Research graph
References from Salmonella infection and biofilms drive anti-C1q and anti-dsDNA autoantibodies in systemic autoimmunity. Local targets link to admitted publications; unresolved targets remain external evidence.
Divergent roles of antiself antibodies during infection
10.1016/j.it.2018.04.003 · 2018 · External reference
Autoantibodies in nonautoimmune individuals during infections
10.1196/annals.1422.061 · 2007 · External reference
ANA testing in the presence of acute and chronic infections
10.1080/15321819.2016.1174136 · 2016 · External reference
Cell protein fractions of bovine and avian tubercle bacillus strains and of the timothy-grass bacillus
10.1016/s0021-9258(18)74098-2 · 1938 · External reference
The isolation of the components of streptococcal nucleoproteins in serologically active form
10.1016/s0021-9258(18)74048-9 · 1938 · External reference
The sensitizing properties of the nucleic acids and their derivatives
10.1126/science.90.2337.356.a · 1939 · External reference
The anti-DNA antibody: Origin and impact, dogmas and controversies
10.1038/nrrheum.2015.69 · 2015 · External reference
Autoantibodies predate the onset of systemic lupus erythematosus in northern Sweden
10.1186/ar3258 · 2011 · External reference
Development of anti-dsDNA autoantibodies prior to clinical diagnosis of systemic lupus erythematosus
10.1046/j.1365-3083.2001.00959.x · 2001 · External reference
Responsiveness of autoimmune and normal mice to nucleic acid antigens
10.4049/jimmunol.132.2.872 · 1984 · External reference
Induction of anti-double stranded DNA antibodies in normal mice by immunization with bacterial DNA
10.4049/jimmunol.142.5.1482 · 1989 · External reference
Induction of inflammatory and immune responses by HMGB1–nucleosome complexes: Implications for the pathogenesis of SLE
10.1084/jem.20081165 · 2008 · External reference
Triggers of autoimmunity: The role of bacterial infections in the extracellular exposure of lupus nuclear autoantigens
10.3389/fimmu.2019.02608 · 2019 · External reference
Autoantibodies in SLE: Specificities, isotypes and receptors
10.3390/antib5010002 · 2016 · External reference
Insights into the epidemiology and management of lupus nephritis from the U.S. Rheumatologist’s perspective
10.1016/j.kint.2016.03.042 · 2016 · External reference
Update on lupus nephritis
10.2215/cjn.05780616 · 2017 · External reference
Causes and predictors of mortality in biopsy-proven lupus nephritis: The Sarawak experience
10.1093/ckj/sfx063 · 2018 · External reference
Linking complement and anti-dsDNA antibodies in the pathogenesis of systemic lupus erythematosus
10.1007/s12026-012-8345-z · 2013 · External reference
Association of autoantibody concentrations and trajectories with lupus nephritis histologic features and treatment response
10.1002/art.42941 · 2024 · External reference
Anti-C1q antibodies have higher correlation with flares of lupus nephritis than other serum markers
10.1177/0961203311411597 · 2011 · External reference
High levels of antibodies against Clq are associated with disease activity and nephritis but not with other organ manifestations in SLE patients
2001 · External reference
Anti-C1q antibodies in nephritis: Correlation between titres and renal disease activity and positive predictive value in systemic lupus erythematosus
10.1136/ard.2004.024943 · 2005 · External reference
Predictive value of IgG autoantibodies against C1q for nephritis in systemic lupus erythematosus
10.1136/ard.52.12.851 · 1993 · External reference
Lack of occurrence of severe lupus nephritis among anti-C1q autoantibody-negative patients
10.1002/1529-0131(199901)42:1<187::aid-anr24>3.0.co;2-u · 1999 · External reference
The pathogenesis of lupus nephritis
2014 · External reference
The classification of glomerulonephritis in systemic lupus erythematosus revisited
10.1111/j.1523-1755.2004.00443.x · 2004 · External reference
Role of nucleosomes for induction and glomerular binding of autoantibodies in lupus nephritis
10.1097/00041552-199905000-00005 · 1999 · External reference
Glomerular apoptotic nucleosomes are central target structures for nephritogenic antibodies in human SLE nephritis
10.1038/sj.ki.5002133 · 2007 · External reference
Nephritogenic lupus antibodies recognize glomerular basement membrane-associated chromatin fragments released from apoptotic intraglomerular cells
10.2353/ajpath.2006.051329 · 2006 · External reference
A prospective study of anti-chromatin and anti-C1q autoantibodies in patients with proliferative lupus nephritis treated with cyclophosphamide pulses or azathioprine/methylprednisolone
10.1136/ard.2006.065425 · 2007 · External reference
High prevalence of anti-C1q antibodies in biopsy-proven active lupus nephritis
10.1093/ndt/gfl436 · 2006 · External reference
Anti-C1q autoantibodies deposit in glomeruli but are only pathogenic in combination with glomerular C1q-containing immune complexes
10.1172/jci200421075 · 2004 · External reference
Human anti-C1q autoantibodies bind specifically to solid-phase C1q and enhance phagocytosis but not complement activation
10.1073/pnas.2310666120 · 2023 · External reference
Anti-C1q autoantibodies amplify pathogenic complement activation in systemic lupus erythematosus
10.1172/jci200422820 · 2004 · External reference
Autoantibodies to the collagen-like region of C1Q deposit in glomeruli via C1Q in immune deposits
10.1016/s0090-1229(05)80030-3 · 1991 · External reference
Infection in systemic lupus erythematosus
10.1016/s0889-857x(05)70016-8 · 1998 · External reference
Risk factors for drug-resistant bloodstream infections in patients with systemic lupus erythematosus
10.3899/jrheum.131261 · 2014 · External reference
Infectious diseases in systemic lupus erythematosus: Risk factors, management and prophylaxis
10.1053/berh.2001.0226 · 2002 · External reference
Incidence of infection in systemic lupus erythematosus
10.1002/art.1780170102 · 1974 · External reference
Salmonella infection in systemic lupus erythematosus
10.1177/096120339300200110 · 1993 · External reference
Persistent bacteriuria and antibodies recognizing curli/eDNA complexes from escherichia coli are linked to flares in systemic lupus erythematosus
10.1002/art.41400 · 2020 · External reference
Risk factors and bacterial profiles of urinary tract infections in patients with systemic lupus erythematosus
2007 · External reference
Bacterial infections in lupus: Roles in promoting immune activation and in pathogenesis of the disease
10.1016/j.jtauto.2020.100078 · 2020 · External reference
Salmonella infections in patients with systemic lupus erythematosus: A case series
10.1111/j.1756-185x.2009.01440.x · 2009 · External reference
Major infections in a cohort of 120 patients with juvenile-onset systemic lupus erythematosus
10.1016/j.clim.2013.08.009 · 2013 · External reference
Non-thyphoidal salmonellosis in patients with systemic lupus erythematosus. A study of fifty patients and a review of the literature
10.1191/096120301675973164 · 2001 · External reference
Risk factors of mortality for salmonella infection in systemic lupus erythematosus
2002 · External reference
Salmonella bacteremia in systemic lupus erythematosus. Eight-year experience at a municipal hospital
10.1002/art.1780280112 · 1985 · External reference
An autoimmunogenic and proinflammatory profile defined by the gut microbiota of patients with untreated systemic lupus erythematosus
10.1002/art.41511 · 2021 · External reference
Gut microbiome and metabolites in systemic lupus erythematosus: Link, mechanisms and intervention
10.3389/fimmu.2021.686501 · 2021 · External reference
Intestinal dysbiosis associated with systemic lupus erythematosus
10.1128/mbio.01548-14 · 2014 · External reference
Microbiome and metabolome analyses reveal the disruption of lipid metabolism in systemic lupus erythematosus
10.3389/fimmu.2020.01703 · 2020 · External reference
Changes of intestinal flora in patients with systemic lupus erythematosus in northeast China
2019 · External reference
Proteobacteria: Microbial signature of dysbiosis in gut microbiota
10.1016/j.tibtech.2015.06.011 · 2015 · External reference
The level of peripheral regulatory T cells is linked to changes in gut commensal microflora in patients with systemic lupus erythematosus
2021 · External reference
Outgrowth of Escherichia is susceptible to aggravation of systemic lupus erythematosus
10.1186/s13075-024-03413-7 · 2024 · External reference
Salmonella Typhimurium Co-Opts the Host Type I IFN System To Restrict Macrophage Innate Immune Transcriptional Responses Selectively
10.4049/jimmunol.1500105 · 2015 · External reference
Gut inflammation provides a respiratory electron acceptor for Salmonella
10.1038/nature09415 · 2010 · External reference
The dynamics of gut-associated microbial communities during inflammation
10.1038/embor.2013.27 · 2013 · External reference
Host-derived nitrate boosts growth of E. coli in the inflamed gut
10.1126/science.1232467 · 2013 · External reference
Salmonella uses energy taxis to benefit from intestinal inflammation
10.1371/journal.ppat.1003267 · 2013 · External reference
Respiration of microbiota-derived 1,2-propanediol drives Salmonella expansion during colitis
10.1371/journal.ppat.1006129 · 2017 · External reference
Systemic exposure to bacterial amyloid curli alters the gut mucosal immune response and the microbiome, exacerbating Salmonella-induced arthritis
10.1080/19490976.2023.2221813 · 2023 · External reference
Amyloid-DNA composites of bacterial biofilms stimulate autoimmunity
10.1016/j.immuni.2015.06.002 · 2015 · External reference
In vivo synthesis of bacterial amyloid curli contributes to joint inflammation during S. Typhimurium infection
10.1371/journal.ppat.1008591 · 2020 · External reference
Assembly of ordered DNA-curli fibril complexes during Salmonella biofilm formation correlates with strengths of the type I interferon and autoimmune responses
10.1371/journal.ppat.1010742 · 2022 · External reference
Biofilms: Survival mechanisms of clinically relevant microorganisms
10.1128/cmr.15.2.167-193.2002 · 2002 · External reference
Biofilms: Microbial shelters against antibiotics
External reference
Microbial biofilms
10.1146/annurev.mi.49.100195.003431 · 1995 · External reference
Curli fibers are required for development of biofilm architecture in Escherichia coli K-12 and enhance bacterial adherence to human uroepithelial cells
10.1111/j.1348-0421.2005.tb03678.x · 2005 · External reference
Bistable expression of CsgD in Salmonella enterica serovar Typhimurium connects virulence to persistence
10.1128/iai.00137-15 · 2015 · External reference
Escherichia coli biofilms have an organized and complex extracellular matrix structure
10.1128/mbio.00645-13 · 2013 · External reference
Disease to dirt: the biology of microbial amyloids
10.1371/journal.ppat.1003740 · 2013 · External reference
Cytotoxic curli intermediates form during Salmonella biofilm development
10.1128/jb.00095-19 · 2019 · External reference
Bacterial amyloid curli acts as a carrier for DNA to elicit an autoimmune response via TLR2 and TLR9
10.1371/journal.ppat.1006315 · 2017 · External reference
Bacterial amyloid curli activates the host unfolded protein response via IRE1α in the presence of HLA-B27
10.1080/19490976.2024.2392877 · 2024 · External reference
A temporary cholesterol-rich diet and bacterial extracellular matrix factors favor Salmonella spp. biofilm formation in the cecum
10.1128/mbio.03242-24 · 2025 · External reference
CsgA is a pathogen-associated molecular pattern of Salmonella enterica serotype Typhimurium that is recognized by Toll-like receptor 2
10.1111/j.1365-2958.2005.04825.x · 2005 · External reference
Toll-like receptors 1 and 2 cooperatively mediate immune responses to curli, a common amyloid from enterobacterial biofilms
10.1111/j.1462-5822.2010.01485.x · 2010 · External reference
Toll-like receptor 2 and NLRP3 cooperate to recognize a functional bacterial amyloid, curli
10.1128/iai.02370-14 · 2015 · External reference
Microbial amyloids induce interleukin 17A (IL-17A) and IL-22 responses via Toll-like receptor 2 activation in the intestinal mucosa
10.1128/iai.00911-12 · 2012 · External reference
Serum Amyloid A3 fuels a feed-forward inflammatory response to the bacterial amyloid curli in the enteric nervous system
10.1016/j.jcmgh.2024.03.013 · 2024 · External reference
Autoantibodies to the collagenous region of C1q occur in three strains of lupus-prone mice
10.1046/j.1365-2249.1996.19725.x · 1996 · External reference
Salmonella typhimurium persists within macrophages in the mesenteric lymph nodes of chronically infected Nramp1+/+ mice and can be reactivated by IFNgamma neutralization
10.1084/jem.20031319 · 2004 · External reference
Identification of a pathogenicity island required for Salmonella survival in host cells
10.1073/pnas.93.15.7800 · 1996 · External reference
Cloning and molecular characterization of genes whose products allow Salmonella typhimurium to penetrate tissue culture cells
10.1073/pnas.86.16.6383 · 1989 · External reference
Cachexia in systemic lupus erythematosus: risk factors and relation to disease activity and damage
10.1002/acr.24395 · 2021 · External reference
Biofilm-associated bacterial amyloids dampen inflammation in the gut: Oral treatment with curli fibres reduces the severity of hapten-induced colitis in mice
10.1038/npjbiofilms.2015.19 · 2015 · External reference
Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease
10.1084/jem.20061341 · 2006 · External reference
Bacterial amyloids promote type I interferon production and accelerate autoimmunity (BA6P.124)
10.4049/jimmunol.194.supp.114.5 · 2015 · External reference
Successful treatment of autoimmunity in NZB/NZW F1 mice with monoclonal antibody to L3T4
10.1084/jem.161.2.378 · 1985 · External reference
Cardiovascular changes in the NZB/W F1 mouse model of lupus nephritis
10.3389/fcvm.2023.1182193 · 2023 · External reference
Temporal hemodynamic changes in a female mouse model of systemic lupus erythematosus
2020 · External reference
Anti-double-stranded DNA antibodies, nucleosomes, and systemic lupus erythematosus: A time for new paradigms?
10.1002/art.10739 · 2003 · External reference
Novel Monoclonal Antibodies Against Mouse C1q: Characterisation and Development of a Quantitative ELISA for Mouse C1q
10.1007/s12035-021-02419-5 · 2021 · External reference
Lupus nephritis is linked to disease-activity associated expansions and immunity to a gut commensal
10.1136/annrheumdis-2018-214856 · 2019 · External reference
Longitudinal gut microbiome analyses and blooms of pathogenic strains during lupus disease flares
10.1136/ard-2023-223929 · 2023 · External reference
Translocation of a gut pathobiont drives autoimmunity in mice and humans
10.1126/science.aar7201 · 2018 · External reference
Fibrillation of the major curli subunit CsgA under a wide range of conditions implies a robust design of aggregation
10.1021/bi200967c · 2011 · External reference
Nucleation and growth of a bacterial functional amyloid at single-fiber resolution
10.1038/nchembio.2413 · 2017 · External reference
Role of Escherichia coli curli operons in directing amyloid fiber formation
10.1126/science.1067484 · 2002 · External reference
Autoimmunity to nucleosomes related to viral infection: A focus on hapten-carrier complex formation
10.1016/s0896-8411(02)00110-5 · 2003 · External reference
Antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptors
10.1084/jem.160.4.1102 · 1984 · External reference
Antigen-specific induction of antibodies against native mammalian DNA in nonautoimmune mice
10.4049/jimmunol.151.3.1614 · 1993 · External reference
Staphylococcus aureus peptidoglycan (PGN) induces pathogenic autoantibody production via autoreactive B cell receptor clonal selection, implications in systemic lupus erythematosus
10.1016/j.jaut.2022.102860 · 2022 · External reference
Pathogenic strains of a gut commensal drive systemic platelet activation and thromboinflammation in lupus nephritis
2025 · External reference
B cells expressing the transcription factor T-bet drive lupus-like autoimmunity
10.1172/jci91250 · 2017 · External reference
Plasmodium DNA-mediated TLR9 activation of T-bet B cells contributes to autoimmune anaemia during malaria
10.1038/s41467-017-01476-6 · 2017 · External reference
The functional amyloid curli protects Escherichia coli against complement-mediated bactericidal activity
10.3390/biom8010005 · 2018 · External reference
Impaired autophagy in amyloid-beta pathology: A traditional review of recent Alzheimer’s research
10.7555/jbr.36.20220145 · 2022 · External reference
Impaired clearance of dying cells in systemic lupus erythematosus
10.1016/j.autrev.2004.10.007 · 2005 · External reference
Complement deficiencies and systemic lupus erythematosus
10.1080/08916930701510673 · 2007 · External reference
Expanding the role of complement therapies: The case for lupus nephritis
10.3390/jcm10040626 · 2021 · External reference
Marked variability in clinical presentation and outcome of patients with C1q immunodeficiency
10.1016/j.jaut.2015.06.002 · 2015 · External reference
C1q, autoimmunity and apoptosis
10.1078/0171-2985-00141 · 2002 · External reference
Autoantibodies against complement C1q specifically target C1q bound on early apoptotic cells1
10.4049/jimmunol.0803573 · 2009 · External reference
C1q deficiency and autoimmunity: The effects of genetic background on disease expression
10.4049/jimmunol.168.5.2538 · 2002 · External reference
An update on lupus animal models
10.1097/bor.0000000000000412 · 2017 · External reference
The MRL/lpr mouse strain as a model for neuropsychiatric systemic lupus erythematosus
10.1155/2011/207504 · 2011 · External reference
Ethanolamine utilization in Salmonella typhimurium: Nucleotide sequence, protein expression, and mutational analysis of the cchA cchB eutE eutJ eutG eutH gene cluster
10.1128/jb.177.5.1357-1366.1995 · 1995 · External reference
Lipocalin-2 resistance confers an advantage to Salmonella enterica serotype Typhimurium for growth and survival in the inflamed intestine
10.1016/j.chom.2009.03.011 · 2009 · External reference
The Vi capsular antigen of Salmonella enterica serotype Typhi reduces Toll-like receptor-dependent interleukin-8 expression in the intestinal mucosa
10.1128/iai.73.6.3367-3374.2005 · 2005 · External reference
Pretreatment of mice with streptomycin provides a Salmonella enterica serovar Typhimurium colitis model that allows analysis of both pathogen and host
10.1128/iai.71.5.2839-2858.2003 · 2003 · External reference
Sialic acid-binding lectin (leczyme) induces apoptosis to malignant mesothelioma and exerts synergistic antitumor effects with TRAIL
10.3892/ijo.2013.2192 · 2014 · External reference
Persistence of Disease-Associated Anti-Citrullinated Protein Antibody-Expressing Memory B Cells in Rheumatoid Arthritis in Clinical Remission
10.1002/art.40053 · 2017 · External reference
Myeloid dendritic cells from B6.NZM Sle1/Sle2/Sle3 lupus-prone mice express an IFN signature that precedes disease onset
10.4049/jimmunol.1101686 · 2012 · External reference
IRF7 controls spontaneous autoimmune germinal center and plasma cell checkpoints
2025 · External reference
