of inducible nitric oxide synthase expression by the attaching and effacing bacterial pathogen citrobacter rodentium in infected mice
10.1128/iai.70.11.6424-6435.2002 · 2002 · External reference
Impaired resistance and enhanced pathology during infection with a noninvasive, attaching-effacing enteric bacterial pathogen, Citrobacter rodentium, in mice lacking IL-12 or IFN-gamma
10.4049/jimmunol.168.4.1804 · 2002 · External reference
Anaerobic Respiration of NOX1-Derived Hydrogen Peroxide Licenses Bacterial Growth at the Colonic Surface
10.1016/j.chom.2020.10.009 · 2020 · External reference
Virulence factors enhance Citrobacter rodentium expansion through aerobic respiration
10.1126/science.aag3042 · 2016 · External reference
Activation of Mast-Cell-Expressed Mas-Related G-Protein-Coupled Receptors Drives Non-histaminergic Itch
10.1016/j.immuni.2019.03.013 · 2019 · External reference
The MRGPR family of receptors in immunity
10.1016/j.immuni.2023.12.012 · 2024 · External reference
Mast cells limit systemic bacterial dissemination but not colitis in response to Citrobacter rodentium
10.1128/iai.73.4.1978-1985.2005 · 2005 · External reference
Human monocytes and macrophages express substance P and neurokinin-1 receptor
10.4049/jimmunol.159.11.5654 · 1997 · External reference
Hypoalgesia in mice with a targeted deletion of the tachykinin 1 gene
10.1073/pnas.95.5.2630 · 1998 · External reference
Critical evaluation of the expression of gastrin-releasing peptide in dorsal root ganglia and spinal cord
10.1177/1744806916643724 · 2016 · External reference
The enteric nervous system and gastrointestinal innervation: integrated local and central control
10.1007/978-1-4939-0897-4_3 · ExternalCitation · doi-reference
Localisation and activation of the neurokinin 1 receptor in the enteric nervous system of the mouse distal colon
10.1007/s00441-014-1822-z · ExternalCitation · doi-reference
Substance P induces the expression of intercellular adhesion molecule-1 on vascular endothelial cells and enhances neutrophil transendothelial migration
10.1016/0196-9781(95)00037-k · ExternalCitation · doi-reference
Dictamnine ameliorates chronic itch in DNFB-induced atopic dermatitis mice via inhibiting MrgprA3
10.1016/j.bcp.2022.115368 · ExternalCitation · doi-reference
Neuro-Immune Interactions at Barrier Surfaces
10.1016/j.cell.2016.04.041 · ExternalCitation · doi-reference
Gut-Innervating Nociceptor Neurons Regulate Peyer’s Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense
10.1016/j.cell.2019.11.014 · ExternalCitation · doi-reference
Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection
10.1016/j.cell.2022.09.008 · ExternalCitation · doi-reference
Anaerobic Respiration of NOX1-Derived Hydrogen Peroxide Licenses Bacterial Growth at the Colonic Surface
10.1016/j.chom.2020.10.009 · ExternalCitation · doi-reference
Enteroendocrine cell types revisited
10.1016/j.coph.2013.09.018 · ExternalCitation · doi-reference
CD4(+) lymphoid tissue-inducer cells promote innate immunity in the gut
10.1016/j.immuni.2010.12.009 · ExternalCitation · doi-reference
Th22 cells are an important source of IL-22 for host protection against enteropathogenic bacteria
10.1016/j.immuni.2012.08.024 · ExternalCitation · doi-reference
Activation of Mast-Cell-Expressed Mas-Related G-Protein-Coupled Receptors Drives Non-histaminergic Itch
10.1016/j.immuni.2019.03.013 · ExternalCitation · doi-reference
Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens
10.1016/j.immuni.2020.10.001 · ExternalCitation · doi-reference
The MRGPR family of receptors in immunity
10.1016/j.immuni.2023.12.012 · ExternalCitation · doi-reference
Cellular Organization of Neuroimmune Interactions in the Gastrointestinal Tract
10.1016/j.it.2016.05.003 · ExternalCitation · doi-reference
The capsaicin receptor: a heat-activated ion channel in the pain pathway
10.1038/39807 · ExternalCitation · doi-reference
Hemokinin 1 is a full agonist at the substance P receptor
10.1038/ni1201-1088 · ExternalCitation · doi-reference
Citrobacter rodentium: infection, inflammation and the microbiota
10.1038/nrmicro3315 · ExternalCitation · doi-reference
Enteric neuroimmune interactions coordinate intestinal responses in health and disease
10.1038/s41385-021-00443-1 · ExternalCitation · doi-reference
C. difficile intoxicates neurons and pericytes to drive neurogenic inflammation
10.1038/s41586-023-06607-2 · ExternalCitation · doi-reference
Substance P receptor signaling contributes to host maladaptive responses during enteric bacterial infection
10.1073/pnas.2415287122 · ExternalCitation · doi-reference
Spatial differentiation of the intestinal epithelium: analysis of enteroendocrine cells containing immunoreactive serotonin, secretin, and substance P in normal and transgenic mice
10.1073/pnas.87.16.6408 · ExternalCitation · doi-reference
Hypoalgesia in mice with a targeted deletion of the tachykinin 1 gene
10.1073/pnas.95.5.2630 · ExternalCitation · doi-reference
Sensory Nociceptive Neurons Contribute to Host Protection During Enteric Infection With Citrobacter rodentium
10.1093/infdis/jiaa014 · ExternalCitation · doi-reference
PrimerBank: a resource of human and mouse PCR primer pairs for gene expression detection and quantification
10.1093/nar/gkp1005 · ExternalCitation · doi-reference
Utility of the Citrobacter rodentium infection model in laboratory mice
10.1097/mog.0b013e3282f2b0fb · ExternalCitation · doi-reference
Substance P in sensory nerve fibres contributes to the development of oedema in the rat hind paw after thermal injury
10.1111/j.1476-5381.1984.tb16461.x · ExternalCitation · doi-reference
Characterization of putative interneurons in the myenteric plexus of human colon
10.1111/nmo.13964 · ExternalCitation · doi-reference
Role of Bacterial Intimin in Colonic Hyperplasia and Inflammation
10.1126/science.285.5427.588 · ExternalCitation · doi-reference
Virulence factors enhance Citrobacter rodentium expansion through aerobic respiration
10.1126/science.aag3042 · ExternalCitation · doi-reference
CD4+ T cells drive goblet cell depletion during Citrobacter rodentium infection
10.1128/iai.00655-13 · ExternalCitation · doi-reference
Modulation of inducible nitric oxide synthase expression by the attaching and effacing bacterial pathogen citrobacter rodentium in infected mice
10.1128/iai.70.11.6424-6435.2002 · ExternalCitation · doi-reference
Mice lacking T and B lymphocytes develop transient colitis and crypt hyperplasia yet suffer impaired bacterial clearance during Citrobacter rodentium infection
10.1128/iai.70.4.2070-2081.2002 · ExternalCitation · doi-reference
Mast cells limit systemic bacterial dissemination but not colitis in response to Citrobacter rodentium
10.1128/iai.73.4.1978-1985.2005 · ExternalCitation · doi-reference
Neuroimmune Interactions in the Intestine
10.1146/annurev-immunol-101921-042929 · ExternalCitation · doi-reference
Glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide stimulate release of substance P from TRPV1- and TRPA1-expressing sensory nerves
10.1152/ajpgi.00189.2019 · ExternalCitation · doi-reference
The enteric nervous system
10.1152/physrev.00018.2022 · ExternalCitation · doi-reference
Neuroimmune Communication in Health and Disease
10.1152/physrev.00035.2017 · ExternalCitation · doi-reference
Critical evaluation of the expression of gastrin-releasing peptide in dorsal root ganglia and spinal cord
10.1177/1744806916643724 · ExternalCitation · doi-reference
A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin
10.1210/en.2012-1595 · ExternalCitation · doi-reference
TRPV1 controls innate immunity during Citrobacter rodentium enteric infection
10.1371/journal.ppat.1011576 · ExternalCitation · doi-reference
Neuropeptides induce rapid expression of endothelial cell adhesion molecules and elicit granulocytic infiltration in human skin
10.4049/jimmunol.151.6.3274 · ExternalCitation · doi-reference
Human monocytes and macrophages express substance P and neurokinin-1 receptor
10.4049/jimmunol.159.11.5654 · ExternalCitation · doi-reference
Role of Substance P Neuropeptide in Inflammation, Wound Healing, and Tissue Homeostasis
10.4049/jimmunol.1601751 · ExternalCitation · doi-reference
Impaired resistance and enhanced pathology during infection with a noninvasive, attaching-effacing enteric bacterial pathogen, Citrobacter rodentium, in mice lacking IL-12 or IFN-gamma
10.4049/jimmunol.168.4.1804 · ExternalCitation · doi-reference
