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References from The mitochondrial ubiquitin ligase MARCHF5 cooperates with MCL1 to inhibit apoptosis in KSHV-transformed primary effusion lymphoma cell lines. Local targets link to admitted publications; unresolved targets remain external evidence.
KSHV/HHV8-mediated hematologic diseases
10.1182/blood.2020005470 · 2022 · External reference
Kaposi’s sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas
10.1056/nejm199505043321802 · 1995 · External reference
KSHV-positive solid lymphomas represent an extra-cavitary variant of primary effusion lymphoma
10.1097/01.pas.0000138177.10829.5c · 2004 · External reference
Primary effusion lymphoma: A distinct clinicopathologic entity associated with the Kaposi’s sarcoma-associated herpes virus
10.1182/blood.v88.2.645.bloodjournal882645 · 1996 · External reference
Clinical features and outcome of primary effusion lymphoma in HIV-infected patients: A single-institution study
10.1200/jco.2003.06.013 · 2003 · External reference
Classic and extracavitary primary effusion lymphoma in 51 HIV-infected patients from a single institution
10.1002/ajh.24251 · 2016 · External reference
Prognosis in primary effusion lymphoma is associated with the number of body cavities involved
10.3109/10428194.2012.694075 · 2012 · External reference
Viral, immunologic, and clinical features of primary effusion lymphoma
10.1182/blood-2019-01-893339 · 2019 · External reference
Prognostic factors and outcome of human herpesvirus 8-associated primary effusion lymphoma in patients with AIDS
10.1200/jco.2005.07.084 · 2005 · External reference
Impact of Myc in HIV-associated non-Hodgkin lymphomas treated with EPOCH and outcomes with vorinostat (AMC-075 trial)
10.1182/blood.2019003959 · 2020 · External reference
Genetic characterization of HHV-8/KSHV-positive primary effusion lymphoma reveals frequent mutations of BCL6: Implications for disease pathogenesis and histogenesis
10.1002/(sici)1098-2264(199901)24:1<16::aid-gcc3>3.0.co;2-f · 1999 · External reference
Molecular characterization of HHV-8 positive primary effusion lymphoma reveals pathogenetic and histogenetic features of the disease
10.1016/s1386-6532(99)00082-7 · 2000 · External reference
Functional p53 signaling in Kaposi’s sarcoma-associated herpesvirus lymphomas: Implications for therapy
10.1128/jvi.01757-06 · 2007 · External reference
Interleukin 1 receptor-associated kinase 1 (IRAK1) mutation is a common, essential driver for Kaposi sarcoma herpesvirus lymphoma
2014 · External reference
Gene essentiality landscape and druggable oncogenic dependencies in herpesviral primary effusion lymphoma
10.1038/s41467-018-05506-9 · 2018 · External reference
Druggable host gene dependencies in primary effusion lymphoma
10.1016/j.coviro.2022.101270 · 2022 · External reference
The landscape of somatic copy-number alteration across human cancers
10.1038/nature08822 · 2010 · External reference
MCL-1 expression in B-cell non-Hodgkin’s lymphomas
10.1016/j.humpath.2004.04.018 · 2004 · External reference
High expression of MCL1 gene related to vascular endothelial growth factor is associated with poor outcome in non-Hodgkin’s lymphoma
10.1046/j.1365-2141.2002.03253.x · 2002 · External reference
The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models
10.1038/nature19830 · 2016 · External reference
BCL2 and MCL1 inhibitors for hematologic malignancies
10.1182/blood.2020006785 · 2021 · External reference
Cell death
10.1016/j.cell.2023.11.044 · 2024 · External reference
BAX, BAK, and BOK: A coming of age for the BCL-2 family effector proteins
10.1101/cshperspect.a036319 · 2020 · External reference
Expression ratios of the antiapoptotic BCL2 family members dictate the selective addiction of Kaposi’s sarcoma-associated herpesvirus-transformed primary effusion lymphoma cell lines to MCL1
10.1128/jvi.01360-22 · 2022 · External reference
Inhibition of MCL1 induces apoptosis in anaplastic large cell lymphoma and in primary effusion lymphoma
10.1038/s41598-022-04916-6 · 2022 · External reference
Kaposi’s sarcoma-associated herpesvirus latency-associated nuclear antigen dysregulates expression of MCL-1 by targeting FBW7
2021 · External reference
Defining a cancer dependency map
10.1016/j.cell.2017.06.010 · 2017 · External reference
Gene essentiality profiling reveals gene networks and synthetic lethal interactions with oncogenic ras
10.1016/j.cell.2017.01.013 · 2017 · External reference
Interrogation of mammalian protein complex structure, function, and membership using genome-scale fitness screens
2018 · External reference
A genome-wide atlas of co-essential modules assigns function to uncharacterized genes
10.1038/s41588-021-00840-z · 2021 · External reference
A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics
10.1038/sj.emboj.7601249 · 2006 · External reference
MARCH-V is a novel mitofusin 2- and Drp1-binding protein able to change mitochondrial morphology
10.1038/sj.embor.7400790 · 2006 · External reference
The mitochondrial ubiquitin ligase MARCH5 resolves MAVS aggregates during antiviral signalling
10.1038/ncomms8910 · 2015 · External reference
Inhibition of MARCH5 ubiquitin ligase abrogates MCL1-dependent resistance to BH3 mimetics via NOXA
10.18632/oncotarget.7558 · 2016 · External reference
MARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1:NOXA complex
10.1038/s41418-020-0517-0 · 2020 · External reference
MARCH5 mediates NOXA-dependent MCL1 degradation driven by kinase inhibitors and integrated stress response activation
10.7554/elife.54954 · 2020 · External reference
Novel regulatory roles of Mff and Drp1 in E3 ubiquitin ligase MARCH5-dependent degradation of MiD49 and Mcl1 and control of mitochondrial dynamics
10.1091/mbc.e16-04-0208 · 2017 · External reference
Kaposi’s sarcoma-associated herpesvirus drives a super-enhancer-mediated survival gene expression program in primary effusion lymphoma
10.1128/mbio.01457-20 · 2020 · External reference
Self-clearance mechanism of mitochondrial E3 ligase MARCH5 contributes to mitochondria quality control
10.1111/febs.13568 · 2016 · External reference
The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division
10.1083/jcb.200611064 · 2007 · External reference
An important role for mitochondrial antiviral signaling protein in the Kaposi’s sarcoma-associated herpesvirus life cycle
10.1128/jvi.03226-13 · 2014 · External reference
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
10.1038/nature07317 · 2008 · External reference
The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation
10.1016/j.immuni.2008.09.003 · 2008 · External reference
Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens
10.1038/ncomms15178 · 2017 · External reference
MARCH5 regulates mitotic apoptosis through MCL1-dependent and independent mechanisms
10.1038/s41418-022-01080-2 · 2023 · External reference
Reactivation of the p53 pathway as a treatment modality for KSHV-induced lymphomas
10.1172/jci30945 · 2007 · External reference
Kaposi’s sarcoma-associated herpesvirus encodes a functional bcl-2 homologue
10.1038/nm0397-293 · 1997 · External reference
Structural insight into KsBcl-2 mediated apoptosis inhibition by Kaposi sarcoma associated herpes virus
10.3390/v14040738 · 2022 · External reference
BH3 domains define selective inhibitory interactions with BHRF-1 and KSHV BCL-2
10.1038/sj.cdd.4402292 · 2008 · External reference
Ubiquitin ligase MARCH5 localizes to peroxisomes to regulate pexophagy
10.1083/jcb.202103156 · 2022 · External reference
Outer mitochondrial membrane E3 Ub ligase MARCH5 controls mitochondrial steps in peroxisome biogenesis
2023 · External reference
Integrated systems biology analysis of KSHV latent infection reveals viral induction and reliance on peroxisome mediated lipid metabolism
10.1371/journal.ppat.1006256 · 2017 · External reference
Efficacy of bortezomib in a direct xenograft model of primary effusion lymphoma
10.1073/pnas.1002985107 · 2010 · External reference
A phase 1 first-in-human study of the MCL-1 inhibitor AZD5991 in patients with relapsed/refractory hematologic malignancies
10.1158/1078-0432.ccr-24-0028 · 2024 · External reference
Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients
10.1038/s43856-023-00380-z · 2023 · External reference
Prostratin and bortezomib are novel inducers of latent Kaposi’s sarcoma-associated herpesvirus
10.1177/135965350501000609 · 2005 · External reference
Patterns of microRNA expression characterize stages of human B-cell differentiation
10.1182/blood-2008-09-178186 · 2009 · External reference
CRISPR screens identify novel regulators of cFLIP dependency and ligand-independent, TRAIL-R1-mediated cell death
10.1038/s41418-023-01133-0 · 2023 · External reference
