Research graph
References from Targeting the Cav1.2-KCa1.1 axis prevents rabies virus internalization and protects against lethal infection. Local targets link to admitted publications; unresolved targets remain external evidence.
Human rabies: Neuropathogenesis, diagnosis, and management
10.1016/s1474-4422(13)70038-3 · 2013 · External reference
Rabies
10.1038/nrdp.2017.91 · 2017 · External reference
Update on rabies
2011 · External reference
Lyssaviruses and rabies: Current conundrums, concerns, contradictions and controversies
10.12688/f1000research.10416.1 · 2017 · External reference
Current status of rabies and prospects for elimination
10.1016/s0140-6736(13)62707-5 · 2014 · External reference
Estimating the global burden of endemic canine rabies
10.1371/journal.pntd.0003709 · 2015 · External reference
Tools to therapeutically harness the human antibody response
10.1038/nri3285 · 2012 · External reference
The cell biology of rabies virus: Using stealth to reach the brain
10.1038/nrmicro2260 · 2010 · External reference
Synthetic peptides corresponding to sequences of snake venom neurotoxins and rabies virus glycoprotein bind to the nicotinic acetylcholine receptor
10.1002/prot.340020406 · 1987 · External reference
The neural cell adhesion molecule is a receptor for rabies virus
10.1128/jvi.72.9.7181-7190.1998 · 1998 · External reference
Low-affinity nerve-growth factor receptor (P75NTR) can serve as a receptor for rabies virus
10.1093/emboj/17.24.7250 · 1998 · External reference
Metabotropic glutamate receptor subtype 2 is a cellular receptor for rabies virus
10.1371/journal.ppat.1007189 · 2018 · External reference
Rabies virus utilizes neuropilin 2 as an endocytic receptor to trigger TGFBR1-mediated actin polymerization
2025 · External reference
Transferrin receptor protein 1 is an entry factor for rabies virus
10.1128/jvi.01612-22 · 2023 · External reference
The Serine/Threonine Kinase AP2-associated kinase 1 plays an important role in rabies virus entry
10.3390/v12010045 · 2019 · External reference
Integrin β1 promotes peripheral entry by rabies virus
10.1128/jvi.01819-19 · 2020 · External reference
Rabies pathogenesis
10.1080/13550280290100725 · 2002 · External reference
Ion channels as therapeutic targets for viral infections: further discoveries and future perspectives
10.3390/v12080844 · 2020 · External reference
Ion channel drug discovery: Challenges and future directions
10.4155/fmc.12.4 · 2012 · External reference
Host calcium channels and pumps in viral infections
10.3390/cells9010094 · 2019 · External reference
Ebola virus. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment
10.1126/science.1258758 · 2015 · External reference
Diltiazem inhibits SARS-CoV-2 cell attachment and internalization and decreases the viral infection in mouse lung
10.1371/journal.ppat.1010343 · 2022 · External reference
A sialylated voltage-dependent Ca2+ channel binds hemagglutinin and mediates influenza A virus entry into mammalian cells
10.1016/j.chom.2018.04.015 · 2018 · External reference
Identification of potassium and calcium channel inhibitors as modulators of polyomavirus endosomal trafficking
10.1016/j.antiviral.2020.104819 · 2020 · External reference
Modulation of potassium channels inhibits bunyavirus infection
10.1074/jbc.m115.692673 · 2016 · External reference
Influenza virus uses mGluR2 as an endocytic receptor to enter cells
10.1038/s41564-024-01713-x · 2024 · External reference
Claudin-11 plays a pivotal role in the clathrin-mediated endocytosis of influenza A virus
10.1007/s11427-024-2856-y · 2025 · External reference
Anomalies in the dosing of diltiazem
10.1002/clc.4960230105 · 2000 · External reference
Diltiazem inhibits coronary spasm via inhibition of Cav1.2Phosphorylation and protein kinase C activation in a mouse model of coronary spastic angina
10.1536/ihj.20-366 · 2021 · External reference
Paxilline inhibits BK channels by an almost exclusively closed-channel block mechanism
10.1085/jgp.201411259 · 2014 · External reference
Glycine311, a determinant of paxilline block in BK channels: a novel bend in the BK S6 helix
10.1085/jgp.201010403 · 2010 · External reference
KCa1.1 channels regulate β 1 ‐integrin function and cell adhesion in rheumatoid arthritis fibroblast‐like synoviocytes
10.1096/fj.201601097r · 2017 · External reference
BKCa-Cav channel complexes mediate rapid and localized Ca2+-activated K+ signaling
10.1126/science.1132915 · 2006 · External reference
Diltiazem: Ten years of clinical experience in the treatment of hypertension
10.1002/j.1552-4604.1995.tb04051.x · 1995 · External reference
Transfer of high sensitivity for benzothiazepines from L-type to class A (BI) calcium channels
10.1074/jbc.271.40.24471 · 1996 · External reference
Interaction of diltiazem with an intracellularly accessible binding site on Ca(V)1.2
10.1111/j.1476-5381.2010.01091.x · 2011 · External reference
Structural bases of inhibitory mechanism of CaV1.2 channel inhibitors
10.1038/s41467-024-47116-8 · 2024 · External reference
Pharmacokinetics of diltiazem and other calcium entry blockers
10.1111/j.1600-0773.1985.tb03570.x · 1985 · External reference
Penetration into and elimination from the cerebrospinal fluid of diltiazem, a calcium antagonist, in anesthetized rabbits
1986 · External reference
Safety and clinical efficacy of human rabies immunoglobulin in post exposure prophylaxis for category III animal exposures
10.1080/21645515.2022.2081024 · 2022 · External reference
Human rabies: A 2016 update
10.1007/s11908-016-0540-y · 2016 · External reference
Human rabies treatment-from palliation to promise
10.3390/v16010160 · 2024 · External reference
Re-evaluating the burden of rabies in Africa and Asia
2005 · External reference
Exposure history, post-exposure prophylaxis use, and clinical characteristics of human rabies cases in China, 2006-2012
10.1038/s41598-018-35158-0 · 2018 · External reference
DrugBank 5.0: A major update to the DrugBank database for 2018
10.1093/nar/gkx1037 · 2018 · External reference
Diltiazem. A reappraisal of its pharmacological properties and therapeutic use
1990 · External reference
The use of diltiazem hydrochloride in cardiovascular disorders
10.1002/j.1875-9114.1982.tb04518.x · 1982 · External reference
Diltiazem. A review of its pharmacological properties and therapeutic efficacy
1985 · External reference
Amlodipine and diltiazem significantly repress human rotavirus infection in vitro
10.2174/2772434418666221107105624 · 2023 · External reference
Diltiazem HCl suppresses porcine reproductive and respiratory syndrome virus infection in susceptible cells and in swine
10.1016/j.vetmic.2024.110054 · 2024 · External reference
Porcine deltacoronavirus (PDCoV) modulates calcium influx to favor viral replication
10.1016/j.virol.2019.10.011 · 2020 · External reference
An attenuated rabies vaccine for domestic animals produced in tissue culture
1964 · External reference
Recombinant canine distemper virus serves as bivalent live vaccine against rabies and canine distemper
10.1016/j.vaccine.2012.06.001 · 2012 · External reference
Genetically modified rabies virus ERA strain is safe and induces long-lasting protective immune response in dogs after oral vaccination
10.1016/j.antiviral.2015.06.011 · 2015 · External reference
