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References from Epithelial interferon-γ responsiveness shapes chemokine induction and clinical outcomes in herpes simplex virus infection. Local targets link to admitted publications; unresolved targets remain external evidence.
Estimated global and regional incidence and prevalence of herpes simplex virus infections and genital ulcer disease in 2020: mathematical modelling analyses
10.1136/sextrans-2024-056307 · 2025 · External reference
Genital herpes simplex virus infections: clinical manifestations, course, and complications
10.7326/0003-4819-98-6-958 · 1983 · External reference
Global and Regional Estimates of Prevalent and Incident Herpes Simplex Virus Type 1 Infections in 2012
10.1371/journal.pone.0140765 · 2015 · External reference
Frequent genital herpes simplex virus 2 shedding in immunocompetent women. Effect of acyclovir treatment
10.1172/jci119237 · 1997 · External reference
Persistence of HIV-1 receptor-positive cells after HSV-2 reactivation is a potential mechanism for increased HIV-1 acquisition
10.1038/nm.2006 · 2009 · External reference
Genital herpes has played a more important role than any other sexually transmitted infection in driving HIV prevalence in Africa
2008 · External reference
Unresolved reference
2021 · External reference
Virologic characteristics of subclinical and symptomatic genital herpes infections
10.1056/nejm199509213331205 · 1995 · External reference
Genital shedding of herpes simplex virus among symptomatic and asymptomatic persons with HSV-2 infection
10.1001/jama.2011.420 · 2011 · External reference
Rapidly cleared episodes of herpes simplex virus reactivation in immunocompetent adults
10.1086/591913 · 2008 · External reference
Tissue-resident T cells: dynamic players in skin immunity
10.3389/fimmu.2014.00332 · 2014 · External reference
Tissue-resident memory T cells: local specialists in immune defence
10.1038/nri.2015.3 · 2016 · External reference
An effector phenotype of CD8+ T cells at the junction epithelium during clinical quiescence of herpes simplex virus 2 infection
10.1128/jvi.01237-12 · 2012 · External reference
T cell memory. Resident memory CD8 T cells trigger protective innate and adaptive immune responses
10.1126/science.1254536 · 2014 · External reference
Virus-specific CD8+ T cells accumulate near sensory nerve endings in genital skin during subclinical HSV-2 reactivation
10.1084/jem.20061792 · 2007 · External reference
Tissue-resident memory T cells
10.1016/j.immuni.2014.12.007 · 2014 · External reference
Immune surveillance by CD8αα+ skin-resident T cells in human herpes virus infection
10.1038/nature12110 · 2013 · External reference
T cell memory. Skin-resident memory CD8⁺ T cells trigger a state of tissue-wide pathogen alert
10.1126/science.1254803 · 2014 · External reference
T-cells in human trigeminal ganglia express canonical tissue-resident memory T-cell markers
10.1186/s12974-022-02611-x · 2022 · External reference
Tissue-Resident-Memory CD8+ T Cells Bridge Innate Immune Responses in Neighboring Epithelial Cells to Control Human Genital Herpes
10.3389/fimmu.2021.735643 · 2021 · External reference
Rapid localized spread and immunologic containment define Herpes simplex virus-2 reactivation in the human genital tract
10.7554/elife.00288 · 2013 · External reference
Mucosal host immune response predicts the severity and duration of herpes simplex virus-2 genital tract shedding episodes
10.1073/pnas.1006614107 · 2010 · External reference
Tissue-resident T cell-derived cytokines eliminate herpes simplex virus-2-infected cells
10.1172/jci132583 · 2020 · External reference
Biologic functions of the IFN-gamma receptors
10.1034/j.1398-9995.1999.00099.x · 1999 · External reference
Interferon-gamma (IFN-γ): Exploring its implications in infectious diseases
10.1515/bmc-2018-0007 · 2018 · External reference
Interferon-stimulated genes and their antiviral effector functions
10.1016/j.coviro.2011.10.008 · 2011 · External reference
Immunomodulatory Role of Interferons in Viral and Bacterial Infections
10.3390/ijms241210115 · 2023 · External reference
Clearance of herpes simplex virus type 2 by CD8+ T cells requires gamma interferon and either perforin- or Fas-mediated cytolytic mechanisms
10.1128/jvi.79.23.14546-14554.2005 · 2005 · External reference
Dysregulated expression of IFN-gamma and IL-10 and impaired IFN-gamma-mediated responses at different disease stages in patients with genital herpes simplex virus-2 infection
10.1046/j.1365-2249.2003.02183.x · 2003 · External reference
Lymphokine-activated killer cell expansion for clinical trials of adoptive immunotherapy with interleukin-2: optimization of the culture technique
1990 · External reference
CXCL10/CXCR3-Dependent Mobilization of Herpes Simplex Virus-Specific CD8+ TEM and CD8+ TRM Cells within Infected Tissues Allows Efficient Protection against Recurrent Herpesvirus Infection and Disease
10.1128/jvi.00278-17 · 2017 · External reference
CXCL9 and CXCL10 expression are critical for control of genital herpes simplex virus type 2 infection through mobilization of HSV-specific CTL and NK cells to the nervous system
10.4049/jimmunol.180.2.1098 · 2008 · External reference
Herpes simplex virus selectively induces expression of the CC chemokine RANTES/CCL5 in macrophages through a mechanism dependent on PKR and ICP0
10.1128/jvi.76.6.2780-2788.2002 · 2002 · External reference
HSV-1 infection-induced herpetic neuralgia involves a CCL5/CCR5-mediated inflammation mechanism
2023 · External reference
IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses
10.1016/s1074-7613(00)80413-6 · 1996 · External reference
IL-12 gene as a DNA vaccine adjuvant in a herpes mouse model: IL-12 enhances Th1-type CD4+ T cell-mediated protective immunity against herpes simplex virus-2 challenge
10.4049/jimmunol.162.5.2912 · 1999 · External reference
Endogenous production of interleukin 15 by activated human monocytes is critical for optimal production of interferon-gamma by natural killer cells in vitro
10.1172/jci118321 · 1995 · External reference
Role of IL-15 in immune-mediated and infectious diseases
10.1016/j.cytogfr.2010.09.003 · 2011 · External reference
Nuclear interferon-inducible protein 16 promotes silencing of herpesviral and transfected DNA
10.1073/pnas.1316194110 · 2013 · External reference
IFI16 is an innate immune sensor for intracellular DNA
10.1038/ni.1932 · 2010 · External reference
Nuclear sensing of viral DNA, epigenetic regulation of herpes simplex virus infection, and innate immunity
10.1016/j.virol.2015.02.009 · 2015 · External reference
The T cell chemoattractant IFN-inducible protein 10 is essential in host defense against viral-induced neurologic disease
10.4049/jimmunol.165.5.2327 · 2000 · External reference
IP-10 is critical for effector T cell trafficking and host survival in Toxoplasma gondii infection
10.1016/s1074-7613(00)80200-9 · 2000 · External reference
IFN-gamma-inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and trafficking
10.4049/jimmunol.168.7.3195 · 2002 · External reference
The inflammatory chemokine CCL5 and cancer progression
10.1155/2014/292376 · 2014 · External reference
A vaccine strategy that protects against genital herpes by establishing local memory T cells
10.1038/nature11522 · 2012 · External reference
Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
10.1146/annurev.iy.13.040195.001343 · 1995 · External reference
IL-12 drives the differentiation of human T follicular regulatory cells
10.1126/sciimmunol.adf2047 · 2024 · External reference
Pretreatment of activated human CD8 T cells with IL-12 leads to enhanced TCR-induced signaling and cytokine production
10.1016/j.molimm.2016.11.008 · 2017 · External reference
The role of interleukin-15 in inflammation and immune responses to infection: implications for its therapeutic use
10.1016/j.micinf.2011.10.006 · 2012 · External reference
IL-15 in T-Cell Responses and Immunopathogenesis
2024 · External reference
An IL-15 adjuvant enhances the efficacy of a combined DNA vaccine against Brucella by increasing the CD8+ cytotoxic T cell response
10.1016/j.vaccine.2009.12.076 · 2010 · External reference
Adaptive immune responses fail to provide protection against genital HSV-2 infection in the absence of IL-15
10.1002/eji.200636997 · 2007 · External reference
Interleukin-15 and natural killer and NKT cells play a critical role in innate protection against genital herpes simplex virus type 2 infection
10.1128/jvi.77.18.10168-10171.2003 · 2003 · External reference
IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses
10.1073/pnas.0607038104 · 2007 · External reference
Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein
10.1073/pnas.1211302109 · 2012 · External reference
Herpes simplex virus infection of human fibroblasts and keratinocytes inhibits recognition by cloned CD8+ cytotoxic T lymphocytes
10.1172/jci116317 · 1993 · External reference
CXCL9, CXCL10, CXCL11/CXCR3 axis for immune activation - A target for novel cancer therapy
10.1016/j.ctrv.2017.11.007 · 2018 · External reference
Incorporation of the green fluorescent protein into the herpes simplex virus type 1 capsid
10.1128/jvi.72.9.7563-7568.1998 · 1998 · External reference
CCR5 is essential for NK cell trafficking and host survival following Toxoplasma gondii infection
2006 · External reference
A role for the CCR5-CCL5 interaction in the preferential migration of HSV-2-specific effector cells to the vaginal mucosa upon nasal immunization
10.1038/s41385-019-0203-z · 2019 · External reference
Specialized roles of the chemokine receptors CCR1 and CCR5 in the recruitment of monocytes and T(H)1-like/CD45RO(+) T cells
10.1182/blood.v97.4.1144 · 2001 · External reference
In vivo production of cytokines and beta (C-C) chemokines in human recurrent herpes simplex lesions--do herpes simplex virus-infected keratinocytes contribute to their production?
10.1086/515236 · 1998 · External reference
Evolution of recurrent herpes simplex lesions. An immunohistologic study
10.1172/jci111678 · 1985 · External reference
CXCL10 is critical for the progression and maintenance of depigmentation in a mouse model of vitiligo
10.1126/scitranslmed.3007811 · 2014 · External reference
Distribution and storage of inflammatory memory in barrier tissues
10.1038/s41577-019-0263-z · 2020 · External reference
Tissue-specific regulation of CXCL9/10/11 chemokines in keratinocytes: Implications for oral inflammatory disease
10.1371/journal.pone.0172821 · 2017 · External reference
Effect of Pinus massoniana bark extract on IFN-gamma-induced ICAM-1 expression in HaCaT human keratinocytes
10.1016/j.jep.2008.11.024 · 2009 · External reference
Combined interferon-gamma and tumor necrosis factor-alpha treatment differentially affects adhesion and migration of keratinocyte-derived cells to laminin-1
10.3109/15419060009015003 · 2000 · External reference
Alpha and gamma interferons inhibit herpes simplex virus type 1 infection and spread in epidermal cells after axonal transmission
10.1128/jvi.75.23.11821-11826.2001 · 2001 · External reference
Intact TRL 9 and type I interferon signaling pathways are required to augment HSV-1 induced corneal CXCL9 and CXCL10
10.1016/j.jneuroim.2006.06.020 · 2006 · External reference
Altered increase in STAT1 expression and phosphorylation in severe COVID-19
10.1002/eji.202149575 · 2022 · External reference
Comparative single-cell analysis reveals IFN-γ as a driver of respiratory sequelae after acute COVID-19
2024 · External reference
CXCL10 produced from hair follicles induces Th1 and Tc1 cell infiltration in the acute phase of alopecia areata followed by sustained Tc1 accumulation in the chronic phase
10.1016/j.jdermsci.2012.12.003 · 2013 · External reference
CXCL10 Chemokine: A Critical Player in RNA and DNA Viral Infections
10.3390/v14112445 · 2022 · External reference
A Method for Isolating and Culturing Skin Cells: Application to Endothelial Cells, Fibroblasts, Keratinocytes, and Melanocytes From Punch Biopsies in Systemic Sclerosis Skin
10.3389/fimmu.2020.566607 · 2020 · External reference
Immunodominance among herpes simplex virus-specific CD8 T cells expressing a tissue-specific homing receptor
10.1073/pnas.2131705100 · 2003 · External reference
