Research graph
References from Structural basis of diverse substrate recruitment by the HIV-1 Vpr-hijacked CRL4(VprBP) E3 ligase. Local targets link to admitted publications; unresolved targets remain external evidence.
Building and remodelling Cullin-RING E3 ubiquitin ligases
10.1038/embor.2013.173 · 2013 · External reference
Function and regulation of cullin-RING ubiquitin ligases
10.1038/nrm1547 · 2005 · External reference
The cullin protein family
10.1186/gb-2011-12-4-220 · 2011 · External reference
Chromatin-bound cullin-ring ligases: regulatory roles in DNA replication and potential targeting for cancer therapy
10.3389/fmolb.2018.00019 · 2018 · External reference
Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery
10.1038/nature05175 · 2006 · External reference
DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases
10.1101/gad.1483206 · 2006 · External reference
Ubiquitin ligases: structure, function, and regulation
2015 · External reference
Novel host restriction factors implicated in HIV-1 replication
10.1099/jgv.0.001026 · 2018 · External reference
Host cell restriction factors that limit influenza A infection
10.3390/v9120376 · 2017 · External reference
Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor
10.1038/nature17170 · 2016 · External reference
Simian Virus 5 V Protein Acts as an Adaptor, Linking DDB1 to STAT2, To Facilitate the Ubiquitination of STAT1
10.1128/jvi.79.21.13434-13441.2005 · 2005 · External reference
Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication
10.1016/j.molcel.2005.04.004 · 2005 · External reference
The DDB1-DCAF1-Vpr-UNG2 crystal structure reveals how HIV-1 Vpr steers human UNG2 toward destruction
10.1038/nsmb.3284 · 2016 · External reference
10.1186/1742-4690-2-11 · 2005 · Admitted local publication
Genetic diversity of Vif and Vpr accessory proteins in HIV-1 Group M clades
10.3390/v18010116 · 2026 · External reference
HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase
10.4161/cc.6.2.3732 · 2007 · External reference
Cytoplasmic retention of HIV-1 regulatory protein Vpr by protein-protein interaction with a novel human cytoplasmic protein VprBP
10.1016/s0378-1119(00)00583-7 · 2001 · External reference
HIV-1 Vpr loads uracil DNA glycosylase-2 onto DCAF1, a substrate recognition subunit of a cullin 4A-ring E3 ubiquitin ligase for proteasome-dependent degradation
10.1074/jbc.m110.133181 · 2010 · External reference
The HIV-1 protein Vpr targets the endoribonuclease Dicer for proteasomal degradation to boost macrophage infection
10.1016/j.virol.2013.06.010 · 2013 · External reference
Premature activation of the SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensing
10.1016/j.cell.2013.12.011 · 2014 · External reference
HIV-1 Vpr degrades the HLTF DNA translocase in T cells and macrophages
10.1073/pnas.1600485113 · 2016 · External reference
Vpr targets TET2 for degradation by CRL4VprBP E3 ligase to sustain IL-6 expression and enhance HIV-1 replication
10.1016/j.molcel.2018.05.007 · 2018 · External reference
HIV-1 Vpr protein enhances proteasomal degradation of MCM10 DNA replication factor through the Cul4-DDB1[VprBP] E3 ubiquitin ligase to induce G2/M cell cycle arrest
10.1074/jbc.m115.641522 · 2015 · External reference
Primate immunodeficiency virus proteins Vpx and Vpr counteract transcriptional repression of proviruses by the HUSH complex
10.1038/s41564-018-0256-x · 2018 · External reference
Structure of HIV-1 Vpr in complex with the human nucleotide excision repair protein hHR23A
10.1038/s41467-021-27009-w · 2021 · External reference
SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx
10.1038/nature10117 · 2011 · External reference
Evolutionary toggling of Vpx/Vpr specificity results in divergent recognition of the restriction factor SAMHD1
10.1371/journal.ppat.1003496 · 2013 · External reference
Discovery of new binders for DCAF1, an emerging ligase target in the targeted protein degradation field
10.1021/acsmedchemlett.3c00104 · 2023 · External reference
DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance
10.1038/s41467-023-44237-4 · 2024 · External reference
Targeted protein degradation by electrophilic PROTACs that stereoselectively and site-specifically engage DCAF1
10.1021/jacs.2c08964 · 2022 · External reference
Developments of CRBN-based PROTACs as potential therapeutic agents
10.1016/j.ejmech.2021.113749 · 2021 · External reference
Targeting the von Hippel-Lindau E3 ubiquitin ligase using small molecules to disrupt the VHL/HIF-1α interaction
10.1021/ja209924v · 2012 · External reference
PROTAC targeted protein degraders: The past is prologue
10.1038/s41573-021-00371-6 · 2022 · External reference
Application of HIV-1 viral protein R-derived-peptides as new E3 ligase-binding components of BRD4 degraders
10.1039/d5cb00125k · 2025 · External reference
Structural insights into Cullin4-RING ubiquitin ligase remodelling by Vpr from simian immunodeficiency viruses
10.1371/journal.ppat.1009775 · 2021 · External reference
DCAF1 (VprBP): emerging physiological roles for a unique dual-service E3 ubiquitin ligase substrate receptor
10.1093/jmcb/mjy085 · 2019 · External reference
GraFix: Sample preparation for single-particle electron cryomicroscopy
10.1038/nmeth1139 · 2008 · External reference
Pronounced sequence specificity of the TET enzyme catalytic domain guides its cellular function
10.1126/sciadv.abm2427 · 2022 · External reference
VprBP directs epigenetic gene silencing through histone H2A phosphorylation in colon cancer
10.1002/1878-0261.13068 · 2021 · External reference
Vpr-binding protein antagonizes p53-mediated transcription via direct interaction with H3 tail
10.1128/mcb.06037-11 · 2012 · External reference
VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation
10.1038/onc.2008.44 · 2008 · External reference
Structural basis of DDB1-and-Cullin 4-associated Factor 1 (DCAF1) recognition by merlin/NF2 and its implication in tumorigenesis by CD4-4-mediated inhibition of merlin suppression of DCAF1 function
10.1111/gtc.12161 · 2014 · External reference
Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus
10.1016/j.cell.2010.01.029 · 2010 · External reference
Novel functional features of the Lis-H domain: Role in protein dimerization, half-life and cellular localization
10.4161/cc.4.11.2151 · 2005 · External reference
Destabilization of the human RED-SMU1 splicing complex as a basis for host-directed antiinfluenza strategy
10.1073/pnas.1901214116 · 2019 · External reference
The structure of the N-terminal domain of the product of the lissencephaly gene Lis1 and its functional implications
10.1016/j.str.2004.03.024 · 2004 · External reference
A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex
2017 · External reference
Structure of DDB1 in complex with a paramyxovirus V protein: viral hijack of a propeller cluster in ubiquitin ligase
10.1016/j.cell.2005.10.033 · 2006 · External reference
Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex
10.1016/j.cell.2008.10.045 · 2008 · External reference
The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation
10.1016/j.cell.2011.10.035 · 2011 · External reference
Mutational analysis of Vpr-induced G2 arrest, nuclear localization, and cell death in fission yeast
10.1128/jvi.73.4.3236-3245.1999 · 1999 · External reference
UCSF ChimeraX: Meeting modern challenges in visualization and analysis
10.1002/pro.3235 · 2018 · External reference
Accurate structure prediction of biomolecular interactions with AlphaFold 3
10.1038/s41586-024-07487-w · 2024 · External reference
Rules of engagement: Molecular insights from host-virus arms races
10.1146/annurev-genet-110711-155522 · 2012 · External reference
Evolutionary insights into host-pathogen interactions from mammalian sequence data
10.1038/nrg3905 · 2015 · External reference
HIV-1 Vpr-mediated G2 arrest involves the DDB1-CUL4AVPRBP E3 ubiquitin ligase
2007 · External reference
Lentiviral Vpr usurps Cul4-DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycle
10.1073/pnas.0702102104 · 2007 · External reference
HIV-1 Vpr Reprograms CLR4DCAF1 E3 Ubiquitin Ligase to Antagonize Exonuclease 1-Mediated Restriction of HIV-1 Infection
2018 · External reference
EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex
10.1016/j.molcel.2012.09.004 · 2012 · External reference
CRL4(VprBP) E3 ligase promotes monoubiquitylation and chromatin binding of TET dioxygenases
10.1016/j.molcel.2014.12.002 · 2015 · External reference
The Cullin-RING E3 Ubiquitin Ligase CRL4−DCAF1 Complex Dimerizes via a Short Helical Region in DCAF1
10.1021/bi101749s · 2011 · External reference
The CRL4DCAF1 cullin-RING ubiquitin ligase is activated following a switch in oligomerization state
10.15252/embj.2021108008 · 2021 · External reference
Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide
10.1038/nature13527 · 2014 · External reference
The HIV-1 vpr R77Q mutant induces apoptosis, G2 cell cycle arrest, and lower production of pro-inflammatory cytokines in human CD4+ T Cells
10.3390/v16101642 · 2024 · External reference
Arginine residues in the C-terminus of HIV-1 Vpr are important for nuclear localization and cell cycle arrest
10.1006/viro.1998.9028 · 1998 · External reference
Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity
10.1038/s41467-024-54500-x · 2024 · External reference
MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy
10.1038/nmeth.4193 · 2017 · External reference
Gctf: Real-time CTF determination and correction
10.1016/j.jsb.2015.11.003 · 2016 · External reference
New tools for automated high-resolution cryo-EM structure determination in RELION-3
10.7554/elife.42166 · 2018 · External reference
cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination
10.1038/nmeth.4169 · 2017 · External reference
Topaz-Denoise: general deep denoising models for cryoEM and cryoET
10.1038/s41467-020-18952-1 · 2020 · External reference
DeepEMhancer: A deep learning solution for cryo-EM volume post-processing
10.1038/s42003-021-02399-1 · 2021 · External reference
Features and development of Coot
10.1107/s0907444910007493 · 2010 · External reference
High-resolution comparative modeling with RosettaCM
10.1016/j.str.2013.08.005 · 2013 · External reference
PHENIX: a comprehensive Python-based system for macromolecular structure solution
10.1107/s0907444909052925 · 2010 · External reference
