Research graph
References from Grass carp reovirus activates fish Ppp1r3g to suppress innate immunity and exacerbate hemorrhage via the 14-3-3ζ/Itgb3 signaling axis. Local targets link to admitted publications; unresolved targets remain external evidence.
RIG-I and other RNA sensors in antiviral immunity
10.1146/annurev-immunol-042617-053309 · 2018 · External reference
Viral evasion of intracellular DNA and RNA sensing
10.1038/nrmicro.2016.45 · 2016 · External reference
Innate immunity: the first line of defense against SARS-CoV-2
10.1038/s41590-021-01091-0 · 2022 · External reference
Structural mechanism of RNA recognition by the RIG-I-like receptors
10.1016/j.immuni.2008.07.009 · 2008 · External reference
Nod-like proteins in immunity, inflammation and disease
10.1038/ni1412 · 2006 · External reference
Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA
10.1126/science.1229963 · 2013 · External reference
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
10.1126/science.1232458 · 2013 · External reference
LGP2 is essential for zebrafish survival through dual regulation of IFN antiviral response
10.1016/j.isci.2022.104821 · 2022 · External reference
RIG-I-like receptors: their regulation and roles in RNA sensing
10.1038/s41577-020-0288-3 · 2020 · External reference
Subnanometer-resolution structures of the grass carp reovirus core and virion
10.1016/j.jmb.2008.06.075 · 2008 · External reference
Complete genome sequence and comparative analysis of grass carp reovirus strain 109 (GCReV-109) with other grass carp reovirus strains reveals no significant correlation with regional distribution
10.1007/s00705-014-2007-5 · 2014 · External reference
NLRP11 disrupts MAVS signalosome to inhibit type I interferon signaling and virus-induced apoptosis
10.15252/embr.201744480 · 2017 · External reference
Systems analysis of a RIG-I agonist inducing broad spectrum inhibition of virus infectivity
2013 · External reference
MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades
2013 · External reference
Zebrafish mylipb attenuates antiviral innate immunity through two synergistic mechanisms targeting transcription factor irf3
2024 · External reference
Interferon-inducible antiviral effectors
10.1038/nri2314 · 2008 · External reference
Cell-specific IRF-3 responses protect against West Nile virus infection by interferon-dependent and -independent mechanisms
10.1371/journal.ppat.0030106 · 2007 · External reference
Intracellular interferons in fish: a unique means to combat viral infection
2013 · External reference
Grass Carp Reovirus (GCRV) giving its all to suppress IFN production by countering MAVS signaling transduction
10.3389/fimmu.2020.545302 · 2020 · External reference
ATG5 negatively regulates grass carp reovirus-induced immune-inflammatory response by degrading RIG-I and MDA5
2025 · External reference
The dexd/H-box helicase DHX40 is a novel negative regulator during GCRV infection via targeting the host RLR helicases and viral nonstructural protein NS38
10.1016/j.fsi.2024.109730 · 2024 · External reference
Grass carp pyruvate kinase PKM acts as a key viral helper by orchestrating NS80-mediated VIB formation and multifaceted inhibition of the RLR-IFN-STAT1 antiviral cascade
10.1016/j.fsi.2026.111237 · 2026 · External reference
Coagulation and innate immune responses: can we view them separately?
10.1182/blood-2009-05-199208 · 2009 · External reference
Blood coagulation in immunothrombosis-At the frontline of intravascular immunity
10.1016/j.smim.2016.10.010 · 2016 · External reference
Thrombosis as an intravascular effector of innate immunity
10.1038/nri3345 · 2013 · External reference
IFN1 Enhances Thrombocyte Phagocytosis through IFN Receptor Complex-JAK/STAT-Complement C3.3-CR1 Pathway and Facilitates Antibacterial Immune Regulation in Teleost
10.4049/jimmunol.2200787 · 2023 · External reference
Deep Illumina sequencing reveals conserved and novel microRNAs in grass carp in response to grass carp reovirus infection
10.1186/s12864-017-3562-4 · 2017 · External reference
Inducible Nitric Oxide Synthase (iNOS) Mediates Vascular Endothelial Cell Apoptosis in Grass Carp Reovirus (GCRV)-Induced Hemorrhage
10.3390/ijms20246335 · 2019 · External reference
Comparison of the blood parameters and histopathology between grass carp infected with a virulent and avirulent isolates of genotype II grass carp reovirus
10.1016/j.micpath.2019.103859 · 2020 · External reference
The 14-3-3ζ-c-Src-integrin-β3 complex is vital for platelet activation
10.1182/blood.2019002314 · 2020 · External reference
Integrins: bidirectional, allosteric signaling machines
10.1016/s0092-8674(02)00971-6 · 2002 · External reference
Platelet-based coagulation: different populations, different functions
10.1111/jth.12045 · 2013 · External reference
The human platelet membrane proteome reveals several new potential membrane proteins
10.1074/mcp.m500209-mcp200 · 2005 · External reference
Identification of a novel 14-3-3zeta binding site within the cytoplasmic tail of platelet glycoprotein Ibalpha
10.1182/blood-2003-08-2881 · 2004 · External reference
Role of 14-3-3ζ in platelet glycoprotein Ibα-von Willebrand factor interaction-induced signaling
10.3390/ijms13055364 · 2012 · External reference
A functional 14-3-3zeta-independent association of PI3-kinase with glycoprotein Ib alpha, the major ligand-binding subunit of the platelet glycoprotein Ib-IX-V complex
10.1182/blood-2007-09-111096 · 2008 · External reference
Essential role of glycoprotein Ibα in platelet activation
10.1182/bloodadvances.2023012308 · 2024 · External reference
14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function
10.1038/ncomms12862 · 2016 · External reference
Mapping the binding domains of the alpha(IIb) subunit. A study performed on the activated form of the platelet integrin alpha(IIb)beta(3)
10.1046/j.1432-1033.2003.03762.x · 2003 · External reference
4’-O-methylbavachalcone B targeted 14-3-3ζ blocking the integrin β3 early outside-in signal to inhibit platelet aggregation and thrombosis
10.1021/acs.jafc.3c05211 · 2024 · External reference
Mechanosensing via a GpIIb/Src/14-3-3ζ axis critically regulates platelet migration in vascular inflammation
2023 · External reference
The 14-3-3zeta-GPIb-IX-V complex as an antiplatelet target
10.1358/dnp.2007.20.5.1120215 · 2007 · External reference
Phosphatases: providing safe passage through mitotic exit
10.1038/nrm3149 · 2011 · External reference
A substrate-trapping strategy for protein phosphatase PP1 holoenzymes using hypoactive subunit fusions
10.1074/jbc.ra118.004132 · 2018 · External reference
Functional diversity of protein phosphatase-1, a cellular economizer and reset button
10.1152/physrev.00013.2003 · 2004 · External reference
Emerging roles of the Protein Phosphatase 1 (PP1) in the context of viral infections
10.1186/s12964-023-01468-8 · 2024 · External reference
Dephosphorylation of the RNA sensors RIG-I and MDA5 by the phosphatase PP1 is essential for innate immune signaling
10.1016/j.immuni.2012.11.018 · 2013 · External reference
Positive regulation of TRAF6-dependent innate immune responses by protein phosphatase PP1-γ
10.1371/journal.pone.0089284 · 2014 · External reference
Porcine epidemic diarrhea virus nsp7 inhibits MDA5 dephosphorylation to antagonize type I interferon production
10.1128/spectrum.05017-22 · 2023 · External reference
The protein phosphatase 1 complex is a direct target of AKT that links insulin signaling to hepatic glycogen deposition
10.1016/j.celrep.2019.08.066 · 2019 · External reference
PPARγ links BMP2 and TGFβ1 pathways in vascular smooth muscle cells, regulating cell proliferation and glucose metabolism
10.1016/j.cmet.2017.03.011 · 2017 · External reference
RIPK1 dephosphorylation and kinase activation by PPP1R3G/PP1γ promote apoptosis and necroptosis
10.1038/s41467-021-27367-5 · 2021 · External reference
Protein phosphatase PP1 negatively regulates IRF3 in response to GCRV infection in grass carp (Ctenopharyngodon idella)
10.3389/fimmu.2020.609890 · 2021 · External reference
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus
10.1073/pnas.0603082103 · 2006 · External reference
Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine
10.1016/s0092-8674(00)81067-3 · 1996 · External reference
14-3-3 binding maintains the Parkinson’s associated kinase LRRK2 in an inactive state
10.1038/s41467-025-62337-1 · 2025 · External reference
Coevolution of the coagulation and immune systems
10.1007/s00011-018-01210-y · 2019 · External reference
Ablation of PPP1R3G reduces glycogen deposition and mitigates high-fat diet induced obesity
10.1016/j.mce.2016.10.036 · 2017 · External reference
Protein phosphatase 1 abrogates IRF7-mediated type I IFN response in antiviral immunity
10.1002/eji.201646491 · 2016 · External reference
Protein synthesis inhibition and GADD34 control IFN-β heterogeneous expression in response to dsRNA
10.15252/embj.201695000 · 2017 · External reference
Whole-body analysis of a viral infection: vascular endothelium is a primary target of infectious hematopoietic necrosis virus in zebrafish larvae
10.1371/journal.ppat.1001269 · 2011 · External reference
Cloning of six serpin genes and their responses to GCRV infection in grass carp (Ctenopharyngodon idella)
10.1016/j.fsi.2018.11.008 · 2019 · External reference
Analysis of the roles of 14-3-3 in the platelet glycoprotein Ib-IX-mediated activation of integrin alpha(IIb)beta(3) using a reconstituted mammalian cell expression model
10.1083/jcb.147.5.1085 · 1999 · External reference
Insights into the antiviral immunity against grass carp (Ctenopharyngodon idella) reovirus (GCRV) in grass carp
2015 · External reference
Type II grass carp reovirus utilizes autophagosomes for viroplasm formation and subclinical persistent infection
10.1128/jvi.00352-25 · 2025 · External reference
Recombinant baculovirus-produced grass carp reovirus virus-like particles as vaccine candidate that provides protective immunity against GCRV genotype II infection in grass carp
10.3390/vaccines9010053 · 2021 · External reference
Protein phosphatase 1 abrogates IRF7-mediated type I IFN response in antiviral immunity
10.1002/eji.201646491 · ExternalCitation · doi-reference
Coevolution of the coagulation and immune systems
10.1007/s00011-018-01210-y · ExternalCitation · doi-reference
Complete genome sequence and comparative analysis of grass carp reovirus strain 109 (GCReV-109) with other grass carp reovirus strains reveals no significant correlation with regional distribution
10.1007/s00705-014-2007-5 · ExternalCitation · doi-reference
The protein phosphatase 1 complex is a direct target of AKT that links insulin signaling to hepatic glycogen deposition
10.1016/j.celrep.2019.08.066 · ExternalCitation · doi-reference
PPARγ links BMP2 and TGFβ1 pathways in vascular smooth muscle cells, regulating cell proliferation and glucose metabolism
10.1016/j.cmet.2017.03.011 · ExternalCitation · doi-reference
Cloning of six serpin genes and their responses to GCRV infection in grass carp (Ctenopharyngodon idella)
10.1016/j.fsi.2018.11.008 · ExternalCitation · doi-reference
The dexd/H-box helicase DHX40 is a novel negative regulator during GCRV infection via targeting the host RLR helicases and viral nonstructural protein NS38
10.1016/j.fsi.2024.109730 · ExternalCitation · doi-reference
Grass carp pyruvate kinase PKM acts as a key viral helper by orchestrating NS80-mediated VIB formation and multifaceted inhibition of the RLR-IFN-STAT1 antiviral cascade
10.1016/j.fsi.2026.111237 · ExternalCitation · doi-reference
Structural mechanism of RNA recognition by the RIG-I-like receptors
10.1016/j.immuni.2008.07.009 · ExternalCitation · doi-reference
Dephosphorylation of the RNA sensors RIG-I and MDA5 by the phosphatase PP1 is essential for innate immune signaling
10.1016/j.immuni.2012.11.018 · ExternalCitation · doi-reference
LGP2 is essential for zebrafish survival through dual regulation of IFN antiviral response
10.1016/j.isci.2022.104821 · ExternalCitation · doi-reference
Subnanometer-resolution structures of the grass carp reovirus core and virion
10.1016/j.jmb.2008.06.075 · ExternalCitation · doi-reference
Ablation of PPP1R3G reduces glycogen deposition and mitigates high-fat diet induced obesity
10.1016/j.mce.2016.10.036 · ExternalCitation · doi-reference
Comparison of the blood parameters and histopathology between grass carp infected with a virulent and avirulent isolates of genotype II grass carp reovirus
10.1016/j.micpath.2019.103859 · ExternalCitation · doi-reference
Blood coagulation in immunothrombosis-At the frontline of intravascular immunity
10.1016/j.smim.2016.10.010 · ExternalCitation · doi-reference
Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine
10.1016/s0092-8674(00)81067-3 · ExternalCitation · doi-reference
Integrins: bidirectional, allosteric signaling machines
10.1016/s0092-8674(02)00971-6 · ExternalCitation · doi-reference
4’-O-methylbavachalcone B targeted 14-3-3ζ blocking the integrin β3 early outside-in signal to inhibit platelet aggregation and thrombosis
10.1021/acs.jafc.3c05211 · ExternalCitation · doi-reference
14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function
10.1038/ncomms12862 · ExternalCitation · doi-reference
Nod-like proteins in immunity, inflammation and disease
10.1038/ni1412 · ExternalCitation · doi-reference
Interferon-inducible antiviral effectors
10.1038/nri2314 · ExternalCitation · doi-reference
Thrombosis as an intravascular effector of innate immunity
10.1038/nri3345 · ExternalCitation · doi-reference
Phosphatases: providing safe passage through mitotic exit
10.1038/nrm3149 · ExternalCitation · doi-reference
Viral evasion of intracellular DNA and RNA sensing
10.1038/nrmicro.2016.45 · ExternalCitation · doi-reference
RIPK1 dephosphorylation and kinase activation by PPP1R3G/PP1γ promote apoptosis and necroptosis
10.1038/s41467-021-27367-5 · ExternalCitation · doi-reference
14-3-3 binding maintains the Parkinson’s associated kinase LRRK2 in an inactive state
10.1038/s41467-025-62337-1 · ExternalCitation · doi-reference
RIG-I-like receptors: their regulation and roles in RNA sensing
10.1038/s41577-020-0288-3 · ExternalCitation · doi-reference
Innate immunity: the first line of defense against SARS-CoV-2
10.1038/s41590-021-01091-0 · ExternalCitation · doi-reference
Mapping the binding domains of the alpha(IIb) subunit. A study performed on the activated form of the platelet integrin alpha(IIb)beta(3)
10.1046/j.1432-1033.2003.03762.x · ExternalCitation · doi-reference
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus
10.1073/pnas.0603082103 · ExternalCitation · doi-reference
A substrate-trapping strategy for protein phosphatase PP1 holoenzymes using hypoactive subunit fusions
10.1074/jbc.ra118.004132 · ExternalCitation · doi-reference
The human platelet membrane proteome reveals several new potential membrane proteins
10.1074/mcp.m500209-mcp200 · ExternalCitation · doi-reference
Analysis of the roles of 14-3-3 in the platelet glycoprotein Ib-IX-mediated activation of integrin alpha(IIb)beta(3) using a reconstituted mammalian cell expression model
10.1083/jcb.147.5.1085 · ExternalCitation · doi-reference
Platelet-based coagulation: different populations, different functions
10.1111/jth.12045 · ExternalCitation · doi-reference
Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA
10.1126/science.1229963 · ExternalCitation · doi-reference
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
10.1126/science.1232458 · ExternalCitation · doi-reference
Type II grass carp reovirus utilizes autophagosomes for viroplasm formation and subclinical persistent infection
10.1128/jvi.00352-25 · ExternalCitation · doi-reference
Porcine epidemic diarrhea virus nsp7 inhibits MDA5 dephosphorylation to antagonize type I interferon production
10.1128/spectrum.05017-22 · ExternalCitation · doi-reference
RIG-I and other RNA sensors in antiviral immunity
10.1146/annurev-immunol-042617-053309 · ExternalCitation · doi-reference
Functional diversity of protein phosphatase-1, a cellular economizer and reset button
10.1152/physrev.00013.2003 · ExternalCitation · doi-reference
Identification of a novel 14-3-3zeta binding site within the cytoplasmic tail of platelet glycoprotein Ibalpha
10.1182/blood-2003-08-2881 · ExternalCitation · doi-reference
A functional 14-3-3zeta-independent association of PI3-kinase with glycoprotein Ib alpha, the major ligand-binding subunit of the platelet glycoprotein Ib-IX-V complex
10.1182/blood-2007-09-111096 · ExternalCitation · doi-reference
Coagulation and innate immune responses: can we view them separately?
10.1182/blood-2009-05-199208 · ExternalCitation · doi-reference
The 14-3-3ζ-c-Src-integrin-β3 complex is vital for platelet activation
10.1182/blood.2019002314 · ExternalCitation · doi-reference
Essential role of glycoprotein Ibα in platelet activation
10.1182/bloodadvances.2023012308 · ExternalCitation · doi-reference
Deep Illumina sequencing reveals conserved and novel microRNAs in grass carp in response to grass carp reovirus infection
10.1186/s12864-017-3562-4 · ExternalCitation · doi-reference
Emerging roles of the Protein Phosphatase 1 (PP1) in the context of viral infections
10.1186/s12964-023-01468-8 · ExternalCitation · doi-reference
The 14-3-3zeta-GPIb-IX-V complex as an antiplatelet target
10.1358/dnp.2007.20.5.1120215 · ExternalCitation · doi-reference
Positive regulation of TRAF6-dependent innate immune responses by protein phosphatase PP1-γ
10.1371/journal.pone.0089284 · ExternalCitation · doi-reference
Cell-specific IRF-3 responses protect against West Nile virus infection by interferon-dependent and -independent mechanisms
10.1371/journal.ppat.0030106 · ExternalCitation · doi-reference
Whole-body analysis of a viral infection: vascular endothelium is a primary target of infectious hematopoietic necrosis virus in zebrafish larvae
10.1371/journal.ppat.1001269 · ExternalCitation · doi-reference
Protein synthesis inhibition and GADD34 control IFN-β heterogeneous expression in response to dsRNA
10.15252/embj.201695000 · ExternalCitation · doi-reference
NLRP11 disrupts MAVS signalosome to inhibit type I interferon signaling and virus-induced apoptosis
10.15252/embr.201744480 · ExternalCitation · doi-reference
Grass Carp Reovirus (GCRV) giving its all to suppress IFN production by countering MAVS signaling transduction
10.3389/fimmu.2020.545302 · ExternalCitation · doi-reference
Protein phosphatase PP1 negatively regulates IRF3 in response to GCRV infection in grass carp (Ctenopharyngodon idella)
10.3389/fimmu.2020.609890 · ExternalCitation · doi-reference
Role of 14-3-3ζ in platelet glycoprotein Ibα-von Willebrand factor interaction-induced signaling
10.3390/ijms13055364 · ExternalCitation · doi-reference
Inducible Nitric Oxide Synthase (iNOS) Mediates Vascular Endothelial Cell Apoptosis in Grass Carp Reovirus (GCRV)-Induced Hemorrhage
10.3390/ijms20246335 · ExternalCitation · doi-reference
Recombinant baculovirus-produced grass carp reovirus virus-like particles as vaccine candidate that provides protective immunity against GCRV genotype II infection in grass carp
10.3390/vaccines9010053 · ExternalCitation · doi-reference
IFN1 Enhances Thrombocyte Phagocytosis through IFN Receptor Complex-JAK/STAT-Complement C3.3-CR1 Pathway and Facilitates Antibacterial Immune Regulation in Teleost
10.4049/jimmunol.2200787 · ExternalCitation · doi-reference
